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Response Evaluation Using Contrast-Enhanced Ultrasound for Unresectable Advanced hepatocellular Carcinoma Treated With Tyrosine Kinase Inh.b.tors Plus Anti-PD-1 Antibody Therapy

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Ultrasound in Medicine and biology 2024年第1期50卷 142-149页

作者： Zhao C.-K. Guan X. Pu Y.-Y. Zhou b.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. han h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (CEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (hCC) treated with tyrosine kinase inh.b.tors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody therapy. Methods: A prospective cohort of consecutive patients with hCC who received combined TKI/anti-PD-1 antibody treatment for unresectable hCC between January 2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and CEUS examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography (MRI/CT) and modified RECIST (mRECIST) with CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 hCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIST version 1.1 of unenhanced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medicine & biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound hepatocellular carcinoma

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia bainto helen harvey Adriana h.Tremoulet Jane C.burns Kirsten b.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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鲜食玉米收获机清选装置设计与试验

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农机化研究 2024年第5期46卷 77-82,86页

作者：张伟阿力木·买买提吐尔逊李谦绪刘希光李维军王善博郝良军新疆农业大学机电工程学院乌鲁木齐830052 新疆新研牧神科技有限公司乌鲁木齐830011

针对4YZ-5自走式鲜食玉米收获机在清选过程中果穗碰撞损失率高、清选效率低等问题,利用鲜食玉米果穗与茎秆等杂质密度不同,设计了二次拉草辊与负压风机相结合的清选装置,确定了拉草辊和负压风机的主要参数理论值,并开展了3因素3水平正... 详细信息

针对4YZ-5自走式鲜食玉米收获机在清选过程中果穗碰撞损失率高、清选效率低等问题,利用鲜食玉米果穗与茎秆等杂质密度不同,设计了二次拉草辊与负压风机相结合的清选装置,确定了拉草辊和负压风机的主要参数理论值,并开展了3因素3水平正交试验研究不同参数组合工况下的清选性能与损伤特性,通过试验确定了最优组合参数。试验结果表明:当行走速度为6.5km/h、拉草辊转速为550r/min、风机转速为1000r/min时,玉米果穗含杂率为6.18%,果穗损失率为1.32%,清选稳定性能较好。试验结果可为鲜食玉米清选装置提供理论依据。

关键词：收获机清选装置最优参数正交试验优化设计

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Optimization of chemistry and process parameters for control of intermetallic formation in Mg sludges

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Journal of Magnesium and Alloys 2024年第4期12卷 1431-1448页

作者： Y.Fu G.G.Wang A.hu Y.Li K.b.Thacker J.P.Weiler h.hu Department of Mechanical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Technology Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,holding and high pressure die casting practices is a very important ***,very often it is overlooked by academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of this study was to minimize the intermetallic formation in Mg sludge via the optimization of the chemistry and process *** Al8Mn5 intermetallic particles were identified by the microstructure analysis based on the Al and Mn *** design of experiment(DOE)technique,Taguchi method,was employed to minimize the intermetallic formation in the sludge of Mg alloys with various chemical compositions of Al,Mn,Fe,and different process parameters,holding temperature and holding *** sludge yield(SY)and intermetallic size(IS)was selected as two *** optimum combination of the levels in terms of minimizing the intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for the holding temperature and holding at 30 mins for the holding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for the holding temperature and holding at 60 mins for the holding time,*** groups of sludge factors,Chemical Sludge(CSF),Physical Sludge(PSF)and Comprehensive Sludge Factors(and CPSF)were established for prediction of sludge yields and intermetallic sizes in Al-containing Mg *** CPSF with five independent variables including both chemical elements and process parameters gave high accuracy in prediction,as the prediction of the PSF with only the two processing parameters of the melt holding temperature and time showed a relatively large deviation from the experimental *** Chemical Sludge Factor was primarily designed for small ingot producers and die casters with a limited melting and holding capacity,of which process parameters could be fixed *** Physical Sludge Factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguchi method Sludge factor Chemical composition Process parameter

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字典积图的任意可分性

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新疆大学学报（自然科学版中英文） 2024年第2期41卷 181-187页

作者：西日尼阿依·努尔麦麦提刘凤霞蔡华喀什大学数学与统计学院新疆喀什844000 新疆大学数学与系统科学学院新疆乌鲁木齐830017 昌吉学院数学与数据科学学院新疆昌吉831100

给定n个顶点的图G,对于满足∑_(i=1)^(k)n_(i)=n的任意一个正整数序列(n_(1),n_(2),…,n_(k)),如果都存在顶点集V(G)的划分(V_(1),V_(2),…,V_(k)),满足Vi导出的子图G[V_(i)]是连通的,并且|V_(i)|=n_(i),其中1≤i≤k,则称图G是任意可分图(简称为AP).两个图G和h的字典积图记为G?h,其顶点集为V(G)×V(h),(g,h)(g,h)是G?h的一条边当且仅当gg∈E(G)或者g=g且hh∈E(h).讨论了可迹图和任意可分图的字典积图的任意可分性,证明了对于最大度至多为n+1的树T,如果T有一条路P满足全部度数为(T)的顶点属于顶点集V(P),则字典积图T○Pn是任意可分图;如果G是一个可迹图且h是任意可分图,则图G○h是任意可分图;如果G=S(2,a,b)是一个满足2≤a≤b的任意可分星型树,则图G○G是任意可分图;如果G是哈密顿图且h是一个图,则G○h是任意可分图.

