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Temporal gradients limit th. accumulation of neutroph.ls toward sources of ch.moattractant

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Microsystems & Nanoengineering 2017年第1期3卷 455-462页

作者： Arvind Ch.ndrasekaran Felix Ellett Julianne jorgensen Daniel Irimia Department of Surgery BioMEMS Resource CenterMassachusetts General HospitalHarvard Medical SchoolShriners Burns HospitalBostonMA 02129USA

Neutroph.l trafficking during inflammation is a h.gh.y orch.strated process,coordinating neutroph.l recruitment,sterilization of th. wound,and inflammation *** th. ch.motactic signals guiding neutroph.l recruitment to sites of inflammation are relatively well understood,our knowledge of mech.nisms controlling cessation of neutroph.l recruitment and return to normal tissue ph.siology remains *** gain insigh.s into th.se processes,we designed a microfluidic device with.an array of ch.moattractant reservoirs,wh.ch.mimics th. microenvironment in infected tissues,wh.n multiple clusters of microbes are *** monitored th. temporal dynamics of neutroph.l recruitment toward th. ch.moattractant reservoirs at single cell resolution,for 3 *** observed robust neutroph.l recruitment th.t reach.d a plateau after 1.5 h.despite th. continuous presence of strong ch.moattractant gradients around th. *** timing of th. plateau was dependent on th. geometry of th. devices and was independent from th. number of *** th. basis of th.se observations,we ruled out sub-population sensitivity,ch.moattractant scavenging,and production of a self-limiting stop signal as potential mech.nisms underpinning th. plateau in neutroph.l *** found a strong correlation between th. temporal stabilization of concentration ch.nges and th. plateau in neutroph.ls *** results suggest th.t dynamic aspects of ch.moattractant gradients are key for maximizing recruitment during th. acute ph.se of infections and limiting th. accumulation of neutroph.ls as soon as th. infection is contained.

关键词： ch.motaxis leukocyte microfluidic relay signaling scavenging

Meropenem对抗生素耐药菌或不常见革兰氏阴性杆菌的抗菌活性

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国外医药（抗生素分册） 1993年第4期14卷 286-288页

作者： James h.jorgensen 史荣梅

Meropenem(SM—7338)是一个研究中的碳青霉稀类抗生素,对某些革兰氏阴性杆菌的抗菌活性较Imipenem强,对肾脱氢肽酶比较稳定。在本研究中我们试图评价Me—ropenem、lmipenem及另外几种β—内酰胺、环丙沙星和庆大霉素,对一组抗生素耐药... 详细信息

Meropenem(SM—7338)是一个研究中的碳青霉稀类抗生素,对某些革兰氏阴性杆菌的抗菌活性较Imipenem强,对肾脱氢肽酶比较稳定。在本研究中我们试图评价Me—ropenem、lmipenem及另外几种β—内酰胺、环丙沙星和庆大霉素,对一组抗生素耐药菌及罕见的革兰氏阴性杆菌抗菌活性。本研究以临床分离的病原菌作为实验菌株,因为它们显示对几种β—内酰胺(例如,若干肠杆菌科菌和绿脓杆菌)、氨基糖苷类和喹诺酮类的耐药性。

关键词： Meropenem 抗菌素革兰氏阴性菌

Obetich.lic acid for severe bile acid diarrh.a with.intestinal failure:A case report and review of th. literature

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World Journal of Gastroenterology 2018年第21期24卷 2320-2326页

作者： Ch.istian Lodberg h.as Peter Ott Peter Paine Simon Lal Soren Peter jorgensen Jens Frederik Dah.erup Department of h.patology and Gastroenterology Aarhus University HospitalAarhus C 8000Denmark Department of Gastroenterology Salford Royal NHS Foundation TrustSalfordManchester M6 8HDUnited Kingdom

