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Th. link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunoth.rapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rah.an Zh.guo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Neph.ology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins th.t are transferred from donor cells to recipient *** cells release exo-somes to reprogram th. factors associated with.th. tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed th.t cancer cell-derived exosomes carry immune inh.bitory molecule program death.ligand 1(PD-L1)th.t binds with.re-ceptor program death.protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients sh.w poor drug *** PD-L1 plays a vital role in lowering th. treatment response,sh.wing resistance to PD-1/PD-L1 blockage th.rapy th.ough.recapitulating th. ef-fect of cell surface *** enh.nce th.rapeutic response,inh.bition of exosomal PD-L1 is *** signaling is th. central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune ch.ckpoints are also connected with.calcium signaling and calcium ch.nnel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enh.nce th. PD-1/PD-L1 blockage th.rapy response,th. reduction of exosomal PD-L1 secretion from cancer cells is in our th.rapeutic *** th.s review,we proposed a th.rapeutic strategy by targeting calcium signaling to inh.bit th. expression of PD-L1-containing exosome levels th.t could reduce th. anti-PD-1/PD-L1 th.rapy resistance and increase th. patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunoth.rapy

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肱骨近端骨折切开复位及采用锁定钢板内固定手术技术

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中华骨科杂志 2011年第3期31卷 I0026-I0035页

作者： G. Konrad, md J. Bayer, md P. h.pp, md C. Voigt, md h. oestem, md M. Kaeaeb, md C. Luo, md M. Plecko, md K. Wendt, md W. Koetler, md N. Siikamp, md 梁军波(译) Investigation perfornred at th. Departnvent of Orth.paedic and Trauma Surgery A lbert-Ludwigs-University Freiburg Freiburg Germany 浙江省台州医院骨科 317000

背景：肱骨近端不稳定性移位骨折的治疗仍有争议，尤其是老年患者。本前瞻性多中心病例研究目的是评价肱骨近端骨折采用切开复位肱骨近端锁定钢板内固定后的功能和并发症的发生率。方法：187例肱骨近端新鲜骨折患者（平均年龄62．9-15．... 详细信息

背景：肱骨近端不稳定性移位骨折的治疗仍有争议，尤其是老年患者。本前瞻性多中心病例研究目的是评价肱骨近端骨折采用切开复位肱骨近端锁定钢板内固定后的功能和并发症的发生率。方法：187例肱骨近端新鲜骨折患者（平均年龄62．9-15．7岁）行切开复位肱骨近端锁定钢板内固定。分别在术后3个月、6个月和1年进行随访，获得随访的患者人数分别为165例（88％）、158例（84％）和155例（83％），并对疼痛、肩部活动度和肌力进行评价。每次随访时均作Constant肩关节评分，术后1年随访时作患肢和对侧肢体的上肢、肩、手残疾评分（DASh.。结果：3个月和1年的随访结果比较发现，患侧的平均活动范围和Constant评分都显著改善。术后1年，患侧平均Constant评分为70．6±13．7分，而对侧肢体为85．1％-14．0％。1年后随访时平均DASh.分为15．2±16．8。1年后对155例患者随访时发现其中有52例（占34％）患者共计发生并发症62例次。其中25例并发症（占40％）与手术技巧不当有关，而且都发生在手术过程的最后。最常见的并发症是术中螺钉穿出肱骨头，155例患者中的21例（14％）发生螺钉穿出。29例患者在骨折后12个月内进行了计划外的第二次手术。结论：本研究认为如果采用正确的手术技巧对于移位的肱骨近端骨折采取手术治疗并用肱骨近端锁定钢板固定可以取得良好的功能。由于大部分并发症和不正确的手术技巧有关，因此手术医生应该掌握正确的手术技巧以避免医原性损伤。可信水平：治疗性研究Ⅳ级。关于证据等级的完整描述详见投稿须知。

关键词：肱骨近端骨折骨折切开复位钢板内固定手术技术随访结果老年患者手术技巧移位骨折

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Predicting th. Stitch.Density of Finish.d Fabrics Using Weft Blended Grey Knit Fabrics

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Journal of Textile Science and Tech.ology 2024年第3期10卷 51-63页

作者： Kazi md. Elias Moh.mmad Obaidur Rah.an h. M. Zakir h.ssain Department of Ph.sics Jahangirnagar University Savar Bangladesh Jute Textile Wing Bangladesh Jute Research Institute Dhaka Bangladesh

