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肝硬化门静脉高压症:采用2D电影相位对比MRI技术测量奇静脉血流量间接评价肝静脉压力梯度

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国际医学放射学杂志 2016年第5期 580-580页

作者： h.gouya S.Grabar O.Vignaux A.Saade S.Pol P.Legmann 贾芳莹 Department of Radiology H?pital Cochin and Paris-Descartes University Assistance Publique-H?pitaux de Paris

摘要目的采用2D电影相位对比法MRI测量肝硬化病人的奇静脉、门静脉、主动脉血流量,与肝静脉压力梯度测量值比较,确定MRI的价值。方法纳入69例肝硬化。所有病人接受以下检查:肝静脉压力梯度测量、上胃肠道内镜检

关键词：肝静脉压力梯度静脉血流肝硬化血流量奇静脉门静脉高压症门脉高血压 MRI

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Safety and efficacy of purified clinoptilolite-tuff treatment in patients with irritable bowel syndrome with diarrhea:Randomized controlled trial

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World Journal of Gastroenterology 2022年第46期28卷 6573-6588页

作者： Karolina Anderle Michael Wolzt Gabriele Moser Bettina Keip Johannes Peter Claudia Meisslitzer Ghazaleh.gouya Michael Freissmuth Cornelius Tschegg Department of Clinical Pharmacology Medical University of ViennaVienna 1090Austria Department of Internal Medicine III Division of Gastroenterology and HepatologyMedical University of ViennaVienna 1090Austria Glock health Science and Research GmbHDeutsch-Wagram 2232Lower AustriaAustria gouya Insights Vienna 1010Austria Institute of Pharmacology and the Gaston h.Glock Research Laboratories for Exploratory Drug Development Center of Physiology and PharmacologyMedical University of ViennaVienna 1090Austria

BACKGROUND Irritable bowel syndrome(IBS)is a highly prevalent gastrointestinal disorder with poor response to *** with predominant diarrhea(IBS-D)is accompanied by abdominal pain as well as high stool frequency and *** clinoptilolite-tuff(PCT),which is approved by the Food and Drug Administration for use as a dietary supplement with the brand name G-PUR®,has previously shown therapeutic potential in other indications based on its physical adsorption *** To assess whether symptoms of IBS-D can be ameliorated by oral treatment with *** In this randomized,placebo-controlled,double-blind pilot study,30 patients with IBS-D diagnosis based on Rome IV criteria were *** a 4-wk run-in phase,14 patients were randomized to receive a 12-wk treatment with G-PUR®(2 g three times daily),and 16 patients received *** relief from IBS-D symptoms as measured by the proportion of responders according to the Subject’s Global Assessment(SGA)of Relief was assessed as the primary *** the secondary outcomes,validated IBS-D associated symptom questionnaires,exploratory biomarkers and microbiome data were *** The proportions of SGA of Relief responders after 12 wk were comparable in both groups,namely 21%in the G-PUR®group and 25%in the placebo *** 4 wk of treatment,36%of patients in the G-PUR®group vs 0%in the placebo group reported complete or considerable *** improvement in daily abdominal pain was noted in 94%vs 83%(P=0.0353),and the median number of days with diarrhea per week decreased by 2.4 d vs 0.3 d in the G-PUR®and placebo groups,*** trends were observed for 50%of responders in the Bristol Stool Form *** trends were also noted for combined abdominal pain and stool consistency response and the Perceived Stress Questionnaire *** 64%in the G-PUR®group compared to 86%in the placebo group required rescue medication intake during the *** microbiome

关键词： Irritable bowel syndrome Diarrhea Functional gastrointestinal disorder Clinoptilolite Zeolite Treatment

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI h.GhANDVAR E.JUMAEV S.KhATIR T.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Fore-aft asymmetry of the ~2h(n,γ)~3h at very low energies

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Chinese Physics C 2013年第9期37卷 13-18页

作者： h.Khalili h.Sadeghi Department of Physics Faculty of ScienceArak University

We have used the recent effective field theory （EFT） which is constructed from two- and three-nucleon interactions, using minimal substitution in the momentum dependence of these interactions. We present the calcula- tions of the fore-aft asymmetry of γ-rays in the reaction 2h（n,γ）3h which are based on EFT up to next-to-next-to leading order （N2LO）. The results are compared with the recently reported calculations and measurements of the fore-aft asymmetry of T-rays from neutron-deuteron radiative capture. The calculated fore-aft asymmetry of the nd radiative capture process above deuteron breakup threshold is in good agreement with the available experimental data up to 20 MeV.

关键词： effective field theory neutron-deuteron radiative capture photonuclear observables fore-aft asymmetry