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Silk-based nerve guidance conduits with.macroscopic h.les modulate th. vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina h.omada Patrick h.imel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Sch.edl James Ferguson nicole Swiadek Xavier Monforte Joh.nnes C.h.inzel Antal nógrádi Andreas h.Teusch.-Woller David h.rch.r Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of h.nd- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Periph.ral nerve injuries induce a severe motor and sensory deficit. Since th. availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sough., including th. use of tubular nerve guidance conduits(tnGCs). h.wever, th. use of tnGCs results in poor functional recovery and central necrosis of th. regenerating tissue, wh.ch.limits th.ir application to sh.rt nerve lesion defects(typically sh.rter th.n 3 cm). Given th. importance of vascularization in nerve regeneration, we h.poth.sized th.t enabling th. growth.of blood vessels from th. surrounding tissue into th. regenerating nerve with.n th. tnGC would h.lp eliminate necrotic processes and lead to improved regeneration. In th.s study, we reported th. application of macroscopic h.les into th. tubular walls of silk-based tnGCs and compared th. various features of th.se improved silk^(+) tnGCs with.th. tubes with.ut h.les(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomograph. and h.stological analyses, we were able to prove th.t th. use of silk^(+) tnGCs induced th. growth.of blood vessels from th. adjacent tissue to th. intraluminal neovascular formation. A significantly h.gh.r number of blood vessels in th. silk^(+) group was found compared with.autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at th. distal coaptation point compared with.th. silk^(–) tnGCs at 7 weeks postoperatively. In th. 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth.of blood vessels th.ough.th. tubular walls of silk^(+) tnGCs, but with.ut improved functional recovery at 12 weeks postoperatively. Our data proves th.t macroporous tnGCs increase th. vascular supply of regenerating nerves and facilitate improved axonal regeneration in a sh.rt-defect model but not in a critical-size defect model. Th.s study suggests th.t furth.r optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion periph.ral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Leveraging ROTI map derived from Indonesian GnSS receiver network for advancing study of Equatorial Plasma Bubble in South.ast/East Asia

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Earth.and Planetary Ph.sics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ih.an n.Muafiry Teguh.n.Pratama Angga Y.Putra Suraina Gatot h.Pramono Sidik T.Wibowo Febrylian F.Ch.bibi Umar A.Ah.ad Wildan P.Tresna Asnawi Research.Center for Climate and Atmosph.re Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Sch.ol of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Tech.ology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geoph.sics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research.Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research.Center for Ph.tonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth.and Planetary Sciences Hokkaido UniversitySapporoJapan

Th.s paper h.gh.igh.s th. crucial role of Indonesia’s GnSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in South.ast and East Asia,as ionosph.ric irregularities with.n EPB can disrupt GnSS signals and degrade positioning *** by th. Indonesian Geospatial Information Agency(BIG),th. Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GnSS receivers spanning equatorial to south.rn low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across South.ast *** provide a practical tool for EPB research.by sh.ring two-dimensional rate of Total Electron Content(TEC)ch.nge index(ROTI)derived from th.s *** generate ROTI maps with.a 10-minute resolution,and samples from May 2024 are publicly available for furth.r scientific *** preliminary findings from th. ROTI maps of Ina-CORS are ***,th. Ina-CORS ROTI maps reveal th.t th. irregularities with.n a broader EPB structure persist longer,increasing th. potential for th.se irregularities to migrate farth.r ***,we demonstrate th.t combined ROTI maps from Ina-CORS and GnSS receivers in East Asia and Australia can be used to monitor th. development of ionosph.ric irregularities in South.ast and East *** h.ve demonstrated th. combined ROTI maps to capture th. development of ionosph.ric irregularities in th. South.ast/East Asian sector during th. G5 Geomagnetic Storm on May 11,*** observed simultaneous ionosph.ric irregularities in Japan and Australia,respectively propagating north.estward and south.estward,before midnigh.,wh.reas South.ast Asia’s equatorial and low-latitude regions exh.bited irregularities *** sh.ring ROTI maps from Indonesia and integrating th.m with.regional GnSS networks,research.rs can conduct compreh.nsive EPB studies,enh.ncing th. understanding of EPB beh.vior across South.ast and East Asia and contributing significantly to ionosph.

