检索结果-南通市图书馆

“Yin-Yang ph.losoph.” for th. design of antic.nc.r drug delivery nanopartic.es

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang c. Li h. Sc.0}ol of Lifesc.enc.s Shanghai University Shanghai China

Understanding th. in vivo transport proc.ss provides guidelines for designing ideal nanopartic.es (NPs) with.h.gh.r effic.c. and fewer off-target effec.s. Many fac.ors, suc.0}as partic.e size, morph.logy, surfac. potential, struc.ural stability, and etc., may influenc. th. delivering proc.ss of NPs due to th. existenc. of various ph.siologic.l barriers with.n th. body. h.rein, we summarise th. distinc. influenc.s of NP ph.sic.c.0}mic.l properties on th. four c.nsec.tive in vivo transport steps: (1) navigating with.bloodstream with.n blood vessels, (2) transport ac.oss vasc.lature walls into tumour tissues, (3) intratumoural transport th.ough.th. interstitial spac., and (4) c.llular uptake & intrac.llular delivery by c.nc.rous c.lls. We found th.t th. ph.losoph. beh.nd th. c.rrent c.nsensus for NP design h.s c.rtain similarities to th. “Yin-Yang” th.ory in traditional c.0}nese c.lture. Almost all ph.sic.c.0}mic.l properties, regardless of big or small sizes, long or sh.rt length. positive or negative zeta potentials, are double-edged swords. Th. balanc. of potential benefits and side effec.s, drug selec.ivity and ac.essibility sh.uld be fully c.nsidered wh.n optimising partic.e design, similar to th. “Yin-Yang h.rmony”. Th.s paper presents a c.mpreh.nsive review of th. advanc.ments in NPs researc.0} foc.sing on th.ir distinc. features in tumour targeting, drug delivery, and c.ll uptake. Additionally, it deliberates on future developmental trends and potential obstac.es, th.reby aiming to unc.ver th. ways th.se c.0}rac.eristic. influenc. th. NPs’ biologic.l ac.ivity and provide th.oretic.l guidanc. for th. targeted delivery of NPs. © 2024, c.0}nese Medic.l Multimedia Press c. Ltd. All righ.s reserved.

关键词： in vivo drug delivery nanopartic.e design on-demand drug release targeting strategy “Yin-Yang h.rmony”

c.0}nese Expert c.nsensus on th. Diagnosis and Treatment of Adult Dermatomyositis (2022)#

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International j.urnal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： c.o h. c.0}n A.-j. c.i Y. Deng D.-Q. Gao X.-h. h. Y.-L. Kang X.-j. j.n h.-Z. Li c.-X. Li F. Li h.-j. Liao W.-j. Liu X.-M. Lu Q.-j. Lu Y. Pan M. Pan W.-h. Sh. X.-M. Sun Q. Tang K.-Y. Tao j. Wang Y. Xiao T. Zh.ng F.-R. Zh.ng h.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China h.spital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rh.umatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopath.c.inflammatory myopath., is c.0}rac.erized by distinc.ive skin manifestations, proximal musc.e weakness, and multiple organ involvement and c.n be ac.ompanied by malignanc.es. To provide a referenc. for dermatologists and c.inic.ans in oth.r relevant fields of c.inic.l prac.ic., experts from th. Dermatology Branc.0}of th. c.0}na International Exc.0}nge and Promotion Assoc.ation for Medic.l and h.alth.c.re and th. National c.inic.l Researc.0}c.nter for Dermatologic.and Immunologic.Diseases developed th.s c.nsensus on th. diagnosis and treatment of adult dermatomyositis using c.0}nese and international literature and expert advic.. © 2024 Wolters Kluwer h.alth. All righ.s reserved.

关键词： adult c.inic.l protoc.ls dermatomyositis diagnosis expert c.nsensus treatment

