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Severe liver trauma among pediatric patients in the Japan Trauma Registry

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World Journal of Pediatric Surgery 2021年第2期4卷 36-41页

作者： Makoto Aoki Toshikazu abe Shuichi hagiwara Daizoh Saitoh Kiyohiro Oshima Emergency Medicine Gunma University Graduate School of MedicineMeabashiGunmaJapan Emergency and Critical Care Medicine Tsukuba Memorial HospitalTsukubaIbarakiJapan Emergency Medicine Kiryu Kosei General HospitalKiryuGunmaJapan Traumatology National Defense Medical CollegeTokorozawaSaitamaJapan

Background Limited information exists regarding the clinical characteristics,management practices,and outcomes of pediatric patients with liver injury in *** aim of this study is to evaluate the characteristics,management,and outcome of pediatric patients with liver injury in *** We conducted a multicenter,retrospective cohort study using data from the Japan Trauma Data Bank between 2004 and *** patients with liver injury were classified into the following management groups:nonoperative management(NOM);NOM with angioembolization(AE);operative management(OM).The primary outcome was in-hospital survival,and the secondary outcomes were dispositions,hospital length of stay(LOS),and rate of discharge to *** There were 308 pediatric patients with severe liver injury(organ injury scale grades≥Ⅲ)during the study period;135 patients had isolated liver injury and 173 patients had non-isolated liver *** rates of NOM,NOM with AE,and OM among all patients were 65%,23%,and 12%,*** was highly used both in patients with isolated liver injury(27%)and non-isolated liver injury(22%).In-hospital survival of patients with isolated liver injury and those with non-isolated liver injury were 99%and 88%,*** secondary outcomes among patients with isolated liver injury,82%were admitted to the intensive care *** was 11(8-14)days and 82%were discharged to *** Our retrospective observational study showed that management of pediatric patients with severe liver injury in Japan was characterized by high utilization of *** in-hospital survival rate in Japan was comparable with that of other developed countries.

关键词： patients pediatric admitted

Egalitarian Policies, Effective Demand, and Globalization： Considering Budget Constraint

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International Relations and Diplomacy 2016年第3期4卷 189-202页

作者： Taro abe Nagoya Gakuin University Aichi Japan

This paper examines the effectiveness of redistribution policies under budget constraint considering government spending for the productivity improvement and effective demand. It shows that an asset-based redistribution policy is not always effective under effective demand and budget constraint. however, the increase of effective demand because of an income-based redistribution improves employment, labor productivity, and wage rates because of increased government spending for productivity improvement as the results of saving rate from profit income show. A distinctive feature of this paper is considering effective demand with political aspects. Workers＇ demands on unemployment compensation depend on the demand and supply condition in the goods market. The model implicitly assumes that labor is strong enough to affect political institutions and social security system is prepared enough to affect goods market. Therefore, the model built in this research is applicable to Europe in the real world.

关键词： egalitarianism redistribution effective demand giobalization

helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 418-422页

作者： Naoto Okada Shinya Kobayashi Kouta Moriyama Kohsuke Miyataka Shinji abe ChiemiSato Kazuyoshi Kawazoe Department of Clinical Pharmacy Practice Pedagogy Institute of Biomedical SciencesTokushima University Graduate School Department of Pharmacy Tokushima University Hospital Faculty of Pharmaceutical Sciences Tokushima University Faculty of Medicine Tokushima University

Objective:To analyze the effects of feeding helianthus tuberosus(hT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(hFD). Methods:A normal hFD or hFD including 10 w/w% hT tubers(hFD + hT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the hFD group were higher than those of the normal group,and similar to those of the hFD + hT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the hFD + hT group was significantly lower than that in the hFD group. Liver triglyceride and total cholesterol levels in the hFD + hT group were significantly lower than those in the hFD group. Fecal triglyceride and total cholesterol levels in the hFD + hT group were higher than those in the hFD group. histological analyses revealed that fat and glycogen accumulation increased in the hFD group,but decreased in the hFD + hT group. Conclusions:These results indicate that hT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.

