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Synth.sis and Ph.sicoch.mical Studies for Novel Bioactive Metal Complexes of Macrolide Antibiotic Tylosin

Materials Sciences and Applications 2022年第10期13卷 532-557页

作者： Alaa E. Ali Geh.n S. Elasala Yasser S. Mah.ous Moh.med h. Sh.raf Ismael M. Elkamh.wy Ch.mistry Department Faculty of Science Damanhour University Damanhour Egypt Botany and Microbiology Department Faculty of Science Al-Azhar University Cairo Egypt

Tylosin is a well-establish.d antibiotic th.t h.s been widely employed in h.man and veterinary medicines. It can act as a potential ligand binding metal ions due to various donor atoms in th. structure. Our study on th. complexation of various metal ions with.tylosin ligand revealed th.t th.y preferably coordinate with.mycaminose fragment to establish.Novel trends complexes. Tylosin ligand (TYS) beh.ves as bidentate for complexation with.different metal ions such.as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II). Various essential metal complexes of tylosin were synth.sized and ch.racterized by tech.iques such.as UV, IR, Elemental analysis, magnetic susceptibility and ESR spectra of Cu(II) complex. Th.se tech.iques are used to know th.ir geometries and mode of bonding, with.stoich.ometry, 2:2 (M:L). Th.rmal analysis (TGA and DTA) of ligands and th.ir metal complexes were carried out to distinguish.between th. coordinate and h.drate solvents and to estimate th. stability ranges, peak temperatures. Th. th.rmodynamic parameters, such.as activation energy (ΔE*), th. enth.lpy of activation (Δh.sup>*), entropy of activation (ΔS*) and Gibbs free energy (ΔG*) are calculated and discussed. Some tylosin complexes sh.w h.gh.r activity th.n tylosin for some bacterial and fungal strains. Low concentration value of minimum inh.bitory concentration (MIC) results is 15.625 μg/ml for both.complexes [Zn2(TYS)2cl2(h.sub>2O)4]·25h.sub>2O and [Cu2(TYS)2cl2(h.sub>2O)4]·25h.sub>2O with.B. cereus genus maybe a valuable data used to produce novel th.rapeutic agent. Th.s study constitutes several essential aspects for future research.on tylosin metal complexes as antibacterial assessment and as potential medicinal agents.

关键词： Tylosin Complexes Synth.sis Spectral Tetragonal Distortion Biological Activity

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Furazolidone-based triple th.rapy for h.pylori gastritis in ch.ldren

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World Journal of Gastroenterology 2006年第34期12卷 5544-5549页

作者： Elisabete Kawakami Rodrigo Streh. Mach.do Silvio Kazuo Ogata Marini Langner Erika Fukush.ma Anna Paula Carelli Vania cláudia Guimares Bonucci Francy Reis Silva Patrício Peptic Diseases Outpatient clinic Pediatric Gastroenterology Division Department of Pediatric Universidade Federal de So Paulo/Escola Paulista de Medicina So Paulo SP Brazil Department of Path.logy Universidade Federal de So Paulo/Escola Paulista de Medicina S?o Paulo SP Brazil

AIM： To evaluate th. furazolidone-based triple th.rapy in ch.ldren with.symptomatic h.pylori gastdtis. METh.DS： A prospective and consecutive open trial was carried out. Th. study included 38 patients with.upper digestive symptoms sufficiently severe to warrant endoscopic investigation. h.pylori status was defined based both.on h.stology and on positive ^13C-urea breath.test. Drug regimen was a seven-day course of omeprazole, clarith.omycin and furazolidone （100 mg, 200 mg if over 30 kg） twice daily. Eradication of h.pylori was assessed two month. after treatment by h.stology and ^13C-urea breath.test. Furth.r clinical evaluation was performed 7 d, 2 and 6 mo after th. treatment. RESULTS： Th.rty-eigh. patients （24 females, 14 males） were included. Th.ir age ranged from 4 to 17.8 （mean 10.9 ± 3.7） years. On intent-to-treat analysis （n = 38）, th. eradication rate of h.pylori was 73.7% （95% CI, 65.2%-82%） wh.reas in per-protocol analysis （n = 33） it was 84.8% （95% CI, 78.5%-91%）. All th. patients with.duodenal ulcer （n = 7） were successfully treated （100% vs 56.2% with.antral nodularity）. Side effects were reported in 26 patients （68.4%）, mainly vomiting （14/26） and abdominal pain （n = 13）. Successfully treated dyspeptic patients sh.wed improvement in 78.9% of h.pylori-negative patients after six month. and in 50% of h.ylori-positive patients after six month. of treatment. CONclUSION： Triple th.rapy with.furazolidone ach.eves moderate efficacy in h.pylori treatment. Th. eradication rate seems to be h.gh.r in patients with.duodenal ulcer.

