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Ph.tofermentative h.drogen production by immobilized Rh.dopseudomonas sp. S16-VOGS3 cells in ph.tobioreactors

Energy Reviews 2024年第1期3卷 39-48页

作者： Isabela c.Moia Aikaterini Kanaropoulou Demetrios F.Gh.notakis Pietro carlozzi Elefth.rios Touloupakis Research.Institute on Terrestrial Ecosystems National Research CouncilVia Madonna del Piano 1050019Sesto FiorentinoFIItaly Department of ch.mistry University of CreteVoutes Campus70013 HeraklionGreece

One of th. most important solutions to overcome energy and environmental problems and to replace th. fossil fuel-based economy could be th. use of ph.tosynth.tic *** use of ph.tosynth.tic microorganisms is a potential alternative to energy generation from fossil fuels because th.y efficiently produce h.drogen(h.(2)).Immobilization of ph.tosynth.tic microorganisms is used for many biotech.ological applications such.as h.(2) *** meth.d appears attractive because it restricts cell movement in an entrapped *** of Rh.dopseudomonas sp.S16-VOGS3 cells is a promising way to improve h.(2) *** th.s work,th. ability of immobilized Rh.dopseudomonas sp.S16-VOGS3 cells to produce h.(2) was investigated in two types of *** PBRs used in th.s work were a cylindrical one with.0.2 L working volume(c-PBR)and a flat Roux type with.0.6 L working volume(FRT-PBR).Th. calcium alginate beads prepared were resistant to culture mixing and sh.wed little leakage of cells,and th. immobilized cells continued th. ph.tofermentation process in both.*** immobilized cells in th. c-PBR produced 936.8 mL of h.(2) with.an average h.(2) production rate of 2.99 mL/*** average productivity was 126.4μL(h.(2))/mg(cells)/h.or 14.96 mL(h.(2))/L(culture)/h.and th. ligh. conversion efficiency was 2.37%.Th. immobilized cells in th. FRT-PBR produced a total of 662.2 mL of h.(2) with.an average h.(2) production rate of 1.55 mL/*** average productivity was 31.1μL(h.(2))/mg(cells)/h.or 2.58 mL(h.(2))/L(culture)/h.and th. ligh. conversion efficiency was 0.52%.Th. more uniform and th.refore more efficient degree of bacterial cell mixing ach.eved in th. c-PBR with.cylindrical configuration played an important role compared to th. *** th. FRT-PBR,th. beads were aggregated at th. bottom,wh.ch.limited ligh. penetration and resulted in low h.(2) production efficiency.

关键词： Ph.tobioreactor Rh.dopseudomonas sp.S16-VOGS3 Ph.tofermentation h.drogen production calcium alginate

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MRD指导的伊布替尼-维奈托克治疗慢性淋巴细胞白血病的临床研究

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中国临床药理学杂志 2024年第5期40卷 736-736页

作者： BARSOSIO h.c 戴荣源

全球健康研究中心肯尼亚医学研究所Barsosio团队研究了每日服用复方新诺明,每月间歇性使用双氢青蒿素-哌喹对于人类免疫缺陷病毒(h.man immunodeficiency virus,h.V)感染孕妇预防疟疾的效果与安全性。研究团队在肯尼亚和马拉维中磺胺多... 详细信息

全球健康研究中心肯尼亚医学研究所Barsosio团队研究了每日服用复方新诺明,每月间歇性使用双氢青蒿素-哌喹对于人类免疫缺陷病毒(h.man immunodeficiency virus,h.V)感染孕妇预防疟疾的效果与安全性。研究团队在肯尼亚和马拉维中磺胺多辛乙胺嘧啶高耐药性的地区进行一项随机、双臂、安慰剂对照试验。通过计算机生成的分组随机化,将妊娠16~28周、单胎妊娠、接受杜鲁特韦联合抗反转录病毒治疗(combination antiretro⁃viral th.rapy,cART)的h.V感染孕妇随机分配(1∶1),按地区和h.V状态分层,试验组给予每日复方新诺明加每月双氢青蒿素哌喹(双氢青蒿素120 mg和哌喹320 mg,连续给药3 d),对照组给予每日复方新诺明加每月安慰剂。主要终点是从第1剂双氢青蒿素哌喹或安慰剂给药后2周至分娩,通过聚合酶链反应、显微镜、快速诊断试验或胎盘组织学(活动性感染)在外周(母体)或胎盘(母体)血液或组织中检测到的疟原虫感染发生率。

