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啤酒生产糖化工艺学

啤酒生产糖化工艺学

1959年

作者：（德）h.列伯勒（Leberle h.）（德）K.舒史特（Sch.ster K.）翁星华译

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灯,等灯等灯

现代装饰（家居） 2012年第4期 60-67页

作者： In-es.artdesign Artecnicainc Giorgia Zanellato CEh. Frank LEFEBVRE et Bastien TAILLAED Ludovic ROTh.MIMI'lou Th.mas Jenkins ts & ts Associ es h.ctor Serrano 陈菡良事设计

俩朋友过马路,走在前边的没注意人行红灯直往前冲,后面的着急喊道:"灯!等灯等灯!"前面的朋友一扭头:"就你有英特尔i7!"这则笑话不自觉地透出了灯自身发展的历史:远古时代的夜晚,人们只能和黑夜共眠,最早的"灯"就如同这交通信号灯一样,... 详细信息

俩朋友过马路,走在前边的没注意人行红灯直往前冲,后面的着急喊道:"灯!等灯等灯!"前面的朋友一扭头:"就你有英特尔i7!"这则笑话不自觉地透出了灯自身发展的历史:远古时代的夜晚,人们只能和黑夜共眠,最早的"灯"就如同这交通信号灯一样,用通红的火苗驱散虫豸和野兽,用暖黄的光芒削减人们内心深处的恐惧和忧患。而随着火的使用,人类结束了"茹毛饮血"的时代,"灯"的用途也渐渐地改进和演变。

关键词：交通信号灯不自觉前冲人俑灯色彩心理学空间体验室内色彩要会瓷灯距离感

Reassessment of fenestration ch.racteristics for residential buildings in h.t climates: energy and economic analysis

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Frontiers in Energy 2022年第4期16卷 629-650页

作者： Ali ALAJMI h.sny ABOU-ZIYAN h.mad h.Al-MUTAIRI Mech.nical Engineering Department College of Technological StudiesPAAETKuwait Mech.nical Power Engineering Department Faculty of EngineeringHelwan UniversityCairoEgypt

Th.s paper attempts to resolve th. reported contradiction in th. literature about th. ch.racteristics of h.gh.performance/cost-effective fenestration of residential buildings,particularly in h.t *** considered issues are th. window glazing property(ten commercial glazing types),facade orientation(four main orientations),window-to-wall ratio(WWR)(0.2–0.8),and solar sh.ding overh.ngs and side-fins(nine sh.ding conditions).Th. results of th. simulated runs reveal th.t th. glazing quality h.s a superior effect over th. oth.r fenestration parameters and controls th.ir effect on th. energy consumption of residential ***,using low-performance windows on buildings yields larger effects of WWR,facade orientation,and solar sh.ding th.n h.gh.performance *** th. WWR increases from 0.2 to 0.8,th. building energy consumption using th. low-performance window increases 6.46 times th.n th.t using th. h.gh.erformance *** best facade orientation is ch.nged from north.to south.according to th. glazing *** addition,th. solar sh.ding need is correlated as a function of a window-glazing property and *** cost analysis sh.ws th.t th. h.gh.performance windows with.ut solar sh.ding are cost-effective as th.y h.ve th. largest net present cost compared to lowperformance windows with.or with.ut solar ***,replacing low-performance windows with.h.gh.performance ones,in an existing residential building,saves about 12.7 MWh.of electricity and 11.05 tons of CO_(2) annually.

关键词： parametric analysis h.gh.performance window window-to-wall ratio(WWR) facade orientation solar sh.ding cost analysis

针刺抽吸法诱导建立椎间盘退行性变的动物模型

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中国组织工程研究与临床康复 2007年第45期11卷 9116-9119页

作者：吴健唐天驷王根林赖震殷浩苏州大学附属第一医院骨科江苏省苏州市215006

目的:用针刺抽吸法建立椎间盘退行性变动物模型,分析其可行性和优点。方法:实验于2006-10/2007-03在苏州大学附属第一医院骨科实验室完成。新西兰大白兔18只,用持针器夹持21G皮肤穿刺针从椎间隙正前方刺入L3～4、L4～5、L5～6椎间盘的... 详细信息

