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Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： Peter h.King Department of Neurology and Center for Neurodegeneration and experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

CLASSIFICATIONS OF DUPIN hYPerSURFACeS IN LIe SPhere GeOMeTRY

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Acta Mathematica Scientia 2024年第1期44卷 1-36页

作者： Thomas e.CeCIL Department of Mathematics and Computer Science College of the Holy CrossWorcesterMA01610USA

This is a survey of local and global classification results concerning Dupin hypersurfaces in S^(n)(or R^(n))that have been obtained in the context of Lie sphere *** emphasis is on results that relate Dupin hypersurfaces to isoparametric hypersurfaces in *** with these classification results,many important concepts from Lie sphere geometry,such as curvature spheres,Lie curvatures,and Legendre lifts of submanifolds of S^(n)(or R^(n)),are described in *** paper also contains several important constructions of Dupin hypersurfaces with certain special properties.

关键词： Dupin hypersurfaces isoparametric hypersurfaces Lie sphere geometry Lie sphere transformations Lie curvatures

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试论中国大运河世界遗产的系列扩展

东南文化 2024年第2期 15-24页

作者：李尔吾西北大学文化遗产学院陕西西安710119

中国大运河世界遗产符合世界文化遗产中的遗产运河、文化景观、文化线路类型。中国大运河基于工程技术类线形遗产的扩展应完善水工遗存的系列完整性并扩大遗产时空范围;基于文化景观的扩展应将沿线展现人们生产生活的各种景观组成大运... 详细信息

中国大运河世界遗产符合世界文化遗产中的遗产运河、文化景观、文化线路类型。中国大运河基于工程技术类线形遗产的扩展应完善水工遗存的系列完整性并扩大遗产时空范围;基于文化景观的扩展应将沿线展现人们生产生活的各种景观组成大运河文化景观群;基于文化线路的扩展应构建大运河水陆遗产综合体,并强调运河与城镇、城镇与城镇间的动态演化关系。

关键词：中国大运河世界遗产系列扩展遗产运河文化景观文化线路价值特征文化价值

Investigating the impact of the universal function of the nuclear proximity potential in heavy-ion fusion cross sections

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Communications in Theoretical Physics 2024年第5期76卷 86-93页

作者： R Gharaei e Sarvari Department of Physics Sciences FacultyHakim Sabzevari UniversityPO Box 397SabzevarIran Department of Physics Faculty of ScienceFerdowsi University of MashhadPO Box 91775-1436MashhadIran Science Faculty Department of PhysicsTarbiat Modares UniversityTehranIran

The fusion barriers and cross sections of 15 colliding systems with 320≤Z_(1)Z_(2)≤1512 are investigated in detail to understand the influence of the universal function of proximity potential formalism in the heavy-ion fusion *** realize this goal,we select three versions of the phenomenological proximity potentials,including Prox.77,Zhang 2013,and Guo 2013,to calculate the nucleus-nucleus *** experimental fusion cross sections for the selected reactions are analyzed using the standard coupled-channel calculations,including couplings to the low-lying 2^(+)and 3^(-)states in the target and *** calculated results show that the universal functions of the Guo 2013 and Prox.77 models provide the lowest and highest fusion barriers,*** addition,it is found that the height of the fusion barriers is enhanced by increasing the mass number of the projectile from light to heavy *** highest sensitivity to the mass number of the projectile belongs to the results of Prox.77.A discussion is also presented on the influence of the universal function on the radial behavior of the interaction potential in the allowed region for overlapping *** results reveal that the best fit to the experimental data of the fusion cross sections for the reactions involving light and medium nuclei is obtained using the universal function of the Zhang 2013 *** the heavier systems,the results of the Guo 2013 model at sub-barrier energies provide a good description of the available data.

关键词： fusion reactions proximity-type potentials universal function coupled-channel calculations

Unlocking the sun’s potential:Vitamin D’s role in battling colorectal cancer

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Journal of Nutritional Oncology 2024年第1期9卷 1-9页

作者： Qing-er Ling Si-Qi Ni Yi Jiao Ling-Xiang Liu Department of Oncology Jiangsu Province HospitalNanjing 210000JiangsuChina

Vitamin D,a fat-soluble hormone precursor primarily derived from sunlight exposure,exerts pleiotropic effects within the body,including anticancer *** has demonstrated an association between vitamin D and colorectal cancer(CRC)from both geoecological and epidemiological perspectives,wherein vitamin D intake and circulating levels have clinical significance for the development of CRC and confer a protective effect against the *** such,a sensible increase in sunlight exposure may be an accessible approach to reducing cancer risk and a low-cost treatment when used in conjunction with vitamin D *** article comprehensively explores the established and emerging mechanisms thought to underlie the impact of vitamin D on *** encompasses recent insights from clinical trials and epidemiological studies,along with recommendations,diverse viewpoints,and future prospects regarding the utilization of vitamin D in the management of CRC.