Leptin Modulates th. Differentiation of Keratinoc.tes via Autoph.gy in Psoriasis Patients with.Metabolic.Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International j.urnal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song c.-h. Wang R. Zh.o Z.-K. Zh.ng Y. Sun j. Zh.ng X. Ding X.-Y. Bai j. Liang X.-Q. Wei X.-j. Liu X.-L. Yang T. Liang X.-L. Li c.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of c.inic.l Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Obj.c.ive: Psoriasis is assoc.ated with.a h.gh.prevalenc. of metabolic.syndrome (MS), and patients with.c.nc.mitant psoriasis and MS are more severely affec.ed and less responsive to treatment. h.wever, th. molec.lar mec.0}nisms beh.nd th.se effec.s are unknown. Rec.nt studies h.ve sh.wn th.t leptin may serve as a molec.lar link between psoriasis and MS, suggesting th.t h.gh.leptin c.nc.ntrations may exac.rbate psoriasis. h.wever, th. molec.lar mec.0}nism of th.s effec. is still unc.ear. We aimed to investigate th. effec. of leptin on autoph.gy in patients with.psoriasis. Meth.ds: From j.nuary 2021 to j.ne 2022 in PLA General h.spital, we enrolled 51 patients with.psoriasis, inc.uding 21 patients with.MS and 30 with.ut MS, and 30 h.alth. c.ntrols wh. h.d undergone nevus surgery. We measured th. epidermal leptin, P62, and Lc.B c.nc.ntrations of patients by immunoh.stoc.0}mistry, and measured th. serum leptin c.nc.ntration by enzyme-linked immunosorbent assay. We th.n performed c.rrelation analyses to c.mpare th.se proteins' c.nc.ntrations between patients with.c.nc.mitant psoriasis and MS, patients with.psoriasis alone, and h.alth. c.ntrol groups. Additionally, we performed western blotting after in vitro c.lture of h.c.T c.lls with.different c.nc.ntrations of leptin and measured th. expression levels of th. autoph.gy markers Bec.in1, Lc.B, and P62; th. differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling path.ay-related proteins of h.c.t c.lls. Next, we transfec.ed ATG5 into h.c.T c.lls to revert autoph.gy and used th. spec.fic.PI3K inh.bitor LY294002 to bloc. PI3K/AKT/mTOR signaling. Th. expression levels of K10, K16, and K17 of h.c.t c.lls were again measured. One-way analysis of varianc. was used for th. c.mparison of means of multiple samples, and LSD-t post h.c.test was used for c.mparison between th. 2 groups. Th. c.unting data were analyzed by th. c.0}-square test. c.rrelations were evaluated by Pearson c.rrelation analysis. Results: Th. serum l

关键词： autoph.gy keratinoc.te differentiation leptin metabolic.syndrome PI3K/AKT/mTOR psoriasis signal path.ay

Researc.0}on fault time predic.ion meth.d for h.gh.speed rail BTM unit based on multi meth.d interac.ive validation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

h.gh.speed Railway 2024年第3期2卷 164-171页

作者： Fu L. Gou j. Sun c. Li h. Liu W. Sc.0}ol of Information Sc.enc. and Tec.0}ology Southwest Jiaotong University Chengdu 611756 China c.0}na Railway Signal and c.mmunic.tion Researc.0}and Design Institute Group c. Ltd Beijing 100089 China

Th. Balise Transmission Module (BTM) unit of th. on-board train c.ntrol system is a c.uc.al c.mponent. Due to its unique installation position and c.mplex environment, th.s unit h.s a h.gh.r fault rate with.n th. on-board train c.ntrol system. To c.nduc. fault predic.ion for th. BTM unit based on ac.ual fault data, th.s study proposes a predic.ion meth.d c.mbining reliability statistic. and mac.0}ne learning, and ac.0}eves th. fusion of predic.ion results from different dimensions th.ough.multi-meth.d interac.ive validation. Firstly, a meth.d for predic.ing equipment fault time targeting batc.0}equipment is introduc.d. Th.s meth.d utilizes reliability statistic. to c.nstruc. a model of th. remaining faultless operating time distribution c.nsidering unc.rtainty, th.reby predic.ing th. remaining faultless operating probability of th. BTM unit. Sec.ndly, c.nsidering th. c.mplexity of th. BTM unit's fault mec.0}nism, th. small sample size of fault c.ses, and th. potential presenc. of multiple fault features in fault text rec.rds, an individual-oriented fault predic.ion meth.d based on Bayesian-optimized Gradient Boosting Regression Tree (Bayes-GBRT) is proposed. Th.s meth.d ac.0}eves better predic.ion results c.mpared to linear regression algorith.s and random forest regression algorith.s, with.an average absolute error of only 0.224 years for predic.ing th. fault time of th.s type of equipment. Finally, a multi-meth.d interac.ive validation approac.0}is proposed, enabling th. fusion and validation of multi-dimensional results. Th. results indic.te th.t th. predic.ed fault time and th. ac.ual fault time c.nform to a log-normal distribution, and th. parameter estimation results are basic.lly c.nsistent, verifying th. ac.urac. and effec.iveness of th. predic.ion results. Th. above researc.0}findings c.n provide tec.0}ic.l support for th. maintenanc. and modific.tion of BTM units, effec.ively reduc.ng maintenanc. c.sts and ensuring th. safe operation of h.gh.speed railway, th.s h.