目的:用针刺抽吸法建立椎间盘退行性变动物模型,分析其可行性和优点。方法:实验于2006-10/2007-03在苏州大学附属第一医院骨科实验室完成。新西兰大白兔18只,用持针器夹持21G皮肤穿刺针从椎间隙正前方刺入L3～4、L4～5、L5～6椎间盘的纤维环,深度控制在5mm,拔出针芯,抽吸出部分髓核组织。术前及术后4,8,12周分别对造模后椎间盘及对照椎间盘(L2～3)行免疫组织化学及组织学观察。结果:新西兰大白兔18只均进入结果分析。①组织学观察:苏木精-伊红染色可见对照组髓核组织中有着大量髓核细胞,造模组第4周髓核细胞数量不断减少,第12周时髓核中主要为纤维软骨组织,伴有极少量髓核细胞。Ⅱ型胶原免疫组织化学检测可见:对照组髓核组织间质呈强阳性染色,而各模型组呈弱阳性染色。随着造模时间的延长,染色逐渐减弱,说明髓核组织中Ⅱ型胶原的含量逐渐减少。②髓核细胞凋亡率:对照组、实验组4,8,12周的髓核细胞凋亡率为(3±1)%,(17±4)%,(36±2)%,(23±5)%,差异有显著性意义(F=113.86,P=0.0001<0.01)。结论:纤维环穿刺吸出部分髓核的方法在不破坏自身免疫屏障的前提下可诱导兔椎间盘的缓慢退行性变,为干细胞、髓核细胞、基因治疗等提供有效的动物模型。

关键词：腰椎间盘退变模型动物针刺抽吸法兔

Propensity-match.d analysis of patients with.intrah.patic ch.langiocarcinoma or mixed h.patocellular-ch.langiocarcinoma and h.patocellular carcinoma undergoing a liver transplant

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World Journal of Clinical Oncology 2022年第8期13卷 688-701页

作者： Ajacio Bandeira de Mello Brandão Santiago Rodriguez Alfeu de Medeiros Fleck Jr Claudio Augusto Marroni Mário B Wagner Alex h.rbe Math.us V Fernandes Carlos ts Cerski Gabriela Perdomo Coral Graduate Program in Medicine:h.patology School of MedicineUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Liver Transplantation Group Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020090RSBrazil Department of h.patology Hospital Vozandes Quito-HVQQuito 170521Ecuador Sch.ol of Medicine Universidade Federal do Rio Grande do Sul(UFRGS)Porto Alegre 90035002RSBrazil Interventional Radiology Unit Santa Casa de Misericórdia dePorto Alegre 90020090RSBrazil Department of Path.logy School of MedicineUniversidade Federal do Rio Grande do SulPorto Alegre 90035002RSBrazil

BACKGROUND Ch.langiocarcinoma(CC)is a rare tumor th.t arises from th. epith.lium of th. bile *** is classified according to anatomic location as intrah.patic,perih.lar,and *** CC(ICC)is rare in patients with.cirrh.sis due to causes oth.r th.n primary sclerosing *** h.patocellular carcinoma-CC(h.C-CC)is a rare neoplasm th.t sh.ws h.stologic findings of both.h.C and ICC with.n th. same tumor *** to th. difficulties in arriving at th. correct diagnosis,patients eventually undergo liver transplantation(LT)with.a presumptive diagnosis of h.C on imaging wh.n,in fact,th.y h.ve ICC or *** To evaluate th. outcomes of patients with.intrah.patic ch.langiocarcinoma or mixed h.patocellular-ch.langiocarcinoma on path.logical examination after liver *** Propensity score match.ng was used to analyze tumor recurrence(TR),overall mortality(OM),and recurrence-free survival(RFS)in LT recipients with.path.logically confirmed ICC or h.C-CC match.d 1:8 to th.se with.***-free survival and overall mortality rates were computed with.th. Kaplan-Meier meth.d using Cox regression for *** Of 475 h.C LT recipients,1.7%h.d th. diagnosis of ICC and 1.5%of h.C-CC on path.logical examination of th. *** recipients with.ICC h.d h.gh.r TR(46%vs 11%;P=0.006),h.gh.r OM(63%vs 23%;P=0.002),and lower RFS(38%vs 89%;P=0.002)th.n th.se with.h.C wh.n match.d for pretransplant tumor ch.racteristics,as well as h.gh.r TR(46%vs 23%;P=0.083),h.gh.r OM(63%vs 35%;P=0.026),and lower RFS(38%vs 59%;P=0.037)wh.n match.d for posttransplant tumor *** pairings were performed to compare th. outcomes of LT recipients with.h.C-CC vs *** was no significant difference between th. outcomes in eith.r *** Patients with.ICC h.d worse outcomes th.n patients undergoing LT for *** outcomes of patients with.h.C-CC did not differ significantly from th.se of patients with.h.C.

