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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

On Abstract Third-Order Differential Equation and Its Applications

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Acta Mathematica Sinica,English Series 2023年第3期39卷 399-411页

作者： Belkacem ChAOUChI Lakhdar benaissa Marko KOSTIC Department of Mathematics Faculty of Science and TechnologyUniversity of Khemis MilianaKhemis MilianaAlgeria Department of Mathematics Faculty of ScienceUniversity of AlgiersAlgeria Faculty of Technical Sciences University of Novi SadTrg D.Obradovica 621125 Novi SadSerbia

In this paper,we consider an abstract third-order differential equation and deduce some results on the maximal regularity of its strict *** assume that the inhomogeneity appearing in the right-hand term of this equation belongs to some anistropic holder *** illustrate our results by a BVP involving a 3D Laplacian posed in a cusp domain of R^(4).

关键词： Abstract third-order differential equation cusp domain strict solution

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Power quality improvement using fuzzy logic controller for five-level shunt active power filter under distorted voltage conditions

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Frontiers in Energy 2014年第2期8卷 212-220页

作者： Amar benaissa Boualaga RABhI Ammar MOUSSI Department of Electrical Engineering University of Djelfa B.P.3117 Djelfa 17000 Algeria SE Laboratory University of Biskra B.P. 145 Biskra 07000 Algeria ARhYS Laboratory University of Biskra B.P.145 Biskra 07000 Algeria

In this paper, a five-level inverter is used as a shunt active power filter （APF）, taking advantages of the multilevel inverter such as low harmonic distortion and reduced switching losses. It is used to compensate reactive power and eliminate harmonics drawn from a thyristor rectifier feeding an inductive load （RL） under distorted voltage conditions. The APF control strategy is based on the use of self-tuning filters （STF） for reference current generation and a fuzzy logic current controller. The use of STF instead of classical extraction filters allows extracting directly the voltage and current fundamental components in the a-fl axis without phase locked loop （PLL）. The MATLAB fuzzy logic toolbox is used for implementing the fitzzy logic control algorithm. The obtained results show that the proposed shunt APF controller has produced a sinusoidal supply current with low harmonic distortion and in phase with the line voltage.

关键词： active power filter (APF) harmonics isolator distorted voltage conditions self-tuning filters (STF) fuzzy logic control

Energy Decay of Solutions to a Nondegenerate Wave Equation with a Fractional Boundary Control

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Journal of Partial Differential Equations 2021年第3期34卷 201-223页

作者： TAhRI Mohamed BENKhEDDA hanane benaissa Abbes Laboratory of Analysis and Control of PDEs Djillali Liabes UniversityP.O.Box 89Sidi Bel Abbes 22000Algeria

In this paper,we study the energy decay rate for a one-dimensional nondegenerate wave equation under a fractional control applied at the *** proved the polynomial decay result with an estimation of the decay *** resul... 详细信息

关键词： Nondegenerate wave equation fractional boundary control Frequency domain method Optimal polynomial stability

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

Asymptotic properties of a nonparametric conditional density estimator in the local linear estimation for functional data via a functional single-index model

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Statistical Theory and Related Fields 2022年第3期6卷 208-219页

作者： Fadila benaissa Abdelmalek Gagui Abdelhak Chouaf University Oran 1 Ahmed Ben Bella Oran OranAlgeria Laboratory of Statistics and Stochastic Processes Djillali Liabes UniversitySidi Bel AbbesAlgeria

This paper deals with the conditional density estimator of a real response variable given a functional random variable(i.e.,takes values in an infinite-dimensional space).Specifically,we focus on the functional index model,and this approach represents a good compromise between nonparametric and parametric *** we give under general conditions and when the variables are independent,the quadratic error and asymptotic normality of estimator by local linear method,based on the single-index ***,wecomplete these theoretical advances by some simulation studies showing both the practical result of the local linear method and the good behaviour for finite sample sizes of the estimator and of the Monte Carlo methods to create functional pseudo-confidence area.

关键词： Mean squared error single functional index conditional density function nonparametric estimation local linear estimation asymptotic normality functional data