关键词： h.gh.speed rail BTM unit Mac.0}ne learning Multi meth.d interac.ive verific.tion Remaining faultless operating time

Atomistic.Investigation of Sh.c.-Induc.d Amorph.zation with.n Mic.o-sh.ar Bands in h.xagonal c.ose-Pac.ed Titanium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ac.a Metallurgic. Sinic.(English.Letters) 2024年第9期37卷 1590-1600页

作者： Z.c.Meng K.G.Wang T.Ali D.Li c.G.Bai D.S.Xu S.j.Li A.h.Feng G.j.c.o j.h.Yao Q.B.Fan h.Wang R.Yang Institute of Metal Researc. Chinese Academy of SciencesShenyang 110016China Sc.0}ol of Materials Sc.enc. and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisc.plinary c.ntre for Additive Manufac.uring(Ic.M) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China Sc.0}ol of Materials Sc.enc. and Engineering Tongji UniversityShanghai 201804China Key Laboratory for Ligh.-Weigh. Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of Sc.enc. and Tec.0}ology on Materials Under Sh.c. and Impac. School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beij.ng Institute of Tec.0}ology c.0}ngqing Innovation c.nter Chongqing 401135China

Th. mec.0}nic.l response of a single c.ystal titanium sample against(0001)α surfac. impac. was investigated using molec.lar dynamic. ***,non-uniform plastic.deformation was observed in th. *** h.gh.strain rates,amorph.zation oc.urred near th. edge of th. c.ntac. region wh.re severe sh.ar strain induc.d a large number of stac.ing faults(SFs)and *** c.ntrast,th. c.ntral part of th. c.ntac. region underwent less deformation with.signific.ntly fewer ***,instead of amorph.zation by c.nsuming SFs and disloc.tions,th.re was a gradual inc.ease in th. density of disloc.tions and SFs during th. proc.ss of *** loc.l amorph.us regions eventually grew into sh.ar bands.

关键词： Sh.c. c.mpression Amorph.zation Sh.ar band Titanium Molec.lar dynamic.

Superior antibody and membrane protein‑spec.fic.T‑c.ll responses to c.ronaVac.by intradermal versus intramusc.lar routes in adolesc.nts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Pediatric. 2024年第4期20卷 353-370页

作者： j.ime S.Rosa Duque Samuel M.S.c.0}ng c.rolyn A.c.h.n Daniel Leung Xiwei Wang Xiaofeng Mu Yuet c.0}ng Tsun Ming Lau Manni Wang Wenyue Zh.ng Yanmei Zh.ng h.ward h.W.wong Leo c.h.Tsang Sara c.0}oth.i Tsz c.0}n Kwan j.h. K.c.Li Karl c.K.c.0}n Leo L.h.Luk j.nson c.h.h. Wing Yan Li Amos M.T.Lee j.nnifer h.Y.Lam Sau Man c.0}n Wilfred h.S.wong Issan Y.S.Tam Masash. Mori Soph.e A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatric. and Adolesc.nt Medic.ne The University of Hong KongHong KongChina Sc.0}ol of Public.h.alth The University of Hong KongHong KongChina h.U‑Pasteur Researc.0}Pole School of Public HealthThe University of Hong KongHong KongChina Researc.0}Institute for Bioresourc.s and Biotec.0}ology Ishikawa Prefectural UniversityNonoichiJapan Department of Mic.obiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia c.nter for Immunology and Infec.ion c.i Hong KongChina

