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The role of landscape setting in minimizing hydrogeomorphic impacts of flow regulation

International Journal of Sediment Research 2013年第2期28卷 149-161页

作者： h.e.reid G.J.BRIeRLeY K.MCFARLANe S.e.COLeMAN S.TROWSDALe School of environment The University of Auckland Department of Civil and environmental engineering The University of Auckland

The Tongariro Power Development Scheme（TPDS） is used to regulate flow in the headwaters of the largest catchment on the North Island of New Zealand（the Waikato）.Two small dams,the Rangipo Dam and the Poutu Intake Dam,were constructed in 1973 and *** flow regime of the river is managed to divert freshes into the power scheme,but allows flows larger than 100 m;s;to be released,to rework and transport sediment through the catchment. Analysis of aerial photos and maps spanning 1928 to 2007,alongside field measurements,show that there have been few hydrogeomorphic adjustments since dam *** includes limited changes to channel geometry,channel planform and bed material organization immediately downstream of the *** addition,offsite effects are minimal, both 500 m downstream of each dam,and in the more sensitive,less confined reaches in the lower catchment（11 km downstream of the Poutu Intake dam）.The limited changes can be attributed to the locations of the dams within reaches characterised by bedrock gorges and confined within *** locations act to flush sediments and impose margins that allow minimal adjustment of the *** material within this reach is characterised by the presence of a boulder *** is sourced from long-term incision into lahar deposits,and acts to limit the rate of incision, creating a steep and stable base upon which active fractions are *** as importantly,significant storage in the low-relief volcanic plateau located in the upper catchment acts to disconnect and store the high sediment yields generated by active volcanic cones in the western sub-catchment upstream of the *** limits the rate of sediment supply to regulated *** from this study show that analysis of reach-scale controls is essential in framing dam site locations in relation to the distribution of reaches and landscape units across the *** this instance, tributary inputs downstream of the dams do not repl

关键词： Flow regulation Landscape setting Landscape connectivity Sediment storage Channel planform

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI h.GhANDVAR e.JUMAeV S.KhATIR T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-ReKABI A.A.ALWAhIB electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 139-156页

作者： h.hOSSeINI O.BALILAShAKI Department of Mechanical engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

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Influence of bed heterogeneity and habitat type on macroinvertebrate uptake in peri-urban streams

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International Journal of Sediment Research 2010年第3期25卷 203-220页

作者： reid, h. e. BRIeRLeY, G. J. BOOThROYD, I. K. G School of environment University of Auckland 10 Symonds St Auckland New Zealand Research Scientist Golder Associates LtD PO Box 33-849 Takapuna 0622 Auckland New Zealand

The role of geomorphic structure, referred to as physical heterogeneity, and its influence upon the colonization of habitat by macroinvertebrates was analysed in the peri-urban, Twin Streams Catchment, in West Auckland, New Zealand. Using a cross-scalar approach, 4 riffle-run assemblages were analysed in each of 2 River Styles (a confined, low sinuosity, gravel bed river and a partly confined, low sinuosity, bedrock, cobble, and gravel bed river). each of these 8 locations comprised 2 distinct sampling areas; the upstream zone had a more heterogeneous river bed with a high diversity of physical features and flow, whilst the downstream area had a more homogeneous structure. Microhabitat features sampled at each site included streambed material, bank margins, fine grained organic debris, wood, and boulders. habitat mosaics and their associated macroinvertebrate relationships followed a semi-predictable but interrupted pattern, supporting the view that river systems are a patchy discontinuum. homogeneous zones were more frequently characterised by higher proportions of Trichoptera than heterogeneous zones, whilst heterogeneous zones were frequently characterised by Plecoptera and ephemeroptera. Diversity was maximised when the species pools from heterogeneous and homogeneous sites were combined for any given site. Functional habitats influenced macroinvertebrate assemblages in non-linear and complex ways. Wood and organic debris habitats were associated with high diversity, abundance, and sensitive species whereas streambed habitat was usually associated with low diversity. A diverse range of physical zones that approximates the ’natural range of behaviour’ for the given type of stream was considered to provide a more effective platform for rehabilitation planning than emphasising heterogeneity of physical structure in its own right.

关键词： heterogeneity Functional habitat Urban stream Rehabilitation Geomorphology Macroinvertebrates

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Carbohydrate biomarkers for future disease detection and treatment

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Science China Chemistry 2010年第1期53卷 3-20页

作者： reid Suazette Department of Chemistry Georgia State University

Carbohydrates are considered as one of the most important classes of biomarkers for cell types,disease states,protein functions,and developmental ***"binders"that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging *** this review,we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic *** are arranged based on disease categories including(1) infectious diseases,(2) cancer,(3) inflammation and immune responses,(4) signal transduction,(5) stem cell transformation,(6) embryo development,and(7) cardiovascular diseases,though some issues cross therapeutic boundaries.

关键词： carbohydrates biomarkers imaging agents boronolectins

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Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells

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Acta Pharmacologica Sinica 2007年第4期28卷 540-548页

作者： Paul reid Celtic Biotech LtdDublinIreland

Aim:To investigate the role of crotoxin (CrTX)-induced autophagy in the death ofMCF-7 cells,a caspase-3-deficient,human breast cancer cell ***:Cul-tured MCF-7 cells were treated with various doses of CrTX,a phospholipase A2(PLA2) isolated from the venom of the South American rattlesnake,Crotalusdurissus *** cytotoxicity of CrTX in the presence and absence ofcaspase inhibitors was measured with methyl thiazolyl tetrazolium (MTT) andlactate dehydrogenase (LDh) leakage *** activation of autophagy wasdetermined with transmission electron microscope and monodansylcadaverin(MDC) *** upregulation of lysosomal enzymes,the release of cyto-chrome c (cyto-c),and the nuclear translocation of the apoptosis inducing factor(AIF) were examined by immunoblotting and ***:CrTXinhibited the viability of MCF-7 cells in a dose-and time-dependent ***-activated autophagy was revealed by punctuate MDC labeling,and an increase inthe formation of autophagosomes as well as apoptosis,as evidenced by nuclearcondensation and *** activation of cathepsin B,D,and L,inaddition to the release of cytochrome c and the relocation of AIF into nuclei,wereobserved after CrTX *** inhibitors 3-methyladenine (3-MA),Nh4Cl,and the pan-caspase inhibitor,Z-Val-Ala-Asp-fluoromethylketone (Z-Vad-fmk),attenuated CrTX-induced cell ***:An autophagic mecha-nism contributes to the apoptosis of MCF-7 cells induced by CrTX.

关键词： crotoxin autophagy apoptosis cytochrome c apoptosis inducing factor

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