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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Comparative study of microwave-assisted versus conventional heated reactions of biomass conversion into levulinic acid over hierarchical Mn_(3)O_(4)/ZSM-5 zeolite catalysts

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Carbon Resources Conversion 2023年第3期6卷 245-252页

作者： Mazizah R.A.helmi Dyah Utami C.Rahayu arnia P.Pratama Irena Khatrin Anita N.Ramadhani Yuni K.Krisnandi Department of Chemistry Faculty of Mathematics and Natural ScienceUniversitas IndonesiaDepok 16424Indonesia Solid Inorganic Framework Laboratory Department of ChemistryFaculty of Mathematics and Natural ScienceUniversitas IndonesiaDepok 16424Indonesia

Conversion of delignified cellulose from rice husk biomass,and model compounds of cellobiose and glucose to levulinic acid(LA)over hierarchical Mn_(3)O_(4)/ZSM-5 catalyst was carried out using a household microwave method,and then compared to the established conventional thermos-reaction *** hierarchical ZSM-5 was prepared using a double template method,aiming for micro and mesoporous systems developed in the *** as-prepared ZSM-5 were modified with Mn3O4 through incipient wetness impregnation with Mn2+solution followed by calcination at 550℃.The catalysts were characterized using various techniques such as powder XRD,SEM,BET,AAS,and FT-IR which indicated the hierarchical structure of MFI zeolite(Si/Al of 30-34)with Mn loading of 2.14 wt%.The conversion products were analyzed using hPLC,1h NMR,and 13C NMR *** microwave-assisted reaction using 600 W for 180 s using delignified cellulose,cellobiose,and glucose gave conversion of 37.27%,46.35%,and 54.29%,respectively which is close to the conversion given by the conventional reaction carried out at 130◦C for 4 h(36.75%,55.62%,and 60.9%,respectively).Interestingly,the LA yield from the microwave-assisted reaction(4.33%,6.12%,and 9.57%)is higher than the yield from the conventional reaction,which only produced 5.2%,4.88%,and 6.93%*** microwaveassisted method is also shown to give less by-products compared to the thermochemical ***,it could be considered an alternative method for converting cellulose to LA.

关键词： hierarchical ZSM-5 zeolite Levulinic acid Lignocellulose conversion Microwave-assisted synthesis Cellobiose Glucose

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena Manuela Samaila Maria Tsekoura Marianna Vlychou Charalampos Matzaroglou Zoe h Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

Computer Simulation of Effect of Intergrain Exchange Interaction on Magnetic Properties of Nanocomposite Magnets

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Journal of Rare Earths 2004年第1期22卷 146-151页

作者： Fukunaga h Mukaino h Department of Electrical Engineering & Electronics Graduate School of Science & Technology Nagasaki University Nagasaki 852-8521 Japan Nagasaki University Nagasaki 852-8521 Japan

Effects of the intergrain exchange interaction on magnetic properties of nanocomposite magnets were investigated by using the computer simulation based on the micromagnetic theory. The simulation was carried out under the assumptions that the strength of the intergrain exchange interaction is weaker than that of the intragrain exchange interaction, that inhomogeneous nanostructures result in the distribution of the strength of the intergrain exchange interaction, and that there exists nonmagnetic intergranular phase (NMIP) between grain boundaries. The distribution of the strength of the intergrain exchange interaction was simulated by the lognormal distribution with the standard deviation of σ.The calculations for Nd 2Fe 14B/α-Fe nanocomposite magnets reveal that a suitably weak intergrain exchange interaction and small grain size enable us to improve magnetic properties. It is also found that a Nd 2Fe 14B/α-Fe nanocomposite magnet has a potential of a (Bh) max value exceeding 300 kJ·m -3. On the other hand, the calculations for Nd 2Fe 14B/Fe 3B nanocomposite magnets reveal that the distribution of the strength of the intergrain exchange interaction deteriorates magnetic properties significantly. Particularly, this tendency is remarkable, when the grain size L is larger than its optimum value, 11 nm. The existence of nonmagnetic boundary layers accelerats this tendency. At σ=0.2, the calculated demagnetization curve for the model magnet composed of Nd 2Fe 14B(36%)/Fe 3B(54%)/NMIP(10%) (Valume fraction) grains (L=15 nm) agrees with that obtained experimentally for a Nd 2Fe 14B/Fe 3B nanocomposite magnet. These results suggest importance of refinement of grain size, suppression of a nonmagnetic intergranular phase, and preparation of homogeneous nanostructure for superior magnetic properties.

关键词： metal materials nanocomposite magnet exchange interaction nanostructure remanence intergranular phase

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： hasan M Isa Marwa J Abdulnabi Nawra S Naser Fatema N Lahmda Noor M AlAnsari Zahra h Isa Afaf M Mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Public health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the Mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Ph more cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Physical findings(P=0.002)than non-IgE-mediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 mo

关键词： Children Milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

A simple tight-binding approach to topological superconductivity in monolayer MoS2

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Chinese Physics B 2020年第2期29卷 425-431页

作者： h Simchi Department of Physics Iran University of Science and TechnologyNarmakTehran 16844Iran Iran Semicondutor Technology Center Tehran 19575-199Iran

Monolayer molybdenum disulfide(MoS2)has a honeycomb crystal ***,with considering the triangular sublattice of molybdenum atoms,a simple tight-binding hamiltonian is introduced(derived)for studying the phase transition and topological superconductivity in MoS2 under uniaxial *** is shown that spin-singlet p+ip wave phase is a topological superconducting phase with nonzero Chern *** the chemical potential is greater(smaller)than the spin-orbit coupling(SOC)strength,the Chern number is equal to four(two)and otherwise it is equal to ***,the results show that,if the superconductivity energy gap is smaller than the SOC strength and the chemical potential is greater than the SOC strength,the zero energy Majorana states ***,we show that the topological superconducting phase is preserved under uniaxial strain.

关键词： MoS2 topological superconductivity Chern number band inversion

Peristaltic flow of Johnson-Segalman fluid in asymmetric channel with convective boundary conditions

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 697-716页

作者： h.YASMIN T.hAYAT A.ALSAEDI h.h.ALSULAMI Department of Mathematics Quaid-i-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Faculty of Science King Abdulaziz University

This work is concerned with the peristaltic transport of the Johnson-Segalman fluid in an asymmetric channel with convective boundary conditions. The mathematical modeling is based upon the conservation laws of mass, linear momentum, and energy. The resulting equations are solved after long wavelength and low Reynolds number are used. The results for the axial pressure gradient, velocity, and temperature profiles are obtained for small Weissenberg number. The expressions of the pressure gra-dient, velocity, and temperature are analyzed for various embedded parameters. Pumping and trapping phenomena are also explored.

关键词： asymmetric channel convective condition pumping and trapping Johnson-Segalman fluid