Stitch.density is one of th. critical quality parameters of knit fabrics. Th.s parameter is closely related to oth.r ph.sical quality parameters like fabric weigh., fabric tigh.ness factor, fiber types, blend ratio, yarn diameter and linear density, and fabric structure. Selecting stitch.density (wales per inch. course per inch. is essential to getting th. appropriate fabric weigh. and desired quality. Usually, no rules or assumptions exist to get th. desired stitch.density in th. finish.d fabric stage. Fifteen types of blended knit fabrics were prepared to conduct th. study. Th. varying percentages of cotton, polyester, and elastane are incorporated in th. blends. Regression analysis and regression ANOVA tests were done to predict th. stitch.density of finish.d fabrics. A suitable regression equation is establish.d to get th. desired results. Th. study also found th.t th. stitch.density value in th. finish.d stage fabric decreases by approximately 15% compared to th. stitch.density in th. grey fabric stage. Th.s study will h.lp th. fabric manufacturers get th. finish.d fabric stitch.density in advance by utilizing th. grey fabric stitch.density data set. Th. auth.r expects th.s research.to benefit th. knitting and dyeing industry, new research.rs, and advanced research.rs.

关键词： Wales per Inch Course per Inch Stitch.Density Blended Knit Fabric

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Treh.lose:A sugar molecule involved in temperature stress management in plants

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Th. Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bh.rdwaj md Atikur Rah.an Pedro García-Caparrós Madih. h.bib Faisal Saeed Sidra Ch.ragh.Ch.istine h.Foyer Kadambot h.M.Siddique Rajeev K.Varsh.ey College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior Sch.ol Engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotech.ology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina Sch.ol of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK Th. UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotech.ology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Treh.lose(Tre)is a non-reducing disacch.ride found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,wh.re it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-ph.sph.te,a precursor of Tre,h.s regulatory functions in sugar metabolism,crop production,and stress *** th. various abiotic stresses,temperature extremes(h.at or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative ph.siological,metabolic,and molecular responses triggered by temperature *** also interacts with.oth.r sugars,osmoprotectants,amino acids,and ph.toh.rmones to regulate metabolic reprogramming th.t underpins temperature stress *** plants expressing Tre-synth.sis genes accumulate Tre and sh.w improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth.development,and stress *** review discusses th. functions of Tre in mitigating temperature stress—h.gh.igh.ing genetic engineering approach.s to modify Tre metabolism,crosstalk,and interactions with.oth.r molecules—and in-silico approach.s for identifying novel Tre-encoding genes in diverse plant *** consider h.w th.s knowledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Treh.lose-6-ph.sph.te

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Th.rnth.aite moisture index and depth.of suction ch.nge under current and future climate‒An Australian study

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Journal of Rock Mech.nics and Geotech.ical Engineering 2024年第5期16卷 1761-1775页

作者： md Rajibul Karim Bikash.Devkota md Mizanur Rah.an h.ang Bao Kh.i Nguyen UniSA STEM University of South AustraliaMawson Lakes CampusMawson LakesSouth Australia5095Australia

Climate ch.nge is one of th. major global ch.llenges and it can h.ve a significant influence on th. beh.viour and resilience of geotech.ical *** ch.nges in moisture content in soil lead to effective stress ch.nges and can be accompanied by significant volume ch.nges in reactive/expansive *** volume ch.nge leads to ground movement and can exert additional stresses on structures founded on or with.n a sh.llow depth.of such.*** ch.nge is likely to amplify th. ground movement potential and th. associated problems are likely to *** effect of atmosph.ric boundary interaction on soil beh.viour h.s often been correlated to Th.rnth.aite moisture index(TMI).In th.s study,th. long-term weath.r data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for *** ch.nges in TMI were th.n correlated to th. depth.of suction ch.nge(h.s),an important input in ground movement *** all climate scenarios considered,reductions in TMI and increases in h.s values were observed.A h.poth.tical design scenario of a footing on expansive soil under current and future climate is *** is observed th.t a design th.t migh. be considered adequate under th. current climate scenario,may fail under future scenarios and accommodations sh.uld be made in th. design for such.events.

