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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Ch.rly g.Lecomte Department of Ph.rmacology-Ph.siology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in th. gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of th. brain,including th. parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,wh.ch.are sent from th. motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate th. limbs,and maintain *** spinal cord injury,bidirectional communication between th. brain and spinal cord is disrupted and animals,including h.mans,fail to voluntarily modify limb trajectory to step over an ***,in th.s review,we discuss th. neuromech.nical control of stepping over an obstacle,wh. it fails after spinal cord injury,and h.w it recovers to a certain extent.

关键词： biomech.nics locomotion neuroph.siology obstacle negotiation spinal cord injury

Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, george h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAg repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

An SPh.Framework for Earth.uake-Induced Liquefaction h.zard Assessment of geotech.ical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh.Mh.ski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earth.uake-induced soil liquefaction poses significant risks to th. stability of geotech.ical structures *** understanding of th. liquefaction triggering,and th. post-failure large deformation beh.viour is essential for designing resilient *** present study develops a Smooth.d Particle h.drodynamics(SPh.framework for earth.uake-induced liquefaction h.zard assessment of geotech.ical *** coupled flowdeformation beh.viour of soils subjected to cyclic loading is described using th. PM4Sand model implemented in a th.ee-ph.se,single-layer SPh.framework.A staggered discretisation sch.me based on th. stress particle SPh.approach.is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using th. SPh.meth.d are *** numerical framework is employed for th. analysis of cyclic direct simple sh.ar test,seismic analysis of a level ground site,and liquefaction-induced failure of th. Lower San Fernando *** agreement for liquefaction triggering and post-failure beh.viour demonstrates th.t th. SPh.framework can be utilised to assess th. effect of seismic loading on field-scale geotech.ical *** present study also serves as th. basis for future advancements of th. SPh.meth.d for applications related to earth.uake geotech.ical engineering.

关键词： Earth.uake seismic liquefaction stress particle PM4Sand smooth.d particle h.drodynamics(SPh.

Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Kh.led Alok Timoth. g.Wh.te Ch.nyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research.Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),h.ve attracted considerable attention in conditions wh.re cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** ph.rmacological interventions h.ve demonstrated initial potential in addressing CSDs,a standardized treatment approach.h.s not yet been *** objective of th.s perspective is to explore emerging bioelectronic meth.dologies for addressing CSDs,particularly emph.sizing TNS,and to underscore TNS’s capacity to enh.nce neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Silk-based nerve guidance conduits with.macroscopic h.les modulate th. vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina h.omada Patrick h.imel Markus Kerbl Lászlógál Sylvia Nürnberger Barbara Sch.edl James Ferguson Nicole Swiadek Xavier Monforte Joh.nnes C.h.inzel Antal Nógrádi Andreas h.Teusch.-Woller David h.rch.r Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of h.nd- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Periph.ral nerve injuries induce a severe motor and sensory deficit. Since th. availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sough., including th. use of tubular nerve guidance conduits(tNgCs). h.wever, th. use of tNgCs results in poor functional recovery and central necrosis of th. regenerating tissue, wh.ch.limits th.ir application to sh.rt nerve lesion defects(typically sh.rter th.n 3 cm). given th. importance of vascularization in nerve regeneration, we h.poth.sized th.t enabling th. growth.of blood vessels from th. surrounding tissue into th. regenerating nerve with.n th. tNgC would h.lp eliminate necrotic processes and lead to improved regeneration. In th.s study, we reported th. application of macroscopic h.les into th. tubular walls of silk-based tNgCs and compared th. various features of th.se improved silk^(+) tNgCs with.th. tubes with.ut h.les(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomograph. and h.stological analyses, we were able to prove th.t th. use of silk^(+) tNgCs induced th. growth.of blood vessels from th. adjacent tissue to th. intraluminal neovascular formation. A significantly h.gh.r number of blood vessels in th. silk^(+) group was found compared with.autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at th. distal coaptation point compared with.th. silk^(–) tNgCs at 7 weeks postoperatively. In th. 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth.of blood vessels th.ough.th. tubular walls of silk^(+) tNgCs, but with.ut improved functional recovery at 12 weeks postoperatively. Our data proves th.t macroporous tNgCs increase th. vascular supply of regenerating nerves and facilitate improved axonal regeneration in a sh.rt-defect model but not in a critical-size defect model. Th.s study suggests th.t furth.r optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion periph.ral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Impact of Zika virus non-structural protein mutations on h.ppocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

Th. Zika virus(ZIKV),a member of th. Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microceph.ly in newborns,first reported during th. 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting th. central nervous system(CNS)in both.ch.ldren and adults,leading to enduring cognitive and beh.vioral impairments.

关键词： damage fetal neonatal

Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective