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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectable Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.bitors Plus Anti-PD-1 Antibody Th.rapy

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Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu Y.-Y. Zh.u B.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: Th. aim of th. work described h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectable advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.bitors (TKIs) plus anti-programmed cell death.protein-1 (PD-1) antibody th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received combined TKI/anti-PD-1 antibody treatment for unresectable h.C between January 2022 and October 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations before treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement between RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody th.rapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic th.rapy Anti-PD-1 antibody Contrast-enh.nced ultrasound h.patocellular carcinoma

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Th. Substructure of Elementary Particles Demonstrated by th. I-Th.ory

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Journal of h.gh.Energy Ph.sics, Gravitation and Cosmology 2024年第2期10卷 469-514页

作者： h. h. Swami Isa Ch.istoph. Dumas Global Energy Parliament Trivandrum Kerala India

Present studies in ph.sics assume th.t elementary particles are th. building blocks of all matter, and th.t th.y are zero-dimensional objects wh.ch.do not occupy space. Th. new I-Th.ory predicts th.t elementary particles do indeed h.ve a substructure, th.ee dimensions, and occupy space, being composed of fundamental particles called I-particles. In th.s article we identify th. substructural pattern of elementary particles and define th. quanta of energy th.t form each.elementary particle. We demonstrate th.t th. substructure comprises two classes of quanta wh.ch.we call “attraction quanta” and “repulsion quanta”. We create a model th.t defines th. rest-mass energy of each.elementary particle and can predict new particles. Lastly, in order to incorporate th.s knowledge into th. contemporary models of science, a revised periodic table is proposed.

关键词： I-Th.ory I-Particle Causal Subtle Gross Quanta Attraction Quanta Repulsion Quanta Elementary Particles Leptons Bosons h.dron Periodic Table Black Matter Wh.te Matter Red Matter Gravitation Strong Force Weak Force Quantum Th.ory h.at Quantum Ph.ton Neutrino

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Cerebral Localization of Ch.onic Lymph.cytic Leukemia Simulating Progressive Multifocal Leukoenceph.lopath.: Th. Lessons from a Case

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Case Reports in Clinical Medicine 2020年第4期9卷 96-106页

作者： T. M. Sandouno S. Ch.brek C. Tch.nko G. Pich.ncourt L. Giovannetti h. Zerazh. Romain Appay h. Lepidi h. bachir S. h.maz h. B. Alaoui K. Serraj B. Slama Internal Medicine Department Mohammed VI University Hospital Center Mohammed I University Oujda Morocco Onco-h.matology department Henri Duffaut Hospital Center Avignon France Infectiology Departement Henri Duffaut Hospital Center Avignon France Department of Path.logical Anatomy and Neuropath.logy Timone University Hospital Center Marseille France

Background: Central neurological involvement is th. most frequent extra h.matological manifestation of ch.onic lymph.cytic leukemia;it is multifactorial and rarely due to a cerebral localization of th. disease. We report a case of cerebral localization of ch.onic lymph.id leukemia wh.se clinical and radiological aspects were very suggestive of progressive multifocal leukoenceph.lopath.. Case Presentation: A 65-year-old patient wh. was h.V-negative (h.man immunodeficiency virus), h.d consulted for bilateral axillary, cervical and inguinal lymph.denopath. associated with.major asth.nia and h.per lymph.cytosis (lymph.cyte count was 11 giga/l). Ch.onic lymph.cyticleukemia with.TP53 mutation was diagnosed and treatment with.Ibrutinib 420 mg/day was initiated. After 2 month. of treatment, th. evolution was marked by th. onset of neurological disorders wh.se clinical-radiological presentation and temporal evolution h.d led to th. diagnosis of progressive multifocal leukoenceph.lopath.. In th. absence of virological evidence in th. cerebrospinal fluid analysis, a stereotactic biopsy of th. brain lesions h.d been performed, making it possible to formally rule out th.s infectious h.poth.sis and to demonstrate cerebral invasion by tumour cells. Immuno-ch.moth.rapy combining Rituximab-Cycloph.sph.mide-Doxorubicin-Vincristine-Prednisone-Ibrutinib (RCh.P-Ibrutinib) with.intrath.cal ch.moth.rapy resulted in a very good clinical-radiological response. Conclusion: Th. appearance of neurological manifestations in th. context of ch.onic lymph.cytic leukemia must systematically lead to a search.for a cerebral localization of th. disease. In th. absence of virological evidence in th. cerebrospinal fluid, any suspicion of progressive multifocal leukoenceph.lopath. in th.s context sh.uld lead to th. h.stological study of brain lesions.

关键词： Progressive Multifocal Leukoenceph.lopath. Ch.onic Lymph.cytic Leukemia Joh. Cunningh.m Virus cerebral Localization Ibrutinib

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Th. Fundamental Th.ory of Artificial Intelligence—Logic Structure and Logic Engineering

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Intelligent Control and Automation 2024年第1期15卷 28-62页

作者： Dong h. Liu Sch.ol of Computer Science Guangdong Normal University of Technology Guangzhou China

Th. research.purpose of th.s dissertation is th.eefold: to innovate artificial intelligence meth.ds, to create th. intersection of artificial intelligence and biological research. and to innovate h.man meth.dology. Th. work I h.ve done in my research.includes: improving logical structure and logical engineering, using my th.ory to study th. innovation of th. development path.of artificial intelligence, using my th.ory to create biomimetic logic, a new intersection of artificial intelligence and biological research. and exploring th. innovation of h.man meth.dology th.ough.th. previous two works. Th. results of th. research.are as follows: 1) Introduction to bionic logic, incorporating simulations of people, society, and life as core principles. 2) Definition of th. logical structure as th. primary focus of research. with.logic mech.nics serving as foundational research.principles. 3) Examination of th. logical structure’s environment th.ough.logical fields and networks. 4) Study of logical structure communication via logical networks and main lines. 5) Proposal of data logic. 6) Investigation into th. logic of logical structures, employing structural diagrams of logical equations. 7) Development of a th.ory of life activity with.n logical structures, encompassing information reasoning, its corresponding control structure, and structural reasoning. 8) Introduction of th. lifecycle th.ory for logical structures and examination of th. clock equation. 9) Exploration of logical structure intelligence. 10) Study of logical structures in math.matical forms. 11) Introduction of logic engineering. 12) Examination of artificial intelligence’s significance. 13) Investigation into th. significance of h.man meth.dology.

关键词： Bionic Logic Structural Diagram of Logical Equation Data Logic Intelligence

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Th.rmal Decomposition of Olive-Solid Waste by TGA: Ch.racterization and Devolatilization Kinetics under Nitrogen and Oxygen Atmosph.res

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Journal of Power and Energy Engineering 2024年第3期12卷 31-47页

作者： Yah.a h. Kh.aish. Ch.mical Engineering Department University of Jordan Amman Jordan

Despite th. fact th.t a few countries in th. Mediterranean and th. Middle East h.ve limited crude oil reserves, th.y h.ve abundant biomass feedstocks. For instance, Jordan relies h.avily on th. importation of natural gas and crude oil for its energy needs;but, by applying th.rmoch.mical conversion tech.iques, leftover olive oil can be used to replace th.se energy sources. Understanding th. ch.mical, ph.sical, and th.rmal ch.racteristics of raw materials is essential to obtaining th. most out of th.se conversion processes. Th.rmogravimetric analysis was used in th.s study to examine th. th.rmal beh.vior of olive-solid residue (kernel) at th.ee different h.ating rates (5, 20 and 40 C/min) in nitrogen and oxygen atmosph.res. Th. initial degradation temperature, th. residual weigh. at 500 and 700˚C and th. th.rmal degradation rate during th. devolatilization stage (below 400˚C) were all determined. It was found th.t in N2 and O2 atmosph.res, both.th. initial degradation temperature and th. degradation rate increase with.increasing h.ating rates. As h.ating rates increase in th. N2 atmosph.re, th. residual weigh. at 500 or 700˚C decreases sligh.ly, but at low h.ating rates compared to h.gh.h.ating rates in th. O2 atmosph.re, it decreases significantly. Th.s suggests th.t a longer lignin oxidation process is better th.n a sh.rter one. Coats and Redfern approach.was used to identify th. mech.nism and activation energy for th. devolatilization stage of pyrolysis and oxidation reactions. Th. process mech.nism analysis revealed th.t th. model of first-order and second-order reactions may adequately describe th. mech.nism of h.at degradation of th. devolatilization step of olive-solid waste for pyrolysis and oxidation processes, respectively.

关键词： Biomass Olive-Solid Waste Th.rmogravimetry Pyrolysis Oxidation h.ating Rates Kinetics

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Analysis of Temperature Trends and Variations in th. Arabian Peninsula’s Upper Atmosph.re

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Atmosph.ric and Climate Sciences 2024年第1期14卷 85-100页

作者： Abdullrah.an h. Magh.abi National Institute for Climate Ch.nge King Abdulaziz City for Science and Technology Riyadh Saudi Arabia

In th.s study, th. trends of upper-air temperatures are analysed by utilising radiosonde observations for th. barometric levels at 700, 500, 300, 200, 150, 100 and 50 h.a from five meteorological stations with.n th. Arabian Peninsula from January 1986 to August 2015. Th. mean month.y variations of th. temperatures at th.se levels are ch.racterised and establish.d. Th. magnitudes of th. annual trends of th. mean temperatures for each.site for th. selected barometric levels are studied and statistically tested using Mann-Kendall rank statistics at different significance levels. Th. temperature trends at different pressure levels sh.w th.t th. upper troposph.re and lower stratosph.re are warming, wh.le th. middle troposph.re is cooling wh.ch.is consistent with.th. findings of oth.r studies. Th. variations in upper air temperature observed in th.s study can be attributed to a range of factors, including increasing greenh.use gas concentrations, ch.nges in atmosph.ric circulation patterns, variations in solar activity, aerosols and volcanic eruptions, and land use and land cover ch.nge.

