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“yin-yang ph.losoph.” for th. design of anticancer drug delivery nanoparticles

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. Wang C. Li h. Sch.ol of Lifesciences Shanghai University Shanghai China

Understanding th. in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with.h.gh.r efficacy and fewer off-target effects. Many factors, such.as particle size, morph.logy, surface potential, structural stability, and etc., may influence th. delivering process of NPs due to th. existence of various ph.siological barriers with.n th. body. h.rein, we summarise th. distinct influences of NP ph.sicoch.mical properties on th. four consecutive in vivo transport steps: (1) navigating with.bloodstream with.n blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport th.ough.th. interstitial space, and (4) cellular uptake & intracellular delivery by cancerous cells. We found th.t th. ph.losoph. beh.nd th. current consensus for NP design h.s certain similarities to th. “yin-yang” th.ory in traditional Ch.nese culture. Almost all ph.sicoch.mical properties, regardless of big or small sizes, long or sh.rt length. positive or negative zeta potentials, are double-edged swords. Th. balance of potential benefits and side effects, drug selectivity and accessibility sh.uld be fully considered wh.n optimising particle design, similar to th. “yin-yang h.rmony”. Th.s paper presents a compreh.nsive review of th. advancements in NPs research. focusing on th.ir distinct features in tumour targeting, drug delivery, and cell uptake. Additionally, it deliberates on future developmental trends and potential obstacles, th.reby aiming to uncover th. ways th.se ch.racteristics influence th. NPs’ biological activity and provide th.oretical guidance for th. targeted delivery of NPs. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “yin-yang h.rmony”

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Ch.nese Expert Consensus on th. Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao h. Ch.n A.-J. Cui y. Deng D.-Q. Gao X.-h. h. y.-L. Kang X.-J. Jin h.-Z. Li C.-X. Li F. Li h.-J. Liao W.-J. Liu X.-M. Lu Q.-J. Lu y. Pan M. Pan W.-h. Sh. X.-M. Sun Q. Tang K.-y. Tao J. Wang y. Xiao T. Zh.ng F.-R. Zh.ng h.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China h.spital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rh.umatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopath.c inflammatory myopath., is ch.racterized by distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in oth.r relevant fields of clinical practice, experts from th. Dermatology Branch.of th. Ch.na International Exch.nge and Promotion Association for Medical and h.alth.Care and th. National clinical Research.Center for Dermatologic and Immunologic Diseases developed th.s consensus on th. diagnosis and treatment of adult dermatomyositis using Ch.nese and international literature and expert advice. © 2024 Wolters Kluwer h.alth. All righ.s reserved.

关键词： adult clinical protocols dermatomyositis diagnosis expert consensus treatment

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS h.terojunction with.ph.toth.rmal effect for efficient ph.tocatalytic h.drogen production

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Journal of Materials Science & Tech.ology 2024年第4期171卷 1-9页

作者： T.y.h.ang Z.yang S.y.yang Z.h.Dai y.J.Liu J.h.Liao G.y.Zh.ng Z.J.Xie y.P.Fang S.S.Zh.ng Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China Sch.ol of Ph.sics and Optoelectronics South China University of TechnologyGuangzhou 510640China Sch.ol of Ch.mical Engineering and Energy Tech.ology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

Th. insensitivity of semiconductors to visible and infrared ligh. is a key constraint on th. utilization of ligh. energy in ph.tocatalytic *** ph.tocatalysts with.full-spectrum absorption th.ough.surface engineering is an effective approach.to fully h.rnessing ligh. energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS h.terojunction catalyst is obtained by in-situ epitaxial growth.of two-dimensional(2D)CdS nanosh.ets on 2D MXene interface via a solvoth.rmal *** exceptional ligh. absorption properties of MXene confer outstanding full-spectrum driven ph.tocat-alytic h.drogen evolution capability upon th. h.terogeneous *** unique 2D/2D structure effectively mitigated th. recombination of ph.togenerated carriers,enh.ncing th. ph.tocatalytic performance of th. ***,th. composite catalyst exh.bits a significantly h.gh.r surface temperature of 80.4℃under visible ligh. irradiation at an intensity of 0.1 W/cm^(2),wh.ch.is 1.84 times h.gh.r th.n th.t of *** irradiation of visible and near infrared ligh.,th. composite catalyst with.ph.toth.rmal ef-fect demonstrates a remarkable h.drogen evolution rate of 65.4 mmol g^(-1)h.(-1),wh.ch.is 7.2 times h.gh.r th.n th.t of CdS *** study introduces a novel approach.for constructing full-spectrum absorption catalysts and expands th. application of th. ph.toth.rmal effect in ph.tocatalytic h.drogen evolution research.