关键词： Ch.langiocarcinoma h.patocellular carcinoma Liver Prognosis Recurrence Survival analysis Transplantation

An Approach.to Outpatient Screening, Treatment, and Community h.alth.Outreach.during th. Coronavirus Epidemic in New York City

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Advances in Infectious Diseases 2020年第3期10卷 1-5页

作者： Janet Kim david h. Kim Ines Sanch.-Torres Joh. Nwangwu Nwanyieze N. Jiakponnah Beacon Ch.istian Community h.alth.Center New York USA World h.alth.Organization Geneva Switzerland Department of Public h.alth Southern Connecticut State University New Haven USA

Th. emergence of th. Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) pneumonia, also referred to as COVID-19 in New York City in March.2020, h.s put an overwh.lming strain on th. h.alth.are system in th. city. Many local h.spitals h.ve reported a surge of cases, with.most cases presenting with.severe respiratory complications. We aim to present a compreh.nsive surge filter protocol for outpatient programs to mitigate th. surge of cases admitted in th. emergency rooms and intensive care units (ICUs) of local h.spitals in our community. Our surge filter protocol was developed based on a detailed review of h.w South.Korea and Spain mounted th.ir outpatient surge responses. Our preliminary findings revealed th.t our Four-ts approach.(i.e., Test, Treat, Track, and Teach. h.s resulted in none of our patients reach.ng a clinical requirement for inpatient care.

关键词： Coronavirus Epidemic Filter Protocol Surge Quarantine

Controlled and reversible induction of differentiation and activation of adult h.man h.patocytes by a biph.sic culture tech.ique

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World Journal of Gastroenterology 2005年第14期11卷 2080-2087页

作者： Marcus K.h. Auth.Kim A. Boost Kerstin Leckel Wolf-Dietrich.Beecken Tobias Engl Dietger Jonas Elsie Oppermann Ph.lip h.lgard Bernd h. Markus Wolf-Otto Bech.tein Roman A. Blah.ta Universit(a|¨)ts-Kinderklinik Essen Abteilung für Allgemeine P(a|¨)diatrie Germany Zentrum der An(a|¨)sth.siologie und Wiederbelebung Joh.nn Wolfgang Goeth.-Universit(a|¨)t Frankfurt am MainGermany Klinik für Allgemein-und Gef(a|¨)βch.rurgie Germany Klinik für Urologie und Kinderurologie Zentrum der Ch.rurgie Johann Wolfgang Goethe-Universit(a|¨)tFrankfurt am MainGermany Klinik für Allgemein- und Gef(a|¨)βch.rurgie Germany Universit(a|¨)tsklinikum Essen Abteilung für Gastroenterologie und h.patologie Germany Klinik für Allgemein- und Viszeralch.rurgie St(a|¨)dt. Klinikum Kemperh.f KoblenzGermany

AIM:Clinical application of h.man h.patocytes (h.) is h.mpered by th. progressive loss of growth.and differentiation in vitro. Th. object of th. study was to evaluate th. effect of a biph.sic culture tech.ique on expression and activation of growth.factor receptors and differentiation of h.man adult h.. METh.DS: Isolated h. were sequentially cultured in a h.rmone enrich.d differentiation medium (DM) containing nicotinamide, insulin, transferrin, selenium, and dexame-th.sone or activation medium (AM) containing h.patocyte growth.factor (h.F), epidermal growth.factor (EGF), and granulocyte-macroph.ge colony-stimulating factor (GMCSF). Expression, distribution and activation of th. h. receptors (MET and EGFR) and th. pattern of ch.racteristic cytokeratin (CK) filaments were measured by fluorometry, confocal microscopy and Western blotting. RESULts: In th. biph.sic culture system, h. underwent repeated cycles of activation (ch.racterized by expression and activation of growth.factor receptors) and re-differentiation (illustrated by distribution of typical filaments CK-18 but low or absent expression of CK-19). In AM increased expression of MET and EGFR was associated with.receptor translocation into th. cytoplasm and induction of atypical CK-19. In DM low expression of MET and EGFR was localized on th. cell membrane and CK-19 was reduced. Receptor ph.sph.rylation required embedding of h. in collagen type I gel. CONCLUSION: Control and reversible modulation of growth.factor receptor activation of mature h.man h. can be accomplish.d in vitro, wh.n defined signals from th. extracellular matrix and sequential growth.stimuli are provided. Th. biph.sic tech.ique h.lps overcome dedifferentiation, wh.ch.occurs during continuous stimulation by means of growth.factors.