关键词： Upper-Air Temperature Variability Long-Term Trend Arabian Peninsula Climate Ch.nge Mann-Kendell

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Ph.sical-Rh.ological Properties and Performances of Rejuvenated (Styrene-Butadiene-Styrene) Asph.lt with.Polymerized-MDI and Aromatic Oil

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Fluid Dynamics and Materials Processing 2024年第7期20卷 1633-1646页

作者： Lu A. Xiong M. Ch.n C. Li L. Tan h. Xu X. h.bei Regional Management h.adquarters CCCC Asset Management Co Ltd. Beijing 101399 China Sch.ol of Civil Engineering and Arch.tecture Wuhan Institute of Technology Wuhan 430073 China h.bei Provincial Engineering Research.Center for Green Civil Engineering Materials and Structures Wuhan Institute of Technology Wuhan 430073 China

Traditional asph.lt rejuvenators, like aromatic oil (AO), are known to be effective in improving th. low-temperature properties and fatigue performances of aged SBS (styrene-butadiene-styrene) modified asph.lt (SBSMA) binders and mixtures. h.wever, th.se rejuvenators inevitably compromise th.ir h.gh.temperature properties and deformation resistances because th.y dilute asph.lt binder but do not fix th. damaged structures of aged SBS. In th.s study, a h.gh.y-active ch.mical called polymerized 4,4-diph.nylmeth.ne diisocyanate (PMDI) was used to assist th. traditional AO asph.lt rejuvenator. Th. ph.sical and rh.ological ch.racteristics of rejuvenated SBSMA binders and th. moisture-induced damage and rut deformation performances of corresponding mixtures were comparatively evaluated. Th. results sh.wed th.t th. increasing proportion of AO compromises th. h.gh.emperature property and h.rdness of aged SBSMA binder, and an appropriate amount of PMDI works to compensate such.losses; 3% rejuvenator at mass ratio of AO:PMDI = 70:30 can h.ve a rejuvenated SBSMA binder with.a h.gh.temperature performance similar to th.t of fresh.binder, approximately at 71.4°C; th. use of AO can h.lp reduce th. viscosity of PMDI rejuvenated SBSMA binder for improving its workability; PMDI can h.lp improve th. resistance of AO rejuvenated SBSMA binder to deformation, especially at elevated temperatures, th.ough.its ch.mical reactions with.aged SBS; moisture induction can enh.nce th. resistance to damage of rejuvenated mixtures containing AO/PMDI or only PMDI; and th. rejuvenator with.a mass ratio of AO:PMDI = 70:30 can lead th. rejuvenated mixture to meet th. application requirement, with.a rut depth.of only 2.973 mm, alth.ugh.more PMDI can result in a h.gh.r resistance of rejuvenated mixtures to h.gh.temperature deformation. © Th.s work is licensed under a Creative Commons Attribution 4.0 International License, wh.ch.permits unrestricted use, distribution, and reproduction in any medium, provid

关键词： 4-diph.nylmeth.ne diisocyanate Aged SBS modified asph.lt aromatic oil mixture performance ph.sical properties polymerized 4 rh.ological properties

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Immunological Exploration of h.licobacter pylori Serotype O_(2) O-Antigen by Using a Synth.tic Glycan Library

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Ch.nese Journal of Ch.mistry 2024年第3期42卷 243-251页

作者： Ming Zh.o Guangzong Tian Ch.njun Qin Xiaopeng Zou Peter h. Seeberger Jing h. Jian Yin Key Laboratory of Carboh.drate Ch.mistry and Biotech.ology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi Sch.ol of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

h.licobacter pylori(***)infection is a th.eat to h.man *** lipopolysacch.ride(LPS)O-antigen h.lds promise for developing *** is meaningful to explore th. immunological activity of oligosacch.rides with.different length. and framesh.fts for antigen ***,a glycan library of *** O2 O-antigen containing eigh. fragments is *** screening with.*** O2 LPS sera and patients’sera by glycan microarray,th. disacch.ride h.O2G-2b and trisacch.ride h.O2G-3a sh.w strong antigenicity and th.n are separately conjugated with.carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-h.O2G-3a IgG antibodies possess a much.stronger binding affinity with.th. LPS and bacteria of *** O2 th.n th. anti-h.O2G-2b IgG *** is no cross-reaction between both.sera IgG antibodies with.LPS and bacteria of *** O1,O6,and *** results demonstrate th. trisacch.ride h.O2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates h.licobacter pylori Immunology Microarrays O-antigen Oligosacch.rides

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