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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： jun Chen shuotao wang department of bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of bio-inspired Materials and Interfacial science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Pd single atoms cooperate with s vacancies in ZnIn_(2)s_(4) nanosheets for photocatalytic pure-water splitting

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science China Chemistry 2024年第3期67卷 855-861页

作者： Lin sun huiping Peng Fei xue shangheng liu Zhiwei hu hongbo Geng Xiaozhi liu dong su Yong xu Xiaoqing huang state Key Laboratory of Physical Chemistry of solid surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Guangzhou Key Laboratory of Low-dimensional Materials and Energy storage devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China Max Planck Institute for Chemical Physics of solids Nothnitzer Strasse 40Dresden 01187Germany school of Materials Engineering Changshu Institute of TechnologyChangshu 215500China beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China Innovation Laboratory for sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

Photocatalytic water splitting has emerged as a new frontier for converting solar energy to green h_(2) and value-added ***,great challenges still remain for developing efficient photocatalysts for pure water splitting without sacrificial *** this work,we demonstrate that doping hexagonal ZnIn_(2)s_(4)(ZIs) with Pd single atoms(Pd_(0.03)/ZIs) can serve as a highly efficient photocatalyst for pure water splitting to simultaneously produce h_(2) and h_(2)O_(2) without any sacrificial *** from aberration-corrected high-angle annular dark field scanning transmission electron microscopy,X-ray fine spectroscopy,insitu electron paramagnetic resonance and diffuse Fourier transform infrared spectroscopy reveal that doping ZIs with Pd single atoms facilitates the formation of s vacancies(s_(v)),where the photogenerated electrons can transfer to Pd single atoms,as a result of enhanced separation of electron-hole pairs and improved photocatalytic ***,Pd_(0.03)/ZIs displays a stoichiometric ratio of h_(2) and h_(2)O_(2) with the productivity of 1,037.9 and 1,021.4μmol g^(-1)h^(-1),respectively,which has largely outperformed pure ZIs and other reported catalysts for pure water *** work provides an efficient photocatalyst for water splitting to produce h_(2) and h_(2)O_(2),which may attract rapid interest in materials science,chemistry,and heterogeneous catalysis.

关键词： ZnIn_(2)s_(4) Pd single atom s vacancy pure water splitting h_(2)O_(2)

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ALs-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating bCL2–bECN1 interaction

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Acta Pharmaceutica sinica b 2024年第5期14卷 2026-2038页

作者： shiqiang xu Qilian Ma junwen shen Ningning Li shan sun Nana wang Yang Chen Chunsheng dong Kin Yip Tam jochen h.M.Prehn hongfeng wang Zheng Ying jiangsu Key Laboratory of Neuropsychiatric diseases and College of Pharmaceutical sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China jiangsu Province Engineering Research Center of Precision diagnostics and Therapeutics development Soochow UniversitySuzhou 215123China dept.of Physiology&Medical Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of health sciences University of MacaoTaipaMacao 999078China Insititutes of biology and Medical science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALs)and frontotemporal dementia(FTd),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALs and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(dPR)*** there is a growing understanding that C9orf72 dPRs have a strong ability to harm neurons and induce C9orf72-linked ALs/FTd,whether these dPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing dPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich dPRs enhance the interaction between bCL2 and bECN1/beclin 1 by inhibiting bCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 dPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using sW063058,a small molecule compound that can disrupt the interaction between bECN1 and bCL2,may reduce C9orf72 dPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy bCL2 bECN1/beclin 1 dipeptide repeat Neurodegeneration

Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

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Matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： j.Lutgert P.hesselbach M.schorner V.bagnoud R.belikov P.drechsel b.heuser O.shumphries P.Katrik b.Lindqvist C.Qu R.Redmer d.Riley G.schaumann s.schumacher A.Tauschwitz d.Varentsov K.Weyrich X.Yu b.Zielbauer Zs.Major P.Neumayer d.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GsI helmholtzzentrum fur schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany helmholtz-Zentrum dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL Gmbh Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany state Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China helmholtz Institut jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

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Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin Xiang shu he Rongjie Chen shanggong liu Minhui liu Liang xu jiajun Zheng Zhouquan jiang Long Ma Ying sun Yongpeng Qin Yi Chen Wen Li Xiangyu wang Gong Chen Wenliang Lei Guangdong-hong Kong-Macao Institute of CNs Regeneration(GhMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory for Neuroimmunology in health and diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIb-KU Leuven Center for brain&disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous *** r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing *** this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor Neurod1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse ***-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local *** addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable ***,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural *** conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocyte-to-neuron conversion Ca2+imaging direct lineage conversion glia astrocyte in vivo reprogramming lineage-tracing mice Neurod1 neuron two-photon imaging

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Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from selaginella uncinata(desv.)spring against inflammatory bowel disease

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journal of Pharmaceutical Analysis 2024年第2期14卷 177-195页

作者： haochen hui Zhuoya wang xuerong Zhao Lina xu Lianhong Yin Feifei wang Liping Qu jinyong Peng department of Pharmaceutical Analysis College of PharmacyDalian Medical UniversityDalianLiaoning116044China Innovation Materials Research and development Center Botanee Research InstituteYunnan Botanee Bio-technology Group Co.Ltd.Kunming650106China department of Traditional Chinese Medicine Pharmacology School of PharmacyAnhui University of Chinese MedicineHefei230012China

Inflammatory bowel disease(Ibd)is a serious disorder,and exploration of active compounds to treat it is *** acidic polysaccharide named sUsP-4 was purified from selaginella uncinata(desv.)spring,which contained galacturonic acid,galactose,xylose,arabinose,and rhamnose with the main chain structure of→4)-α-d-GalAp-(1→and→6)-β-d-Galp-(1→and the branched structure of→5)-α-l-Araf-(1→.Animal experiments showed that compared with Model group,sUsP-4 significantly improved body weight status,disease activity index(dAI),colonic shortening,and histopathological damage,and elevated occludin and zonula occludens protein 1(ZO-1)expression in mice induced by dextran sulfate sodium salt(dss).16s ribosomal RNA(rRNA)sequencing indicated that sUsP-4 markedly downregulated the level of Akkermansia and *** results confirmed that sUsP-4 obviously elevated thiamine levels compared with Model mice by adjusting thiamine metabolism,which was further confirmed by a targeted metabolism *** transplantation experiments showed that sUsP-4 exerted an anti-Ibd effect by altering the intestinal flora in mice.A mechanistic study showed that sUsP-4 markedly inhibited macrophage activation by decreasing the levels of phospho-nuclear factor kappa-b(p-NF-κb)and cyclooxygenase-2(COX-2)and elevating NF-E2-related factor 2(Nrf2)levels compared with Model *** conclusion,sUsP-4 affected thiamine metabolism by regulating Akkermania and inhibited macrophage activation to adjust NF-κb/Nrf2/COX-2-mediated inflammation and oxidative stress against *** is the first time that plant polysaccharides have been shown to affect thiamine metabolism against Ibd,showing great potential for in-depth research and development applications.

关键词： Gut microbiota Inflammatory bowel disease Polysaccharide selaginella uncinata(desv.)spring Thiamine metabolism

design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

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Acta Pharmaceutica sinica b 2024年第3期14卷 1283-1301页

作者： Qian Zhao jiale dong han liu hui Chen huan Yu shuyin Ye shuangjin Yu Yu Li Longhui Qiu Nazi song hongjiao xu Qi liu Zhiteng Luo Yuyi Li Rui wang Guodong Chen Xianxing jiang school of Pharmaceutical sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan school of Medicine Sun Yat-sen UniversityGuangzhou 510006China shenzhen Turier biotech.Co. Ltd.Shenzhen 518118China school of Life sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKd)remains *** we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKd compared to healthy mice and were correlated with disease ***,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).based on the importance of GLP-1R and GCGR in CKd,we reported a novel monomeric peptide,1907-b,with dual-agonism on both GLP-1R and *** data confirmed that 1907-b had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKd than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO *** lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-b’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon *** findings highlight that 1907-b,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKd treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease diabetic nephropathy Kidney fibrosis dual-agonism

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slow magnetic relaxation behaviors and diamagnetic dilution studies of a carboxyl bridged dinuclear dysprosium(Ⅲ) complex

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journal of Rare Earths 2024年第11期42卷 2088-2096页

