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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

Th. Ph.ton Polarization Parameter of 2h.n, γ）3h.reaction with.Inclusion of th. Electric Quadrupole Contribution

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Ch.nese Ph.sics Letters 2014年第9期31卷 32-35页

作者： h. Sadegh. M. Mosavi-Kh.nsari Department of Ph.sics Faculty of Science Arak University Arak 8349-8-38156 Iran

We use effective field th.ory （EFT） for th. calculation of neutron-deuteron radiative capture at very low energies. We present h.re th. use of EFT to calculate a low-energy ph.to-nuclear observable in th.ee-body systems, th. ph.ton polarization parameter and and fore-aft asymmetry at th.rmal neutron energies up to next-to-next to leading order （N2 LO）, with.inclasion of th. electric quadrupole contribution. Th. ph.ton polarization parameter in total is found to be Rc = -0.421±0.003 and is in good agreement with.th. oth.r modern th.oretical calculations based on modern nucleon-nucleon potentials. In comparison with.our previous work, a satisfactory agreement with.th. available experimental data is found by inclusion of th. electric quadrupole contribution.

关键词： Ph.TONS -- Polarization RESEARCh FIELD th.ory (Ph.sics) NEUTRON-deuteron interactions QUADRUPOLES Th.EE-body problem (Ph.sics)

Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

FLOW STRESS MODEL FOR h.RD MACh.NING OF AISI h.3 WORK TOOL STEEL

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Acta Metallurgica Sinica(English.Letters) 2005年第6期18卷 741-748页

作者： h. Yan J. h.a R. Sh.vpuri Sch.ol of Mech.nical-Electrical Engineering Nanchang University Nanchang 330029China Th. Oh.o State University Columbus OH 43210 USA

An approach.is presented to ch.racterize th. stress response of workpiece in h.rd mach.ning, accounted for th. effect of th. initial workpiece h.rdness, temperature, strain and strain rate on flow stress. AISI h.3 work tool steel was ch.sen to verify th.s meth.dology. Th. proposed flow stress model demonstrates a good agreement with.data collected from publish.d experiments. Th.refore, th. proposed model can be used to predict th. corresponding flow stress-strain response of AISI h.3 work tool steel with.variation of th. initial workpiece h.rdness in h.rd mach.ning.

关键词： flow stress model h.rd mach.ning AISI h.3 work tool steel

1A6/DRIM, th. h.man UTP20 functions in 28S and 5.8S rRNA processing

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Ch.nese Science Bulletin 2010年第17期55卷 1770-1776页

作者： KONG RuiRui h.N Wei ulrich h. Weidle NING Tao DU XiaoJuan KE Yang Key Laboratory of Carcinogenesis and Translational Research.(Ministry of Education) Genetics Laboratory Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China Cancer Research.Center Peking University Health Science Center Beijing 100191 China Roch. Diagnostics Gmbh Division Pharma 82372 Penzberg Germany Department of Cell Biology Peking University Health Science Center Beijing 100191 China

1A6/DRIM h.s been identified as UTP20, a small subunit processome component, functioning in 18S rRNA processing. In th. present study, th. maturation of 28S rRNA and 5.8S rRNA was inh.bited wh.n 1A6/DRIM was silenced in h.La cells; and coincidently, an accumulation of 32S rRNA precursor was observed. Immunoprecipitation was performed with.th. anti-1A6/DRIM antibody, followed by North.rn blot with.th. ITS2 probe. Th. results sh.wed th.t 1A6/DRIM was associated with.both.32S and 12S rRNA precursors in vivo. Th. expression profile of 1A6/DRIM during rRNA processing was investigated by sucrose density gradient fractionation in combination with.Western blot analysis. Th. results demonstrated th.t 1A6/DRIM was involved in th. pre-60S particles in addition to th. pre-40S particles and co-sediment with.th. 32S and 12S rRNA precursors in th. nucleolus. Furth.rmore, th. interaction of U8 snoRNA with.1A6/DRIM was revealed by immunoprecipitation. Th.se results demonstrated th.t 1A6/DRIM interacted with.both.32S rRNA and U8 snoRNA, being involved in 28S rRNA and 5.8S rRNA processing.

关键词： rRNA基因加工过程 snoRNA 职能人类 h.La细胞免疫印迹分析免疫沉淀

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. Utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Comment on 'Math.matical structure of th. th.ee-dimensional (3D) Ising model'

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Ch.nese Ph.sics B 2013年第8期22卷 356-360页

作者： Jacques h. h. Perk Department of Ph.sics Oklahoma State UniversityStillwater OK 74078-3072 USA

Th. review paper by Zh.ng Zh.-Dong （Zh.ng Z D 2013 Ch.n. Ph.s. B 22 030513, arXiv：1305.2956） contains many errors and is based on several earlier works th.t are equally wrong.

关键词： Ising model Lie algebra series analysis th.rmodynamic limit