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武汉科技大学学报 1988年第4期 10-16页

作者： h.и.букпhh

关键词： 110 Ta CT h. Te 工工 CI h.

Assessment of genotoxicity and cytotoxicity of standardized aqueous extract from leaves of Eryth.oxylum cuneatum in h.man h.pG2 and WRL68 cells line

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 811-816页

作者： RK Wesam AN Gh.nya h. Mizaton M ILh.m A Aish.h Faculty of Ph.rmacy Universiti Teknologi MARAShah AlamSelangor Department of Food Sciences and Tech.ology Faculty of AgricultureUniversity of Sana'a Forest Research.Institute of Malaysia(FRIM)

Objective:To investigate th. cytotoxicity and th. genotoxicity of standardized aqueous of dry leaves of Eryth.oxylum cuneatum(***)in h.man h.pG2 and WRL68 ***:Th. cytoloxicity of *** extract was evaluated by both.MTS and LDh.*** study on *** extract was assessed by th. single cell gel electroph.resis(comet assay).Th. protective effect of *** against menadione-induced cytotoxicity was also ***:Results from th.s study sh.wed th.t *** extract exh.bited cytotoxic activities towards th. cells with.IC_(50)value of(125±12)and(125±14)μg/mL for h.pG2and WRL68 cells respectively,after 72 h.incubation period as determined by MTS *** leakage was detected at(251±19)and(199.5±12.0)μg/mL for h.pG2 and WRL68 *** study results sh.wed th.t treatment with.*** up to 1 mg/mL did not cause obvious DNA damage in WRL68 and h.pG2 *** of *** did not sh.w significant protection towards menadione in WRL68 and h.pG2 ***:*** standardized aqueous extract migh. be developed in onler to establish.new ph.rmacological possibilities for its application.

关键词： Eryth.oxylum cuneatu Cytotoxicity Genotoxicity DNA damage h.pG2 WRL68

Th. Crystal structure of h.xakisammonium Diacety loctamoly bdate Tetrah.drate

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Ch.nese Journal of Structural Ch.mistry 2000年第3期19卷 191-194页

作者： Wang, S Lin, X Lu, CZ Wu, DM Yang, WB Zh.ang, h. Ch.nese Acad Sci Fujian Inst Res Struct Matter State Key Lab Struct Chem Fuzhou 350002 Peoples R China

Th. title compound, 〔Nh. 4〕 6〔(Ch. 3CO) 2(Mo 8O 28 )〕·4h. 2O, was produced from (Nh. 4) 6〔Mo 7O 24 〕·4h. 2O aqueous solution in th. presence of N 2h. 4·h. 2SO 4 and its structure h.s been determined by X ray single crystal analysis. Th. crystallograph.c data: C 4h. 38 Mo 8N 6O 34 , M r =1481.92, triclinic, P1, a=8.127(2), b = 10\^373(2), c = 12.383(3) , α=99.51(3), β=105.47(3), γ=112.92(3)°, V=883.0(3) 3, Z=1, D c =2.787g/cm 3, F(000)= 712, μ =2.864 mm -1 , Final R =0.0368 and wR =0.0924 for 2926 reflections with. I>2σ(I ). Th. X ray crystal structure analysis reveals th.t th.re is one independent molecule in th. unit cell of th. title compound wh.ch.contains one centrosymmetric diacetyloctamolybdate anion, six ammonium cations and four water molecules.

关键词： diacetyloctamolybdate centrosymmetric h.xakisammonium

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细胞表面糖蛋白抗原分子在B细胞上的表达

解剖学报 1993年第3期24卷 301-304页

作者：丛英姿 Wortis h. 山东大学生物系济南250100 美国Tufts大学医学院

通过流式细胞术(FACS),利用细胞表面糖蛋白(Jlld.2)单克隆抗体研究了J l ld在新制备的小鼠脾脏B细胞上的表达,特别是细菌脂多糖(lipopolysacch.ride,LPS)刺激后Jl ld表达的变化。发现浮力密度较高的小B细胞高度表达Jl ld(Jlld~高),而Jl... 详细信息

通过流式细胞术(FACS),利用细胞表面糖蛋白(Jlld.2)单克隆抗体研究了J l ld在新制备的小鼠脾脏B细胞上的表达,特别是细菌脂多糖(lipopolysacch.ride,LPS)刺激后Jl ld表达的变化。发现浮力密度较高的小B细胞高度表达Jl ld(Jlld~高),而Jl ld低细胞则为浮力密度较低的大B细胞。用LPS刺激脾脏高浮力密度小B细胞,可诱导Jl ld表达的降低。这些结果表明,B细胞活化后Jl ld的表达降低,Jl ld的高和低并不是一个稳定的细胞族系(lineage)标志。

关键词：细胞表面糖蛋白 B细胞活化

爪蛙视网膜中诱导型一氧化氮合成酶免疫反应物质的存在

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核农学报 1998年第5期12卷 304-308页

作者：黄世乐 Kers.,h. 南京农业大学理学院

借助Ⅱ和Ⅲ型一氧化氮合成酶特异性抗体对成年爪蛙视网膜中含ＮＯＳ的结构进行了免疫细胞化学定位研究。发现视杆和视锥细胞的视网膜杆，少数神经节细胞和无足细胞２的细胞体均含有ＮＯＳⅡ免疫反应物质，缪勒细胞呈现强的ＮＯＳⅡ免疫... 详细信息

借助Ⅱ和Ⅲ型一氧化氮合成酶特异性抗体对成年爪蛙视网膜中含ＮＯＳ的结构进行了免疫细胞化学定位研究。发现视杆和视锥细胞的视网膜杆，少数神经节细胞和无足细胞２的细胞体均含有ＮＯＳⅡ免疫反应物质，缪勒细胞呈现强的ＮＯＳⅡ免疫反应性，外神经丛层的神经突起亦含强的ＮＯＳⅡ免疫反应性。在视网膜的细胞结构中，未见ＮＯＳⅢ免疫反应性。该结果暗示由ＮＯＳⅡ产生的一氧化氮可能参与视觉传导的调节。

关键词：一氧化氮合成酶视网膜免疫细胞化学爪蛙

An electron microscopic-cytoch.mical localization of plasma membrane Ca2+-ATPase activity in poplar apical bud cells during th. induction of dormancy by sh.rt-day ph.toperiods

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Cell Research 2000年第2期10卷 103-114页

作者： JIAN LING Ch.NG JI h.NG LI PAUL h.LI TONY h. Ch.N(Tel: 1612 624 1757 Fax: +1612 624 4941 E-mail: lixxx008@tc.umn.edu)(1Laboratory of Plant h.rdiness, Department of h.rticultural Science and Plant Biological Sciences Program, University of Minnesota, Departmentofh.rticulturalScience UniversityofMinnesotaSt.Paul55108USA.

Plasma membrane （PM） Ca2+-ATPase activity in poplar apical bud meristematic cells during sh.rt-day （SD）-induced dormancy development was examined by a cerium precipitation EM-cytoch.mical meth.d. Ca2+-ATPase activity, indicated by th. status of cerium ph.sph.te precipitated grains, was localized mainly on th. interior face （cytoplasmic side） of th. PM wh.n plants were grown under long days and reach.d a deep dormancy. A few reaction products were also observed on th. nuclear *** plant buds were developing dormancy after 28 to 42 d of SD exposure, almost no reaction products were present on th. interior face of th. PM. In contrast, a large number of cerium ph.sph.te precipitated grains were distributed on th. exterior face of th. PM. After 70 d of SD exposure, wh.n buds h.d developed a deep dormancy, th. reaction products of Ca2+-ATPase activity again appeared on th. interior face of th. PM. Th. results seemed suggesting th.t two kinds of Ca2+-ATPases may be present on th. PM during th. SD-induced dormancy in *** is th. Ca2+-punlping ATPase, wh.ch.is located on th. interior face of th. PM, for maintaining and restoring th. Ca2+h.meostasis. Th. oth.r migh. be an ecto-Ca2+-ATPase, wh.ch.is located on th. exterior face of th. PM, for th. exocytosis of cell wall materials as suggested by th. fact of th. cell wall th.ckening during th. dormancy developlnent in poplar.

关键词： Ca2+-h.meostasis Ca2+-ATPase ecto-Ca2+-ATPase poplar dormancy populus deltoides

Epidemiology of liver diseases:global disease burden and forecasted research.trends

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Science Ch.na Life Sciences 2024年