关键词：图的任意可分性字典积图星型树可迹图

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应用钆布醇的稳态MR血管成像评估股骨头缺血性坏死病人的血供变化

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国际医学放射学杂志 2024年第1期 129-130页

作者： Z.h.Liao C.Liu b.Wu C.Ma b.Ming Q.Zhou 陈莉

摘要目的探讨应用钆布醇行稳态（SS）MR血管成像（MRA）评价股骨头坏死（ONFh）血供变化的可行性。方法前瞻性纳入2021年12月—2022年5月招募的参与者。比较

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火星探测:黄钾铁矾原地K-Ar定年

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中国科学：地球科学 2024年第3期54卷 661-676页

作者：杨静郑德文武颖陈虹杨莉张斌中国地质科学院地质力学研究所自然资源部活动构造与地质安全重点实验室北京100081 中国地震局地质研究所地震动力学国家重点实验室北京100037 中国地质大学(北京)科学研究院北京100083 中国科学院地质与地球物理研究所中国科学院新生代地质与环境重点实验室北京100029

为了更好地确定火星不同地形所记录的气候变化的时间尺度,确定火星历史上重大事件的绝对年龄,并校准陨石坑率,需要从火星原地或从返回样品中获得精确的年龄数据.原地K-Ar定年是目前比样品返回更为实用的一种精确远程定年技术.黄钾铁矾(K... 详细信息

为了更好地确定火星不同地形所记录的气候变化的时间尺度,确定火星历史上重大事件的绝对年龄,并校准陨石坑率,需要从火星原地或从返回样品中获得精确的年龄数据.原地K-Ar定年是目前比样品返回更为实用的一种精确远程定年技术.黄钾铁矾(KFe_(3)(SO_(4))_(2)(Oh)_(6)),是火星上广泛存在的唯一一种通过就位探测、轨道遥感探测、陨石研究三种手段都确定存在的含钾硫酸盐矿物,它已被用于K-Ar和^(40)Ar/^(39)Ar精确定年.火星上黄钾铁矾的保存提供了火星上含水过程的性质和持续时间的信息,不同年龄的黄钾铁矾能有效地解读火星历史上地表水流动时期及过渡到当前干旱气候之间的演变历史.本文总结了近年来火星上黄钾铁矾存在的区域、矿物学特征、在火星上的稳定性、原地K-Ar定年的研究现状、黄钾铁矾氩扩散动力学等,探讨了黄钾铁矾原地K-Ar定年的关键科学问题、火星采样返回需求、未来研究方向等.

关键词：火星黄钾铁矾原地K-Ar定年氩扩散稳定性

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Cellulose synthesis in land plants

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Molecular Plant 2024年第2期17卷 359-361页

作者： Gustav b.Pedersen Leonard blaschek Kristian E.h.Frandsen Lise C.Noack Staffan Persson 不详

After the original publication of the above article,we and/or attentive readers identified several instances of unclear or erroneous writing that needed correcting,as *** are added for emphasis.

关键词： synthesis instance identif

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Greatly enhanced corrosion/wear resistances of epoxy coating for Mg alloy through a synergistic effect between functionalized graphene and insulated blocking layer

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Journal of Magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.J.Li J.h.Chu M.M.Li D.N.Zou L.b.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and Manufacturing for Vehicle body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on Mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare Mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exh.b.ts great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys.

关键词： Mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance blocking layer

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中昆仑山北坡水汽含量的计算及其特征分析

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暴雨灾害 2024年第2期43卷 224-233页

作者：刘晶杨莲梅李俊江郭玉琳李阿桥中国气象局乌鲁木齐沙漠气象研究所乌鲁木齐830002 新疆云降水物理与云水资源开发实验室乌鲁木齐830002 西天山云降水物理野外科学观测基地乌鲁木齐830002 新疆气象信息中心乌鲁木齐830002 新疆维吾尔自治区气候中心乌鲁木齐830002

干旱区水汽变化影响区域水资源系统的结构和演变,基于2020年1月—2022年12月中昆仑山北坡地区4个地基GPS遥感大气可降水量资料(GPS-PWV)、2个探空站观测资料和108个地面气象观测站逐时水汽压资料,利用一元线性拟合方法建立了适用于中昆... 详细信息

干旱区水汽变化影响区域水资源系统的结构和演变,基于2020年1月—2022年12月中昆仑山北坡地区4个地基GPS遥感大气可降水量资料(GPS-PWV)、2个探空站观测资料和108个地面气象观测站逐时水汽压资料,利用一元线性拟合方法建立了适用于中昆仑山北坡地区的大气水汽含量(W-PWV)和地面水汽压计算模型(W-e)并对计算结果进行评估,分析了中昆仑山北坡地区东段、中段、西段W-PWV的时空分布特征及降水开始时刻与W-PWV峰值的关系。结果表明:(1)W-PWV年平均高值区位于研究区西段,中段次之,东段沙漠南缘W-PWV最低。海拔高度大于1500 m测站W-PWV随高度升高逐渐减少。夏季地面气象观测站平均W-PWV是春、秋季的2倍左右;(2)研究区W-PWV月变化具有单峰型特征,其中海拔高度1300~1500 m测站的W-PWV在7月和8月达到峰值,其余测站的W-PWV在8月达到峰值,海拔低于2000m和高于2000m测站W-PWV分别在夜间和白天维持较高值;(3)水汽含量模型计算的测站W-PWV与降水开始时刻有较好的对应关系,降水前各站W-PWV均存在不同程度跃变过程,降水过程前1~2h内W-PWV峰值达到测站W-PWV月平均值的1.5倍以上。

关键词：中昆仑山北坡水汽含量地基GPS 水汽含量计算模型

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