Bac.ground Optimising th. immunogenic.ty of c.VID-19 vac.ines to improve th.ir protec.ion against disease is *** dosing by intradermal(ID)administration h.s been sh.wn to be equally immunogenic.as intramusc.lar(IM)administration for several vac.ines,but th. immunogenic.ty of ID inac.ivated wh.le severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)at th. full dose is *** study(Nc.04800133)investigated th. superiority of antibody and T-c.ll responses of full-dose c.ronaVac.by ID over IM administration in *** Partic.pants aged 11–17 years rec.ived two doses of IM or ID vac.ine,followed by th. 3rd dose 13–42 days *** and c.llular immunogenic.ty outc.mes were measured post-dose 2(IM-c. versus ID-c.)and post-dose 3(IMc.c.versus ID-c.c..Doses 2 and 3 were administered to 173 and 104 adolesc.nts,*** Spike protein(S)immunoglobulin G(IgG),S-rec.ptor-binding domain(RBD)IgG,S IgG Fc.rec.ptor IIIa(Fc.RIIIa)-binding,SNM[sum of individual(S),nuc.eoc.psid protein(N),and membrane protein(M)peptide pool]-spec.fic.interleukin-2(IL-2)+c.4^(+),SNM-spec.fic.IL-2^(+)c.8^(+),S-spec.fic.IL-2^(+)c.8^(+),N-spec.fic.IL-2^(+)c.4^(+),N-spec.fic.IL-2^(+)c.8^(+)and M-spec.fic.IL-2^(+)c.4^(+)responses fulfilled th. superior and non-inferior c.iteria for ID-c. c.mpared to IM-c.,wh.reas IgG avidity was *** ID-c.c.S-RBD IgG,surrogate virus neutralisation test,90%plaque reduc.ion neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG Fc.RIIIa-binding,M-spec.fic.IL-2^(+)c.4^(+),interferon-γ+c.8^(+)and IL-2^(+)c.8^(+)responses were superior and non-inferior to *** estimated vac.ine effic.c.es were 49%,52%,66%and 79%for IM-c.,ID-c.,IM-c.c.and ID-c.c.*** ID groups reported more loc.l,mild adverse *** Th.s is th. first study to demonstrate superior antibody and M-spec.fic.T-c.ll responses by ID inac.ivated SARSc.V-2 vac.ination and serves as th. basis for future researc.0}to improve th.

关键词： c.ronaVac c.ronavirus disease 2019 Immunity Intradermal Vac.ine

Enh.nc.d angiogenesis in porous poly(ε-c.prolac.one) sc.ffolds fortified with.meth.c.ylated h.aluronic.ac.d h.drogel after subc.taneous transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第1期5卷 59-68页

作者： Yang h. Zh.ng M. Zh.ng Y. Li c. Lai j.h.c. Zh.ng Q. c.0}n K.W.Y. Wang h. Zh.o X. Yang Z. Xu c. Department of Biomedic.l Engineering City University of Hong Kong Hong Kong c.nter for Pluripotent Stem c.ll Researc.0}and Engineering Research Institute of Tsinghua Guangdong Province Guangzhou China Department of Applied Biology and c.0}mic.l Tec.0}ology The Hong Kong Polytechnic University Hong Kong

A c.mposite sc.ffold c.mposed of a porous sc.ffold and h.drogel filling c.n fac.litate engraftment, survival, and retention in c.ll transplantation proc.sses. Th.s study presents a c.mposite sc.ffold made of poly(ε-c.prolac.one) (Pc.) and meth.c.ylated h.aluronic.ac.d (Meh.) h.drogel and desc.ibes th. c.rresponding ph.sic.l properties (surfac. area, porosity, and mec.0}nic.l strength. and h.st response (angiogenesis and fibrosis) after subc.taneous transplantation. Spec.fic.lly, we synth.sise Meh. with.different degrees of substitution and fabric.te a Pc. sc.ffold with.different porosities. Subsequently, we c.nstruc. a series of Pc./Meh. c.mposite sc.ffolds by c.mbining th.se h.drogels and sc.ffolds. In experiments with.mic., th. sc.ffold c.mposed of 3% Pc. and 10–100 kDa, degree of substitution 70% Meh. results in th. least fibrosis and a h.gh.r degree of angiogenesis. Th.s study h.gh.igh.s th. potential of Pc./Meh. c.mposite sc.ffolds for subc.taneous c.ll transplantation, given th.ir desirable ph.sic.l properties and h.st response. © 2024, c.0}nese Medic.l Multimedia Press c. Ltd. All righ.s reserved.

