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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot h.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

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Non-relativistic scattering amplitude for a new multi-parameter exponential-type potential

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Chinese Physics B 2016年第8期25卷 21-25页

作者： Yazarloo B h Mehraban h hassanabadi h Physics Department Semnan University Physics Department Shahrood University of Technology

In this paper, we study the scattering properties of s-wave Schrdinger equation for the multi-parameter potential,which can be reduced into four special cases for different values of potential parameters, i.e., hulthn, Manning–Rosen,and Eckart potentials. We also obtain and investigate the scattering amplitudes of these special cases. Some numerical results are also obtained and reported.

关键词： scattering amplitude Schrodinger equation multi-parameter potential phase shifts cross section

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Photocurrent improvement of an ultra-thin silicon solar cell using the localized surface plasmonic effect of clustering nanoparticles

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Chinese Physics B 2020年第6期29卷 532-537页

作者： F Sobhani h heidarzadeh h Bahador Department of Electrical and Computer Engineering University of Mohaghegh ArdabiliArdabilIran

The cluster-shaped plasmonic nanostructures are used to manage the incident light inside an ultra-thin silicon solar *** we simulate spherical,conical,pyramidal,and cylindrical nanoparticles in a form of a cluster at the rear side of a thin silicon cell,using the finite difference time domain(FDTD)*** calculating the optical absorption and hence the photocurrent,it is shown that the clustering of nanoparticles significantly improves *** photocurrent enhancement is the result of the plasmonic effects of clustering the *** comparison,first a cell with a single nanoparticle at the rear side is *** four smaller nanoparticles are put around it to make a *** photocurrents of 20.478 mA/cm2,23.186 mA/cm2,21.427 mA/cm2,and 21.243 mA/cm2 are obtained for the cells using clustering conical,spherical,pyramidal,cylindrical NPs at the backside,*** values are 13.987 mA/cm2,16.901 mA/cm2,16.507 mA/cm2,17.926 mA/cm2 for the cell with one conical,spherical,pyramidal,cylindrical NPs at the backside,***,clustering can significantly improve the ***,the distribution of the electric field and the generation rate for the proposed structures are calculated.

关键词： clustering nanoparticles plasmonic solar cell localized surface plasmon resonance photocurrent finite difference time domain(FDTD)method light management

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Gaussian process hydrodynamics

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Applied Mathematics and Mechanics(English Edition) 2023年第7期44卷 1175-1198页

作者： h.OWhADI California Institute of Technology MC 9-94PasadenaCA 91125U.S.A.

We present a Gaussian process(GP)approach,called Gaussian process hydrodynamics(GPh)for approximating the solution to the Euler and Navier-Stokes(NS)*** to smoothed particle hydrodynamics(SPh),GPh is a Lagrangian particle-based approach that involves the tracking of a finite number of particles transported by a ***,these particles do not represent mollified particles of matter but carry discrete/partial information about the continuous *** is achieved by placing a divergence-free GP priorξon the velocity field and conditioning it on the vorticity at the particle *** physics(e.g.,the Richardson cascade and velocityincrement power laws)is incorporated into the GP prior by using physics-informed additive *** is equivalent to expressingξas a sum of independent GPsξl,which we call modes,acting at different scales(each modeξlself-activates to represent the formation of eddies at the corresponding scales).This approach enables a quantitative analysis of the Richardson cascade through the analysis of the activation of these modes,and enables us to analyze coarse-grain turbulence statistically rather than *** GPh is formulated by using the vorticity equations,it does not require solving a pressure *** enforcing incompressibility and fluid-structure boundary conditions through the selection of a kernel,GPh requires significantly fewer particles than *** GPh has a natural probabilistic interpretation,the numerical results come with uncertainty estimates,enabling their incorporation into an uncertainty quantification(UQ)pipeline and adding/removing particles(quanta of information)in an adapted *** proposed approach is suitable for analysis because it inherits the complexity of state-of-the-art solvers for dense kernel matrices and results in a natural definition of turbulence as information *** experiments support the importance of selecting physics-informed kernels and

关键词： I Navier-Stokes(NS)equation Euler Lagrangian vorticity Gaussian pro-cess(GP) physics-informed kernel

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Systems engineering optimization of Omid-2 in the conceptual design phase

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Journal of Systems Engineering and Electronics 2016年第3期27卷 634-648页