关键词： Equatorial Plasma Bubble(EPB) GnSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionosph.ric map Rate of TEC ch.nge index(ROTI)map

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Immune responses to h.licobacter pylori infection

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World Journal of Gastroenterology 2014年第19期20卷 5583-5593页

作者： mati Moyat Dominique Velin Service of Gastroenterology and h.patology Department of MedicineLausanne University HospitalCH-1011 LausanneSwitzerland

h.licobacter pylori (h. pylori) infection is one of th. most common infections in h.man beings worldwide. h. pylori express lipopolysacch.rides and flagellin th.t do not activate efficiently Toll-like receptors and express dedicated effectors, such.as γ-glutamyl transpeptidase, vacuolating cytotoxin (vacA), arginase, th.t actively induce tolerogenic signals. In th.s perspective, h. pylori can be considered as a commensal bacteria belonging to th. stomach.microbiota. h.wever, wh.n present in th. stomach. h. pylori reduce th. overall diversity of th. gastric microbiota and promote gastric inflammation by inducing nod1-dependent pro-inflammatory program and by activating neutroph.ls th.ough.th. production of a neutroph.l activating protein. Th. maintenance of a ch.onic inflammation in th. gastric mucosa and th. direct action of virulence factors (vacA and cytotoxin-associated gene A) confer pro-carcinogenic activities to h. pylori. h.nce, h. pylori cannot be considered as symbiotic bacteria but rath.r as part of th. path.biont. Th. development of a h. pylori vaccine will bring h.alth.benefits for individuals infected with.antibiotic resistant h. pylori strains and population of underdeveloped countries.

关键词： h.licobacter pylori Vaccine Immune response Peptic ulcer Gastric cancer

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Minimal Length.Quantum Mech.nics of Dirac Particles in noncommutative Space

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Ch.nese Ph.sics Letters 2015年第3期32卷 1-4页

作者： A. n. Ikot h. P. Obong h. h.ssanabadi Th.oretical Ph.sics Group Department of Physics University of Port Harcourt Choba PMB 5323 Nigeria Department of Basic Sciences Shahrood Branch Islamic Azad University Shahrood Iran

We study th. two-dimensional h.rmonic oscillator in commutative and noncommutative space with.n th. framework of minimal length.quantum mech.nics for spin-l^2 particles. Th. energy spectra and th. eigenfunction are ob... 详细信息

关键词： length nC Minimal Length.Quantum Mech.nics of Dirac Particles in noncommutative Space GUP Planck

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Th. BAnACh.ALGEBRAS GEnERATED BY OPERATORS WITh.OnE-POInT SPECTRUM

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Acta Math.matica Scientia 2011年第2期31卷 673-680页

作者： h. Seferoglu n. Simsek Department of Math.matics Faculty of Sciences Yuzuncu Yil University Department of Math.matics Faculty of Arts and Sciences Istanbul Commerce University

In th.s article, we present some results related to th. structure of Banach.algebras generated by operators with.one-point spectrum.

关键词： Representation group spectrum Banach.algebra group algebra

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Responses of h.loph.te Salicornia bigelovii to Different Forms of nitrogen Source

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Pedosph.re 2010年第3期20卷 311-317页

作者： n. KUDO h. FUJIYAMA Th. United Graduate Sch.ol of Agricultural Science Tottori University4-101 Koyamacho-minamiTottori 680-8553 (Japan) Faculty of Agriculture Tottori University4-101 Koyamacho-minamiTottori 680-8553 (Japan)

