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Ascorbic Acid Attenuates Acute Eth.nol-Induced Liver Injury in Sm.30 Knockout m.ce

Food and Nutrition Sciences 2017年第12期8卷 1114-1126页

作者： Eun-m. Ch. h. m. arif ullah Ah.ed K. Elfadl m.ung-Jin Ch.ng Soong-Koo Kim.Yong Deuk Kim.Eun-Joo Lee Kyu-Sh.k Jeong College of Veterinary m.dicine Kyungpook National University Daegu Republic of Korea

Ascorbic acid (AA) is recognized as a free radical scavenger th.t protects cells from.oxidative stress-induced dam.ge. h.wever, no studies h.ve investigated th. role of AA in acute alcoh.lic liver disease using senescence m.rker protein-30 (Sm.30) knockout (KO) m.ce. Sm.30 is a novel 34-kDa protein involved in AA biosynth.sis. Th. present study aim.d to elucidate th. ph.siological functions of AA in acute eth.nol-induced liver injury using Sm.30 KO m.ce, wh.ch.cannot synth.size AA in vivo. After a 4-week experim.ntal period, m.ce were divided into six groups. Th. following th.ee groups com.rised th. eth.nol treatm.nt groups: WT-E group (wild-type), KV-E group (AA-supplem.nted), and KT-E group (AA-deficient). m.ce were exposed to an acute dose of eth.nol (6 g eth.nol/kg) adm.nistered by gavage once a day for th.ee days. Th. oth.r th.ee control groups, nam.ly, WT-C, KV-C, and KT-C control groups, received an equal volum. of water via oral adm.nistration. Analysis of ch.nges in body weigh. sh.wed th.t m.ce in th. KT-E group h.d significant loss of body weigh. com.ared to th. control, KV-E, and WT-E groups. Beh.vioral analysis revealed th.t alcoh.l exposure significantly increased alcoh.l sensitivity in th. KT-E group, wh.reas th. WT-E, KV-E, and control groups developed eth.nol tolerance. Aspartate transam.nase (AST) levels in th. KT-E group were significantly h.gh.r th.n th.se in th. control, KV-E, and WT-E groups. Th. num.er of large and binucleated h.patocytes was significantly h.gh.r in th. KT-E group th.n in th. KV-E and WT-E groups. In addition, cytoch.om. P450 2E1 (CYP2E1) was over expressed in th. central vein in th. KT-E group wh.n com.ared to th. KV-E and WT-E groups. Our current findings indicate th.t AA supplem.ntation in Sm.30 KO m.ce can alleviate alcoh.l-induced liver dam.ge by down regulating CYP2E1 expression. Th.se results suggest th.t reduced CYP2E1 expression is a novel m.ch.nism.responsible for AA-induced reduction of eth.nol-m.diated oxidative str

关键词： Ascorbic Acid Alcoh.l Liver Sm.30

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h.patic Protective Effects of <i>S</i>-Allyl-L-Cysteine (SAC) in Rats with.Carbon Tetrach.oride (CCl<sub>4</sub>) Induced Liver Injury

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Food and Nutrition Sciences 2020年第12期11卷 1053-1069页

作者： Soo-Nyun Ch.i h. m. arif ullah Il-h.a h.ng Jin-Kyu Park SunYoung Park m.ung-Jin Ch.ng Ji-Yoon Son h.un-h. Yun Jae-h.uk Yim.Seung-Jun Jung h.e-Young Ch.ng Kyu-Sh.k Jeong Departm.nt of Path.logy College of Veterinary Medicine Kyungpook National University Daegu Republic of Korea Stem.Cell Th.rapeutic Research.Institute Kyungpook National University Daegu Republic of Korea Departm.nt of Path.logy College of Veterinary Medicine Gyeongsang National University Jinju Republic of Korea Departm.nt of Ph.rm.cy College of Pharmacy Pusan National University Busan Republic of Korea