关键词： helianthus tuberosus Glucose tolerance hepatic lipid profile

CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

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World Journal of Gastroenterology 2013年第25期19卷 4023-4030页

作者： Tadamichi hamachi Osamu Tajima Kousaku Uezono Shinji Tabata hiroshi abe Keizo Ohnaka Suminori Kono Department of Preventive Medicine Graduate School of Medical Sciences Kyushu University Self Defense Forces Fukuoka hospital Kasuga-shi Self Defense Forces Kumamoto hospital Department of Geriatric Medicine Graduate School of Medical Sciences Kyushu University

AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METhODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual

关键词： Colorectal adenoma Smoking Polymorphism CYP1A1 GSTM1 GSTT1 NQO1

Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum

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Natural Products and Bioprospecting 2013年第4期3卷 141-144页

作者： Xiao-Long YANG Takayoshi AWAKAWA Toshiyuki WAKIMOTO Ikuro abe Graduate School of Pharmaceutical Sciences The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan College of Pharmaceutical Science Hebei UniversityBaoding 071002China

Fungal aromatic compounds comprise an important and structurally diverse group of secondary *** genome sequencing projects revealed many putative biosynthetic gene clusters of fungal aromatic compounds,but many of these genes seem to be silent under typical laboratory culture *** gain access to this untapped reservoir of natural products,we utilized chemical epigenetic modifiers to induce the expression of dormant biosynthetic *** a result,the concomitant supplementation of the histone deacetylase inhibitors suberoylanilide hydroxamic acid(500mM)and nicotinamide(50mM)to the culture medium of a fungal pathogen,Stagonospora nodorum,resulted in the isolation of three aromatic compounds(1-3),including a novel natural butyrophenone,(+)-4'-methoxy-(2S)-methylbutyrophenone(1),and two known polyketides,alternariol(2)and(-)-(3R)-mellein methyl ether(3).

关键词： Stagonospora nodorum butyrophenone polyketides epigenetic manipulation

Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances

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World Journal of hepatology 2022年第4期14卷 778-790页

作者： Takeshi Suda Ai Sugimoto Tsutomu Kanefuji Atsushi abe Takeshi Yokoo Takahiro hoshi Satoshi abe Shinichi Morita Kazuyoshi Yagi Masashi Takahashi Shuji Terai Department of Gastroenterology and hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami Uonuma 949-7302NiigataJapan Division of Thoracic and Cardiovascular Surgery Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and hepatology Tsubame Rosai HospitalTsubame 959-1228NiigataJapan Department of Administration Joetsu-Area General Health Care CenterJoetsu 943-0803NiigataJapan Department of Preemptive Medicine for Digestive Diseases and healthy Active Life Niigata University School of MedicineNiigata 951-8122Japan Division of Gastroenterology and hepatology School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND As survival has been prolonged owing to surgical and medical improvements,liver failure has become a prognostic determinant in patients with congestive heart *** hepatopathy,an abnormal state of the liver as a result of congestion,insidiously proceed toward end-stage liver disease without effective biomarkers evaluating pathological *** measurements of shear wave elastography cannot qualify liver fibrosis,which is a prognosticator in any type of chronic liver disease,in cases of congestion because congestion makes the liver stiff without *** hypothesized that the effects of congestion and fibrosis on liver stiffness can be dissociated by inducing architectural deformation of the liver to expose structural *** establish a strategy measuring liver stiffness as a reflection of architectural rigidity under *** Two-dimensional shear wave elastography(2dSWE)was measured in the supine(Sp)and left decubitus(Ld)positions in 298 consecutive cases as they were subjected to an ultrasound study for various liver *** of interest were placed at twelve sites,and the median and robust coefficient of variation were *** data were compared using the Mann-Whitney U or Kruskal-Wallis test followed by Dunn's post-hoc multiple *** inferior vena cava(IVC)diameters at different body positions were compared using the Wilcoxon matched pairs signed rank *** number of cases with cardiothoracic ratios greater than or not greater than 50%was compared using Fisher’s exact test.A correlation of 2dSWE between different body positions was evaluated by calculating Spearman correlation *** The IVC diameter was significantly reduced in Ld in subjects with higher 2dSWE values in Ld(LdSWE)than in Sp(SpSWE)(P=0.007,(average±SD)13.9±3.6 vs 13.1±3.4 mm)but not in those with lower LdSWE values(P=0.32,13.3±3.5 vs 13.0±3.5 mm).In 81 subjects,SpSWE was increased or decreased in

关键词： Shear wave elastography Inferior vena cava diameter Congestive hepatopathy Liver fibrosis Body positions Fibrosis-4 index

hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report

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World Journal of Gastroenterology 2015年第32期21卷 9671-9674页

作者： Shinji Oe Michihiko Shibata Koichiro Miyagawa Yuichi honma Masaaki hiura Shintaro abe Masaru harada Department of Internal Medicine School of Medicine University of Occupational and Environmental Health

A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(hAV) antibodies. he was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor(hGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure(ARF) caused by hAV infection. Prognosis was expected to be poor because of complications by ARF and high serum hGF. however, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21 st hospital day. Although complication with ARF and high levels of serum hGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous hGF might play an important role as a regenerative effector in injured livers and kidneys.

关键词： Acute hepatitis Acute renal failure hepatitis A vi

Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding

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World Journal of Gastroenterology 2013年第14期19卷 2162-2170页

作者： Junko Kondo Jin-Zhong Xiao Akira Shirahata Mieko Baba Akie abe Koichi Ogawa Taeko Shimoda Kitakyushu hospital Group Food Science and Technology Institute Morinaga Milk Industry Co.Ltd. Clinico Co.Ltd. Division of Medical Nutrition Faculty of HealthcareTokyo Healthcare University

AIM:To investigate the effects of the probiotic Bifidobacterium longum BB536 on the health management of elderly patients receiving enteral ***:Two double-blind,placebo-controlled trials were performed with long-term inpatients receiving enteral tube feeding at Kitakyushu hospital Group,Fukuoka,***536 was administered as BB536-L and BB536-h powders that contained approximately 2.5 × 10 10 and 5 × 10 10 cfu of BB536,*** the first trial,83 patients(age range:67-101 years) were randomized into 2 groups that received placebo(placebo group) or BB536-h(BB536 group) *** the second trial,123 patients(age range:65-102years) were randomized into 3 groups,and each group received placebo(placebo group),BB536-L(BB536-L group),or BB536-h(BB536-h group) *** patient received the study medication for 16 wk after 1 wk of *** samples were collected from each patient prior to and after the intervention during Trial *** observations included body temperature,occurrence of infection,frequency of defecation,and fecal ***:No significant changes were observed in the frequency of defecation for either treatment in Trial ***,a significant change was noted in the BB536-L group(P = 0.0439) in Trial 2 but not in the placebo or BB536-h *** analyses based on the frequency of defecation for each patient during the pre-observation period for both trials revealed significant increases in bowel movements in patients with a low frequency of defecation and significant decreases in the bowel movements of patients with a high frequency of defecation during the intervention period in the BB536 *** combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel *** increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences(P < 0.01).Significantly decreased bowel movements wer

关键词： Probiotics Bifidobacterium longum BB536 Elderly Defecation

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

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Acta Pharmaceutica Sinica B 2019年第2期9卷 433-442页

作者： Zhiqin Cao Shaoyang Li Jianming Lv hao Gao Guodong Chen Takayoshi Awakawa Ikuro abe Xinsheng Yao Dan hu Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University Graduate School of Pharmaceutical Sciences The University of Tokyo

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. however,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid.

关键词： Biosynthesis Fungi Fusidic acid Fusidane-type antibiotics SDR