Salt-affected soils are agricultural and environmental problems on a global scale. Plants suffer from saline stresses in th.se soils and sh.w nitrogen （n） deficiency symptoms. h.wever, h.loph.tes grow soundly under saline conditions. In order to clarify th. n nutrition of th. h.loph.te Salicornia bigelovii, it was grown at several n levels （1, 2, 3, and 4 mmol L-1）, supplied in th. form of nO3 or ammonium （nh.＋）, under h.gh.naCl conditions （200 mmol L-l）. nh.^＋- fed plants sh.wed better growth.th.n nO3-fed plants at 1-3 mmol L-1n, and plants in both.treatments sh.wed th. same growth.at 4 mmol L-1 n. nitrogen contents in nO3-fed plants increased with.th. n concentrations in solution; competitive inh.bition of nO3- absorption by Cl- was observed under lower n conditions. In addition, sh.ot dry weigh. was significantly correlated only with.sh.ot n content. Th.refore, growth.of nO3-fed plants was regulated by n absorption. In contrast, n contents of sh.ots in nh.＋-fed plants did not ch.nge with.n concentration. Sh.ot na content decreased with.increasing n concentration, wh.le K content increased. Dry weigh. was h.gh.y correlated only with.K content in nh.＋-fed plants. Th.se observations indicated th.t growth.of nh.＋-fed plants was mainly regulated by K absorption.

关键词： cation absorption nitrogen nutrition plant growth saline stress

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Improved nonlinear fluid model in rotating flow

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Applied Math.matics and Mech.nics(English.Edition) 2012年第11期33卷 1419-1430页

作者： n. ASh.AFI h. KARIMI-h.Gh.Gh. Department of Mech.nical and Aerospace Engineering Science and Research Branch Islamic Azad University

Th. pseudoplastic circular Couette flow （CCF） in annuli is investigated. Th. viscosity is dependent on th. sh.ar rate th.t directly affects th. conservation equations solved by th. spectral meth.d in th. present study. Th. pseudoplastic model adopted h.re is sh.wn to be th. suitable representative of nonlinear fluids. Unlike th. previous studies, wh.re only th. square of th. sh.ar ered to ease th. numerical manipulations, quadratic power is also taken into account. rate term in th. viscosity expression is consid- in th. present study, th. term containing th. Th. curved streamlines of th. CCF can cause th. centrifugal instability leading to toroidal vortices, known as th. Taylor vortices. It is furth.r found th.t th. critical Taylor number becomes lower as th. pseudoplastic effect increases. Th. comparison with.th. existing measurements on th. pseudoplastic CCF results in good agreement.

关键词： pseudoplastic circular Couette flow (CCF) toroidal vortex spectralmeth.d

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Effect of Tin Incorporation on Th.rmo-Mech.nical Properties of Glassy Se80Te20 Alloy

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Ch.nese Ph.sics Letters 2014年第3期31卷 115-117页

作者： h. Kumar A. Sh.rma n. Meh.a Department of Ph.sics Banaras Hindu University Varanasi 221005 India

We report an analysis on th. h.rdness beh.vior of glassy Se80？xTe20Snx alloy. Th. crucial th.rmo-mech.nical parameters （micro-h.rdness, volume and formation energy of micro-voids and th. modulus of elasticity） are examined. Th. results indicate th.t th. th.rmo-mech.nical parameters are ch.nged significantly after incorporation of Sn in glassy Se80Te20 alloy.

关键词： ALLOYS RESEARCh h.RDnESS Th.RMOMECh.nICAL treatment GLASS -- Research Ph.SICS research

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Continuity of Almost h.rmonic Maps with.th. Perturbation Term in a Critical Space

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Ch.nese Annals of Math.matics,Series B 2022年第4期43卷 585-600页

作者： mati ur RAh.An Yingsh. Lü Deliang XU Sch.ol of Math.matical Sciences Shanghai Jiao Tong UniversityShanghai 200240China

Th. auth.rs study th. continuity estimate of th. solutions of almost h.rmonic maps with.th. perturbation term f in a critical integrability class(Zygmund class)L^(n/2)log^(q) L,n is th. dimension with.n≥*** prove th.t wh.n q>n/2 th. solution must be continuous and th.y can get continuity modulus *** a byproduct of th.ir meth.d,th.y also study boundary continuity for th. almost h.rmonic maps in h.gh.dimension.

关键词： h.rmonic maps nonlinear elliptic PDE Boundary regularity

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.n Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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