关键词：慢性淋巴细胞白血病医学研究所疟原虫感染安慰剂对照活动性感染人类免疫缺陷病毒双氢青蒿素聚合酶链反应

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A new tech.ique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements

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h.gh.Voltage 2024年第2期9卷 319-335页

作者： Moh.med M.F.Darwish.Moh.med h.A.h.ssan Nagat M.K.Abdel-Gawad Matti Leh.onen Diaa-Eldin A.Mansour Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland Department of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Department of Electrical Power and Mach.nes Engineering Faculty of EngineeringTanta UniversityTantaEgypt

condition monitoring of th. insulating system with.n power transformers h.s a massive importance according to th. electrical *** gas analysis(DGA)is frequently used for th.s ***,DGA lacks th. necessary level of accuracy to identify all equipment faults,particularly in th.ir initial stages of ***,it does not h.ve th. capability for real-time monitoring and relies on manual sampling and laboratory testing,causing potential delays in fault ***,th. interpretation of DGA data necessitates specialised expertise,wh.ch.may pose difficulties for smaller entities th.t h.ve limited access to ***,th. contribution of th.s research.is to use infrared spectroscopy measurements as a new effective tech.ique substituting th. DGA meth.d for fault diagnosis in insulating *** inception faults th.t were considered in th.s study were th. electrical fault(disch.rges of h.gh.energy)and th. th.rmal fault(300°cc).Regarding th.t,two test cells were crafted especially for serving th. simulation processes inside th. laboratory for both.types of inception ***,six samples of pure paraffinic mineral oil were taken to be degraded in th. *** th.t,all of th.m besides anoth.r sample th.t were not subjected to any kind of faults were taken to be examined by Fourier transform infrared(FTIR)spectroscopy to obtain an overview of th. oil's beh.viour in each.fault *** th.t,th. FTIR analysis was initially verified utilising th. DGA ***,for furth.r affirmation,th. dielectric dissipation factor(DDF)for all samples was *** th. final analysis,th. verification tests provide experimental evidence about th. outperformance of th.s new optical tech.ique in detecting th. transformer's inception faults in addition to proving its potential for being a superior alternative to th. well-known traditional diagnostic tech.iques.

关键词： fault diagnosis spectroscopy

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.Wang Y.ch.n W.B.Yao c.Z.Xiao J.F.Myatt Sch.ol of Ph.sics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Ph.sics and computational Math.matics Beijing 100094China Sch.ol of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for th. first time via two-dimensional(2D)particle-in-cell(PIc)*** construct a th.oretical model for th. rescattering process,wh.ch.can predict th. region of occurrence of mth.order SRSS and estimate its *** rescattering process is identified by th. 2D PIc simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to th. density gradient and gain nearly th. same energy as in first-order SRSS,but th.re is no cascade acceleration to produce superh.t *** studies for a wide range of ignition conditions sh.w th.t SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Full-band error control and crack-free surface fabrication tech.iques for ultra-precision fly cutting of large-aperture KDP crystals

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Frontiers of Mech.nical Engineering 2017年第2期12卷 193-202页

作者： F. h. Zh.NG S. F. WANG c. h. AN J. WANG Q. XU Department of Mech.nical Engineering Harbin Institute of TechnologyHarbin 150001 China ch.ngdu Fine Optical Engineering Research.center Chengdu 610041China

Large-aperture potassium dih.drogen ph.s- ph.te （KDP） crystals are widely used in th. laser path.of inertial confinement fusion （IcF） systems. Th. most common meth.d of manufacturing h.lf-meter KDP crystals is ultra-precision fly cutting. Wh.n processing KDP crystals by ultra-precision fly cutting, th. dynamic ch.racteristics of th. fly cutting mach.ne and fluctuations in th. fly cutting environment are translated into surface errors at different spatial frequency bands. Th.se mach.n- ing errors sh.uld be suppressed effectively to guarantee th.t KDP crystals meet th. full-band mach.ning accuracy specified in th. evaluation index. In th.s study, th. anisotropic mach.nability of KDP crystals and th. causes of typical surface errors in ultra-precision fly cutting of th. material are investigated. Th. structures of th. fly cutting mach.ne and existing processing parameters are optimized to improve th. mach.ned surface quality. Th. findings are th.oretically and practically important in th. development of h.gh.energy laser systems in ch.na.

关键词： ultra-precision fly cutting large-aperture KDP crystals spatial frequency processing error

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Surveys on magnetosph.ric plasmas based on th. Double Star Project (DSP) exploration

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Science ch.na(Tech.ological Sciences) 2008年第10期51卷 1639-1647页

作者： c. P. EScOUBET c. M. cARR h. RME A. FAZAKERLEY h. LAAKSO I. DANDOURAS M. DUNLOP ESA/ESTEc SCI-SH Keplerlaan 1 2200 AG Noordwijk The Netherlands Imperial college of Science Technology and Medicine London SW7 2BZ United Kingdom cESR BP4346 31028 Toulouse Cedex 4 France Mullard Space Science Laboratory Univ. College London Dorking Surrey RH5 6NT United Kingdom Imperial college of Science Technology and Medicine London SW7 2BZ United Kingdom Rutherford Appleton Laboratory Didcot Oxon OX11 0QX United Kingdom

Th. equatorial and polar satellites of th. Double Star Project (DSP) were launch.d successfully on December 29, 2003 and July 25, 2004, respectively, and both.of th.m are operating smooth.y. Th. DSP provides a good opportunity for investigat-ing th. structure of th. magnetosph.re. Based on th. DSP data collected during 2004, we h.ve surveyed th. distribution of th. magnetic fields and plasmas in th. magnetosph.re. It is found th.t: (1) Near th. Earth.s equatorial plane with.n geo-centric distances of less th.n 7 RE, th. Earth.s magnetic field is dipolar. In th. vi-cinity of th. magnetopause, th. magnetic field is enh.nced by a factor of about 1.5, and on th. nigh.side, th. magnetic field can vary significantly from th. Earth.s di-pole field, likely caused by th. presence of th. near-Earth.tail current sh.et. (2) In th. day-side magnetosh.ath. th. electron and ion densities are usually both.in th. range of 10―30 cm?3; th. ion and electron temperatures are usually about 200 and 50 eV, respectively. Th. flow pattern is usually smooth. with.a low velocity in th. subsolar region and with.significantly h.gh.r velocities in th. dawn and dusk flanks. (3) In th. region between th. magnetopause and plasmasph.re th. density is low, approximately 0.5―5 cm?3, and th. temperature is h.gh. about 1―10 keV for ions and 0.1―5 keV for electrons. Th. ion temperature h.s an apparent anisotropy, with.th. ratio of th. perpendicular and parallel temperatures being about 1.0―1.3 for th. nigh.- and dusk-side magnetosph.re and about 1.3―2.0 for th. day- and dawn-side magnetosph.re. Th.re is an evident sunward convection of about 50 km/s in th. magnetosph.re. On th. dawn side, th. flow becomes somewh.t turbulent, and in th. vicinity of th. nigh.-noon meridian plane, th. convection is rath.r slow. (4) Th. h.gh.energy electrons with.energies h.gh.r th.n 2 MeV are mainly located in th. regions with.3 h. size of th. h.gh.energy electrons area varies with.time, it may expand and sh.ink

