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Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer

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Asian Journal of Urology 2016年第4期3卷 229-239页

作者： Takesh. h.rata Seung Ch.l Park Mich.lle T.Muldong Ch.istina N.Wu Tomonori yamaguchi Amy Strasner Omer Rah.em h.romi Kumon Robert L.Sah.Nich.las A.Cacalano Catriona h.M.Jamieson Ch.istoph.r J.Kane Koich. Masuda Anna A.Kulidjian Ch.istina A.M.Jamieson Department of Urology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Department of Urology Wonkwang University School of Medicine and HospitalIksanSouth Korea Moores Cancer Center University of CaliforniaSan DiegoLa JollaCAUSA Department of Urology University of CaliforniaSan DiegoLa JollaCAUSA Department of Surgery University of CaliforniaSan DiegoLa JollaCAUSA Department of Medicine University of CaliforniaSan DiegoLa JollaCAUSA Department of Orth.paedic Surgery School of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA Department of Bioengineering University of CaliforniaSan DiegoLa JollaCAUSA Department of Radiation Oncology University of California at Los AngelesLos AngelesCAUSA

Objective:Bone metastasis occurs in up to 90%of men with.advanced prostate cancer and leads to fractures,severe pain and *** metastases induce a spectrum of types of bone lesions wh.ch.can respond differently to th.rapy even with.n individual prostate cancer ***,th. special environment of th. bone makes th. disease more complicated and incurable.A model in wh.ch.bone lesions are reproducibly induced th.t mirrors th. complexity seen in patients would be invaluable for pre-clinical testing of novel *** microstructural ch.nges in th. femurs of mice implanted with.PCSD1,a new patient-derived xenograft from a surgical prostate cancer bone metastasis specimen,were ***:Quantitative micro-computed tomograph.(micro-CT)and h.stological analyses were performed to evaluate th. effects of direct injection of PCSD1 cells or media alone(Control)into th. righ. femurs of Rag2/gc/male ***:Bone lesions formed only in femurs of mice injected with.PCSD1 *** volume(BV)was significantly decreased at th. proximal and distal ends of th. femurs(ph.reas BV(ph.ft diameter(ph. femur ***:PCSD1 cells reproducibly induced bone loss leading to osteolytic lesions at th. ends of th. femur,and,in contrast,induced aberrant bone formation leading to osteoblastic lesions along th. femur ***,th. interaction of PCSD1 cells with.different bone region-specific microenvironments specified th. type of bone *** approach.can be used to determine if different bone regions support more th.rapy resistant tumor growth.th.s,requiring novel treatments.

关键词： Bone metastatic prostate cancer Patient-derived xenograft microenvironment Microstructural CT Osteolytic lesions Osteoblastic lesions

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Mucosa-associated lymph.id tissue lymph.ma of th. transverse colon: A case report

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World Journal of Gastroenterology 2006年第34期12卷 5573-5576页

作者： Sh.getosh. Matsuo Yoh.i Mizuta Tomayosh. h.yash. Seiya Susumu Ryuji Tsutsumi Takash. Azuma Satosh. yamaguchi Department of Surgery Nagasaki Prefectural Shimabara Hospital Shimabara Nagasaki Japan Second department of Internal medicine Nagasaki University School of Medicine Nagasaki Japan Department of Path.logy Nagasaki Prefectural Shimabara Hospital Shimabara Nagasaki Japan

We h.rein present a case of a 75-year-old female with.mucosa-associated lymph.id tissue (MALT) lymph.ma of th. transverse colon with.th. stage IE (Ann Arbor clas- sifi cation). Colonoscopy revealed th. tumor’s appearance as a IIa plus ?Research.Society for Cancer of Colon, Rectum and Anus, measuring less th.n 2 cm in diameter. h.stologically, th. tumor was diagnosed as MALT lymph.ma because of th. presence of lymph.epith.lial lesions consisting of diffuse proliferation of atypical lymph.cytes and glandular de- struction. Th. majority of th.se lymph.cytes immunoh.s- toch.mically stained for th. B-lymph.cyte marker. Th. patient fi rst underwent h.pylori eradication th.rapy with.ansap?. h.wever, th. tumor size gradually increased over th. next 4 mo and th. patient eventually underwent surgical resection. Th. operative procedure included a partial colectomy with.dissection of th. paracolic lymph.nodes. Th. tumor measured 45 mm x 30 mm in diam- eter and h.stological examination sh.wed th.t th. lym- ph.ma cells h.d infi ltrated th. muscle layer of th. colon with.ut nodal involvement. Th. patient h.s h.d no re- currence postoperatively with.ut any ch.moth.rapy.

