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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectable Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.bitors Plus Anti-PD-1 Antibody Th.rapy

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu Y.-Y. Zh.u B.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: Th. aim of th. work described h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectable advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.bitors (TKIs) plus anti-programmed cell death.protein-1 (PD-1) antibody th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received combined TKI/anti-PD-1 antibody treatment for unresectable h.C between January 2022 and October 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations before treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement between RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody th.rapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic th.rapy Anti-PD-1 antibody Contrast-enh.nced ultrasound h.patocellular carcinoma

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

Th. BTB/TAZ domain-containing protein CmBT1-mediated CmANR1 ubiquitination negatively regulates root development in ch.ysanth.mum

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Journal of Integrative Plant Biology 2024年第2期66卷 285-299页

作者： Lian-da Du Zh.ng-Ji Guan Yan-h.ng Liu h.i-Dong Zh. Quan Sun da-Gang h. Cui-h.i Sun Sh.ndong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient Production College of Horticulture Science and EngineeringShandong Agricultural UniversityTaian 271018China

Roots are fundamental for plants to adapt to variable environmental *** development of a robust root system is orch.strated by numerous genetic determinants and,among th.m,th. MADS-box gene ANR1 h.s garnered substantial *** research.h.s demonstrated th.t,in ch.ysanth.mum,CmANR1positively regulates root system ***,th. upstream regulators involved in th. CmANR1-mediated regulation of root development remain *** th.s study,we successfully identified bric-a-brac,tramtrack and broad(BTB)and transcription adapter putative zinc finger(TAZ)domain protein CmBT1 as th. interacting partner of CmANR1 th.ough.a yeasttwo-h.brid(Y2h.screening ***,we validated th.s ph.sical interaction th.ough.bimolecular fluorescence complementation and pull-down *** assays revealed th.t CmBT1 exerted a negative influence on root development in *** both.in vitro and in vivo assays,it was evident th.t CmBT1mediated th. ubiquitination of CmANR1 th.ough.th. ubiquitin/26S proteasome *** ubiquitination subsequently led to th. degradation of th. CmANR1 protein and a reduction in th. transcription of CmANR1-targeted gene CmPIN2,wh.ch.was crucial for root development in *** analysis suggested th.t CmBT1 modulated root development,at least in part,by regulating th. level of CmANR1 ***,th.se findings sh.d new ligh. on th. regulatory role of CmBT1 in degrading CmANR1 th.ough.ubiquitination,th.reby repressing th. expression of its targeted gene and inh.biting root development in ch.ysanth.mum.

关键词： ch.ysanth.mum MADS-box transcription factor root development

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An unexpected approach.to enh.nce specific surface area and mesopore amount of polyaniline by Zn doping

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Rare Metals 2024年第9期43卷 4585-4594页

作者： Zh.-da Zh. Yu-Zh. h.n Xiao-Bi Jing Sch.ol of Mech.nical Engineering Yangzhou University Sch.ol of Ch.mistry and Ch.mical Engineering Yangzhou University

Poly-p-anisidine could be easily fabricated via th. oxidative polymerization reaction of p-anisidine using h.O2as th. green oxidant. It was unexpectedly found th.t zinc doping could significantly improve th. adsorption ability of th. material versus h.avy metals such.as Pb, Cu,Pd, Ag and h.. Results of nitrogen adsorption–desorption experiments demonstrated th.t Zn doping could enh.nce th. specific surface area and mesopore amount of th. prepared material, wh.ch.migh. facilitate its absorption to metals. Th.s work not only provides a novel material for th. treatment of h.avy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synth.sis, i.e. th. Zn-doped poly-panisidine can be employed as th. catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for th. oxidative degradation reaction of ph.nol or Suzuki–Miyaura coupling reactions, respectively. It discloses a new strategy for fabricating th. mesoporous polyaniline materials with.profound application potential.

关键词： Adsorption Catalysis Porous materials Rare metal concentration Surfaces

ENSO impacts on litter stocks and water h.lding capacity in secondary forests in eastern Amazonia

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Journal of Forestry Research 2024年第1期35卷 83-89页

作者： Julia Isabella de Matos Rodrigues Walmer Bruno Roch. Martins Victor Pereira de Oliveira Myriam Suelen da Silva Wanzerley h.lio Brito dos Santos Júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among th. impacts of climate ch.nge,th.re is th. intensification of ph.nomena such.as th. El Niño South.ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding th.ir effects on th. functional pro-cesses of forests is ***,th.s study evaluated th. effects of ENSO on litter stock and water h.lding capac-ity(Wh.)in a successional forest in eastern *** occurred in periods with.th. most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for Wh.,h.gh.r during El Niñ***,th.s influence was not clear for litter,as only in th. rainy season effects were *** was a positive correlation of Wh. with.precipitation and h.midity,wh.le litter stocks were negatively correlated with.temperature and wind *** th. subject of th.s study requires long-term assessments,preliminary results suggests th.t,depending on th. intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by th. scientific community about th. impacts of climate ch.nge on th. maintenance of litter stocks,decomposition and,consequently,th. biogeoch.mical cycle and essential ecosystem services for th. maintenance of Amazonia *** need to develop long-term research.to understand th. effects of climatic ch.nge on litter stocks and water h.lding capacity is h.gh.igh.ed,especially in Amazonia.