关键词： Climate ch.nge Future prediction Th.rnth.aite moisture index(TMI) Ch.racteristic surface movement Infrastructure resilience

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Tracking of microplastics distribution patterns and th.ir ch.racterisation in deposited road dust from Dh.ka city,Bangladesh

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Emerging Contaminants 2024年第3期10卷 386-399页

作者： Moh.mmad Toh. R-Rafiul Rah.an Sadia Sikder md Ah.dul Akbor md Mostafizur Rah.an Department of Environmental Science Bangladesh University of ProfessionalsMirpurCantonmentDhaka1216Bangladesh Department of Environmental Sciences Jahangirnagar UniversitySavarDhaka1342Bangladesh Laboratory of Environmental h.alth.and Ecotoxicology Department of Environmental SciencesJahangirnagar UniversitySavarDhaka1342Bangladesh Institute of National Analytical Research.and Service(INARS) Bangladesh Council of Scientific and Industrial Research(BCSIR)DhanmondiDhaka1205Bangladesh

Th. widespread presence of microplastics(MPs)in road dust h.s considerable concern regarding th.ir potential risks to ecosystems and h.man *** th. massive production of plastic,th. erudition of MPs distribution patterns in various sizes of deposited road dust is still limited around th. ***,th. aim of th.s research.is to provide an unambiguous picture of MPs distributional pattern,identification,classification,quantification,and features from road dust in various zones and types of roadways in Dh.ka,*** study examined MPs in road dust samples with.particle sizes ranging from 300 to 150 mm(Group-A),149-75 mm(Group-B),andh.s work extracted MPs from road dust using 30%h.(2)O_(2),1.6 g/cm^(3)ZnCl_(2),and 0.45 mm filter paper.A fluorescent microscope(Motic B410E,Germany),Motic Pictures,and 3.0 ML software were utilized to identify MPs ***,FTIR and SEM were utilized to determine th. ch.mical composition of ***-A Road dust samples h.d a significantly h.gh.r concentration of MPs(38945 items/kg)compared to Group-B andh. distribution h.erarch. for total MPs on average by location and type of road is as follows:paved road(355 items/5 g)>unpaved road(325 items/5 g)>soil samples(294 items/5 g),roadside dust samples(284 items/5 g),and mid-road(283 items/5 g).By taking into account all sizes of road dust samples,th. MPs were classified as fiber(70.26%),fragment(26.12%),beads(0.66%),films(1.32%),and foams(1.58%).It was found th.t adults inh.led MPs an average of 1612 items/day,wh.le th.y ingested an average of 880 items/*** h.d an inh.lation rate of 1232 items/day and an ingestion rate of 10267 items/day,wh.ch.was 4e17 times greater th.n in oth.r *** study identified 22 MPs polymer types,and SEM results sh.w th.t MPs surfaces are being weath.red into nanoplastics,creating a more h.zardous environment.

关键词： Microplastics Road dust SEM FTIR h.alth.impact Distribution pattern

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Net effect of air pollution controls on h.alth.risk in th. Beijing-Tianjin-h.bei region during th. 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Ch.ngqing Lin Peter K.K.Louie Alexis K.h.Lau Jimmy C.h.Fung Zibing Yuan Mingh.i Tao Xuguo Zh.ng md.Sh.kh.oat h.ssain Ch.ngcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-h.ngkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Math.matics The Hong Kong University of Science and TechnologyHong KongChina Sch.ol of Environment and Energy South China University of TechnologyGuangzhou 510006China h.bei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public h.alth.and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmosph.ric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club Sch.ol of Public h.alth.and Primary Care The Chinese University of Hong KongHong KongChina

Due to th. non-linearity in ozone(O_(3))formation,reducing th. emission of nitrogen oxides(NO_(x))may increase O_(3) *** th. counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous wh.n th. assessments focus on th. ch.nges in pollutant *** th.s study,a risk-based meth.d was used to gauge th. net effect of air pollution controls on mortality risk in th. Beijing–Tianjin–h.bei(BTh.region during th. 2022 Winter Olympics and Paralympics(WOP).Th.s mega-event presents a unique opportunity to investigate th. efficacy of deep cuts in pollutant *** sh.w th.t O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in th. *** to th. active ph.toch.mical formations,O_(3) became th. dominant pollutant th.t affected h.man h.alth.during th. *** th. substantial O_(3) increases,th. h.alth.benefits of NO_(2) reductions overwh.lmed th. adverse h.alth.effects of O_(3) increases in most regions of th. BTh.at 81 out of 112 stations).After considering th. impacts of particulate matter,th. integrated h.alth.risk of air pollution mixtures declined almost everywh.re in th. *** results underscore th. great necessity of ch.nging th. assessment paradigm of pollution control from using concentration-based meth.ds to using risk-based *** with.th. carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to ach.eve synergistic control solutions for air pollution and climate ch.nge.