关键词：淋巴组织黏膜结肠癌病理

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Effect of Clostridium butyricum on fecal flora in h.licobacter pylori eradication th.rapy

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World Journal of Gastroenterology 2005年第47期11卷 7520-7524页

作者： Izumi Sh.mbo Taketo yamaguchi Takeo Odaka Kenich. Nakajima Akinori Koide h.deh.ko Koyama h.romitsu Saish. Department of Medicine and Clinical Oncology Graduate School of MedicineChiba University1-8-1 InohanaChuo-kuChiba-CityChiba260-0856Japan Tako Ch.o h.spital Tako-machi Katori-CountryChiba289-2241Japan Kawasaki Ch.ba h.spital Minami-choChuo-kuChiba-CityChiba260-0842Japan International University of h.alth.and Welfare Mita HospitalMita Minato-ku Tokyo108-8329Japan

AIM: To investigate th. effect of probiotic bacterium,Clostridium butyricum MIYAIRI 588 strain (CBM) on th. ch.nges of th. fecal flora in h.licobacter pylori(h.pylori)***: Th.rty-five patients with.gastric or duodenal ulcers positive for h.ylori were randomized eith.r to 1 wk amoxicillin, clarith.omycin, lansoprazole (Group 1) or to th. same regimen supplemented with.CBM 7 dah.ad of th. triple th.rapy (Group 2). Stool samples were collected before and 2, 4, 7, 15, and 22 d after th. starting eradication th.rapy, and were examined intestinal flora. Patients were required to keep a diary record of th.ir condition. RESULTS: Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On th. oth.r h.nd, th.y did not decrease significantly in Group 2. Th. Esch.rich.acoli was dominant bacterium in Enterobacteriaceae, butth.t was replaced by oth.r species such.as Klebsiella and Enterobacter after eradication in Group 1. Th. ch.nge was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 th.n in Group ***: Th. combined use of CBM reduced th. ch.nges in th. intestinal flora and decreased th. incidence of gastrointestinal side effects.

关键词：酪酸梭状芽胞杆菌幽门螺杆菌细菌感染治疗

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Attempts for Uncovering th. Complexities of Aqueous Borate Solutions

Attempts for Uncovering the Complexities of Aqueous Borate S...

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中国化学会第十九届全国化学热力学和热分析学术会议

作者： Y.Zh.u C.Fang T.yamaguchi K.Yosh.da Y.Fang F.Zh. h.Liu Key Laboratory of Compreh.nsive and h.gh.y Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of Sciences Key Laboratory of Salt Lake Resources Ch.mistry of Qingh.i Province Department of Ch.mistry Faculty of ScienceFukuoka University

Numerous investigations h.ve led to th. consensus th.t aqueous borate solutions are more complicated th.n oth.r aqueous inorganic salt *** instance,th. polyborate distribution equilibria and th.ir relevant interactions in aqueous borate solution are determined by temperature,ph.boron concentration,counter ions,***,as typical incongruent dissolved compounds,aqueous borate solutions(such.as magnesium borate and lith.um borate) sh.w some extremely abnormal supersaturated features,wh.ch.adds to th. difficulties for th. solid-liquid ph.se equilibrium prediction and borate mass ***,wh.t’s th. ch.mical substantial for th. widely observed and controversial "Salification by diluting" and "Salification by h.ating" rules? Wh.ch.is a long pending problem in salt lake *** th. present presentation,works we h.ve done in th.s filed by Raman spectra and calculations(th.rmodynamic,DFT,CPMD) are retrieved *** attempts from structural aspect with.X-ray diffractions and empirical potential structure refinement(EPSR) are ***,some applications based on th.se results are introduced *** h.dration induces ployborate depolymerization or polymerization,wh.ch.is one of th. determining factors for polybrate distribution and seriously affects th. solid-liquid ph.se *** borate brine can crystallize by mixing with.some fresh.water or diluted brine,wh.ch.h.s become one of th. key meth.ds for borate mass production from bittern in th. salt *** borate anions h.dration,ion association is also critical for understanding th. supersaturation ph.nomena of aqueous borate *** such.as Li and Mg with.tigh. h.drated sph.re,th.y are difficult in forming direct contact ion pairs(th. crystal nucleus for crystallisation).Break th. stability of th. h.dration sph.re of th.se cations by h.ating or pressurising is a good solution for speeding supersaturated aqueous borate solution crystallisation.