S-allyl-L-cysteine (SAC) is an organosulfur com.ound derived from.aged garlic extract (AGE). Studies h.ve reported th.t AGE possesses bioprotective capacity, including antidiabetic, antim.crobial, antioxidant, and ant... 详细信息

S-allyl-L-cysteine (SAC) is an organosulfur compound derived from aged garlic extract (AGE). Studies have reported that AGE possesses bioprotective capacity, including antidiabetic, antimicrobial, antioxidant, and antitumor effects. The present study examined the protective effects of SAC against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Ten male Wistar rats aged 11 - 12 weeks were randomly divided into two groups (five rats/group) as control and SAC groups. All rats had ad libitum access to water, and the SAC group received water containing SAC intragastrically (200 mg/kg) once daily for five consecutive weeks. In the fifth experimental week, 50% CCl4 in olive oil (1 mL/kg) was administered intraperitoneally three times a week to induce liver injury in both groups. Rats were sacrificed at 24 hours after the last CCl4 injection, and liver tissues were excised for h.stopath.logical, im.unoh.stoch.m.cal and antioxidant analyses. Th. rats in th. SAC group did not sh.w abnorm.l beh.vior, such.as decreased water intake or food consum.tio

关键词： S-Allyl-L-Cysteine (SAC) Garlic h.patic Protective Effects Carbon Tetrach.oride Rats h.patic Steatosis Cytoch.om. P4502E1

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m.nte-Carlo sim.lation of a stoch.stic differential equation

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Plasm. Science and Tech.ology 2017年第12期19卷 6-14页

作者： arif ullah m.jid Kh.N m.KAm.AN R Kh.N 盛正卯 h.fei National Laboratory for Ph.sical Sciences at th. m.croscale University of Science and Technology of ChinaHefei 230026People's Republic of China Departm.nt of Ph.sics Quaid-i-Azam.University Islam.bad Pakistan Departm.nt of Ph.sics Institute of Fusion Theory and SimulationsZhejiang UniversityHangzhou 310027People's Republic of China Departm.nt of Ph.sics COMSATS Institute of Information TechnologyChack ShahzadIslamabadPakistan Departm.nt of Ph.sics Abdul Wali Khan University23200 MardanKPKPakistan

For solving h.gh.r dim.nsional diffusion equations with.an inh.m.geneous diffusion coefficient,m.nte Carlo（m.） tech.iques are considered to be m.re effective th.n oth.r algorith.s, such.as finite elem.nt m.th.d or finite difference m.th.d. Th. inh.m.geneity of diffusion coefficient strongly lim.ts th. use of different num.rical tech.iques. For better convergence, m.th.ds with.h.gh.r orders h.ve been kept forward to allow m. codes with.large step size. Th. m.in focus of th.s work is to look for operators th.t can produce converging results for large step sizes. As a first step, our com.arative analysis h.s been applied to a general stoch.stic ***, our form.lization is applied to th. problem.of pitch.angle scattering resulting from.Coulom. collisions of ch.rge particles in th. toroidal devices.

关键词： m.nte-Carlo sim.lation stoch.stic differential equations toroidal plasm.s num.rical m.th.ds

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h.alth.m.nitoring of tim.-varying stoch.stic structures by latent com.onents and fuzzy expert system

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Earth.uake Engineering and Engineering Vibration 2008年第1期7卷 91-106页

作者： m. m. Ettefagh.m. h. Sadegh. Vibration and m.dal Analysis Laboratory Department of Mechanical Engineering University of Tabriz Tabriz 51666 Iran

In th.s paper, a novel param.tric m.del-based decom.osition m.th.d is proposed for structural h.alth.m.nitoring of tim.-varying structures. For th.s purpose, th. advanced Functional-Series Tim.-dependent Auto Regressive m.ving Average （FS-TARm.） tech.ique is used to estim.te th. param.ters and innovation variance used in th. param.tric signal decom.osition sch.m.. Additionally, a unique feature extraction and reduction m.th.d based on th. decom.osed signals, known as Latent Com.onents （LCs）, is proposed. To evaluate th. efficiency of th. proposed m.th.d, num.rical sim.lation and an experim.ntal study in th. laboratory were conducted on a tim.-varying structure, wh.re various types of dam.ge were introduced. Th. Fuzzy Expert System.（FES） was used as a classification toot to dem.nstrate th.t th. proposed m.th.d successfully identifies different structural conditions wh.n com.ared with.oth.r m.th.ds based on non-reduced and ordinary feature extraction.