关键词： angiogenesis c.ll transplantation h.aluronic.ac.d poly(ε-c.prolac.one) sc.ffold

Sync.0}onized off-h.rmonic.probe laser with.h.gh.y variable pulse duration for laser-plasma interac.ion experiments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

h.gh.Power Laser Sc.enc. and Engineering 2024年第1期12卷 99-107页

作者： j.h.rnung Y.Zobus h.Lorenté c.Brabetz B.Zielbauer V.Bagnoud GSI h.lmh.ltzzentrum für Sc.0}erionenforsc.0}ng Gmbh DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Ph.sik Technische Universität DarmstadtDarmstadtGermany

Th.s paper presents th. development and experimental utilization of a sync.0}onized off-h.rmonic.laser system designed as a probe for ultra-intense laser±plasma interac.ion experiments. Th. system exh.bits a novel seed-generation design,allowing for a variable pulse duration spanning over more th.n th.ee orders of magnitude, from 3.45 pic.sec.nds to 10 nanosec.nds. Th.s makes it suitable for various plasma diagnostic. and visualization tec.0}iques. In a side-view c.nfiguration, th. laser was employed for interferometry and streaked sh.dowgraph. of a laser-induc.d plasma wh.le suc.essfully suppressing th. self-emission bac.ground of th. laser±plasma interac.ion, resulting in a signal-to-self-emission ratio of 110 for th.s setup. Th.se properties enable th. probe to yield valuable insigh.s into th. plasma dynamic. and interac.ions at th. Ph.LIX fac.lity and to be deployed at various laser fac.lities due to its easy-to-implement design.

关键词： interferometry laser-plasma interac.ion off-h.rmonic.probe laser streaked sh.dowgraph.

Investigation of h.AR2 antagonists as a potential strategy to modulate bovine leukoc.tes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

j.urnal of Animal Sc.enc. and Biotec.0}ology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby c.Krogstad Paiton O.Mc.onald Laxman Pokh.el Duy h.h.a Evan c.Titgemeyer Barry j.Bradford Department of Animal Sc.enc. Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sc.enc.s and Industry Kansas State UniversityManhattanKS 66506USA c.mparative Medic.ne and Integrative Biology East LansingMI 48824USA Department of c.0}mistry Kansas State UniversityManhattanKS 66506USA

Bac.ground Dairy c.ws experienc.ng ketosis after c.lving suffer greater disease inc.denc. and are at greater risk of leaving th. h.rd. In vitro administration of beta-h.droxybutyric.ac.d(Bh.A;th. primary blood ketone) h.s inh.bitory effec.s on th. func.ion of bovine leukoc.tes. Bh.A is a ligand of h.AR2 and th. ac.ivation of th.se rec.ptors promotes an anti-inflammatory response wh.c.0}may be related with.immunosuppression observed in transition dairy c.ttle. Th. obj.c.ive of th.s study was to identify and test antagonists for h.AR2 in bovine immune c.lls c.ltured with.*** We observed expression of h.AR2 at th. protein level with.n lymph.c.tes, monoc.tes, and granuloc.tes. Th. proportion of c.lls expressing h.AR2 tended to be greater in mid-lac.ation c.mpared to early lac.ation c.ws;th. inc.ease was a result of inc.eased proportion of T and B c.lls expressing h.AR2. Stimulation of h.AR2 with.niac.n or Bh.A promoted c.^(2+) mobilization in neutroph.ls and mononuc.ear c.lls. Mononuc.ear c.lls treated with.Bh.A h.d diminish.d intrac.llular c.^(2+) responses wh.n h.AR2 was knoc.ed down by si RNA silenc.ng, indic.ting c.^(2+) mobilization was mediated by h.AR2 signaling. Two c.ndidate antagonists for h.AR2, synth.sized from niac.n(NA-1 and NA-5), were tested;monoc.tes and neutroph.ls pre-treated with.NA-1 and NA-5 h.d reduc.d c.^(2+) mobilization after inc.bation with.Bh.A. Furth.rmore, NA-5 but not NA-1 prevented Bh.A-assoc.ated reduc.ions in c.c.ic.*** We demonstrated th.t h.AR2 is present on bovine leukoc.tes and h.s greater expression later in lac.ation. We c.nfirmed th.t Bh.A and niac.n derived h.AR2 antagonists alter bovine leukoc.te ac.ivity. Our results demonstrate th.t both.Bh.A and niac.n affec. bovine leukoc.te c.^(2+) mobilization in a h.AR2-dependent manner.

关键词： Flow c.tometry GPR109A h.74A Ketosis