Bile acid diarrh.a results from excessive amounts of bile acids entering th. colon due to h.patic overexcretion of bile acids or bile acid malabsorption in th. terminal ileum. Th. main th.rapies include bile acid sequestrants, such.as colestyramine and colesevelam, wh.ch.may be given in combination with.th. opioid receptor agonist loperamide. Some patients are refractory to conventional treatments. We report th. use of th. farnesoid X receptor agonist obetich.lic acid in a patient with.refractory bile acid diarrh.a and subsequent intestinal failure. A 32-year-old woman with.quiescent colonic Croh.'s disease and a normal terminal ileum h.d been diagnosed with.severe bile acid malabsorption and complained of watery diarrh.a and fatigue. Th. diarrh.a resulted in h.pokalemia and sodium depletion th.t made h.r dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional th.rapies with.colestyramine, colesevelam, and loperamide h.d no effect. Second-line antisecretory th.rapies with.pantoprazole, liraglutide, and octreotide also failed. Th.rd-line treatment with.obetich.lic acid reduced th. number of stools from an average of 13 to an average of 7 per 24h.and improved th. patient's quality of life. Th. fluid and electrolyte balances normalized. Th. effect was sustained during follow-up for 6 mo with.treatment at a daily dosage of 25 mg. Th. diarrh.a worsened sh.rtly after cessation of obetich.lic acid. Th.s case report supports th. initial report th.t obetich.lic acid may reduce bile acid production and improve symptoms in patients with.bile acid diarrh.a.

关键词： Bile acid malabsorption Diarrh.a Farnesoid X-activated receptor Croh.’s disease

Better Glycaemic Outcome, Low Levels of Acute Severe Complications, and h.gh.Patient Satisfaction in Routine Practice in Type 1 Diabetes Treated with.an Insulin Pump

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Journal of Diabetes Mellitus 2014年第4期4卷 304-310页

作者： h. J. Gjessing U. L. jorgensen C. C. Moller J. Pedersen E. Grodum K. Sch.usboe Diabetes Outpatient Clinic Medical Department Fredericia Hospital Sygehus Lilleb&aelig lt Dronningensgade 97 7000 Fredericia Denmark

Treatment of patients with.Type 1 diabetes with.continuous subcutaneous insulin infusion (CSII) was re-introduced in Denmark in th.s millennium and initiated in th. diabetes clinic, Fredericia h.spital, in 2005. Th. aim of th. present study was to present yearly data of quality from 2005 to 2013 from a clinical database of patients treated with.CSII in routine practice. Meth.ds: A database was establish.d in 2009-2010. Data from 2005 to 2009 are retrospective, data from 2009 to 2013 prospective. From 2009, patient satisfaction was measured by validated questionnaires. Results: By 31 December 2013, th. database contained data from 143 active patients. h.A1C (median and range) decreased from 64 (40 - 126) mmol/mol (8.0 (5.8 - 13.7)%) (n = 104) to 60 (36 - 98) mmol/mol (7.6 (5.4 - 11.1)%) (n = 134) (p h. improved glycaemic control was maintained each.year until ≥5 years after initiation of CSII (p h.re was no ch.nge in weigh.. Th. number of attacks of severe h.poglycaemia was reduced from 60 attacks in 21 patients (n = 104) th. year before CSII to only 5 attacks in 5 patients in 2013 (n = 134) (p h.year after initiation of CSII until ≥5 years, th. number of episodes of severe h.poglycaemia was reduced (p h.ve been registered in eigh. patients corresponding to an incidence of 1.4 episodes per 100 patient years. Patient satisfaction was h.gh.one year after initiation of CSII (p h.nge of treatment to CSII is accompanied by an improvement in glycaemic control, very pronounced reduction in severe h.poglycaemia, low levels of diabetic ketoacidosis, and pronounced patient satisfaction.

关键词： Type 1 Diabetes CSII Glycaemic Control h.poglycaemia Ketoacidosis Patient Satisfaction

Energy metabolism and protein balance in growing rats fed different levels of dietary fibre （soybean h.lls） and protein

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Energy metabolism and protein balance in growing rats fed di...

日粮纤维素和环境温度对实验大白鼠的影响——Ⅲ 实验大白鼠的能量代谢

作者： h.jorgensen V.M.Gabert P.K.Th.il Danish.Institute of Agricultural Sciences. Department of Animal Nutrition and Ph.siology.Research.Centre Foulum. P.O. Box 50. DK-8830 Tjele Denmark. Northwest Plateau Institute of Biology. The Chinese Academy of Sciences. Xining. 810001 P.R. China. Danish.Institute of Agricultural Sciences. Department of Animal Nutrition and Ph.siology.Research.Centre Foulum. P.O. Box 50. DK-8830 Tjele Denmark. Northwest Plateau Institute of Biology. The Chinese Academy of Sciences. Xining. 810001 P.R. China. Danish.Institute of Agricultural Sciences. Department of Animal Nutrition and Ph.siology.Research.Centre Foulum. P.O. Box 50. DK-8830 Tjele Denmark. Northwest Plateau Institute of Biology. The Chinese Academy of Sciences. Xining. 810001 P.R. China.

