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Differentiation of Menstrual Blood Derived Stem Cell (MensSCs) to hepatocyte-Liked Cell on Three Dimensional Nanofiberscaffold: Poly Caprolacton (PCL)

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Journal of Biomedical Science and Engineering 2016年第4期9卷 216-225页

作者： Farnaz Sani Giti Borzooeian Somayeh Kazemnejad Sepideh Ebrahimi Masoomeh Mohamadpour Sayeh Khanjani Mona Latifi Seyed Mojtaba hosseini Mahin Salmannejad Fatemeh Aleahmad hossein Mehraban Jahromi Mahsa Sani Laboratory for Stem Cell Research Anatomy Department Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran Departments of Embryology and Stem Cells Reproductive Biotechnology Research Center Avicenna Research Institute ACECR Tehran Iran Department of Biochemistry Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Anatomy Histomorphometry and Stereology Research Center Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran

Menstrual blood stem cells (MensSCs) have enormous potential as a source for cell replacement therapies. Since there is a major concern in utilization of nanofibers in tissue engineering of stem cells, we examined the potential of MensSCs to differentiate into hepatocytes, using different protocols and compare cells, with two-dimensional (2D) and three-dimensional (3D) culture systems. Cell characterization experiments of MensSCs have demonstrated that they are multipotent stem cells similar to mesenchymal stem cells, which can successfully differentiate into osteogenic and adipogenic lineages. The efficiency of the cells on the scaffold was appraised by scanning electron microscopy (SEM), MTT assay, and hematoxylin and eosin (h&E) staining. Thereafter, the differentiation protocols were developed by hepatocyte growth factor (hGF) and oncostatin M (OSM) with serum-supplemented or serum-free culture media up to 30 days. Immunofluorescence analysis and ELISA assay revealed the expression of albumin (ALB) in differentiated cells. hepatocyte-like cells expressed liver-specific gene such as albumin(ALB), α-fetoprotein (AFP), tyrosine aminotransferase (TAT) and cytochrome P450 subunit 7a1 (Cyp7a1) at mRNA levels. In conclusion, the evidences presented in this study show that the nanofiber scaffold and MensSCs may provide a source of differentiated cells for treatment of liver diseases.

关键词： Differentiation hepatocyte Menstrual Blood Stem Cell 3D Cultures

应用新型探头瞬时弹性成像对肥胖病人非酒精性脂肪肝进行无创性分期

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国际医学放射学杂志 2010年第6期 591-592页

作者： M.Friedrich-Rust h.hadji-hosseini S.Kriener E.herrmann I.Sircar A.Kau 何岸苇 Department of Internal Medicine 1 Johann Wolfgang Goethe-University HospitalTheodor-Stern-Kai 760590Frankfurt am MainGermany.Mireen

目的瞬时弹性成像(TE)在非酒精性脂肪肝(NAFLD)和脂肪肝(NASh)病人的肝纤维化分期中已显示出显著的结果,而25%的肥胖病人使用标准TE探头时不能检查出上述病变。这项研究的目的是评价一种新型的XL

关键词：超声纤维扫描肝脏活检脂肪肝非酒精性脂肪肝

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视网膜脱离手术后LASIK

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 58-58页

作者： Farvardin M. hosseini h. 宋虎平(译) Department of Ophthalmology Khalili Hospital Shiraz University of Medical Sciences Shiraz 71934 Iran 不详

Purpose:To compare,in the same individuals,the safety and efficacy of laser in situ keratomileusis(LASIK)in eyes with and without previous retinal detachment ***:In a prospective clinical trial,seven myopic patients who had previously undergone scleral buckling surgery in one eye underwent conventional LASIK surgery in both *** visual acuity(UCVA),best corrected visual acuity(BCVA),refraction,Orbscan topography and pachymetry were recorded before and 1,3,6 and 12 months after *** eyes were divided into two groups:group 1 consisted of eyes that had undergone previous surgery for retinal detachment,and group 2 consisted of the fellow eyes of the same patients,which had not undergone any previous ocular ***’ s t-test for match-paired data was used to evaluate the significance of ***:LASIK was performed successfully in all *** UCVA improved in all eyes in both *** mean change in the spherical equivalent between 1 and 12 months after LASIK surgery was 1.7± 1.1 and 0.6± 0.5 diopter in groups 1 and 2,respectively(p=0.019).Conclusion:LASIK may be considered for treatment of myopia in eyes that have had previous surgery for retinal ***,the risk of regression may be higher in such eyes than in eyes with no previous scleral buckling surgery.