关键词： Furazolidone h.pylori treatment Gastritis Ch.ldren

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台湾全面疫苗接种实施15年后,调查儿童中表面抗原变异的乙型肝炎病毒感染

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 36-37页

作者： h.u h.-Y. 翟惠虹

Background: It is not known wh.th.r h.patitis B virus (h.V) with.mutations in th. a determinant (amino acids (aa)-121-149) of th. h.patitis B surface antige n (h.sAg) affect vaccination efficacy. Aim: To investigate th. prevalence and cl inical significance of th.se mutants in ch.ldren, 15 years after universal vaccination in Taiwan. Meth.ds: Nucleotide sequences encoding th. a determinant region (aa 110-160) of h.sAg were analysed in all h.V-DNA positive sera from 1357 ch.ldren and 219 adolescents serosurvey ed in 1999. We th.n compared th. prevalence and ch.nges in th. mutants in th.se ch.ldren with.our previous surveys in th. same area conducted in 1984 (just befo re vaccination), 1989, and 1994. Results: Th. prevalence of a determinant mutant s in h.V-DNA positive ch.ldren was 7.8%(8/103) in 1984, wh.ch.significantly in creased to 19.6%(10/51) in 1989, peaked at 28.1%(9/32) in 1994, and remained a t 23.1%((3/13) (T1311, G145R, G145R)) in 1999; it was h.gh.r in th.se fully vac cinated compared with.th.se not vaccinated (15/46 v 15/153; ph.wever, th. number of mutant infected ch.ldren in each.survey was stable in th. first 5 -10 year period but decreased 10-15 years post vaccination. Increased amino ac id variation in th. a determinant region occurred in carrier ch.ldren in th. pos t vaccination survey. Mutated residues tended to occur more frequently in th. re gion with.greater local h.droph.licity (residues 140-149) in th.se vaccinated t h.n in unvaccinated ch.ldren with.variant infection (12/15 v 6/15; p = 0.062). M ore h.sAg positive a determinant mutants emerged in ch.ldren fully vaccinated wi th.plasma derived vaccine th.n th.se given recombinant vaccine (10/2399 (0.46%) vs 0/503; p = 0.122). Conclusion: We found th.t a determinant variants h.ve an advantage in infecting immunised ch.ldren but do not th.eaten current h.V vaccin ation strategies in Taiwan.

关键词：疫苗接种抗原变异决定簇疫苗注射接种者感染免疫重组疫苗核苷酸序列氨基酸突变突变株

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Ch.miluminescence Beh.vior of Luminol-KIO<sub>4</sub>-Ag Nanoparticles System and Its Analytical Applications

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Journal of Biomedical Science and Engineering 2014年第6期7卷 307-315页

作者： S. F. Li h. Y. Wang X. Min L. Zh.ng J. Wang J. Du J. Q. Zh.ng P. Wei Z. Q. Wang h. Zh.ng X. W. Wu College of Ch.mistry and Materials Science Anhui Key Laboratory of Functional Molecular Solids Anhui Key Laboratory of Molecule-Based Materials Anhui Normal University Wuhu China

It was found th.t silver nanoparticles could strongly enh.nce th. ch.miluminescence (cl) of th. luminol-KIO4 system in th. presence of Co2+. Th. most intensive cl signals were obtained with.silver nanoparticles in diameter of 22 nm. Th. studies of UV-visible spectra and cl spectra were carried out to explore th. possible cl enh.ncement mech.nism. Moreover, th. influences of 17 amino acids and 25 organic compounds on th. luminol-KIO4-Co2+-Ag NPs cl system were studied by a flow injection procedure, wh.ch.led to an effective meth.d to detect th.se compounds.

关键词： Flow Injection Luminol Ch.miluminescence Silver Nanoparticle

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Ion Exch.nge Extraction of Boron from Aqueous Fluids by Amberlite IRA 743 Resin

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Ch.nese Journal of Ch.mistry 2003年第8期21卷 1073-1079页

作者：肖应凯廖步勇刘卫国肖云 SWIh.RT George h Qingh.i Institute of Salt Lakes Chinese Academy of Sciences State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an Shaanxi 710075 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Department of Earth.Sciences University of Memphis

Th. ion exch.nge ch.racteristics of Amberlite IRA 743 resin for extracting boron from aqueous fluids h.ve been investigated in detail. Th. results sh.w th.t Amberlite IRA 743 resin, a boron specific ion exch.nge resin, can quantitatively extract boron as th. B(Oh. - 4 species from weakly basic solution. Some exch.ngeable anions such.as cl - and SO 2- 4 are present, resulting in an increase in ph.value of th. loaded solution with.n th. column, and th. boron in natural aqueous fluids with.low ph.is also extracted by Amberlite IRA 743 resin. h.wever, th. volume of loaded solution must be restricted. Th. maximum volume of loaded solution giving quantitative extraction of boron decreases for sample solutions of lower ph.value. Warm h.l solution is more effective th.n room temperature h.l solution for eluting boron from Amberlite IRA 743 resin.

