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Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for biointerface and biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-hIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exh.b.ted more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles h.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exh.b.ting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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Response Evaluation Using Contrast-Enhanced Ultrasound for Unresectable Advanced hepatocellular Carcinoma Treated With Tyrosine Kinase Inh.b.tors Plus Anti-PD-1 Antibody Therapy

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Ultrasound in Medicine and biology 2024年第1期50卷 142-149页

作者： Zhao C.-K. Guan X. Pu Y.-Y. Zhou b.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. han h. xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (CEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (hCC) treated with tyrosine kinase inh.b.tors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody therapy. Methods: A prospective cohort of consecutive patients with hCC who received combined TKI/anti-PD-1 antibody treatment for unresectable hCC between January 2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and CEUS examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography (MRI/CT) and modified RECIST (mRECIST) with CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 hCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIST version 1.1 of unenhanced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medicine & biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound hepatocellular carcinoma

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From 0D to 3D:hierarchical structured high-performance free-standing silicon anodes based on binder-induced topological network architecture

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Journal of Energy Chemistry 2024年第6期93卷 16-23,I0002页

作者： Yihong Tong Ruicheng Cao Guanghui xu Yifeng Xia hongyuan xu hong Jin hui xu Xi’an Jiaotong University Suzhou Academy Suzhou 215123JiangsuChina Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123JiangsuChina

Free-standing silicon anodes with high proportion of active materials have aroused great attention;however,the mechanical stability and electrochemical performance are severely ***,to resolve the appeal issues,a free-standing anode with a"corrugated paper"shape on micro-scale and a topological crosslinking network on the submicron and nano-scale is ***,an integrated three-dimensional electrode structure is constructed based on robust carbon nanotubes network with firmly anchored SiNPs via forming interlocking *** which,the hierarchical interlocking structure is achieved by directional induction of the binder,which ensures well integration during cycling so that significantly enhances mechanical stability as well as electronic and ionic conductivity of *** from it,this anode exh.b.ts outsta nding performance under harsh service conditions including high Si loading,ultrahigh areal capacity(33.2 mA h cm^(-2)),and high/low temperatures(-15-60℃),which significantly extends its practical ***,the optimization mechanism of this electrode is explored to verify the crack-healing and structure-integration maintaining along cycling via a unique self-stabilization ***,from both the fundamental and engineering views,this strategy offers a promising path to produce high-performance free-standing electrodes for flexible device applications especially facing volume effect challenges.

关键词： Topological network Self-stabilization Flexibility Free-standing Silicon anode

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Traffic-Aware Fuzzy Classification Model to Perform IoT Data Traffic Sourcing with the Edge Computing

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Computers, Materials & Continua 2024年第2期78卷 2309-2335页

作者： huixiang xu College of Information Engineering Zhengzhou University of TechnologyZhengzhou450044China

The Internet of Things(IoT)has revolutionized how we interact with and gather data from our surrounding *** devices with various sensors and actuators generate vast amounts of data that can be harnessed to derive valuable *** rapid proliferation of Internet of Things(IoT)devices has ushered in an era of unprecedented data generation and *** IoT devices,equipped with many sensors and actuators,continuously produce vast volumes of ***,the conventional approach of transmitting all this data to centralized cloud infrastructures for processing and analysis poses significant ***,transmitting all this data to a centralized cloud infrastructure for processing and analysis can be inefficient and impractical due to bandwidth limitations,network latency,and scalability *** paper proposed a Self-Learning Internet Traffic Fuzzy Classifier(SLItFC)for traffic data *** proposed techniques effectively utilize clustering and classification procedures to improve classification accuracy in analyzing network traffic *** addresses the intricate task of efficiently managing and analyzing IoT data traffic at the *** employs a sophisticated combination of fuzzy clustering and self-learning techniques,allowing it to adapt and improve its classification accuracy over *** adaptability is a crucial feature,given the dynamic nature of IoT environments where data patterns and traffic characteristics can evolve *** the implementation of the fuzzy classifier,the accuracy of the clustering process is improvised with the reduction of the computational *** can reduce computational time while maintaining high classification *** efficiency is paramount in edge computing,where resource constraints demand streamlined data ***,SLItFC’s performance advantages make it a compelling choice for organizations seeking to harness the potential of IoT data for real-time insig

关键词： Internet of Things(IoT) edge computing traffic data self-learning fuzzy-learning

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Coupling effect on the thermal hazard assessment of hazardous chemical materials via calorimetric technologies and simulation approaches

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Defence Technology（防务技术） 2024年第2期32卷 644-654页

作者： Yabei xu Jiankun Shao Wei Wang Shengliang xu Dongping Chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang 441003China

The coupling effect of heat absorption and release exists in the thermal decomposition of a few chemical ***,the impact of the above coupling on thermal hazard assessment is not considered in the literature *** this work,nitroguanidine(NQ)and 1,3,5-trinitro-1,3,5-triazine(RDX)are selected as representative materials to explore the influence of the coupling effect on the thermal hazard assessment of chemical *** linear heating experiments of NQ and RDX are carried out by a microcalorimeter and synchronous thermal *** thermal decomposition curves are decoupled by advanced thermokinetics *** thermal decomposition and kinetic parameters before and after decoupling are *** results of TG experiment show that both NQ and RDX began to lose mass during the endothermic *** endothermic melting and exothermic decomposition of NQ and RDX are coupled within this *** coupling effect has different degrees of influence on its initial decomposition temperature and safety *** with the parameters in the coupling state,the initial decomposition temperature and adiabatic induction period after decoupling *** self-accelerating decomposition temperature increases,and internal thermal runaway time *** the thermal hazard assessment of chemical materials with coupling effects,the calculated parameters after decoupling should be taken as an important safety index。

关键词： Calorimetric technologies Kinetics Thermal hazard Phase transformation Thermal decomposition

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blockade of Rho-associated kinase prevents inh.b.tion of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés berardo Cristian R.bacaglio bárbara b.báez Rubén Sambuelli Kazim A.Sheikh Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química biológica-Centro de Investigaciones en Química biológica de Córdoba(CIQUIbIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inh.b.tion of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inh.b.tors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inh.b.tor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inh.b.tory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inh.b.tion of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inh.b.tion of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-barrésyndrome nerve repair ROCK Y-27632

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Identification of high oxygen-consuming substances in stormwater drainage systems illicitly connected with sewage system

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Journal of Environmental Sciences 2024年第4期138卷 132-140页

作者： Chen xu Zuxin xu Wenhai Chu Shanshan Wu Rong Xiao Lei Su State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Ministry of Education Key Laboratory of Yangtze River Water Environment Tongji UniversityShanghai 200092China Guangzhou Resource Environmental Protection Technology Co. Ltd.Guangzhou 510030China

The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological *** a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in ***,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the *** induces seasonal or year-round black and stink phenomena in urban ***,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is *** a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino *** comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.

关键词： Urban drainage system Oxygen-consuming substances Domestic sewage Amino acid

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Influence of the penetration of adjacent X-section cast-in-place concrete(XCC)pile on the existing XCC pile in sand

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 557-572页

作者： Peng ZhOU Jianhui xu Changjie xu Guangwei CAO Jie CUP xuanming DING School of Civil Engineering and Architecture State Key Laboratory of Performance Monitoring and Protecting of Rail Transit InfrastructureEast China Jiaotong UniversityNanchang330013China Guangdong Key Laboratory of Earthquake Engineering and Application Technology Earthquake Engineering Research&Test CenterGuangzhou UniversityGuangzhou510006China Key Laboratory of New Technology for the Construction of Cities in Mountain Areas College of Civil EngineeringChongqing UniversityChongqing400045China Zijin School of Geology and Mining Fuzhou UniversityFuzhou350116China

A series of small-scale 1g X-section cast-in-place concrete(XCC)pile-penetration model tests were conducted to study the effects of soil density and pile geometry on the lateral responses of an existing pile and the variations in surrounding soil *** results showed that the bending patterns of existing XCC piles varied with penetration *** lateral response of the existing pile was sensitive to the change in relative density and pile *** example,the bending moment of the existing pile increased along with these *** development of the radial stressσ′r/σ′v0 of the soil around an existing pile showed different trends at various depths during the penetration of the adjacent ***,the change in radial stress during the penetration of the XCC pile did not exh.b.t the“h/R effect”that was observed in the free-field soil,due to the shielding effect of the existing *** peak value of radial stressσ′r_max/σ′v0 decreased exponentially as the radial distance r/R *** attenuation ofσ′r_max/σ′v0 with r/R in the loose sand was faster than in the medium-dense or dense ***σ′r_max/σ′v0 at the same soil location increased with the cross-section geometry parameter.

关键词： X-section cast-in-place concrete(XCC)pile Test Penetration Sand Lateral response Radial stress

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bio-inspired inorganic-protein coating on Mg-based biomaterials for bioengineering applications

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Science China Materials 2024年第5期67卷 1678-1680页

作者： xuwen Peng haolan xu Department of Chemistry Engineering Tsinghua UniversityBeijing100084China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusAdelaideSouth Australia5095Australia

Developing smart and advanced functional materials inspired by the unparalleled complexity and efficiency of biological tissues has received much attention across various *** alloys,particularly pure magnesium,have emerged as notable candidates in orthopedics and dentistry due to their exceptional biocompatibility,degradability,and ability to promote bone regeneration[1].however,the highly reactive chemical nature of magnesium and its rapid degradation upon exposure to water.

关键词： coating alloys magnesium

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