关键词： param.tric m.deling signal decom.osition feature extraction/reduction fuzzy classification

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Active Force with.Fuzzy Logic Control of a Two-Link Arm.Driven by Pneum.tic Artificial m.scles

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Journal of Bionic Engineering 2011年第4期8卷 474-484页

作者： h. Jah.nabadi m. m.ilah.m. Z. m. Zain h. m. h.oi Departm.nt of System.Dynam.cs and Control Faculty of Mechanical Engineering Universiti Teknologi Malaysia 81310 UTM Johor Bahru Skudai Johor Malaysia

In th.s paper, th. practicality and feasibility of Active Force Control （AFC） integrated with.Fuzzy Logic（AFCAFL） applied to a two link planar arm.actuated by a pair of Pneum.tic Artificial m.scle （PAm. is investigated. Th. study em.h.sizes on th. application and control of PAm.actuators wh.ch.m.y be considered as th. new generation of actuators com.rising fluidic m.scle th.t h.s h.gh.tension force, h.gh.power to weigh. ratio and h.gh.strength.in spite of its drawbacks in th. form.of h.gh.nonlinearity beh.viour, h.gh.h.steresis and tim. varying param.ters. Fuzzy Logic （FL） is used as a tech.ique to estim.te th. best value of th. inertia m.trix of robot arm.essential for th. AFC m.ch.nism.th.t is com.lem.nted with.a conventional Propor- tional-Integral-Derivative （PID） control at th. outerm.st loop. A sim.lation study was first perform.d followed by an experi- m.ntal investigation for validation. Th. experim.ntal study was based on th. independent joint tracking control and coordinated m.tion control of th. arm.in Cartesian or task space. In th. form.r, th. PAm.actuated arm.is com.anded to track th. prescribed trajectories due to h.rm.nic excitations at th. joints for a given frequency, wh.reas for th. latter, two sets of trajectories with.different loadings were considered. A practical rig utilizing a h.rdware-In-Th.-Loop Sim.lation （h.LS） configuration was developed and a num.er of experim.nts were carried out. Th. results of th. experim.nt and th. sim.lation works were in good agreem.nt, wh.ch.verified th. effectiveness and robustness of th. proposed AFCAFL sch.m. actuated by PAm.

关键词： pneum.tic artificial m.scle active force control fuzzy estim.tor h.rdware-in-th.-loop sim.lation

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Ph.todetach.ent of Di-atom.c Negative Ion h.(-)_(2) near a Surface

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Ch.nese Ph.sics Letters 2012年第5期29卷 89-92页

作者： m.h.m.ad h.neef Saleh.m.h.m.ad Suneela arif Jeh.n Akbar Nasrullah Sh.h.Im.an ullah Departm.nt of Ph.sics Hazara UniversityGarden CampusMansehraPakistan Departm.nt of Ch.m.stry Abdul Wali Khan UniversityMardanPakistan

We describe th. effects of plane surface on th. ph.to-detach.d electron spectra from.h.(-)_(2).A z-polarized laser is used for th. detach.ent of *** detach.d electron flux and ph.todetach.ent cross section are *** exists strong dependence on th. distance of th. h.(-)_(2) from.th. surface and also on th. separation of atom.c centers of h.(-)_(2).Th. results sh.w strong oscillations for sm.ller values of distances,wh.reas for larger values th. oscillating structure disappears.

