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脱硫微生物生产和燃油脱有机硫

科学通报 2001年第18期46卷 1529-1533页

作者：许平李福利俞坚马翠卿钟建江曲音波 h.d.blankespoor 山东大学微生物技术国家重点实验室济南250100 香港科技大学化工系华东理工大学生物反应器国家重点实验室上海200237 Biology department HopeCollege

利用计算机控制的发酵缸，对脱硫微生物的生产条件进行了初步的探讨，分别进行了ph条件，碳源的选择、最适碳源浓度、氮源浓度和硫源浓度的确定等研究，采用ph恒定、流加碳源工艺可大大提高菌体生产浓度，利用具有专一性脱硫活力的微生... 详细信息

利用计算机控制的发酵缸，对脱硫微生物的生产条件进行了初步的探讨，分别进行了ph条件，碳源的选择、最适碳源浓度、氮源浓度和硫源浓度的确定等研究，采用ph恒定、流加碳源工艺可大大提高菌体生产浓度，利用具有专一性脱硫活力的微生物休止细胞和细胞理裂解液，处理加氢精制柴油（来自抚顺石油研究院，硫含量对206μg/mL左右），用于脱硫的微生物包括lawq，IG，X7B，ZT，ZCR，5和6号菌混合液，燃油的实际有机硫脱除率分别为10．6％－90．3％。

关键词：二苯并噻吩生物脱硫加氢脱硫燃油脱硫微生物有机硫化石燃料

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微生物脱有机硫的催化剂制备和条件

科学通报 2002年第4期47卷 275-279页

作者：许平马翠卿李福利曾义勇王书宁宋波佟明友 h.d.blankespoor 山东大学微生物技术国家重点实验室济南250100 中国石油化工股份有限公司抚顺石油化工研究院抚顺113001 Biology

从石油污染土壤中筛选到的一株能专一性降解二苯并噻吩（dibenzothiophene,dBT）生成2-羟基联苯（2-hydfoxybiphenyl,2-hBP）的红球属（Rhodococcus）菌株lawq出发,研究了影响该菌株生长和脱硫的因素.2-hBP对菌体生长、降解dBT酶系的产... 详细信息

从石油污染土壤中筛选到的一株能专一性降解二苯并噻吩（dibenzothiophene,dBT）生成2-羟基联苯（2-hydfoxybiphenyl,2-hBP）的红球属（Rhodococcus）菌株lawq出发,研究了影响该菌株生长和脱硫的因素.2-hBP对菌体生长、降解dBT酶系的产生及脱硫活力都有抑制作用.研究了生长反应系统中硫酸盐和dBT同时存在条件下,硫酸盐的存在对产生降解dBT酶系的影响作用.对休止细胞脱有机硫反应体系进行了研究,并确定了最佳细胞浓度和反应条件.研究结果表明红球菌lawq具有对硫酸盐不敏感的特点,较适合于生物脱有机硫工艺.

关键词：微生物脱有机硫催化剂制备二苯并噻吩石油产品

Microbial desulfurization of fuel oil

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Chinese Science Bulletin 2002年第5期47卷 365-369页

作者： h. d. blankespoor Biology department of hope College Holland

Culture conditions of desulfurization microbes were investigated with a bioreactor controlled by computer. Factors such as ph, choice of carbon source, optimal concentrations of carbon, nitrogen and sulfur sources were determined. The addition of carbon in a culture with a constant ph greatly improved the growth of Rhodococcus. Cells and cell debris from microbes rested using a sulfur-specific pathway were used to desulfurize diesel oil treated by hy-drodesulfurization (acquired from the Research Institute of Fushun Petroleum with total sulfur level at 205μg/mL). Strains lawq, IG, X7B, ZT, ZCR, and a mixture of No. 5 and No. 6, were used in the biodesulfurization process. The reduction of total sulfur was between 10.6% and 90.3%.

关键词： dibenzothiophene (dBT) biodesulfurization (BdS) hy-drodesulfurization (hdS) fuel oil.

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3d) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hd) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hd)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hd results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru