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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectable Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.bitors Plus Anti-PD-1 Antibody Th.rapy

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Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu y.-y. Zh.u B.-y. Wang L.-F. Sun y.-K. yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: Th. aim of th. work described h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectable advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.bitors (TKIs) plus anti-programmed cell death.protein-1 (PD-1) antibody th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received combined TKI/anti-PD-1 antibody treatment for unresectable h.C between January 2022 and October 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations before treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement between RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody th.rapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic th.rapy Anti-PD-1 antibody Contrast-enh.nced ultrasound h.patocellular carcinoma

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Viral Diseases of Olive Flounder in Korean h.tch.ries

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Journal of Ocean University of Ch.na 2006年第1期5卷 45-48页

作者： Oh.M.-J. S.-J.Jung S.-I.Kitamura h.-y.kim Department of Aqua-Life Medicine yosu National University Dun-Duk Dong 96-1Yeosu Chunnam 550-749Republic of Korea

以便阐明，并且阻止病毒的疾病发生在橄榄疾病的状态，特别病毒的疾病挣扎育种站，包括流行病学的学习，研究的一个范围从 1997 ～ 2003 被执行。调查的育种站的地点在东方包括几个代表性的地点( Kangnung ， Uljin ， Poh.ng ， yangs... 详细信息

以便阐明，并且阻止病毒的疾病发生在橄榄疾病的状态，特别病毒的疾病挣扎育种站，包括流行病学的学习，研究的一个范围从 1997 ～ 2003 被执行。调查的育种站的地点在东方包括几个代表性的地点( Kangnung ， Uljin ， Poh.ng ， yangsan ，Ul圣，釜山)，南方( Wando ， Ch.ngh.ung ， Goh.ung ， yeosu ， Namh.e ， Tongyeong ， Geoje ， Jeju )并且西方( Seosan ， Kunsan ， Goch.ng ， yeongkwang ， Mokpo ， Ch.ndo )朝鲜半岛的肋骨的区域。A 总数 of2000 案例在 7 年，死亡由病毒的代理人报道 for22% ，或 446 个案例在引起了里被检验了。更加与病毒的感染联系的死亡在 2003 从 14% in1997 增加了到 27% 。许多病毒的疾病被观察，并且病毒的表皮的增生，病毒的腹水和病毒的畸形，病毒的紧张的坏死，和 h.ramerh.bdoviral 疾病的出现分别地是 14% ， 51% ， 25% ，和 8% 。由调查病毒的感染 ofbroodstock 挣扎，在育种站的海洋的 birnavirus (MABV ) 的感染率被识别因此，是约 30% 获得并且使窝雪鱼干非感染是高度必要的。

关键词：比目鱼孵卵所滤过性毒菌韩国

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS h.terojunction with.ph.toth.rmal effect for efficient ph.tocatalytic h.drogen production

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Journal of Materials Science & Tech.ology 2024年第4期171卷 1-9页

作者： T.y.h.ang Z.yang S.y.yang Z.h.Dai y.J.Liu J.h.Liao G.y.Zh.ng Z.J.Xie y.P.Fang S.S.Zh.ng Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China Sch.ol of Ph.sics and Optoelectronics South China University of TechnologyGuangzhou 510640China Sch.ol of Ch.mical Engineering and Energy Tech.ology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

Th. insensitivity of semiconductors to visible and infrared ligh. is a key constraint on th. utilization of ligh. energy in ph.tocatalytic *** ph.tocatalysts with.full-spectrum absorption th.ough.surface engineering is an effective approach.to fully h.rnessing ligh. energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS h.terojunction catalyst is obtained by in-situ epitaxial growth.of two-dimensional(2D)CdS nanosh.ets on 2D MXene interface via a solvoth.rmal *** exceptional ligh. absorption properties of MXene confer outstanding full-spectrum driven ph.tocat-alytic h.drogen evolution capability upon th. h.terogeneous *** unique 2D/2D structure effectively mitigated th. recombination of ph.togenerated carriers,enh.ncing th. ph.tocatalytic performance of th. ***,th. composite catalyst exh.bits a significantly h.gh.r surface temperature of 80.4℃under visible ligh. irradiation at an intensity of 0.1 W/cm^(2),wh.ch.is 1.84 times h.gh.r th.n th.t of *** irradiation of visible and near infrared ligh.,th. composite catalyst with.ph.toth.rmal ef-fect demonstrates a remarkable h.drogen evolution rate of 65.4 mmol g^(-1)h.(-1),wh.ch.is 7.2 times h.gh.r th.n th.t of CdS *** study introduces a novel approach.for constructing full-spectrum absorption catalysts and expands th. application of th. ph.toth.rmal effect in ph.tocatalytic h.drogen evolution research.

关键词： Two-dimensional structure h.terostructure Ph.toth.rmal effect Ph.tocatalyst h.drogen evolution

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Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mech.nisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong S.W.Lee W.J.kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

Th. superplastic beh.vior and associated deformation mech.nisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm,primarily composed of th. BCCβph.se and a small amount of th. h.Pαph.se,were examined in a temperature range of 473 K to 623 *** microstructural refinement of th.s alloy was ach.eved by employing h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.re tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider th.s effect wh.n analyzing and understanding th. superplastic deformation beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation climb creep was th. rate-controlling deformation *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deformation at 523 K,it was observed th.t grain boundary sliding led to th. agglomeration of th.αph.se,resulting in significant strain *** mech.nism maps were constructed forβ-Mg-Li alloys in th. form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using th. constitutive equations for various deformation mech.nisms derived based on th. data of th. current tests.

关键词： Magnesium-lith.um alloy Superplasticity Severe plastic deformation Grain size Grain growth

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Rational design of AgGaS/ZnS/ZnS quantum dots with.a near-unity ph.toluminescence quantum yield via double sh.lling sch.me

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Journal of Materials Science & Tech.ology 2024年第2期169卷 235-242页

作者： h.X.Lu h.Liu Z.Z.Fu y.y.Ch.n h.Q.Dai Z.h. W.L.Zh.ng R.Q.Guo Institute for Electric Ligh. Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Ligh.ing Academy for Engineering and TechnologyFudan UniversityShanghai 200433China yiwu Research.Institute of Fudan University YiwuZhejiang 322000China Zh.ngsh.n-Fudan Joint Innovation Center Zhongshan 528437China

In th.s study,a two-step meth.d was used to synth.size h.gh.y luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In th. first step,an inner ZnS sh.ll was formed via a one-pot meth.d,wh.ch.resulted in a smaller lattice mismatch.between th. AgGaS core and th. outer ZnS sh.ll,th.reby facilitating th. formation of a th.ck outer *** th. two-step sh.lling process,th. synth.sized AgGaS/ZnS/ZnS QDs sh.wed an excellent ph.toluminescence quantum yield(PLQy)of 96.4%with.a peak wavelength.of 508 nm,repre-senting th. h.gh.st PLQy reported th.s far for AgGaS ***,th. effect of h.logen ions in Zn precursors on th. sh.lling process was *** was proposed th.t th. capacity of h.logen ions to coordinate with.th. QDs influenced th. balance between Zn cation diffusion and ZnS sh.lling ***,th. ZnS sh.lling reaction was dominant wh.n ZnCl_(2)was employed,wh.le Zn cation diffusion was th. dominant process under th. I^(−)-rich.*** work provides insigh.s into th. interfacial restructuring during th. ZnS sh.lling and offers a clear map for th. tailored synth.sis of core/sh.ll QDs.

关键词： AgGaS Quantum dots Ph.toluminescence Core/sh.ll Alloyed core/sh.ll interface

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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An update on h.rmonal regulation of early embryo-fallopian tube interactions: insigh.s for improvements of assisted reproductive tech.ology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodith.wakku Suranga P. Ng Ernest h. y. yeung William S. B. Lee Kai-Fai Department of Obstetrics and Gynaecology LKS Faculty of Medicine 3. Th. University of h.ng Kong 4. h.ng Kong SAR 999077 5. Ch.na

h.man fallopian tubes (FTs) play important roles in th. wh.le reproductive process. FTs are th. site for th. final maturation of gametes, fertilization, transport of preimplantation embryos, and early embryonic development before entering th. uterus. All th.se functions are critical in th. establish.ent of a successful pregnancy. Wh.n th. embryo is in transit th.ough.th. FT, th. FT microenvironment ch.nges th.ough.endocrine, paracrine, autocrine, and juxtacrine mech.nisms wh.ch.involve various h.rmones and bioactive substances mainly from th. neigh.oring cells. Th.refore, th. interactions between th. embryo and th. FT may be th. earliest embryo-maternal communications th.t are essential for th. establish.ent of pregnancy. Th.s review critically discusses th. evidence of various h.rmonal and bioactive mediated control of th. microenvironment in th. FTs during th. earliest embryo-maternal communications. Moreover, we h.gh.igh. existing gaps in th. knowledge and th. importance of exploring more of th. ph.siology of FTs wh.ch.will h.ld th. key to producing h.gh.quality embryos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication h.rmonal control

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Microstructure evolution and sh.pe memory beh.viors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep th.rmomech.nical loading with.different prestrain levels

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Journal of Materials Science & Tech.ology 2024年第4期171卷 80-93页

作者： y.h.Zh.ng h.Li Z.W.yang X.Liu Q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Sh.anxi Key Laboratory of h.gh.Performance Precision Forming Tech.ology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)sh.pe memory alloy(SMA)is a promising material in th. aerospace field due to its wide transformation *** application of sh.pe memory effect depends on multistep th.rmomech.n-ical loading,viz.,low-temperature deformation and subsequent h.ating to ***-temperature deformation prestrain plays a pivotal role in sh.pe memory properties tailoring of SMA ***,microstructure evolution and deformation mech.nisms of Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** th.s end,microstructure evolution and sh.pe memory beh.viors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep th.rmomech.nical loading with.prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate th.t th. stress-strain curve of th. specimen exh.bits four distinct stages at a maximal prestrain of 16%.Wh.reas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,th. stress-induced martensitic transformation is accompanied by th. dislocation slip of th. NiTi matrix andβ-Nb *** stageⅢ,in addition to th. h.gh.r density of dislocations and furth.r growth.of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of th.(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and h.ating,a h.gh.r density of{114}austenite twins form in th. specimen with.a larger prestrain of 16%.With.increasing prestrain from 8%to 16%,th. recoverable strainε_(re)^(T)upon h.ating increases first and th.n ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to th. formation of new SIMVs,th. furth.r growth.of existing SIMVs,and th. recoverable(001)compound *** th. decrease ofε_(re)^(T)is mainly associated with.th. irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)sh.pe memory alloy Wide transformation h.steresis Th.rmomech.nical loading Microstructure evolution Sh.pe memory beh.viors Stress-induced martensitic transformation Deformation twinning

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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h.perreflective ph.tonic crystals created by sh.aring colloidal dispersions at ultrah.gh.volume fraction

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Microsystems & Nanoengineering 2024年第1期10卷 161-173页

作者： Minji kim Jong Bin kim Sh.n-h.un kim Department of Ch.mical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Colloidal crystallization serves as one of th. most economic and scalable production meth.ds for ph.tonic ***,insufficient optical performance,nonuniformity and low reproducibility remain ch.llenges for advanced h.gh.value *** th.s study,we optimally formulate a ph.tocurable dispersion of silica particles and apply sh.ar flow to unify th. orientation of th. colloidal crystals,ensuring h.gh.optical performance and *** silica particles experience strong repulsion at ultrah.gh.volume fractions of 50%but demonstrate low mobility,leading to polycrystalline *** sh.ar flow to th. dispersions allows th. silica particles to rearrange into larger crystalline domains with.a unidirectional orientation along th. *** sh.ar-induced structural ch.nge produces absolute reflectivity at th. stopband as h.gh.as 90%and a h.gh.transparency of 90%at off-resonant wavelength. with.minimal diffusive ***,th. strong interparticle repulsion ensures a uniform volume fraction of particles th.ough.ut th. dispersion,reducing deviations in th. optical *** intricately micropattern th. ph.tocurable dispersions using ***,th. ph.tonic films and patterns can be stacked to form multiple layers,displaying mixed structural colors and multiple reflectance peaks with.ut sacrificing *** superior ph.tonic materials h.ld promise for various optical applications,including optical components and anticounterfeiting patch.s.

关键词： properties. dispersion reflectivity

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