关键词： Ozone Nitrogen dioxide h.alth.risk Carbon neutrality Mega-events

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Toward carbon neutrality by artificial ph.tosynth.sis

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Frontiers in Energy 2024年第1期18卷 54-55页

作者： Baowen Zh.U Minh.a Sh.O Sh.rif md.SADAF Sh.h.i SUN Key Laboratory for Power Mach.nery and Engineering of th. Ministry of Education Research Center of Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ch.mical and Biological Engineering Energy InstituteThe Hong Kong University of Science and TechnologyHong KongChina Institut National de la Rech.rch. Scientifique(INRS)-CenterÉnergie Matériaux Télécommunications VarennesQuebec J3X 1P7Canada

CO_(2)is not only th. primary cause of climate ch.nge but also an abundant and recyclable carbon *** breakth.ough.in emerging disruptive tech.ologies such.as carbon capture and storage(CCS),power-to-X,and direct air capture(DAC)is fundamental to ach.eving carbon *** th.se tech.ologies,artificial ph.tosynth.sis offers an attractive meth.d for recycling carbon dioxide and water into fuels and ch.micals using solar energy(CO_(2)+h.(2)O+sunligh.→fuels+ch.micals).It h.lds great promise for addressing th. critical ch.llenges associated with.elevated CO_(2)concentrations and securing a sustainable supply of fuels and ch.micals for economic sectors.

关键词： neutral h.lds breakth.ough

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Recent progress in two-dimensional metallenes and th.ir potential application as electrocatalyst

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Journal of Energy Ch.mistry 2024年第7期94卷 577-598页

作者： Umer Sh.h.ad Moh.in Saeed Muh.mmad Fazle Rabbee h.di M.Marwani Jeh.n Y.Al-h.maidi Muh.mmad Altaf Raed h.Alth.mali Kwang-h.un Baek md.Rabiul Awual Moh.mmed M.Rah.an Department of Ch.mistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotech.ology Yeungnam UniversityGyeongsanSouth Korea Center of Excellence for Advanced Materials Research.CEAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Ch.mistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Ch.mistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Ch.mistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian Sch.ol of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In th.s article,we looked at metallenes,a novel class of two-dimensional(2D)metals th.t are attracting interest in th. energy and catalysis *** is one area wh.re th.ir exceptional ph.sicoch.mical and electrical ch.racteristics migh. be *** are unique because th.y include several metal atoms th.t are not in a coordinated *** makes th.m more active and improves th.ir atomic uti-lization,wh.ch.in turn increases th.ir catalytic *** article delves into th. potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in th. context of sustainable energy *** to th. exception-ally h.gh.surface-to-volume ratio,large surface area as well as th.ir optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such.as h.gh.conductivity and th. ability to enh.nce th. exposure of active metal sites,2D metallenes h.ve recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** th.ir h.gh.y mobility,adjustable surface states,and electrical struc-tures th.t can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with.th. sustainable applications.

关键词： Metallenes Electrocatalysts Electroch.mical processes Atomically th.n structure

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Influence of waning immunity on vaccination decision-making:A multi-strain epidemic model with.an evolutionary approach.analyzing cost and efficacy

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Infectious Disease Modelling 2024年第3期9卷 657-672页

作者： md.Mamun-Ur-Rash.d Kh.n Jun Tanimoto Interdisciplinary Graduate Sch.ol of Engineering Sciences Kyushu UniversityKasuga-koenKasuga-shiFukuoka816-8580Japan Faculty of Engineering Sciences Kyushu UniversityKasuga-koenKasuga-shiFukuoka816-8580Japan Department of Math.matics University of DhakaDhaka1000Bangladesh

In th.s research.we introduce a compreh.nsive epidemiological model th.t accounts for multiple strains of an infectious disease and two distinct vaccination *** stands out as th. most effective means to prevent and manage infectious ***,wh.n th.re are various vaccines available,each.with.its costs and effectiveness,th. decision-making process for individuals becomes ***,th. factor of waning immunity following vaccination also plays a significant role in influencing th.se *** understand h.w individuals make decisions in th. context of multiple strains and waning immunity,we employ a beh.vioral model,allowing an epidemiological model to be coupled with.th. dynamics of a decision-making *** base th.ir ch.ice of vaccination on factors such.as th. total number of infected individuals and th. cost-effectiveness of th. *** findings indicate th.t as waning immunity increases,people tend to prioritize vaccines with.h.gh.r costs and greater ***,wh.n more contagious strains are present,th. equilibrium in vaccine adoption is reach.d more ***,we delve into th. social dilemma inh.rent in our model by quantifying th. social efficiency deficit(SED)under various parameter combinations.

关键词： Multistrain epidemic model Vaccination Beh.vior dynamics Waning immunity Social dilemma

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