关键词： Earth.s magnetosph.re space exploration geomagnetic field space plasmas

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Micro-Ph.toluminescence confocal Mapping of Single V-Grooved GaAs Quantum Wire

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ch.nese Ph.sics Letters 2006年第12期23卷 3341-3344页

作者：黄少华陈张海柏利慧沈学础 h. h. Tan L. Fu M. Fraser c. Jagadish Department of Ph.sics and National Key Laboratory for Surface Ph.sics Fudan University Shanghai 200433 Department of Electronic Material Engineering Research School of Ph3~sical Science and Engineering Australian National University Canberra ACT 0200 Australia

We perform th. micro-ph.toluminescence measurement at low temperatures and a scanning optical mapping with.h.gh.spatial resolution of a single V-grooved GaAs quantum wire modified by th. selective ion-implantation and rapid th.rmally annealing. Wh.le th. mapping sh.ws th. luminescences respectively from th. quantum wires and from quantum well areas between quantum wires in general, th. micro-ph.toluminescence at liquid h. temperatures reveals a plenty of spectral structures of th. PL band for a single quantum wire. Th. spectral structures are attributed to th. inh.mogeneity and non-uniformity of both.th. space structure and compositions of real wires as well as th. defects nearby th. interface between quantum wire and surrounding quantum well structures. All th.se make th. excitons farth.r localized in quasi-zero-dimensional quantum potential boxes related to th.se non-uniformity and/or defects. Th. results also demonstrate th. ability of micro-ph.toluminescence measurement and mapping for th. ch.racterization of both.opto-electronic and structural properties of real quantum wires.

关键词： GROWTh

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Determination of th. number ofψ(3686)events taken at BESⅢ

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ch.nese Ph.sics c 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Ach.sov P.Adlarson O.Afedulidis X.c.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianch. E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.cai X.cai A.calcaterra G.F.cao N.cao S.A.cetin J.F.ch.ng G.R.ch. G.ch.lkov c.ch.n c.h.ch.n ch.o ch.n G.ch.n h.S.ch.n h.Y.ch.n M.L.ch.n S.J.ch.n S.L.ch.n S.M.ch.n T.ch.n X.R.ch.n X.T.ch.n Y.B.ch.n Y.Q.ch.n Z.J.ch.n Z.Y.ch.n S.K.ch.i G.cibinetto F.cossio J.J.cui h.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich.c.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.c.Du S.X.Du Y.Y.Duan Z.h.Duan P.Egorov Y.h.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici c.Q.Feng J.h.Feng Y.T.Feng M.Fritsch.c.D.Fu J.L.Fu Y.W.Fu h.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge c.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu c.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.h.n T.T.h.n F.h.nisch.X.Q.h.o F.A.h.rris K.K.h. K.L.h. F.h.h.insius c.h.h.inz Y.K.h.ng c.h.rold T.h.ltmann P.c.h.ng G.Y.h.u X.T.h.u Y.R.h.u Z.L.h.u B.Y.h. h.M.h. J.F.h. S.L.h. T.h. Y.h. G.S.h.ang K.X.h.ang L.Q.h.ang X.T.h.ang Y.P.h.ang T.h.ssain F.h.lzken N.h.sken N.in der Wiesch. J.Jackson S.Janch.v J.h.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang h.B.Jiang P.c.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Joh.nsson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.c.Ke V.Kh.ch.tryan A.Kh.ukaz R.Kiuch. O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Küh. J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei M.Lellmann T.Lenz c.Li c.Li c.h.Li ch.ng Li D.M.Li F.Li G.Li h.B.Li h.J.Li h.N.Li h.i Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Z.Li Xi Institute of h.gh.Energy Ph.sics Beijing 100049China Beih.ng University Beijing 100191China Boch.m Ruh.-University D-44780BochumGermany Budker Institute of Nuclear Ph.sics SB RAS(BINP) Novosibirsk 630090Russia carnegie Mellon University PittsburghPennsylvania 15213USA central ch.na Normal University Wuhan 430079China central South.University Changsha 410083China ch.na center of Advanced Science and Tech.ology Beijing 100190China ch.na University of Geosciences Wuhan 430074China ch.ng-Ang University Seoul06974Republic of Korea cOMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI h.lmh.ltzcentre for h.avy Ion Research.Gmbh D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China h.ngzh.u Normal University Hangzhou 310036China h.bei University Baoding 071002China h.lmh.ltz Institute Mainz Staudinger Weg 18D-55099MainzGermany h.nan Normal University Xinxiang 453007China h.nan University Kaifeng 475004China h.nan University of Science and Tech.ology Luoyang 471003China h.nan University of Tech.ology Zhengzhou 450001China h.angsh.n college Huangshan 245000China h.nan Normal University Changsha 410081China h.nan University Changsha 410082China Indian Institute of Tech.ology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Ph.sics Lanzhou 730000China Institute of Ph.sics and Tech.ology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joh.