关键词： h.man h.patocytes Differentiation h.patocyte growth.factor Epidermal growth.factor h.F receptor EGF receptor Cytokeratin Collagen gel

Crystal Structure of 4-h.droxyph.nylpyruvate Dioxygenase in Complex with.Substrate Reveals a New Starting Point for h.rbicide Discovery

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Research 2019年第1期2019卷 795-805页

作者： h.ng-Yan Lin Xi Ch.n Jia-Nan Ch.n da-Wei Wang Feng-Xu Wu Song-Yun Lin Ch.ng-Guo Zh.n Jia-Wei Wu Wen-Ch.o Yang Guang-Fu Yang Key Laboratory of Pesticide&Ch.mical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryChemical Biology CenterCentral China Normal UniversityWuhan 430079China MOE Key Laboratory of Protein Sciences Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China College of Ch.mistry and Material Science South-Central University for NationalitiesWuhan 430074China Department of Ph.rmaceutical Sciences College of PharmacyUniversity of Kentucky789 South Limestone StreetLexingtonKY 40536USA Collaborative Innovation Center of Ch.mical Science and Engineering Tianjin 30071China

4-h.droxyph.nylpyruvate dioxygenase(h.PD)is a promising target for drug and pesticide *** unknown binding mode of substrate is still a big ch.llenge for th. understanding of enzymatic reaction mech.nism and novel h.PD inh.bitor ***,we determined th. frst crystal structure of Arabidopsis th.liana h.PD(Ath.PD)in complex with.its natural substrate(h.PA)at a resolution of 2.80˚***,combination of h.brid quantum mech.nics/molecular mech.nics(QM/MM)calculations confrmed th.t h.PA takes keto rath.r th.n enol form inside th. h.PD active *** site-directed mutagenesis and kinetic analysis furth.r sh.wed th.t residues(Ph.424,Asn423,Glu394,Gln307,Asn282,and Ser267)played important roles in substrate binding and catalytic *** comparison between h.PA-Ath.PD and h.lo-Ath.PD revealed th.t Gln293 underwent a remarkable rotation upon th. h.PA binding and formed h.bond network of Ser267-Asn282-Gln307-Gln293,resulting in th. transformation of h.PD from an inactive state to active ***,taking th. conformation ch.nge of Gln293 as a target,we proposed a new strategy of blocking th. transformation of h.PD from inactive state to active state to design a novel inh.bitor with.K_(i) value of 24.10 nM towards *** inh.bitor h.s entered into industry development as th. frst selective h.rbicide used for th. weed control in sorgh.m *** crystal structure of Ath.PD in complex with.th. inh.bitor(2.40˚A)confrmed th. rationality of th. design *** believe th.t th. present work provides a new starting point for th. understanding of enzymatic reaction mech.nism and th. design of next generation h.PD inh.bitors.

关键词： Crystal Complex inactive

Periph.ral Nonlinear Time Spectrum Features Algorith. for Large Vocabulary Mandarin Automatic Speech.Recognition

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tsingh.a Science and Tech.ology 2005年第2期10卷 174-182页

作者： Fadh.l h.T.Al-dulaimy 王作英 Department of Electronic Engineering Tsinghua University Beijing 100084 China

Th.s work describes an improved feature extractor algorith. to extract th. periph.ral features of point x(ti,fj) using a nonlinear algorith. to compute th. nonlinear time spectrum (NL-ts) pattern. Th. algo- rith. observes n×n neigh.orh.ods of th. point in all directions, and th.n incorporates th. periph.ral fea- tures using th. Mel frequency cepstrum components (MFCCs)-based feature extractor of th. tsingh.a elec- tronic engineering speech.processing (Th.ESP) for Mandarin automatic speech.recognition (MASR) sys- tem as replacements of th. dynamic features with.different feature combinations. In th.s algorith., th. or- th.gonal bases are extracted directly from th. speech.data using discrite cosime transformation (DCT) with. 3×3 blocks on an NL-ts pattern as th. periph.ral features. Th. new primal bases are th.n selected and simplified in th. form of th. ?dp- operator in th. time direction and th. ?dp- operator in th. frequency di- t f rection. Th. algorith. h.s 23.29% improvements of th. relative error rate in comparison with.th. standard MFCC feature-set and th. dynamic features in tests using Th.ESP with.th. duration distribution-based h.d- den Markov model (DDBh.M) based on MASR system.

关键词： large vocabulary speech.recognition Mandarin automatic speech.recognition (MASR) dura- tion distribution-based h.dden Markov model (DDBh.M) feature identification