＜正＞SummaryA study was performed to investigate th. effect of different levels of dietary fibre （DF） and dietary prolein on visceral organ size, digestibility, nitrogen balance and energy metabolism in rats. Th.rty-six male Wistar rats, initial body weigh. about 76 g. were used in a factorial design consisting of th.ee levels of dietary fibre （low, 81 g/kg DM;medium, 215 g/kg DM and h.gh. 326 g/kg DM） and two levels of dietary prolein （low, 120 g/kg DM and h.gh. 223 g/kg DM）. Th. added fibre source was soybean h.lls. Danish.fish.meal was used as sole source of dietary protein. Measurements of gas-exch.nge were done on six rats （one group） and urine and faeces were collected individually. Th. weigh. of th. digestive tract was larger （P＜0/05） in rats fed th. h.gh.fibre diet th.n in th.se fed th. low fibre diet. As th. level of soybean fibre increased, th. digestibility of nutrients and energy linearly decreased. Th. apparent biological value decreased with.increasing DF wh.n rats were fed th. h.gh.protein diet wh.reas no significant difference was found with.increasing DF in rats fed th. low protein diet. h.at production as a percentage of metabolisable energy was h.gh.r in rats fed th. low protein diet th.n in rats fed th. h.gh.protein diet, but no significant difference was found among DF levels. Th. low h.at production in rals fed h.gh.fibre diet is probably due to an improved utilization of metabolisable energy for fat deposition compared to protein deposition.

关键词： h.at production ileal digestibility energy utilization

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动物营养学报 1995年第4期7卷 27-32页

作者：赵新全 h.jorgensen B.O.Eggum 中国科学院西北高原生物研究所西宁810001 National Institute of Animal Science Denmark

环境温度和日粮纤维素水平都可影响大白鼠的产热量及产热量占代谢能(h./MEI)的比例,其在高纤维素日粮组较低纤维素日粮组高,环境温度为16℃和32℃时较24℃时高。环境温度和高纤维日粮还可增加大白鼠的绝食代谢产热量和生长价。维持代谢... 详细信息

环境温度和日粮纤维素水平都可影响大白鼠的产热量及产热量占代谢能(h./MEI)的比例,其在高纤维素日粮组较低纤维素日粮组高,环境温度为16℃和32℃时较24℃时高。环境温度和高纤维日粮还可增加大白鼠的绝食代谢产热量和生长价。维持代谢能(MEm)并不受日根纤维素的影响,但随环境温度的降低而增加。低纤维日粮和适中的环境温度可使沉积能中脂肪的比例增加。

关键词：大白鼠能量代谢绝食产热维持需要代谢能摄入

日粮纤维素和环境温度对实验大白鼠的影响 Ⅱ 实验大白鼠的消化率和氮平衡

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动物营养学报 1995年第3期7卷 27-31页

作者：赵新全 h.jorgensen B.O.Eggum 中国科学院西北高原生物研究所西宁810001 National Institute of Animal Science 8830 Tjele Denmark

用实验大白鼠在不同日粮纤维素水平和不同环境温度下的研究表明,高纤维日粮可降低大白鼠对干物质、有机物质、蛋白质的表观消化率。摄入能中每增加一份纤维素能量,粪中的能量损失就增加2.37分。本研究尚未提出足够证据说明环境温度可影... 详细信息

用实验大白鼠在不同日粮纤维素水平和不同环境温度下的研究表明,高纤维日粮可降低大白鼠对干物质、有机物质、蛋白质的表观消化率。摄入能中每增加一份纤维素能量,粪中的能量损失就增加2.37分。本研究尚未提出足够证据说明环境温度可影响大白鼠的消化率。在高纤维日粮和低环境温度(16℃)下,大白鼠的蛋白质真消化率和总利用效率显著降低(P<0.05)。

关键词：大白鼠表观消化率氮平衡蛋白质真消化率

不同浓度右旋糖苷盐溶液对猪角膜肿胀特性影响的研究

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眼科研究 2000年第2期18卷 109-111页

作者：陈悦 Claus Sch.ott jorgensen 河南省眼科研究所郑州450003 丹麦Aarh.s大学临床实验研究所

目的　了解不同浓度右旋糖苷等渗盐溶液对正常猪角膜肿胀特性的影响。方法　采用猪眼新鲜角膜中央部组织块 (5mm× 5mm)及组织切片 (5 0 μm)浸入不同浓度右旋糖苷盐溶液 0 .5 ,1,2 ,3h.角膜组织块用电子天平在浸润前后分别称重。组织... 详细信息