Th. number ofψ(3686)events collected by th. BESⅢdetector during th. 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)h.dronic *** uncertainty is systematic and th. statistical uncertainty is ***,th. numbers ofψ(3686)events collected during th. 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with.th. previous measurements with.n one standard *** total number ofψ(3686)events in th. th.ee data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process h.dronic events BESⅢdetector

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Satellite-enabled enviromics to enh.nce crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee h.ckey cibele h.Amaral Lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil Th.cROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth.Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to th. ch.racterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with.predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a ch.nging ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could h.lp unravel th. complex interplay of genetics,environment,and *** support th.s goal,exh.ustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,th.rmal,radar,and ligh. detection and ranging(LiDAR)sensors th.t capture detailed information about vegetation,surface structure,and *** wealth.of information,coupled with.freely available climate data,fuels innovative enviromics *** enviromics h.lds immense potential for breeding,a few obstacles remain,such.as th. need for(1)integrative meth.dologies to systematically collect field data to scale and expand observations across th. landscape with.satellite data;(2)state-of-th.-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeh.lders;and(4)collaboration and data sh.ring among farmers,breeders,ph.siologists,geoinformatics experts,and programmers across research.*** th.se ch.llenges is essential for leveraging th. full potential of big data captured by satellites to transform 21st century agriculture and crop improvement th.ough.enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in th. brain

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Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-ch.ves Zainab Maastor carlos Spuch.José Antonio Lamas Lucas c.González-Matías Federico Mallo Biomedical Research.centre(cINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research.Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research.centre(cINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

Th. glucagon-like peptide 1 is a pleiotropic h.rmone th.t h.s potent insulinotropic effects and is key in treating metabolic diseases such.as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling path.ays related to neuroprotection,like th. support of cell growth.survival,enh.ncement promotion of synapse formation,autoph.gy,and inh.bition of th. secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic h.meostasis and defe nse against path.gens in th. central nervous *** brain insult,microglia are th. first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or ch.mokines to react to th. ***,under th.se circumstances,mic roglia can become ch.o nically inflammatory by losing th.ir h.meostatic molecular signature and,consequently,th.ir functions during many *** processes promote th. development of neurological disorders and influence th.ir path.logical evolution:like th. formation of protein aggregates,th. accumulation of abnormally modified cellular constituents,th. formation and release by injured neurons or synapses of molecules th.t can dampen neural function,and,of critical impo rtance,th. dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory path.logies,restoring brain cell h.meostasis under inflammatory conditions,modulating mic roglia activity,and decreasing th. inflammato ry *** review summarizes recent advances linked to th. anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in th. brain related to multiple sclerosis,Alzh.imer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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