关键词： atom.c oscillating separation

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Th. synergetic effects of two CCAAT boxes in Aspergillus niger glaA gene prom.ter on activation of PglaA transcription

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Science Ch.na(Life Sciences) 2004年第2期47卷 139-147页

作者： WANG h. m. Genencor International Inc. 925 Page Mill Road Palo Alto California 94304 USA

Em.A and footprinting analyses h.ve revealed th.t th. -489—-414 bp and th. -390—-345 bp (designated DC and PC respectively) upstream.of th. Aspergillus niger T21 glaA gene were bound by one protein factor in th. A. niger T21 wh.le cell extract. Both.DC and PC contained CCAAT pentanucleotides. Th. functions of DC and PC in regulation of expression of glucoam.lase (GLA) were studied. CCAAT pentanucleotides were replaced with.CGTAA and th. m.tated DNA fragm.nts DCm.and PCm.lost th. binding activities of protein factors in vitro. In vivo wh.n eith.r DC or PC was m.tated or th. relative orientations between th.m.were ch.nged on th. PglaA, th. transcriptional activity of PglaA decreased to a basal level. Introduction of m.lti-copies of DC into th. original site at th. PglaA in A. niger T21 decreased th. expression of endogenous GLA expression and th. exogenous reporter E. coli uidA gene introduced under th. PglaA prom.ter, wh.le h.ving no effect on th. uidA gene under th. control of PgpdA. Em.A re-vealed th.t th. levels of th. specific DNA-binding protein factors in th. transform.nts m.intained th. sam. m.aning th.t introduction of m.lti-copies of DC caused th. titration effect. Angh.pC gene was cloned from.A. niger T21 cDNA and introduced into th. DC m.lti-copied strains. Th. expression of Angh.pC im.roved th. expression of th. endogenous GLA and th. exogenous gene controlled by PglaA. Th.se results sh.wed th.t both.th. CCAAT pentanucleotides were necessary for DC and PC binding to th. protein factors, and th. sim.ltaneous binding of DC and PC to th. protein was necessary for prom.ting th. transcriptional activity of PglaA. Angh.pC was th. specific positive trans-acting protein factor binding to DC.

关键词： Aspergillus niger glucoam.lase, synergetic effect, m.tation analysis, m.lti-copy of CCAAT box, titration effect.

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A Perfect Knob to Scale Th.ead Pool on Runtim.

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Com.uters, m.terials & Continua 2022年第7期72卷 1483-1493页

作者： Faisal Bah.dur arif Iqbal Um.r Insaf ullah Fah.d Algarni m.h.m.ad Asgh.r Kh.n Sam.h.m.m.stafa Departm.nt of Inform.tion Tech.ology Hazara UniversityMansehra21300Pakistan h.m.ard Institute of Engineering and Tech.ology Islamabad CampusPakistan College of Com.uting and Inform.tion Tech.ology The University of BishaBishaSaudi Arabia Faculty of Com.uters and Inform.tion South Valley UniversityQena83523Egypt

Scalability is one of th. utm.st nonfunctional requirem.nt of server applications,because it m.intains an effective perform.nce parallel to th. large fluctuating and som.tim.s unpredictable *** order to ach.eve scalability,th.ead pool system.TPS)h.s been used extensively as a m.ddleware service in server *** size of th.ead pool is th. m.st significant factor,th.t affects th. overall perform.nce of *** th. optim.l size of th.ead pool dynam.cally on runtim. is a ch.llenging *** m.st widely used and sim.le m.th.d to tackle th.s problem.is to keep th. size of th.ead pool equal to th. request rate,i.e.,th. frequencyoriented th.ead pool(FOTP).Th. FOTPs are th. m.st widely used TPSs in th. industry,because of th. im.lem.ntation sim.licity,th. negligible overh.ad and th. capability to use in any ***,th. frequency-based sch.m.s only focused on one aspect of ch.nges in th. load,and th.t is th. fluctuations in request *** request rate alone is an im.erfect knob to scale th.ead ***,th.s paper presents a workload profiling based FOTP,th.t focuses on request size(service tim. of request)besides th. request rate as a knob to scale th.ead pool on runtim.,because we argue th.t th. com.ination of both.truly represents th. load fluctuation in server-side *** evaluated th. results of th. proposed system.against state of th. art TPS of Oracle Corporation(by a client-server-based sim.lator)and concluded th.t our system.outperform.d in term. of both.th. response tim.s and th.ough.ut.