作者： h.Shahrabi Seid h.Pourtakdoust Department of Mechanical and Aerospace Engineering Science and Research BranchIslamic Azad University

Due to the importance and role of systems engineering in space mission developments, optimization of Omid＇s systems engineering as a milestone to its current and future generations is focused. In this regard systems engineering management organization as the basis of optimization work flow in the conceptual design phase is proposed for improvement. To improve the systems engineering management, an agile enhanced organization chart is developed that defines various system duties. This is a type of concurrent engineering approach that promotes direct communication and data interchange between the team members. Due to the importance of decision making in the conceptual design phase, two design matrices are constructed that portray merits of various design options in terms of improved satellite life as well as specific choices of remote sensing capability for the Omid second generation（Omid-2）. Conceptual design optimization is explored considering several structural objectives as well as optimal solar energy absorption utilizing a multiple criteria decision making approach. The Eigenvector method is utilized to formulate the objective function via expert judgment. This approach is robust with respect to designer probable miss-judgment. The optimized version of Omid-2 turned out to be a passive Z-axis spin stabilized satellite made of hexagonal honeycomb configuration with carbon-epoxy side panels and Aluminum bottom plate.

关键词： Omid satellite systems engineering optimization conceptual design

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Influence of stretch and temperature on the energy density of dielectric elastomer generators

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Applied Mathematics and Mechanics(English Edition) 2019年第11期40卷 1547-1560页

作者： h.KhAJEhSAEID h.BAGhShOMAL AZAR School of Engineering-Emerging Technologies University of Tabriz

Application of dielectric elastomers (DE) has remarkably increased in mechatronics because they are suitable candidates for energy harvesting due to their low cost,light weight,and high energy *** dielectric elastomer generators (DEGs) exhibit high performance regardless of the applications ***,functioning as a generator,a DE may lose its efficiency due to several failure modes including material rupture,loss of tension (LT),electrical breakdown (EB),and electromechanical instability (EMI).The failure modes confine the area of allowable states for generation *** constant and dielectric strength of such elastomers depend on the amount of applied deformation and also working temperature,which are often ignored in theoretical *** this paper,variations of the above-mentioned parameters are considered in mechanical and electrical modellings to investigate their effects on energy density and efficiency of *** results show that,ignoring the variations of material dielectric constant and dielectric strength leads to overestimation of the specific ***,it is shown that,for an acrylic-based generator,the specific energy sharply decreases with temperature rise.

关键词： renewable energy dielectric elastomer generator (DEG) stretch temperature

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Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 543-562页

作者： h.M.FEIZABAD M.h.YAS Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent *** fibers are renowned for their good mechanical properties,abundance,and short cycle *** beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic *** different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the *** elastic properties of the composite are determined with the law of *** hamilton’s principle,the governing equations of motion are *** generalized differential quadrature method(GDQM)is then applied to the equations to obtain the *** achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam ***,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature method(GDQM)

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Quantitative hazard assessment for Zonguldak Coal Basin underground mines

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International Journal of Mining Science and Technology 2019年第3期29卷 453-467页

作者： h.h.Erdogan h.S.Duzgun A.S.Selcuk-Kestel Directorate for Strategy Development Ministry of Energy and Natural ResourcesAnkara 06520Turkey Department of Mining Engineering Colorado School of MinesIL 80401USA Institute of Applied Mathematics Middle East Technical UniversityAnkara 06531Turkey

Underground coal mining is one of the most dangerous occupations throughout the *** reasons behind an underground occupational accident are too complex to analyze mainly due to many uncertainties which may arise from geological,operational conditions of the mine or individual characteristics of *** study proposes implementing a quantitative methodology for the analysis and assessment of hazards associated with occupational *** application of the proposed approach is performed on the mines of Turkish hard Coal Enterprises(TTK).The accidents in TTK between the years 2000 and 2014 are firstly statistically analyzed with respect to the number,type and location of accidents,age,experience,education level and main duty of the casualties and also injuries resulting from such *** hazards are classified as individual,operational and locational hazards and quantified using contingency tables,conditional and total probability *** and upper boundaries of hazards are determined and event trees for each hazard class are *** hazard evaluation results show that Armutcuk,Karadon and Uzulmez mines have relatively high hazard levels while Amasra and Kozlu mines have relatively lower hazard values.

关键词： Underground coal mining Occupational accidents hazard assessment Contingency tables Zonguldak Coal Basin

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