关键词： Colorectal cancer Vitamin D Calcitriol

CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan haiyan Tan Jing Wu ha Won Lee Andrew D.huber William C.Wright Ji-hoon Cho Jiyang Yu Junmin Peng Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is a cytochrome P450(CYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether CYP3A5 directly influences cancer *** this report,we demonstrate that CYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that CYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that CYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,CYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4eBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of CYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

experimental and numerical investigation on alternatives to sandy gravel

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Defence Technology（防务技术） 2024年第1期31卷 130-141页

作者： V.Denefeld h.Aurich Fraunhofer Institute for high-Speed Dynamics Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunhofer Institute for high-Speed Dynamics Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

The NATO agreement STANAG 4569 defines the protection levels for the occupants of logistic and light armored *** Allied engineering Publication,AeP-55,Volume 2 document outlines the test conditions for underbelly improvised explosive device(IeDs),which must be buried in water-saturated sandy *** use of sandy gravel has some drawbacks,for instance reproducibility,time consumption,and *** paper focuses on the investigation of four alternatives to sandy gravel,which could produce similar specific and cumulative impulses:a concrete pot filled with water,a concrete pot filled with quartz sand,a steel pot without filling and a concrete pot filled with glass spheres(diameter 200μm—300μm)and different water *** impulses are measured with a ring technology developed at the Fraunhofer eMI.A numerical soil model based on the work of Marrs,2014 and Fi serov a,2006 and considering the soil moisture was used to simulate the experiments with glass spheres at different water contents,showing much better agreement with the experiments than the classical Laine&Sandvik model,even for high saturation *** results can be used to create new test conditions at original scale that are more cost-effective,more reproducible and simpler to manage in comparison to the current tests carried out with STANAG sandy gravel.

关键词： Improvised explosive device(IeD) Specific impulse Momentum transfer Sandy gravel Glass spheres Numerical model Soil moisture

Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control

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Traditional Medicine Research 2024年第12期9卷 13-30页

作者： Qi-er Mu Yi-Sa A Yan-Qiu Bai Chu-La Sa College of Mongolian Medicine Inner Mongolian Medical UniversityJinshan Economic and Technological Development ZoneTumote Left BannerHohhot 010110China

Gentiana macrophylla Pall.(***),whose genus and family belong to the Gentianaceae and *** main distribution centers of *** resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in ***,as a traditional medicine,has a long history and was used in different ethnic *** roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing *** previous studies,it could be found that there were more than forty components isolated and identified from *** main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and *** terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of ***,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract *** flower mainly contains isoorientin and isovitexin as the representative of *** have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of *** could be seen from previous studies that the research on *** was mainly focused on the root,and the flower was rarely *** was reported that the experimental data of the anti-inflammatory and anti-tumor effects of *** flowers show that its curative effect was very ***,the flowers of the flower of *** can be used as potential medicinal parts for *** that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about ***’s potential medical *** on botanical books,Chi

关键词： Gentiana macrophylla Pall. basic source chemical component pharmacological activity quality control

A hybrid machine-learning model for solar irradiance forecasting

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CLeAN eNerGY 2024年第1期8卷 100-110页

作者： Almarzooqi, Ameera M. Maalouf, Maher el-Fouly, Tarek h. M. Katzourakis, Vasileios e. el Moursi, Mohamed S. Chrysikopoulos, Constantinos, V Khalifa Univ Dept Ind & Syst Engn POB 127788 Abu Dhabi U Arab Emirates Khalifa Univ Abu Dhabi Elect Engn & Comp Sci Dept Abu Dhabi U Arab Emirates Khalifa Univ Dept Civil Infrastruct & Environm Engn POB 127788 Abu Dhabi U Arab Emirates Tech Univ Crete Sch Chem & Environm Engn Khania 73100 Greece

Nowcasting and forecasting solar irradiance are vital for the optimal prediction of grid-connected solar photovoltaic (PV) power plants. These plants face operational challenges and scheduling dispatch difficulties due to the fluctuating nature of their power output. As the generation capacity within the electric grid increases, accurately predicting this output becomes increasingly essential, especially given the random and non-linear characteristics of solar irradiance under variable weather conditions. This study presents a novel prediction method for solar irradiance, which is directly in correlation with PV power output, targeting both short-term and medium-term forecast horizons. Our proposed hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression model. The proposed method excels in forecasting solar irradiance, especially during highly intermittent weather periods. A key strength of our model is the incorporation of multiple historical weather parameters as inputs to generate accurate predictions of future solar irradiance values in its scalable framework. We evaluated the performance of our model using data sets from both cloudy and sunny days in Seattle and Medford, USA and compared it against three forecasting models: persistence, modified 24-hour persistence and least squares. Based on three widely accepted statistical performance metrics (root mean squared error, mean absolute error and coefficient of determination), our hybrid model demonstrated superior predictive accuracy in varying weather conditions and forecast horizons. A novel prediction method for solar irradiance, targeting both short-term and medium-term forecast horizons, is proposed to improve PV power production. The hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression model. Graphical Abstract

关键词： solar power generation kernel ridge regression hybrid model forecasting BATTerY eNerGY-STORAGe POWer PV RADIATION PReDICTION CeLLS