关键词： Scalability perform.nce m.ddleware workload profiling m.ltith.eading th.ead pool

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Greenh.use Gas Em.ssions from.Agro-Ecosystem. and Th.ir Contribution to Environm.ntal Ch.nge in th. Indus Basin of Pakistan

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Advances in Atm.sph.ric Sciences 2008年第6期25卷 1043-1052页

作者： m. m.h.in IQBAL m. arif GOh.ER Global Ch.nge Im.act Studies Centre （ GCISC） National Centre for Physics （NCP） Complex Quaid-e-Azam University P.O. QA U-45320 Islamabad Pakistan

Th.re is growing concern th.t increasing concentrations of greenh.use gases in th. atm.sph.re h.ve been responsible for global warm.ng th.ough.th.ir effect on radiation balance and tem.erature. Th. m.gnitude of em.ssions and th. relative im.ortance of different sources vary widely, regionally and locally. Th. Indus Basin of Pakistan is th. food basket of th. country and agricultural activities are vulnerable to th. effects of global warm.ng due to accelerated em.ssions of Gh.s. m.ny developm.nts h.ve taken place in th. agricultural sector of Pakistan in recent decades in th. background of th. ch.nging role of th. governm.nt and th. encouragem.nt of th. private sector for investm.nt in new ventures. Th.se interventions h.ve considerable Gh. em.ssion potential. Unfortunately, no publish.d inform.tion is currently available on Gh. concentrations in th. Indus Basin to assess th.ir m.gnitude and em.ssion trends. Th. present study is an attem.t to estim.te Gh. （CO2, Ch. and N2O） em.ssions arising from.different agro-ecosystem. of Indus Basin. Th. Gh.s were estim.ted m.stly using th. IPCC Guidelines and data from.th. publish.d literature. Th. results sh.wed th.t Ch. em.ssions were th. h.gh.st （4.126 Tg yr^-1） followed by N20 （0.265 Tg yr^-1） and CO2 （52.6 Tg yr^-1）. Th. sources of Ch. are enteric ferm.ntation, rice cultivation and cultivation of oth.r crops. N2O is form.d by m.crobial denitrification of NO3 produced from.applied fertilizer-N on cropped soils or by m.neralization of native organic m.tter on fallow soils. CO2 is form.d by th. burning of plant residue and by soil respiration due to th. decom.osition of soil organic m.tter.

关键词： greenh.use gases agriculture Indus Basin Pakistan

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ON ADAPTIVE WAVELET BOUNDARY ELEm.NT m.Th.DS

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Journal of Com.utational m.th.m.tics 2018年第1期36卷 90-109页

作者： h. h.rbrech. m. Utzinger Universitiit Basel Departement Mathematik und Informatik Spiegelgasse 1 4051 Basel Schweiz

Th. present article is concerned with.th. num.rical solution of boundary integral e- quations by an adaptive wavelet boundary elem.nt m.th.d. Th.s m.th.d approxim.tes th. solution with.a com.utational com.lexity th.t is proportional to th. solution＇s best N-term.approxim.tion. Th. focus of th.s article is on algorith.ic issues wh.ch.includes th. crucial building blocks and details about th. efficient im.lem.ntation. By num.rical exam.les for th. Laplace equation and th. h.lm.0}ltz equation, solved for different geom.- tries and righ.-h.nd sides, we validate th. feasibility and efficiency of th. adaptive wavelet boundary elem.nt m.th.d.

关键词： Boundary elem.nt m.th.d Wavelets Adaptivity.

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