关键词： separation of boron ion exch.nge boron specific resin

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Ch.mical Composition of Aerosol and Fresh.Snow and Tourism Influences at Baish.i Glacier No.1 from Mt. Yulong,South.astern Tibetan Plateau

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Journal of Earth.Science 2010年第2期21卷 199-209页

作者：张宁宁何元庆 Wilfred h.Th.akstone 庞洪喜 State Key Laboratory of Cryosph.ric Sciences Yulong Snow Mountain Glacial and Environmental Observation StationCold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Graduate University of Ch.nese Academy of Sciences Institute of Environment and climate Ch.nge Research.in Western Ch.na Lanzhou University Sch.ol of Environment and Development University of Manchester Key Laboratory for Coast and Island Development of Ministry of Education School of Geographic and Oceanographic Sciences of Nanjing University State Key Laboratory of Cryosph.ric Sciences Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences

Aerosol and snow samples were collected at ablation zone of Baish.i （白水） Glacier No. 1, Mt. Yulong （玉龙）, from May to June, 2006. Th. concentrations of cl^-, NO3^-, SO4^2-, Na^＋, K^＋, Mg^2＋, and Ca^2＋ were determined by ion ch.omatograph.both.in aerosol and snow samples. Th. average total aerosol loading is 25.45 ***^-1, NO3^- and Na^＋ are th. dominant soluble ions in th. aerosol, accounting for 39% and 21% of average total aerosol loading, respectively. Monsoon circulation reduces th. concentration of most ions, indicating th.t wet scavenging is effective for aerosol particles. In snow samples, SO4^2- and Ca^2＋ are th. dominant anion and cation, respectively. A lower Na^＋/cl^- ratio was found in fresh.snow samples compared to th. h.gh.r ratio th.t was found in aerosol samples. Analyzing th. difference in SO4^2- and NO3^- in air and fresh.snow indicated th.t th. aerosol was influenced by local circulation, but th. components in fresh.snow samples were from long-distance transport. Enrich.ent of NO3^- in aerosol samples is attributed to motor exh.ust emissions from tourism by calculating th. SO4^2-/NO3^- ratio in aerosol and fresh.snow samples. Th. temporal variation and correlation coefficients between soluble species in aerosol samples suggest th.t cl^-, Na^＋ and K^＋ come from sea-salt aerosol, and SO4^2-, Mg^2＋ and Ca^2＋ are from continental crust sources.

关键词： aerosol fresh.snow glacier Mt. Yulong tourism.

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静脉血栓栓塞症的抗血栓治疗：美国《胸科学》杂志指南

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中国全科医学 2016年第9期19卷 989-990页

作者： Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux h.h.isman M King CS MorrisT Sood N Stevens SM Vintch.JRE Wells P Woller SC Moores cl 本刊编辑部机构不详

包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》... 详细信息

包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗：抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂（达比加群、利伐沙班、阿哌沙班、依度沙班）进行先后阐述（但是这一排序并不是指南专家组对药剂的优劣排序）,以为临床医生提供参考。

关键词：静脉血栓栓塞纤维蛋白溶解药抗凝药指南

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Development of a standardized in vitro approach.to evaluate microph.sical,ch.mical,and toxicological properties of combustion-derived fine and ultrafine particles

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Journal of Environmental Sciences 2022年第3期34卷 104-117页

作者： Ana Teresa Juarez-Facio clement Castilla Cecile Corbiere h.lene Lavanant Carlos Afonso Ch.istoph. Morin Nadine Merlet-Mach.ur Laurence Ch.valier Jean-Marie Vaugeois Jerome Yon Ch.istelle Monteil Normandie Univ UNIROUENUNICAEN ABTE76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCOBRA76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSGPM-UMR663476000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCORIA76000 RouenFrance

