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无损检测 1995年第1期17卷 28-30页

作者： R.Kawase h.haraguchi T.hamamoto 孙国平

本研究旨在建立热喷涂陶瓷涂层超声无损评价的方法。热喷涂二氧化二铝涂层中的超声速度由所试制的实验装置测得,并对超声速度与喷涂涂层特性的关系作了探讨。

关键词：超声检验覆层陶瓷热喷涂

ICP/AES法测定地质样品中的稀土元素——草酸盐沉淀和离子交换分离

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国外铀金地质 1991年第1期7卷 88-92页

作者： K.Iwasaki h.haraguchi 刘然

本文叙述了一种分离测定地质样品中14个稀土元素(REEs)的方法,它是相继以钙作载体草酸盐沉淀稀土和硝酸体系离子交换分离之后,用等离子体发射光谱测定。当仅用离子交换分离时,特别是富铁、钙样品,发现Sm、Eu、Gd的回收率低,两种分离技... 详细信息

本文叙述了一种分离测定地质样品中14个稀土元素(REEs)的方法,它是相继以钙作载体草酸盐沉淀稀土和硝酸体系离子交换分离之后,用等离子体发射光谱测定。当仅用离子交换分离时,特别是富铁、钙样品,发现Sm、Eu、Gd的回收率低,两种分离技术和结合可以使这种情况得到改善。此法已用于分析地质标准物质,NBS SRM693(玄武岩)、NBS SRM278(黑曜岩)、GSJ JB-1(玄武岩)、GS JA-2(安山岩)和CCRMP SY-3(正长岩)。在球粒陨石归一化稀土元素分布模式的基础上评价了本方法的分析结果。

关键词：地质样品稀土元素测定 ICP AES

等离子喷涂WC-Co-Ni涂层的高频感应加热后处理

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中国表面工程 1999年第3期12卷 42-44页

作者： MatsubaraY TomiguchiA haraguchi h hayashi h Itoh. 王华仁东方汽轮机厂表面工程研究所

Preparation and Evaluation of Poly-γ-Glutamic Acid hydrogel Mixtures with Basic Drugs or Acidic Drugs: Effect on Ease of Swallowing and Taste Masking

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Pharmacology & Pharmacy 2019年第10期10卷 427-444页

作者： honami Kojima Saeri Ikegami Shiho Nakamura haruka Nishikawa Tamami haraguchi Miyako Yoshida Minoru Ozeki Ikuo Kawasaki Takahiro Uchida Faculty of Pharmaceutical Sciences Mukogawa Women’s University Nishinomiya Japan

The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste sensor. Using TPA, 0.5% and 1.0% PGA gels, 0.5% and 1.0% agar and 1.0% ι-carrageenan in the absence of drug was examined the hardness, adhesiveness and cohesiveness, ranked according to permission criteria published by the Japanese Consumers Affairs Agency. 0.5% PGA gel and 1.0% agar were classified into grade II. In the taste sensor measurement, the bitterness suppressions by 0.5% PGA gel were larger than that by 1.0% agar in all drugs and the bitterness suppressions of basic drugs in 0.5% PGA gel were more potent than those of acidic drugs in 0.5% PGA gel. 1h-nuclear magnetic resonance spectroscopic analysis was carried out to examine the difference in mechanism of bitterness suppression between basic drugs and acidic drugs mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of basic drugs shifted clearly upfield, suggesting an interaction between the amino group of basic drugs and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs;it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred.

关键词： Poly-γ-Glutamic Acid hydrogel Bitterness Taste Sensor

Evolution of the East Asian monsoon inferred from environmental magnetic record from Lake Biwa,central Japan

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地球环境学报 2011年第1期 313-313页

作者： hayashida A Yamamoto T Yasuda M Tanigawa Y Ishikawa N Kitagawa h Torii M haraguchi T Takemura K Affiliated Institution Doshisha University Institute of Geothermal Sciences Kyoto University

Lake Biwa,located in central Japan,contains a thick sedimentary sequence deposited in lacustrine or fluvial environments during the *** and magnetostratigraphic analysis of deep-drilling cores from the central basin showed that about 800 m thick sediment has been deposited for the last 1.3 *** uppermost 250 m clay unit has provided important paleoclimate records,which can be correlated to major glacial-interglacial cycles for the last 0.45 ***,the Lake Biwa sediment is expected to offer detailed records of Asian monsoon activity from the Middle Pleistocene to the *** demonstrate that anhysteretic remanent magnetization(ARM),a measure of magnetic mineral content in sediment,provides a good proxy of hydrological changes around Lake Biwa since the last glacial *** low-field magnetic susceptibility is most widely used for stratigraphic correlation of core samples and detection of paleoenvironmental changes,ARM is more sensitive to concentration of ferrimagnetic minerals such as small magnetite *** previous study on a piston-core recovered in 1995 revealed that the ARM increases in the postglacial interval and that the variation in the lower part is likely linked to millennial-scale climate changes during the last glacial *** finding was confirmed by analysis of new piston-cores recovered from other sites in *** ARM records reproducibly extend back to 46 ka,featuring major interstadials of Dansgaard-Oeschger cycles and heinrich *** ARM record shows variation similar to total organic carbon(TOC) content,suggesting that flux of finegrained magnetite was increased during the post-glacial and interstadial warm periods as well as flux of wash in nutrients and organic matter.A high-resolution pollen analysis showed that the ARM peaks correspond to regional vegetation response with rapid climate changes in the last glacial *** interpret that the increased ARM represents enhanced precipitation pro

关键词： Lake Evolution of the East Asian monsoon inferred from environmental magnetic record from Lake Biwa,central Japan ARM

生物钟缺陷的Cry-null小鼠的盐敏感性高血压的发生与肾上腺hsd3b6的功能失调有关

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中华高血压杂志 2010年第7期18卷 699-699页

作者：张玲玉叶鹏 Doi M Takahashi Y Komatsu R Yamazaki F Yamada h.haraguchi S Emoto N Okuno Y Tsujimoto G Kanematsu A Ogawa O Todo T Tsut-sui K van der horst GT Okamura h

生物钟功能失调与多种疾病的发生有关。缺乏主要生物钟组成成分隐花色素1(Cryptochrome-1,Cry1)和隐花色素2(Cryptochrome-2,Cry2)的小鼠(Cry-null mice),由于肾上腺不正常地,过高地合成盐皮质激素醛固酮,从而发生盐敏感性高血压。为寻... 详细信息

生物钟功能失调与多种疾病的发生有关。缺乏主要生物钟组成成分隐花色素1(Cryptochrome-1,Cry1)和隐花色素2(Cryptochrome-2,Cry2)的小鼠(Cry-null mice),由于肾上腺不正常地,过高地合成盐皮质激素醛固酮,从而发生盐敏感性高血压。为寻求上述现象的发生机制,通过大量的研究发现,小鼠的Ⅳ型3-β羟基类固醇脱氢酶(3beta-hydroxyl-steroid de-hydrogenase,hsd3b6)是新的高血压危险因子。hsd3b6仅表达于醛固酮生成细胞,其转录受生物钟调控。[第一段]

关键词：盐敏感性高血压生物钟调控功能失调小鼠肾上腺醛固酮发生机制类固醇脱氢酶隐花色素