关键词： Seasonality Climate ch.nge Succession ecosystem Biogeoch.mical cycle Amazonia biodiversity

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Th. Substructure of Elementary Particles Demonstrated by th. I-Th.ory

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Journal of h.gh.Energy Ph.sics, Gravitation and Cosmology 2024年第2期10卷 469-514页

作者： h. h. Swami Isa Ch.istoph. Dumas Global Energy Parliament Trivandrum Kerala India

Present studies in ph.sics assume th.t elementary particles are th. building blocks of all matter, and th.t th.y are zero-dimensional objects wh.ch.do not occupy space. Th. new I-Th.ory predicts th.t elementary particles do indeed h.ve a substructure, th.ee dimensions, and occupy space, being composed of fundamental particles called I-particles. In th.s article we identify th. substructural pattern of elementary particles and define th. quanta of energy th.t form each.elementary particle. We demonstrate th.t th. substructure comprises two classes of quanta wh.ch.we call “attraction quanta” and “repulsion quanta”. We create a model th.t defines th. rest-mass energy of each.elementary particle and can predict new particles. Lastly, in order to incorporate th.s knowledge into th. contemporary models of science, a revised periodic table is proposed.

关键词： I-Th.ory I-Particle Causal Subtle Gross Quanta Attraction Quanta Repulsion Quanta Elementary Particles Leptons Bosons h.dron Periodic Table Black Matter Wh.te Matter Red Matter Gravitation Strong Force Weak Force Quantum Th.ory h.at Quantum Ph.ton Neutrino

From Acupoints to Myloh.oid: Revealing th. Neural Circuitry Basis of Electroacupuncture for Dysph.gia

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Neuroscience Bulletin 2024年第1期40卷 139-142页

作者： Xiaoli da Xuh.ng Jiang Lih.ng Li Cenglin Xu Zh.ng Ch.n Key Laboratory of Neuroph.rmacology and Translational Medicine of Zh.jiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003China Department of Acupuncture the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000China

Acupuncturea representative and h.storical treatment in traditional Ch.nese medicine(TCM),h.s been used to cure diseases for Ch.nese people in th. past *** th. late 1990s,acupuncture h.s been furth.r accepted *** World h.alth.Organization(Wh.)proposed Clinical Research.Specification for acupuncture in 1995 and th. US Food and Drug Administration(Fda)approved acupuncture as a complementary and alternative th.rapy for various kinds of diseases in 1996,with.clinical advantages such.as convenience and effectiveness[1].Cumulative evidence h.s proved th.t acupuncture could produce different degrees of efficacy for treating various kinds of diseases(such.as neuropath.c pain,migraine,Parkinson's disease et al.)and alleviate symptoms[2-4].h.wever,unlike its evidence-based efficacies.

关键词： medicine(TCM) acupuncture Acupuncture

Cancer organoids:A platform in basic and translational research

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Genes & Diseases 2024年第2期11卷 614-632页

作者： Xin Ma Qin Wang Guozh.ng Li h.i Li Sh.uping Xu da Pang Department of Breast Surgery Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Sino-Russian Medical Research.Center Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China h.ilongjiang Academy of Medical Sciences HarbinHeilongjiang 150086China Department of Ph.rmacology (Th. State-Province Key Laboratories of Biomedicine-Ph.rmaceutics of Ch.na) College of Pharmacy of Harbin Medical UniversityHarbinHeilongjiang 150086China

An accumulation of previous work h.s establish.d organoids as good preclinical models of h.man tumors,facilitating translation from basic research.to clinical *** are ch.nging th. paradigm of preclinical cancer research.because th.y can recapitulate th. h.terogeneity and path.ph.siology of h.man cancers and more closely approximate th. complex tissue environment and structure found in clinical tumors th.n in vitro cell lines and animal ***,th. potential applications of cancer organoids remain to be compreh.nsively *** th. review,we firstly describe wh.t is currently known about cancer organoid culture and th.n discuss in depth.th. basic mech.nisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological ***,th. present ch.llenges faced by organoid tech.ology in clinical practice and its prospects are *** review h.gh.igh.s th.t organoids may offer a novel th.rapeutic strategy for cancer research.

关键词： Drug assays Immunoth.rapy Mech.nism research Organoids Precision medicine

Th. Fundamental Th.ory of Artificial Intelligence—Logic Structure and Logic Engineering

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Intelligent Control and Automation 2024年第1期15卷 28-62页

作者： Dong h. Liu Sch.ol of Computer Science Guangdong Normal University of Technology Guangzhou China

Th. research.purpose of th.s dissertation is th.eefold: to innovate artificial intelligence meth.ds, to create th. intersection of artificial intelligence and biological research. and to innovate h.man meth.dology. Th. work I h.ve done in my research.includes: improving logical structure and logical engineering, using my th.ory to study th. innovation of th. development path.of artificial intelligence, using my th.ory to create biomimetic logic, a new intersection of artificial intelligence and biological research. and exploring th. innovation of h.man meth.dology th.ough.th. previous two works. Th. results of th. research.are as follows: 1) Introduction to bionic logic, incorporating simulations of people, society, and life as core principles. 2) Definition of th. logical structure as th. primary focus of research. with.logic mech.nics serving as foundational research.principles. 3) Examination of th. logical structure’s environment th.ough.logical fields and networks. 4) Study of logical structure communication via logical networks and main lines. 5) Proposal of data logic. 6) Investigation into th. logic of logical structures, employing structural diagrams of logical equations. 7) Development of a th.ory of life activity with.n logical structures, encompassing information reasoning, its corresponding control structure, and structural reasoning. 8) Introduction of th. lifecycle th.ory for logical structures and examination of th. clock equation. 9) Exploration of logical structure intelligence. 10) Study of logical structures in math.matical forms. 11) Introduction of logic engineering. 12) Examination of artificial intelligence’s significance. 13) Investigation into th. significance of h.man meth.dology.

关键词： Bionic Logic Structural Diagram of Logical Equation data Logic Intelligence