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Simultaneously Enhanced Mechanical Properties and Damping Capacities of ZK60 Mg Alloys Processed by Multi-Directional Forging

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Acta Metallurgica Sinica(English Letters) 2021年第2期34卷 265-277页

作者： L.B.Tong J.h.Chu D.N.Zou Q.Sun S.Kamado h.g.brokmeier M.Y.Zheng School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055China School of Materials Science and Engineering.harbin Institute of Technology Harbin 150001China College of Materials Science and Engineering.Jilin University Changchun 130025China Department of Mechanical Engineering Nagaoka University of TechnologyNagaoka 940-2188Japan Institute of Materials Science and Engineering Clausthal University of TechnologyAgricolastrasse 638678 Clausthal-Zellerfeld.Germany

In this study,the mechanical properties and damping capacities of cast Mg-5.5 Zn-0.6 Zr(weight percent,ZK60)alloys have been simultaneously improved by a facile multi-directional forging(MDF)processing,and the mechanisms of microstructure evolution and texture modification are systematically *** activation of tension twinning occurs during the initial MDF stage,due to the coarse-grained structure of the as-cast *** increasing MDF passes,the continuous dynamic recrystallization(CDRX)results in a fine equiaxed-grain *** typical non-basal texture is formed in the as-MDFed alloy for 6 passes,with the(0001)planes inclined 60°–70°to forged direction and 10°–20°to transverse direction,respectively.A good balance between the strength(~194.9 MPa)and ductility(~24.9%)has been achieved,which can be ascribed to the grain refinement,non-basal texture and fine precipitate *** damping capacity is remarkably improved after MDF processing,because the severe deformation increases the dislocation density,which effectively enlarges the sweep areas of mobile dislocations.

关键词： Mg alloy Multi-directional forging Microstructure Texture evolution Mechanical properties Damping capacity

室温累积叠轧Mg/Al多层复合板材织构演变(英文)

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稀有金属材料与工程 2013年第3期42卷 441-446页

作者：常海郑明毅甘为民徐超 h.g.brokmeier 北京科技大学国家材料服役安全科学中心哈尔滨工业大学 Institute of Materials Research GKSS out Station at FRM-IID-85747 GarchingGermany Institute of Materials Science and Engineering Clausthal University of TechnologyClausthal-ZellerfeldGermany

以商业纯Mg、纯Al板材为初始材料,采用累积叠轧法(ARB)在室温下成功制备出Mg/Al多层复合板材。在累积叠轧过程中,复合板材中Mg层和Al组织随着循环次数的提高而细化。通过中子衍射技术对复合板材的织构进行测试后表明:在初始复合后的Al/M... 详细信息

以商业纯Mg、纯Al板材为初始材料,采用累积叠轧法(ARB)在室温下成功制备出Mg/Al多层复合板材。在累积叠轧过程中,复合板材中Mg层和Al组织随着循环次数的提高而细化。通过中子衍射技术对复合板材的织构进行测试后表明:在初始复合后的Al/Mg/Al三明治复合板材中,Mg层和Al层主要织构类型均为剪切织构。而在后续的累积叠轧过程当中,由于其工艺特点,导致Mg层和Al层中轧制织构组分出现,最终Mg层主要呈现出典型轧制织构而Al层则表现出以轧制织构组分为主并伴有剪切织构的混合织构类型。

关键词：累积叠轧织构 Mg Al 复合板材

Deformation behavior of Mg-Y-Ni alloys containing different volume fraction of LPSO phase during tension and compression through in-situ synchrotron diffraction

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Journal of Magnesium and Alloys 2024年第9期12卷 3631-3645页

作者： S.Z.Wu Y.Q.Chi g.garces X.h.Zhou h.g.brokmeier X.g.Qiao M.Y.Zheng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China Department of Physical Metallurgy CENIM-CSICAvenida Gregorio del Amo 828040 MadridSpain Institute of Materials Science and Engineering Clausthal University of TechnologyAgricolastrasse 6D-38678 Clausthal-ZellerfeldGermany

The deformation behavior of the as-extruded Mg-Y-Ni alloys with different volume fraction of long period stacking ordered(LPSO)phase during tension and compression was investigated by in-situ synchrotron *** micro-yielding,macro-yielding,tension-compression asymmetry and strain hardening behavior of the alloys were explored by combining with deformation *** micro-yielding is dominated by basal slip of dynamic recrystallized(DRXed)grains in tension,while it is dominated by extension twinning of non-dynamic recrystallized(non-DRXed)grains in *** macro-yielding,the non-DRXed grains are still elastic deformed in tension and the basal slip of DRXed grains in compression are ***,the LPSO phase still retains elastic deformation,but can bear more load,so the higher the volume fraction of hard LPSO phase,the higher the tensile/compressive macro-yield strength of the *** from the low volume fraction of the non-DRXed grains and the delay effect of LPSO andγphases on extension twinning,the as-extruded alloys exhibit excellent tension-compression *** the volume fraction of LPSO phase reaches∼50%,tension-compression asymmetry is reversed,which is due to the fact that the LPSO phase is stronger in compression than in *** tensile strain hardening behavior is dominated by dislocation slip,while the dominate mechanism for compressive strain hardening changes from twinning in theα-Mg grains to kinking of the LPSO phase with increasing volume fraction of LPSO *** activation of kinking leads to the constant compressive strain hardening rate of∼2500 MPa,which is significantly higher than the tensile strain hardening rate.

关键词： Mg-Y-Ni alloys LPSO phase In-situ synchrotron diffraction Micro-yielding Tensile-compression asymmetry Strain hardening

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, george huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAg repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl Lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). however, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization