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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Collapse assessment of steel moment frames using endurance time method

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earthquake engineering and engineering Vibration 2015年第2期14卷 347-360页

作者： e.Rahimi h.e.estekanchi Department of Civil engineering Sharif University of Technology (SUT)

In endurance time(eT) method structures are subjected to a set of predesigned intensifying excitations. These excitations are produced in a way that their response spectrum, while complying with a specifi ed spectrum, intensifi es with time so they can be used approximately to simulate the average effects of several ground motions scaled to different intensities. In this paper applicability of the eT method for evaluating collapse potential of buildings is investigated. A set of four steel moment frames is used for collapse assessment. The process of using eT method in collapse evaluation is explained and the results are compared with incremental dynamic analysis(IDA) results. It is shown that although the computational effort using the eT method is much less than the IDA analysis, the results of both methods are consistent. Finally collapse fragility curves using eT and IDA methods are produced and it is shown that the probabilities of collapse in different hazard levels are also consistent.

关键词： endurance time method collapse analysis incrementa

Schrodinger equation for an Open System

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Chinese Physics Letters 2002年第9期19卷 1238-1243页

作者：毕桥 h.e.Ruda ComplexityScienceCenter YangzhouUniversityYangzhou225002 energeniusCentreforAdvancednanotechnology UniversityofTorontoTorontoM5S3E4Canada

We present a Schr?dinger (Liouville) type of equation for a quantum open system. It has a correlated part, and various master equations may be its special cases. It also has significant applications for constructing decoherence-free subspace for quantum computation. It is related to the original Schrodinger (Liouville) equation for the total system through a non-unitary similarity transformation. It is unnecessary for its correlated part to be self-adjoint, so there is a complex spectrum for the corresponding hamiltonian (Liouvillian), which enables the time evolution of states to be asymmetric. This shows just the correlation to produce evolution of world.

关键词： Liouville equation

First-principles study of the structural,elastic,electronic,optical,and vibrational properties of intermetallic Pd_2Ga

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Chinese Physics B 2012年第3期21卷 341-348页

作者： Yildirim A Koc h Deligoz e Department of Physics Siirt University Department of Physics Aksaray University

The structural, elastic, electronic, optical, and vibrational properties of the orthorhombic Pd2Ga compound are investigated using the norm-conserving pseudopotentials within the local density approximation in the frame of density functional theory. The calculated lattice parameters have been compared with the experimental values and found to be in good agreement with these results. The second-order elastic constants and the other relevant quantities, such as the Young＇s modulus, shear modulus, Poisson＇s ratio, anisotropy factor, sound velocity, and Debye temperature, have been calculated. It is shown that this compound is mechanically stable after analysing the calculated elastic constants. Furthermore, the real and imaginary parts of the dielectric function and the optical constants, such as the optical dielectric constant and the effective number of electrons per unit cell, are calculated and presented. The phonon dispersion curves are derived using the direct method. The present results demonstrate that this compound is dynamically stable.

关键词： Pd2Ga vibrational properties optical properties elastic constants

Magnetic properties of Mn-doped GaN with defects:ab-initio calculations

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Chinese Physics B 2011年第8期20卷 297-303页

作者： e.Salmani A.Benyoussef h.ez-Zahraouy e.h.Saidi LMPhe Departement de PhysiqueFacult'e des SciencesUniversit'e Mohammed V-AgdalRabatMorocco LPhe Departement de PhysiqueFacult'e des SciencesUniversit'e Mohammed V-AgdalRabatMorocco

According to first-principles density functional calculations, we have investigated the magnetic properties of Mn- doped GaN with defects, Ga1-x-yVGxMny N1-z-tVNzOt with Mn substituted at Ga sites, nitrogen vacancies VN, gallium vacancies VG and oxygen substituted at nitrogen sites. The magnetic interaction in Mn-doped GaN favours the ferromagnetic coupling via the double exchange mechanism. The ground state is found to be well described by a model based on a Mn3＋-d5 in a high spin state coupled via a double exchange to a partially delocalized hole accommodated in the 2p states of neighbouring nitrogen ions. The effect of defects on ferromagnetic coupling is investigated. It is found that in the presence of donor defects, such as oxygen substituted at nitrogen sites, nitrogen vacancy antiferromagnetic interactions appear, while in the case of Ga vacancies, the interactions remain ferromagnetic; in the case of acceptor defects like Mg and Zn codoping, ferromagnetism is stabilized. The formation energies of these defects are computed. Furthermore, the half-metallic behaviours appear in some studied compounds.

关键词： diluted magnetic semiconductor GaN:Mn defects ab-initio magnetic properties

Recent results from the heRMeS experiment

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Chinese Physics C 2010年第9期34卷 1247-1253页

作者： h.e.Jackson Physics Division Argonne National Laboratory

Results are presented from the hermes experiment which uses semi-inclusive deep inelastic lepton scattering to study the flavor structure of the *** have been accumulated for pion and kaon double spin asymmetries,single-spin azimuthal asymmetries for meson electroproduction,deep virtual Compton scattering （DVCS）,and meson *** results provide information on the properties of the strange sea in the proton,constraints on transverse momentum dependent quark parton distributions,and demonstrate the promise of DVCS for isolating the total angular momentum carried by the quarks in the proton.

关键词： lepton-nucleon scattering spin asymmetries strange quarks parton distributions

DNA Dynamics Studied Using the homogeneous Balance Method

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Chinese Physics Letters 2012年第8期29卷 9-11页

作者： e.M.e.Zayed A.h.Arnous Mathematics Department Faculty of ScienceZagazig UniversityP.O.Box 44519ZagazigEgypt

We employ the homogeneous balance method to construct the traveling waves of the nonlinear vibrational dynamics modeling of *** new explicit forms of traveling waves are *** is shown that this method provides us with a powerful mathematical tool for solving nonlinear evolution equations in mathematical *** and weaknesses of the proposed method are discussed.

关键词： traveling nonlinear method

Design of area and power efficient Radix-4 DIT FFT butterfly unit using floating point fused arithmetic

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Journal of Central South University 2016年第7期23卷 1669-1681页

作者： Prabhu e Mangalam h Karthick S Department of electronics and Communication engineering Amrita School of EngineeringCoimbatore Amrita Vishwa Vidyapeetham Amrita University Department of electronics and Communication engineering Sri Krishna College of Engineering and Technology Department of electronics and Communication engineering Bannari Amman Institute of Technology

In this work, power efficient butterfly unit based FFT architecture is presented. The butterfly unit is designed using floating-point fused arithmetic units. The fused arithmetic units include two-term dot product unit and add-subtract unit. In these arithmetic units, operations are performed over complex data values. A modified fused floating-point two-term dot product and an enhanced model for the Radix-4 FFT butterfly unit are proposed. The modified fused two-term dot product is designed using Radix-16 booth multiplier. Radix-16 booth multiplier will reduce the switching activities compared to Radix-8 booth multiplier in existing system and also will reduce the area required. The proposed architecture is implemented efficiently for Radix-4 decimation in time(DIT) FFT butterfly with the two floating-point fused arithmetic units. The proposed enhanced architecture is synthesized, implemented, placed and routed on a FPGA device using Xilinx ISe tool. It is observed that the Radix-4 DIT fused floating-point FFT butterfly requires 50.17% less space and 12.16% reduced power compared to the existing methods and the proposed enhanced model requires 49.82% less space on the FPGA device compared to the proposed design. Also, reduced power consumption is addressed by utilizing the reusability technique, which results in 11.42% of power reduction of the enhanced model compared to the proposed design.

关键词： floating-point arithmetic floating-point fused dot product Radix-16 booth multiplier Radix-4 FFT butterfly fast fouriertransform decimation in time