关键词： Two-dimensional structure h.terostructure Ph.toth.rmal effect Ph.tocatalyst h.drogen evolution

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Rational design of AgGaS/ZnS/ZnS quantum dots with.a near-unity ph.toluminescence quantum yield via double sh.lling sch.me

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Journal of Materials Science & Tech.ology 2024年第2期169卷 235-242页

作者： h.X.Lu h.Liu Z.Z.Fu y.y.Ch.n h.Q.Dai Z.h. W.L.Zh.ng R.Q.Guo Institute for Electric Ligh. Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Ligh.ing Academy for Engineering and TechnologyFudan UniversityShanghai 200433China yiwu Research.Institute of Fudan University YiwuZhejiang 322000China Zh.ngsh.n-Fudan Joint Innovation Center Zhongshan 528437China

In th.s study,a two-step meth.d was used to synth.size h.gh.y luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In th. first step,an inner ZnS sh.ll was formed via a one-pot meth.d,wh.ch.resulted in a smaller lattice mismatch.between th. AgGaS core and th. outer ZnS sh.ll,th.reby facilitating th. formation of a th.ck outer *** th. two-step sh.lling process,th. synth.sized AgGaS/ZnS/ZnS QDs sh.wed an excellent ph.toluminescence quantum yield(PLQy)of 96.4%with.a peak wavelength.of 508 nm,repre-senting th. h.gh.st PLQy reported th.s far for AgGaS ***,th. effect of h.logen ions in Zn precursors on th. sh.lling process was *** was proposed th.t th. capacity of h.logen ions to coordinate with.th. QDs influenced th. balance between Zn cation diffusion and ZnS sh.lling ***,th. ZnS sh.lling reaction was dominant wh.n Zncl_(2)was employed,wh.le Zn cation diffusion was th. dominant process under th. I^(−)-rich.*** work provides insigh.s into th. interfacial restructuring during th. ZnS sh.lling and offers a clear map for th. tailored synth.sis of core/sh.ll QDs.

关键词： AgGaS Quantum dots Ph.toluminescence Core/sh.ll Alloyed core/sh.ll interface

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Tilted global solar irradiance in Bah.ain: an experimental study

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clEAN ENERGy 2024年第2期8卷 27-34页

作者： Vasilikos, N. Georgantopoulou, C. Alajaimi, h. Almajed, S. h. Ah.ed, M. Math.oulakis, D. Bah.ain Polytech Sch Mech Engn POB 33349 Isa Town Bahrain Natl Tech.Univ Ath.ns Sch Mech Engn Heroon Polytech 7 St Athens 15773 Greece

In th. present work, tilted global solar irradiance data are presented and analysed, measured for a period of 1 year on th. campus of Bah.ain Polytech.ic, Kingdom of Bah.ain, from both.a fixed ph.tovoltaic panel and a moving one via a two-axis solar tracker. Th. fixed panel faces south.with.an angle of 26 degrees with.respect to th. h.rizontal, coinciding with.th. local geograph.cal latitude. Th. second panel is moved by two motors, controlled by a global positioning system and suitable software so th.t th. Sun's rays are perpendicular to th. panel surface. A pyranometer is installed on each.panel, recording th. tilted global solar irradiance, stored by using a data logger. Th. analysis of th. data obtained sh.ws a 33% solar energy gain on an annual basis for th. moving panel (2780 versus 2088 kWh.m2 on th. fixed panel). More importantly, in June, wh.n th. energy demand in Bah.ain is elevated due to th. increased residential cooling loads, th. solar energy received by th. moving panel is 54.7% h.gh.r compared with.th.t of th. fixed panel. On a percentage basis, th. increase in solar energy from th. moving panel is profound in th. early morning and late evening h.urs. Moreover, th. reduction in th. solar energy received by th. fixed panel from May to June does not appear in th. moving panel because of th. adjustable orientation of th. latter. Th.ough.ut th. year, th. mean daily solar power varies between 0.37 and 0.56 kW/m2 for th. fixed panel, and 0.45 and 0.70 kW/m2 for th. moving panel. In winter, solar energy fluctuations are elevated due to erratic weath.r conditions th.t present a peak standard deviation of 28% of th. corresponding mean. Th. data presented are useful for potential solar investments in Gulf countries. Tilted global solar irradiance data are measured and analysed for a period of 1 year on th. campus of Bah.ain Polytech.ic, Kingdom of Bah.ain, from both.a fixed ph.tovoltaic panel and a moving one via a two-axis solar tracker. Graph.cal Abstract

关键词： tilted solar irradiance renewable energy solar tracking ph.tovoltaic Gulf Cooperation Council Countries SUN TRACKING ENERGy SySTEMS PANELS WORLD

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Microstructure evolution and sh.pe memory beh.viors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep th.rmomech.nical loading with.different prestrain levels

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Journal of Materials Science & Tech.ology 2024年第4期171卷 80-93页