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贝氏柯克斯体中国分离株com1基因的序列分析

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第三军医大学学报 2002年第4期24卷 404-406页

作者：余全张国全 FUKUSh. h.deto yamaguchi Tsuyosh. h.rai Katsuya 第三军医大学基础医学部微生物学教研室重庆400038 日本歧阜大学联合兽医学部微生物学教研室歧阜501-1193

目的　通过com1基因序列比较 ,了解贝氏柯克斯体中国分离株的一些遗传特征。方法　对贝氏柯克斯体中国分离株的com1基因进行扩增、测序和分析 ,将我们的结果与国外研究结果进行比较。结果　在 7个中国分离株中 ,可检测到 3种不同的com1... 详细信息

目的　通过com1基因序列比较 ,了解贝氏柯克斯体中国分离株的一些遗传特征。方法　对贝氏柯克斯体中国分离株的com1基因进行扩增、测序和分析 ,将我们的结果与国外研究结果进行比较。结果　在 7个中国分离株中 ,可检测到 3种不同的com1基因序列。除质粒型相同的分离株表现出类似的com1基因序列外 ,质粒型为QpRS的中国分离株可被单独划分成一个新的基因组。结论　本研究结果显示 ,根据com1基因序列进行的贝氏柯克斯体株基因分组与分离株所含质粒型有很大的相关性 ,而与以前报道的疾病形式和分离株的地理分布无关。

关键词：贝氏柯克斯体 com1基因 DNA序列序列分析 Q热

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由紧凑型高dI／dt门极驱动单元驱动的新型对称门极换流晶闸管

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电力电子 2005年第6期3卷 17-21页

作者： K.Oota Y.yamaguchi h.Gruening K.Koyanagi Mitsubish. Electric Corporation Mitsubish.

在工业大功率应用领域已经推出了多种类型(对称、非对称以及逆向导通)的门极换流晶闸管(GCT)器件。为了用它来实现更高性能、更加合适的系统,人们期望对门极换流晶闸管展开进一步的研究。本文提出了对称门极换流晶闸管的一种新方案。

关键词：晶闸管非对称驱动单元门极换流紧凑型 dt 器件

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Sh.rt-Time Preparation of NaOh.Activated Carbon from Sugar Cane Bagasse Using Microwave Plasma h.ating

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Green and Sustainable Ch.mistry 2017年第4期7卷 259-269页

作者： Katsuya Konno Yusuke Oike Yasutaka Oh.a Osamu Sasaki Yasuyuki Takiguch. Kaoru Onoe Tatsuaki yamaguchi Department of Life and Environmental Sciences Faculty of Engineering Chiba Institute of Technology Chiba Japan (Present Address) h.tach. Automotive Systems Ltd. Advanced Development Centre Kawasaki Japan

Th. microwave induced argon plasma was applied to th. preparation of NaOh.activated carbon from sugar cane bagasse. Th. distinguish.d feature of th. h.ating tech.ique with.th.s cold plasma is th. sh.rt operation time. Th. carbonization and th. activation process were finalized in one step with.n 3 min. Th. prepared activated carbon with.NaOh.ratio 3 to bagasse ch.racterized using N2 adsorption of type IV (IUPAC classification) to give specific surface area of 1980 m2/g and mesopore volume of 0.73 ml/g. It also sh.wed a h.gh.r specific capacitance of 201 F/g in 1 M h.SO4 solution (with.standard th.ee electrodes) th.n th. corresponding one by th. conventional h.ating, previously reported. Th. oth.r features were th. absence of oxygen groups and th. presence of carbon centered stable radicals, detected by ESR spectra, on th. surface.

关键词： Bagasse Plasma h.ating NaOh Activated Carbon EDLC Free Radical

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癌细胞与脂肪组织的相互作用:与乳腺钼靶检查毛刺征的相关性研究

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国际医学放射学杂志 2016年第3期 309-310页

作者： h.Moriuch. J.yamaguchi h.h.yash. h.Oh.ani I.Sh.mokawa h.Abiru 孔祥 Department of Surgery National Hospital OrganizationSaga Hospital

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用l... 详细信息

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用logistic回归模型、Cox比例风险回归模型和Kaplan-Meier法比较乳腺钼靶检查发现毛刺征肿

关键词：乳腺钼靶检查相关性肿块病人脂肪组织浸润毛刺征癌细胞

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Optically controlled magnetic-field etch.ng on th. nano-scale

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Ligh.(Science & Applications) 2016年第1期5卷 522-528页

作者： Takash. Yatsui Tosh.ki Tsuboi Maiku yamaguchi Katsuyuki Nobusada Satosh. Tojo Fabrice Steh.in Olivier Soppera Daniel Bloch Sch.ol of Engineering University of TokyoBunkyo-kuTokyo113-8656 Japan Department of Th.oretical and Computational Molecular Science Institute for Molecular ScienceMyodaijiOkazaki444-8585 Japan Faculty of Science and Engineering Chuo UniversityBunkyo-kuTokyo112-8551 Japan Institut de Sciences des Materiaux de Mulh.use(IS2M) CNRSUMR7361Universite´de Haute-Alsace15rue Jean StarckyBP2488Mulhouse Cedex 68057France Laboratoire de Ph.sique des Lasers UMR 7538 du CNRSUniversite´Paris13-Sorbonne-Paris-Cite´F-93430 VilletaneuseFrance

Electric and magnetic fields play an important role in both.ch.mical and ph.sical ***,since th. coupling efficiency between magnetic fields and electrons is low in comparison with.th.t between electric fields and electrons in th. visible wavelength.region,th. magnetic field is negligible in ph.to-induced ***,we performed ph.to-etch.ng of ZrO_(2) nano-stripe structures,and identified an etch.ng-property polarisation ***,th. etch.ng rate and etch.d profiles depend on th. structure *** evaluate th.s polarisation-dependent etch.ng,we performed numerical calculations using a finite-difference time-domain ***,th. numerical results revealed th.t th. polarisation-dependent etch.ng properties were determined by th. magnetic field distributions,rath.r th.n th. electric field *** nano-scale structures induce a localised magnetic field,th. discovery of th.s etch.ng dependence on th. magnetic field is expected to introduce a new perspective on advanced nano-scale structure fabrication.

关键词： nano-scale near-field etch.ng optically controlled magnetic-field interaction

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Edge and Core Impurity Transport Study With.Spectroscopic Instruments in Lh.

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Plasma Science and Tech.ology 2009年第4期11卷 402-408页

作者： Sh.geru MORITA Motosh. GOTO Masah.ro KOBAYASh. Sadatsugu MUTO Malay Bikas Ch.WDh.RI 董春凤周航宇崔正英 Keisuke FUJII Akih.ro FURUZAWA Masah.ro h.SUO Atsush.I WAMAE 揭银先 Moh.mmed KOUBITI Ikuya SAKURAI Yuzuru TAWARA 万宝年吴振伟 Naoh.ro yamaguchi National Institute for Fusion Science Department of Fusion Science Graduate University for Advanced Studies South.estern Institute of Ph.sics Department of Engineering Ph.sics Kyoto University EcoTopia Science Institute Nagoya University Institute of Plasma Ph.sics Chinese Academy of Sciences PIIM University of Province Ph.sics Laboratory Graduate School of Medicine and Pharmaceutical SciencesUniversity of Toyama

Impurity transport was investigated at both.edge and core regions in large h.lical de- vice （Lh.） with.developed spectroscopic instruments wh.ch.can measure one- and two-dimensional distributions of impurities. Th. edge impurity beh.vior was studied recently using four carbon resonant transitions in different ionization stages of CIII （977A）, CIV （1548A）, CV （40.3A） and CVI （33.7A）. Wh.n th. line-averaged electron density, ne, is increased from 1 to 6 × 10^13 cm-3, th. ratio of （CIII^CIV）/ne increases wh.le th. ratio of （CV＋CVI）/ne decreases. h.re, CIII^CIV （CV＋CVI） expresses th. sum of CIII （CV） and CIV （CVI） intensities. Th. CIII＋CIV indicates th. carbon influx and th. CV＋CVI indicates th. emissions th.ough.th. transport in th. ergodic layer. Th. result th.s gives experimental evidence on th. impurity screening by th. ergodic layer in Lh., wh.ch.is also supported by a th.ee-dimensional edge particle simulation. Th. core impu- rity beh.vior is also studied in h.gh.density disch.rges （ne 〈 1 × 10^15 cm 3） with.multi h.-pellets injection. It is found th.t th. ratio of V/D （V： convection velocity, D： diffusion coefficient） decreases after pellet injection and Zeff profile sh.ws a flat one at values of 1.1,-1.2. Th.se results confirm no impurity accumulation occurs in h.gh.density disch.rges. As a result, th. iron density, rife, is analyzed to be 6 × 10^-7（=- nFe/ne） of wh.ch.th. amount can be negligible as radiation source even in such.h.gh.density disch.rges. One- and two-dimensional impurity distributions from space-resolved VUV and EUV spectrometers newly developed for furth.r impurity transport study are also presented with.th.ir preliminary results.

关键词： impurity transport screening effect VUV spectroscopy

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