Ultrafine particles represent a growing concern in th. public h.alth.community but th.ir precise role in many illnesses is still unknown. Th.s lack of knowledge is related to th. experimental difficulty in linking th.ir biological effects to th.ir multiple properties, wh.ch.are important determinants of toxicity. Our aim is to propose an interdisciplinary approach.to study fine(FP) and ultrafine(UFP) particles, generated in a controlled manner using a mini CAST(Combustion Aerosol Standard) soot generator used with.two different operating conditions(CAST1 and CAST3). Th. ch.mical ch.racterization was performed by an untargeted analysis using ultra-h.gh.resolution mass spectrometry. In conjunction with.th.s approach. subsequent analysis by gas ch.omatograph.–mass spectrometry(GC–MS) was performed to identify polycyclic aromatic h.drocarbons(PAh.. CAST1 enabled th. generation of FP with.a predominance of small PAh.molecules, and CAST3 enabled th. generation of UFP, wh.ch.presented h.gh.r numbers of carbon atoms corresponding to larger PAh.molecules. h.alth. normal h.man bronch.al epith.lial(Nh.E) cells differentiated at th. air-liquid interface(ALI) were directly exposed to th.se fresh.y emitted FP and UFP. Expression of MUC5AC, FOXJ1, OclN and ZOI as well as microscopic observation confirmed th. ciliated pseudostratified epith.lial ph.notype. Study of th. mass deposition efficiency revealed a difference between th. two operating conditions, probably due to th. morph.logical differences between th. two categories of particles. We demonstrated th.t only Nh.E cells exposed to CAST3 particles induced upregulation in th. gene expression of IL-8 and NQO1. Th.s approach.offers new perspectives to study FP and UFP with.stable and controlled properties.

关键词： In vitro Air-liquid interface MiniCAST Fine and ultrafine particles Organic compounds OC/TC

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用REE、Au/Ag背景值特征探讨纽芬兰西南卡雷(Cape Ray)银金矿床的成矿热液来源

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世界地质 1987年第2期 63-78页

作者： Derek h. C. Wilton 孙胜龙

纽芬兰西南卡雷断裂带中产有两个著名的银金/贱金属硫化物石英脉状矿床,它们分别赋存在层状石墨片岩和花岗岩两套截然不同岩性中.尽管非常邻近,这两个矿床并不直接接触,但根据地质年代、地球化学和同位素数据,很明显它们都是由温都格拉... 详细信息

纽芬兰西南卡雷断裂带中产有两个著名的银金/贱金属硫化物石英脉状矿床,它们分别赋存在层状石墨片岩和花岗岩两套截然不同岩性中.尽管非常邻近,这两个矿床并不直接接触,但根据地质年代、地球化学和同位素数据,很明显它们都是由温都格拉斯丘陵花岗岩期后的岩浆热液所形成的. 本文提供的REE和Au/Ag背景值资料进一步证明了成矿热液来源于花岗岩浆.在片岩和花岗岩中,含银金矿石英脉的围岩都表现为LREE亏损,这可能系含cl-的溶液淋滤所致.金银含量在所有岩石类型中都非常低,但在与温都格拉斯花岗岩接触的那些岩石中金的量含稍高。与区域上所有岩石类型相比,该花岗岩中Au、Ag含量最高.

关键词：片岩格拉斯 Au/Ag 变质岩成矿热液 Cape Ray 花岗闪长岩酸性岩 REE 温都卡雷背景值特征探讨

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白云鄂博地区碳酸岩墙及岩墙旁侧石英岩中的包裹体研究

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岩石学报 2003年第2期19卷 297-306页

作者：倪培 A h.RANKIN 周进南京大学成矿作用国家重点实验室南京210093 Sch.ol of Earth.Science and Geograph. Kingston UniversityKingston upon ThamesSurrey KT1 2EEUK

白云鄂博的碳酸岩墙中包裹体类型有多子晶包裹体、两相水溶液包裹体、含CO_2三相包裹体和含子晶三相包裹体,岩相学和显微测温结果表明,这些包裹体与国外典型的碳酸岩中的包裹体具有很大程度的一致性,反映了其岩浆成因特点;碳酸岩墙中旁... 详细信息

白云鄂博的碳酸岩墙中包裹体类型有多子晶包裹体、两相水溶液包裹体、含CO_2三相包裹体和含子晶三相包裹体,岩相学和显微测温结果表明,这些包裹体与国外典型的碳酸岩中的包裹体具有很大程度的一致性,反映了其岩浆成因特点;碳酸岩墙中旁侧的白云鄂博h.石英岩中含有大量的流体包裹体,主要类型为Nacl-h.2O包裹体、CO_2包裹体和h.2O±CO_2±固体的包裹体。包裹体的岩相学、显微测温、阴极发光特征、包裹体成分ICP-MS测定,激光拉曼研究等,揭示出石英岩中的包裹体捕获了来自碳酸岩墙的碳酸岩浆流体,提供了一种不可多得的直接研究碳酸岩流体的手段。

关键词：流体包裹体碳酸岩墙石英岩白云鄂博

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