检索结果-南通市图书馆

德国医学 1997年第2期14卷 112-113页

作者： h.c.diener 朱学海 Neurologische Universittslink Hufelandstr.55D-45122 EssenGermany 同济医科大学附属同济医院

外周动脉闭塞性疾病的主要因素是吸烟与糖尿病,高血压尚为次要危险因素。而脑血管病的主要危险因素则是高血压,其它因素如心源性栓子、动脉狭窄、高胆固醇血症也较重要。现对脑血管病,主要是脑卒中的一级预防和二级预防的研究综述如下。

关键词：脑血管疾病危险因素预防

噻氯匹定(Ticlopidin):缺血性脑梗塞的二级预防

在线全文

学校读者我要写书评

暂无评论

德国医学 1994年第3期11卷 155-156页

作者： h.c.diener c.Weiller 郭志凌 Neurologisehe Universittsklinik Essen Hufelandstr.55D-45122 EssenGermany 同济医科大学附属同济医院

临床存在的问题目前临床上已开展对曾发生过短暂脑血流紊乱或卒中的患者行药物二级预防治疗。也就是用血小板功能抑制剂(TFh)或抗凝剂,以阻止卒中或心肌梗塞再发,此外,也须治疗引起卒中的主要危险因素高血压。大样本随机临床研究表明,T... 详细信息

临床存在的问题目前临床上已开展对曾发生过短暂脑血流紊乱或卒中的患者行药物二级预防治疗。也就是用血小板功能抑制剂(TFh)或抗凝剂,以阻止卒中或心肌梗塞再发,此外,也须治疗引起卒中的主要危险因素高血压。大样本随机临床研究表明,TFh 可预防短暂性脑缺血发生(TIA)或卒中的复发。它可使血管性疾患如心肌梗塞。

关键词：噻氯匹定脑栓塞预防缺血性

在线全文

学校读者我要写书评

暂无评论

中风病人的溶栓治疗

德国医学 1999年第3期16卷 133-135页

作者： h.c.diener W.hacke 施琪嘉 Klinik und Poliklinik für Neurologie der Universitt hufelandstr.55 D-45122 EssenGermany 同济医科大学附属同济医院

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓... 详细信息

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓治疗的目的在于尽早恢复脑血流,以减少由缺血引起的脑组织损害。

关键词：中风溶栓疗法疗效

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). however, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

A continental back-arc setting for the Namaqua belt:Evidence from the Kakamas Domain

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2022年第4期13卷 193-221页

作者： P.h.Macey R.J.Thomas A.F.M.Kisters J.F.A.diener M.Angombe S.Doggart c.A.Groenewald c.W.Lambert J.A.Miller h.Minnaar h.Smith h.F.G.Moen E.Muvangua A.Nguno G.Shifotoka J.Indongo D.Frei c.Spencer P.le Roux R.A.Armstrong c.Tinguely council for Geoscience P.O.Box 572BellvilleSouth Africa Department of Geology University of StellenboschSouth Africa Department of Geological Sciences University of Cape TownSouth Africa Geological Survey of Namibia WindhoekNamibia Department of Geology University of Free StateSouth Africa Department of Earth Sciences University of the Western CapeSouth Africa The Institute of Geoscience Research Dept.Applied GeologyCurtin UniversityPerthAustralia Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonCanada Geochronology and Tracers Facility British Geological SurveyNottingham NG125GGUK RSES Australian NationalUniversityCanberraACTAustralia

A study of the NW Kakamas Domain in South Africa/Namibia provides a new,unified lithostratigraphy and evolutionary history applicable to the whole Namaqua *** Mesoproterozoic history ranges from~1350 Ma to 960 Ma,but isotopic evidence suggests it was built upon pre-existing Paleoproterozoic continental crust that extended west from the Archaean *** eastern Namaqualand,early rift-related magmatism and sedimentation at~1350 Ma occurred in a confined ocean *** tectonic reversal and subduction at~1290–1240 Ma led to establishment of the Areachap,Konkiep and Kaaien *** the Kakamas Domain,widespread deposition of pelitic sediments occurred at~1220 Ma(Narries Group).These contain detrital zircons derived from proximal crust with ages between~2020 Ma and 1800 Ma(western Palaeoproterozoic domains)and 1350–1240 Ma(eastern early Namaqua domains),suggesting pre-sedimentation *** pelites underwent granulite grade metamorphism at~1210 Ma(peak conditions:4.5–6 kbar and 770–850°c),associated with voluminous,predominantly S-type granitoid orthogneisses between~1210 Ma and 1190 Ma(Eendoorn and ham River Suites)and low-angle ductile(D_(2))deformation which continued until~1110 Ma,interspersed with periods of *** enduring P-T regime is inconsistent with the expected crustal over-thickening associated with the generally-accepted collision-accretion Namaqualand ***,we propose the Namaqua Sector is a‘hot orogen’developed in a wide continental back-arc with subduction west of the present-day *** observed high geotherm resulted from thinned back-arc lithosphere accompanied by an influx of mantle-derived *** D_(2)deformation resulted from"bottom-driven"tectonics and viscous drag within the crust by convective flow in the underlying asthenospheric *** extended tectonothermal regime ceased at~1110 Ma when SW-directed thrusting stacked the Namaqua Domains into their current positions,constrained in

关键词： Kakamas Namaqua Geodynamics Geochronology hot orogeny Mesoproterozoic

Formation of TiN Grid on NiTi by Laser Gas Nitriding for Improving Wear Resistance in hanks' Solution

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2016年第5期32卷 459-464页

作者： c.h.Ng O.K.chan h.c.Man Department of Industrial and Systems Engineering The Hong Kong Polytechnic University

Laser gas nitriding （LGN） is a common surface modification method to enhance the wear resistance of titanium （Ti） alloys, which are known to have poor tribological properties. In the present study, a titanium nitride （TIN） grid network was fabricated on the surface of nickel titanium （NiTi） by LGN. The laser processing parameters were selected to achieve nitriding without surface melting and hence to＇maintain a smooth surface finish. The characteristics of the grid-nitrided samples were investigated by scanningelectron microscopy, X-ray diffractometry, optical microscopy, 2-D profilometry, contact angle measurements and nanoindentation. The wear resistance of the nitrided samples was evaluated using reciprocating wear test against ultra-high-molecular-weight polyethylene （UhMWPE） in hanks＇ solution. The results indicate that the wear rates of the grid-nitrided samples and the UhMWPE counter-body in the wear pair are both significantly reduced. The decrease in wear rates can be attributed to the combination of a hard TiN grid and a soft NiTi substrate. In hanks＇ solution, the higher hydrophilicity of the nitrided samples also contributes to the better performance in wear test against hydrophobic UhMWPE.

关键词： Laser Nitriding Surface patterning Titanium alloys Wear

Numerical simulation and experimental study for rheo-forged component using direct and indirect die system

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of china 2010年第9期20卷 1799-1804页

作者： h.h.KIM c.G.KANG Precision Manufacturing Systems Division Pusan National University School of Mechanical Engineering Pusan National University

Sand casting and die casting processes have been used widely for complex automotive products such as knuckle, arm, ***, a part fabricated by casting has limited strength due to manufacturing defects such as the dendrite structure, segregation and *** an attempt to offer a solution to these problems, forging has been used as an alternative ***, the forging process provides limited formability for complex shape ***-forging of metal offers not only superior mechanical strength but also requires significantly lower machine loads than solid forming *** order to produce semi-solid materials of the desired microstructure, a stirring process is applied during solidification of molten *** results of an A356 aluminum alloy sample, which are obtained by experiment and by simulation using DEFORM 3D, are present.

关键词： rheo-forging A356 alloy formability forming defects

Temperature and Thermal Stress Distribution for Metal Mold in Squeeze casting Process

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第3期24卷 347-350页

作者： c.h.Lee S.h.Lee Institute of Technology and Science Chung-Ang University

In the squeeze casting process, loaded high pressure （over approximately 200 MPa） and high temperature influence the thermo-mechanical behavior and performance of the used metal mold. Therefore, to safely maintain the metal molds, the thermo-mechanical characteristics （temperature and thermal stress） of metal mold in the squeeze casting must be investigated. In this paper, temperature and thermal stress distribution of steel mold in squeeze casting process were investigated by using a three-dimensional non-steady heat conduction analysis and a three-dimensional thermal elastic-plastic analysis considering temperature-dependent thermophysical and mechanical properties of the steel mold.

关键词： Squeeze casting Steel mold Thermal stress Thermo-Mechanical analysis

Roles of soil-structure interaction and damping in base-isolated structures built on numerous soil layers overlying a half-space

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2016年第2期15卷 387-400页

作者： c.S.Tsai c.I.hsueh h.c.Su Department of civil Engineering Feng Chia University Graduate Institute of civil & hydraulic Engineering Feng Chia University Department of Water Resources Engineering and conservation Feng Chia University

This study examines the roles of soil-structure interaction （SSI）, higher modes, and damping in a base-isolated structure built on multiple layers of soil overlying a half space. closed-form solutions for the entire system, including a superstructure, seismic isolator, and numerous soil layers overlying a half-space, were obtained. The formulations obtained in this study simply in terms of well-known frequencies and mechanical impedance ratios can explicitly interpret the dynamic behavior of a base-isolated structure interacting with multiple soil layers overlying a half-space. The key factors influencing the performance of the isolation system are the damping ratio of the isolator and the ratio of the natural frequency of the fixed-base structure to that of the isolated structure by assuming that the superstructure moves as a rigid body. This study reveals that higher damping in the base isolator is unfavorable to higher mode responses that usually dominate the responses of the superstructure and that the damping mechanism plays an important role in transmitting energy in addition to absorbing energy. It is also concluded that it is possible to design a soft soil layer as an isolation system for isolating vibration energy.

关键词： base isolation seismic isolation soil-structure interaction closed- form solution higher-mode effects soilstratum passive control damping effects