作者： Wenting liu Yibo Qiu Weiqin xu Manli Cao Xin deng Weiquan Lin school of Chemistry and Materials science Guangdong University of Education school of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials Guangzhou University

by using a rigid bulky carboxylic ligand a-cyanocinnamic acid（CCA）,a dinuclear dysprosium（Ⅲ） complex [dy2（CCA）6（MeOh）4]（1） was *** crystal X-ray crystallography reveals that the two eight-coordinate dysprosium ions are bridged by four deprotonated carboxyl groups,forming a centrosymmetric paddle-wheel-1ike *** magnetic property measurements indicate that complex 1 displays field-induced slow magnetic *** temperature-dependent relaxation times can be fitted using Orbach and Raman processes with parameters of n=2.8（2）,C=27（8） s-1/K~n,τ0=5（2） × 10-10s and Ueff=40（3） *** studies on the diamagnetic YⅢ-diluted analogue[dy0.206Y1.794（CCA）6（MeOh）4]（2） reveal its slow magnetic relaxation behavior without external dc field and the antiferromagnetic coupling between the dyⅢions in *** on the obtained relaxation times of 2lead to the parameters of n=4.5（3）,C=0.7（2） s-1/K~n,τ0=2.8（2） × 10-9s and Ueff=38（2） *** results suggest that slow magnetic relaxation originates from the single-ion relaxation of dyⅢ***,the diamagnetic dilution can suppress other fast relaxation pathways at low temperature,on account of the elimination of magnetic coupling and dipolar *** initio calculations were then performed on the single dyⅢion species {Ydy} and indicate that the first excited Kramers doublets（Kds）lie at ca.76 cm-1,which is slightly higher than the experimental *** intramolecular magnetic interactions were also calculated and indicate a weak ferromagnetic dipole-diploe magnetic interaction and an antiferromagnetic exchange coupling.

关键词： diamagnetic dilution dilanthanide complexes Rare earths single-molecule magnets

β-1，3-glucans-rich Euglena gracilis supplementation alleviates high-fat-high-fructose diet-induced cognitive impairment in middle-aged mice via the gut-brain axis

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Food science and human Wellness 2024年

作者： haoxie xu Yachao wang Xiangzhu Li xuli Wu Louise Weiwei Lu jiayi he Mingfu wang bin liu hui xu jiehua Chen Kawing Cheng shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Advanced study， shenzhen University department of Food science and Engineering， College of Chemistry and Environmental Engineering， shenzhen University Institute for Innovative development of Food Industry， shenzhen University department of Neurosurgery， The Institute Translational Medicine， The First Affiliated hospital of shenzhen University， shenzhen second People's hospital shenzhen Traditional Chinese Medicine hospital school of Public health， shenzhen University school of biological sciences， Faculty of science， the University of Auckland

The growing aging population along with the shifting dietary paradigm to Western-type diet worldwide has been implicated in the increasing prevalence of cognitive impairment. Emerging evidence suggests that a high-fiber diet may help improve cognitive function through the gut-brain axis. Euglena gracilis， a unicellular microalga rich in β-1，3-glucans， has gained attention due to its modulatory effect on gut dysbiosis and inflammatory response. This study aimed to explore the efficacy and mechanism of β-1，3-glucans-rich Euglena gracilis powder (EG) against high-fat-high-fructose (hFhF) diet-induced cognitive disorders in mice. A middle-aged (52-week-old C57bL/6j) mouse model with the following groups was adopted: hFhF， hFhF+EG， and control. At the end of the dietary intervention (8 weeks)， cognitive behaviors， metabolic parameters， endotoxin levels， gut microbiota composition， and colon and brain pathology were examined. The results showed that EG supplementation attenuated hFhF-induced cognitive impairment， promoted synaptogenesis in the hippocampus， and improved synaptic ultrastructure. These beneficial effects were partly mediated through the upregulation of PTP1b-IRs-pAKT-pGsK3β-pTau signaling. Furthermore， it prevented gut dysbiosis as evidenced by an increase in β-diversity and enrichment of Akkermansia relative to control. EG supplementation was also able to partly reverse the hFhF-induced disruption of intestinal barrier， which was accompanied by reduced systemic and neuronal inflammation， normalized short-chain fatty acid production， and decreased serum lipopolysaccharide concentration. The findings from the present study support that β-1，3-glucans-rich EG is a promising natural agent for the prevention of hFhF diet-induced deterioration in cognitive function that merits further investigation.

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