关键词： LASIK 视网膜脱离手术后

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弹性基础上的变厚度径向功能梯度扇形板的振动分析

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钢结构(中英文) 2010年第9期 82-82页

作者： Sh.hosseini-hashemi h.Rokni Damavandi Taher h.Akhavan

在Pasternak弹性基础上,对变厚度径向功能梯度圆(环)扇形薄板进行自振分析。基于古典板理论,利用微积分方法分别求解简支和固支边界条件下的自振频率。假定薄板的径向杨氏模量和质量密度呈指数变化,泊松比恒定。研究频率的收敛性以检查... 详细信息

在Pasternak弹性基础上,对变厚度径向功能梯度圆(环)扇形薄板进行自振分析。基于古典板理论,利用微积分方法分别求解简支和固支边界条件下的自振频率。假定薄板的径向杨氏模量和质量密度呈指数变化,泊松比恒定。研究频率的收敛性以检查求解的可行性。将结果与已有文献数据对比,验证了本方法的精确性。

关键词：自由振动功能梯度扇形板变厚度弹性基础微积分方法

无名动脉闭锁与原发性抗磷脂综合征的联系:血管成形术的治疗(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 53-53页

作者： Dumurgier J. Desgranges P. Chapoy E h. hosseini 王晓琳 Service de Neurologie CHU Henri Mondor 94010 Cré teil Cedex France

Introduction. Antiphospholipid syndrome may be associated with stroke. Case report. We report a case of a symptomatic occlusion of the innominate artery in a 37- year- old patient, who developed primary anti- phospholipid syndrome. This association, to our knowledge, has not been reported in the literature. Occlusion of the innominate artery was treated by angioplastystenting. Effective oral anticoagulation was given to prevent a new thrombotic event. Conclusion. Systematic search for antiphospholipid antibodies is needed as part of the etiology work- up in young stroke victims.

关键词：动脉闭锁抗磷脂综合征血管成形术脑梗死病文献报道抗凝剂

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儿科日间手术中超重（或肥胖症）与胃液特性的关系：在禁食指南和误吸风险评估方面的意义

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麻醉与镇痛 2010年第6期6卷 38-49页

作者： Scott D. Cook-Sather Paul R. Gallagher Lydia E. Kruge Jonathan M. Beus Brian P. Ciampa Kevin Conor Welch Sina Shah.hosseini Jieun S. Choi Reshma Pachikara Kim Minger Ronald S. Litman Mark S. Schreiner 周洁(译) 李士通(校) Departments of Anesthesiology and Critical Care Medicine Departments of Biostatistics and Epidemiology Nursing The Children's Hospital of Philadelphia The University of Pennsylvania School of Medicine Philadelphia Pennsylvania 不详

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假... 详细信息

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假设不管是体重指数还是禁食时间均不会对GFV或胃液ph值产生显著的影响。所有受试儿童均于手术前禁清水2小时，并假设超重或肥胖患儿的GFV不会多于偏瘦或正常体重患儿，而呕吐或误吸的风险也很低。方法本研究中连续纳入了1000例2－12岁行日间手术的患儿，记录人口统计学资料、病史、身高和体重。另外纳入1000例需全麻插管的日间手术患儿（2。12岁）进行研究。气管插管后，经口插入一根14—18F的胃管，抽空胃内容物。用药情况、禁食时间、GFV、ph值和呕吐事件均被详细记录。采用疾病预防及控制中心的生长图表（2000）评定理想体重（IBW=第50个百分位数），并对患儿进行分层：偏瘦或正常体重（BMI在第25—75个百分位数）、超重（第95个百分位数〈BMI≥第85个百分位数）、肥胖（BMI≥第95个百分位数）。结果在所有的日间手术患儿中有14％属于超重，13．3％属于肥胖。肥胖儿按公斤体重算出的GFV较低（P〈0．001）。当我们用IBW进行校正后，所有BMI组中GFV（mw校正后）的容量都相等（均值为0．96ml／kg，SD为0．71；中位数为0．86ml／kg，IQR为0．96）。手术前使用对乙酰氨基酚和咪达唑仑均导致GFV（1BW校正后）增加（P=0．025和P=0．001）。而ASA11I级（P=0．024）、男性（P=0．012）、胃食管反流性疾病（P=0．049）和使用质子泵抑制剂（P=0．018）患儿的GFV（mw校正后）较低。GFV（IBw校正后）与禁食时间和年龄无关。胃液酸度较低与年龄较小（P=0．005）、BMI较高（P=0．036）和美国非洲裔（P=0．033）患儿等因素相关。有8例患儿在全麻诱导时发生了呕吐（其中50％有肥胖症，P=0．052，75％患有阻塞性睡眠呼吸暂停症，P=0．061）。呕吐与ASA分级较高有关，但却与禁食时间的长短无关。研究中没有出现误吸事件。结论27％的儿科日闻手术患儿属超重或肥胖儿童。无论进食时间长短或BMI如何，GFV（IBw校正后）均为1ml／kg，因此这些患儿均可以在手术前2小时饮清水。在此研究群体中，罕见的呕吐事件与禁食时间的缩短并无相关性。

关键词：禁食时间儿科患者风险评估肥胖症超重症胃液量误吸阻塞性睡眠呼吸暂停症