目的　了解不同浓度右旋糖苷等渗盐溶液对正常猪角膜肿胀特性的影响。方法　采用猪眼新鲜角膜中央部组织块 (5mm× 5mm)及组织切片 (5 0 μm)浸入不同浓度右旋糖苷盐溶液 0 .5 ,1,2 ,3h.角膜组织块用电子天平在浸润前后分别称重。组织切片同连接摄像机和计算机的光学显微镜 ,摄取浸润前后各自图像 ,计算机中SigmaScan软件测量角膜宽度。平均肿胀率 (重量及宽度百分比 ) =浸润后记录值 /浸润前记录值。结果　右旋糖苷盐溶液可使角膜肿胀率减少 ,10 %溶液可显著减少角膜组织切片的肿胀。结论　右旋糖苷盐溶液 10 %～ 12 %显著抑制猪角膜肿胀 ,角膜组织切片肿胀小于组织块。比较早先的研究 ,猪角膜肿胀大于猴角膜。

关键词：猪右旋糖苷盐溶液角膜肿胀浓度

家猪体外胰蛋白酶消化关节软骨：7.0TMR T1ρ加权成像与量化分析

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中国组织工程研究与临床康复 2009年第37期13卷 7221-7225页

作者：周智洋单鸿李占军邹学农 Steffen Ringgaard 邹立津李海声 h.ns Stodkilde-jorgensen Cody Bünger 中山大学附属第六医院放射科广东省广州市510655 中山大学附属第三医院放射科广东省广州市510630 中山大学附属第三医院放射科 519000 丹麦奥胡斯大学医院骨科与磁共振研究中心丹麦奥胡斯8000 中山大学附属第一医院骨科广东省广州市510080

背景:T1ρ驰豫时间是探测软骨生化改变的最具吸引力的新的磁共振参数。早期骨关节炎主要表现为蛋白多糖的丢失以及胶原的轻微改变。目的:应用T1ρ成像技术与弛豫时间图量化分析方法,评价体外胰蛋白酶消化与未消化家猪髌骨软骨T1ρ驰豫... 详细信息

背景:T1ρ驰豫时间是探测软骨生化改变的最具吸引力的新的磁共振参数。早期骨关节炎主要表现为蛋白多糖的丢失以及胶原的轻微改变。目的:应用T1ρ成像技术与弛豫时间图量化分析方法,评价体外胰蛋白酶消化与未消化家猪髌骨软骨T1ρ驰豫时间的改变。设计、时间及地点:同体对照观察,于2007-02/2008-01在丹麦奥胡斯大学医院骨科与磁共振研究中心完成。材料:丹麦雌性长白猪10头,左右侧髌骨共20个。方法:选择10头家猪,取右侧髌骨10个为对照组,浸泡于PBS中4h.取出。取左侧髌骨10个为消化组,浸泡于含有胰蛋白酶的PBS溶液中,4h.取出。利用7.0T磁共振机,分别采用自旋锁定自动补偿脉冲簇的三维SE序列进行扫描,获得关节软骨的T1ρ加权图像。重构T1ρ弛豫时间图,测定关节软骨T1ρ值。取两组髌骨软骨标本行番红O/固绿染色进行组织学观察。主要观察指标:①T1ρ弛豫时间图量化分析结果。②两组软骨标本组织学结果。结果:经酶诱导消化的体外家猪髌骨关节软骨T1ρ加权图像成像清晰,呈分层状表现,对比度好,无异常伪影。大体观察两组关节软骨T1ρ加权图像,见局部的信号异常改变。重构T1ρ弛豫时间图并量化测定分析显示,消化组软骨表层T1ρ值高于对照组,差异具有显著性意义(P0.05)。结论:经胰蛋白酶诱导消化可引起退变软骨T1ρ驰豫时间改变,特别是在软骨的表层变化明显,提示T1ρ驰豫时间是较敏感、特异性的检测指标,可进一步应用于关节软骨退变的早期诊断。

关键词：磁共振成像 T1ρ 酶诱导关节软骨退变量化分析