作者： Jia Xiao Fei Wang Yuan Yuan Jinh.ng Gao Lu Xiao Ch.o Yan Feifei Guo Jiajun Zh.ng Zh.odi Ch. Wei Li Tian Lan Frank Tacke Vijay h.Sh.h.Cui Li h.a Wang Erdan Dong Division of Gastroenterology and h.patology Mayo Clinic Department of h.alth.Sciences National Natural Science Foundation of China Department of Oncology The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated Diseases Laboratory of Anh.i Province Anhui Medical University Research.Center for Cardiopulmonary Reh.bilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University Sch.ol of Biological Sciences Jinan University Aier Institute of Oph.h.lmology Central South University Lab of Gastroenterology and h.patology West China Hospital Sichuan University Clinical Medicine Research.Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Faculty of Ph.rmaceutical Sciences Toho University Department of h.patology and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed th. global incidence, mortality, and disability-adjusted life years(DALYs) associated with.various liver diseases, including alcoh.l-related liver disease(ALD), h.patitis B/C virus infections(h.V or h.V), liver cancer, metabolic dysfunction-associated steatotic liver disease(MASLD), and oth.r ch.onic liver diseases, from th. 2019 Global Burden of Disease study. Additionally, we analyzed th. global trends in h.patology research.and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and oth.r liver diseases, wh.le th.y decreased for h.V, h.V, and liver cancer. Countries with.a h.gh.socio-demograph.c index(SDI) exh.bited th. lowest mortality rates and DALYs. Th. burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD,along with.h.patobiliary cancer, sh.wed h.gh.st increase in funding in h.patology research. Globally, th. major research.categories in h.patology papers from 2000 to 2019 were cancer, path.biology, and MASLD. Th. United States(U.S.) was at th. forefront of h.patology research. with.Ch.na gradually increasing its influence over time. h.patologists worldwide are increasingly focusing on studying th. communication between th. liver and oth.r organs, wh.le underestimating th. research.on ALD. Cancer, h.V, and MASLD were th. primary diseases targeted for th.rapeutic development in clinical trials. h.wever, th. proportion of new drugs approved for th. treatment of liver diseases was relatively low among all newly approved drugs in th. U.S., Ch.na, Japan, and th. European Union. Notably, th.re were no approved drug for th. treatment of ALD in th. world.

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基础神经心理学及其临床应用

中国组织工程研究与临床康复 2007年第17期11卷 3404-3406,3410页

作者：宋伟石慧方环海刘涛徐州师范大学语言研究所首都医科大学附属北京朝阳医院神经内科北京市100020

目的:通过对脑的功能组织与心理活动(基本原则),脑的局部系统及其功能,心理过程及其脑机构的分析,进一步明确基础神经心理学对临床诊断、治疗及康复的意义。资料来源:通过检索中国期刊全文数据库1994-01/2006-05、荷兰Elsevier公司期刊... 详细信息

目的:通过对脑的功能组织与心理活动(基本原则),脑的局部系统及其功能,心理过程及其脑机构的分析,进一步明确基础神经心理学对临床诊断、治疗及康复的意义。资料来源:通过检索中国期刊全文数据库1994-01/2006-05、荷兰Elsevier公司期刊数据库1984-01/2006-05和美国EBSCOh.st数据库1984-01/2006-05中Academic Source Premier和MEDLINE两个子数据库中的与基础神经心理学及其临床应用相关的文献,检索词为“neuropsych.logy,clinic alapplication”,并限定语言种类为英文,同时手工检索与之内容相关的书籍。资料选择:脑功能组织与功能系统的基本关系及在临床上的应用文章。纳入标准:脑区与功能的联系;排除标准:只谈脑区而无功能联系的文章。资料提炼:纳入30篇符合标准的文献。资料综合:脑是一个复杂的高度集成的神经组织,与它能执行各种复杂的心理活动相辅相成。目前,研究神经心理的脑组织和功能的方法已经多样化,可以更逼真地观察和了解临床上的多种神经心理障碍及其病变机制,为临床治疗康复提供了极大的帮助。结论:各种神经心理学理论和观点正在逼进脑和脑功能的真实联系;在临床上的应用也会更加广泛,又反过来推动神经心理学的发展。

关键词：脑神经心理学综述文献

Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

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Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： Ch. B.Ah. Ji-h.un Lee Joo h.Kim Tae h.Kim h.e-Sook Jun Kuk h.Son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of h.alth.Sciences and Tech.ology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Ph.rmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Th.racic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to th. loss of beta cells in th. islets of *** severe cases,islet transplantation into th. portal vein is ***,due to th. loss of transplanted islets and th. failure of islet function,th. 5-year insulin independence rate of th.se patients ish.s study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with.th. aim of preventing islet *** bioprinted construct was fabricated by th. multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed th.t th. bioprinted constructs proliferated and released insulin normally during th. 4-week in vitro *** MIN-6 generated clusters with.a diameter of 100-200μm,similar to th. original pancreatic islets in th. *** an in vivo study using type 1 diabetes mice,animals implanted with.bioprinted constructs sh.wed th.ee times h.gh.r insulin secretion and controlled glucose levels at 8 weeks after *** th. implanted,bioprinted constructs h.d a positive effect on insulin secretion in th. experimental animals,th. survival rate of th. implanted group(75%)was th.ee times h.gh.r th.n th.t of th. non-implanted group(25%).Th. results suggest th.t th. proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

Identification of th. tuberculous pleurisy by medical-th.racoscopy in 61 refractory patients

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Identification of the tuberculous pleurisy by medical-thorac...