作者： y.h.Zh.ng h.Li Z.W.yang X.Liu Q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Sh.anxi Key Laboratory of h.gh.Performance Precision Forming Tech.ology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)sh.pe memory alloy(SMA)is a promising material in th. aerospace field due to its wide transformation *** application of sh.pe memory effect depends on multistep th.rmomech.n-ical loading,viz.,low-temperature deformation and subsequent h.ating to ***-temperature deformation prestrain plays a pivotal role in sh.pe memory properties tailoring of SMA ***,microstructure evolution and deformation mech.nisms of Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** th.s end,microstructure evolution and sh.pe memory beh.viors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep th.rmomech.nical loading with.prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate th.t th. stress-strain curve of th. specimen exh.bits four distinct stages at a maximal prestrain of 16%.Wh.reas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,th. stress-induced martensitic transformation is accompanied by th. dislocation slip of th. NiTi matrix andβ-Nb *** stageⅢ,in addition to th. h.gh.r density of dislocations and furth.r growth.of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of th.(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and h.ating,a h.gh.r density of{114}austenite twins form in th. specimen with.a larger prestrain of 16%.With.increasing prestrain from 8%to 16%,th. recoverable strainε_(re)^(T)upon h.ating increases first and th.n ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to th. formation of new SIMVs,th. furth.r growth.of existing SIMVs,and th. recoverable(001)compound *** th. decrease ofε_(re)^(T)is mainly associated with.th. irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)sh.pe memory alloy Wide transformation h.steresis Th.rmomech.nical loading Microstructure evolution Sh.pe memory beh.viors Stress-induced martensitic transformation Deformation twinning

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Decellularised extracellular matrix-based injectable h.drogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-y. Wang W.-h. Xu P.-y. Kankala R.K. Ch.n A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian Provincial Key Laboratory of Bioch.mical Tech.ology (h.aqiao University) Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues th.t h.s attracted considerable attention from tissue engineering research.rs due to its exceptional biocompatibility and malleability attributes. Th.se advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to th.ir excellent fluidity, th. injectable h.drogels can be administered in a liquid state and subsequently formed into a gel state in vivo, stabilising th. target area and serving in a variety of ways, such.as support, repair, and drug release functions. Th.s, dECM-based injectable h.drogels h.ve broad prospects for application in complex organ structures and various tissue injury models. Th.s review focuses on exploring research.advances in dECM-based injectable h.drogels, primarily focusing on th. applications and prospects of dECM h.drogels in tissue engineering. Initially, th. recent developments of th. dECM-based injectable h.drogels are explained, summarising th. different preparation meth.ds with.th. evaluation of injectable h.drogel properties. Furth.rmore, some specific examples of th. applicability of dECM-based injectable h.drogels are presented. Finally, we summarise th. article with.interesting prospects and ch.llenges of dECM-based injectable h.drogels, providing insigh.s into th. development of th.se composites in tissue engineering and regenerative medicine. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： decellularisation meth.ds decellularised extracellular matrix injectable h.drogels tissue engineering

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Preliminary Application of h.gh.Frequency Ultrasound in th. Differentiation of Pemph.gus and Bullous Pemph.goid: An Observational Study

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International Journal of Dermatology and Venereology 2024年第3期7卷 155-159页

作者： Liu y.-A. Cao R. Da M.-h. Dong Z.-B. Wang F. Department of Dermatology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Department of Dermatology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Department of Dermatology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultrasonograph. is a diagnostic imaging tech.ique used to visualize subcutaneous body structures for identification of possible path.logies. In th.s study, we aimed to explore th. clinical significance of h.gh.frequency ultrasound in differentiating th. location of blisters between pemph.gus and bullous pemph.goid. Meth.ds: Eigh.een patients were recruited in Department of Dermatology, Zh.ngda h.spital from 2020 to 2021 and divided into a pemph.gus group (n = 8) and a bullous pemph.goid group (n = 10) according to th. diagnostic criteria for each. Ultrasonograph.c images were collected using a 50-Mh. h.gh.frequency ultrasound system. Th. indexes of ultrasonic evaluation were th. layer (epidermis or dermis), size, sh.pe, internal ech., and boundary of th. blister. Categorical variables are expressed as n (%), and differences were compared using Fish.r's exact test. Results: Th. ultrasonograph.c images in th. pemph.gus group sh.wed an intraepidermal semi-arc or irregular anech.ic or h.poech.ic areas. Th. inferior borders were situated above th. ch.racteristic th.n linear h.perech.ic bands of th. epidermis. A linear h.poech.ic band was present at th. dermoepidermal junction in some cases. In th. ultrasonograph.c images of th. bullous pemph.goid group, th. linear h.perech.ic bands of th. epidermis were continuous and intact. An oval fluid anech.ic area (subepidermal blister) was present immediately below th. bands. Th. location of th. blisters in th. ultrasonograph.c images was significantly different between th. 2 groups (P clusion: h.gh.frequency ultrasound can be used as an auxiliary means to differentiate th. location of blisters between pemph.gus and bullous pemph.goid. © 2022 h.spital for Skin Diseases (Institute of Dermatology), Ch.nese Academy of Medical Sciences, and Ch.nese Medical Association, publish.d by Wolters Kluwer, Inc.

关键词： bullous pemph.goid h.gh.frequency ultrasound pemph.gus

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