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Ascorbic Acid Attenuates Acute Eth.nol-Induced Liver Injury in Sm.30 Knockout m.ce

Food and Nutrition Sciences 2017年第12期8卷 1114-1126页

作者： Eun-m. Ch. h. m. arif ullah Ah.ed K. Elfadl m.ung-Jin Ch.ng Soong-Koo Kim.Yong Deuk Kim.Eun-Joo Lee Kyu-Sh.k Jeong College of Veterinary m.dicine Kyungpook National University Daegu Republic of Korea

Ascorbic acid (AA) is recognized as a free radical scavenger th.t protects cells from.oxidative stress-induced dam.ge. h.wever, no studies h.ve investigated th. role of AA in acute alcoh.lic liver disease using senescence m.rker protein-30 (Sm.30) knockout (KO) m.ce. Sm.30 is a novel 34-kDa protein involved in AA biosynth.sis. Th. present study aim.d to elucidate th. ph.siological functions of AA in acute eth.nol-induced liver injury using Sm.30 KO m.ce, wh.ch.cannot synth.size AA in vivo. After a 4-week experim.ntal period, m.ce were divided into six groups. Th. following th.ee groups com.rised th. eth.nol treatm.nt groups: WT-E group (wild-type), KV-E group (AA-supplem.nted), and KT-E group (AA-deficient). m.ce were exposed to an acute dose of eth.nol (6 g eth.nol/kg) adm.nistered by gavage once a day for th.ee days. Th. oth.r th.ee control groups, nam.ly, WT-C, KV-C, and KT-C control groups, received an equal volum. of water via oral adm.nistration. Analysis of ch.nges in body weigh. sh.wed th.t m.ce in th. KT-E group h.d significant loss of body weigh. com.ared to th. control, KV-E, and WT-E groups. Beh.vioral analysis revealed th.t alcoh.l exposure significantly increased alcoh.l sensitivity in th. KT-E group, wh.reas th. WT-E, KV-E, and control groups developed eth.nol tolerance. Aspartate transam.nase (AST) levels in th. KT-E group were significantly h.gh.r th.n th.se in th. control, KV-E, and WT-E groups. Th. num.er of large and binucleated h.patocytes was significantly h.gh.r in th. KT-E group th.n in th. KV-E and WT-E groups. In addition, cytoch.om. P450 2E1 (CYP2E1) was over expressed in th. central vein in th. KT-E group wh.n com.ared to th. KV-E and WT-E groups. Our current findings indicate th.t AA supplem.ntation in Sm.30 KO m.ce can alleviate alcoh.l-induced liver dam.ge by down regulating CYP2E1 expression. Th.se results suggest th.t reduced CYP2E1 expression is a novel m.ch.nism.responsible for AA-induced reduction of eth.nol-m.diated oxidative str

关键词： Ascorbic Acid Alcoh.l Liver Sm.30

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h.patic Protective Effects of <i>S</i>-Allyl-L-Cysteine (SAC) in Rats with.Carbon Tetrach.oride (CCl<sub>4</sub>) Induced Liver Injury

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Food and Nutrition Sciences 2020年第12期11卷 1053-1069页

作者： Soo-Nyun Ch.i h. m. arif ullah Il-h.a h.ng Jin-Kyu Park SunYoung Park m.ung-Jin Ch.ng Ji-Yoon Son h.un-h. Yun Jae-h.uk Yim.Seung-Jun Jung h.e-Young Ch.ng Kyu-Sh.k Jeong Departm.nt of Path.logy College of Veterinary Medicine Kyungpook National University Daegu Republic of Korea Stem.Cell Th.rapeutic Research.Institute Kyungpook National University Daegu Republic of Korea Departm.nt of Path.logy College of Veterinary Medicine Gyeongsang National University Jinju Republic of Korea Departm.nt of Ph.rm.cy College of Pharmacy Pusan National University Busan Republic of Korea

S-allyl-L-cysteine (SAC) is an organosulfur com.ound derived from.aged garlic extract (AGE). Studies h.ve reported th.t AGE possesses bioprotective capacity, including antidiabetic, antim.crobial, antioxidant, and ant... 详细信息

S-allyl-L-cysteine (SAC) is an organosulfur compound derived from aged garlic extract (AGE). Studies have reported that AGE possesses bioprotective capacity, including antidiabetic, antimicrobial, antioxidant, and antitumor effects. The present study examined the protective effects of SAC against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Ten male Wistar rats aged 11 - 12 weeks were randomly divided into two groups (five rats/group) as control and SAC groups. All rats had ad libitum access to water, and the SAC group received water containing SAC intragastrically (200 mg/kg) once daily for five consecutive weeks. In the fifth experimental week, 50% CCl4 in olive oil (1 mL/kg) was administered intraperitoneally three times a week to induce liver injury in both groups. Rats were sacrificed at 24 hours after the last CCl4 injection, and liver tissues were excised for h.stopath.logical, im.unoh.stoch.m.cal and antioxidant analyses. Th. rats in th. SAC group did not sh.w abnorm.l beh.vior, such.as decreased water intake or food consum.tio

关键词： S-Allyl-L-Cysteine (SAC) Garlic h.patic Protective Effects Carbon Tetrach.oride Rats h.patic Steatosis Cytoch.om. P4502E1

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Effect of cold-working on corrosion induced dam.ge in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ram.nath.m.N Ch.km.th.L. m.rth. h. Departm.nt of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Departm.nt of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent com.onents in aerospace *** experience corrosion due to environm.ntal conditions,im.roper surface finish.s and rubbing displacem.nt between th. pin and *** causes dam.ge of different sizes and sh.pes near th. *** degradation due to corrosion-induced dam.ge is m.delled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended perform.nce of th. lug joint during th. dam.ges due to corrosion are brough. out and com.ared with.non-cold-worked *** analysis is perform.d on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. m.th.dology can be extended to dam.ge growth.and analyse th. effect of surface treatm.nts for better structural integrity of com.onents of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Unveiling th. Nexus th. link between water quality index and ph.h.lic acid ester concentrations in Tigris River

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Em.rging Contam.nants 2024年第1期10卷 108-116页

作者： Sh.ym.a arif Sh.kur Fikrat m.h.ssan Saad Sabah.Fakh.y Departm.nt of Biology College of Science for WomenUniversity of BaghdadIraq m.nistry of Science and Tech.ology/Food Contam.nation Research.Center Iraq

m.nitoring water quality in an aquatic system.is a crucial objective in pursuing sustainable developm.nt,despite th. ch.llenges posed by water scarcity and th. im.act of clim.te *** objective of th. present study was to exam.ne th. water quality of th. Tigris River along its course from.th. point of entry into Bagh.ad city to its exit,particularly in th. presence of Ph.h.lic Acid Esters(PAEs).In both.dry and wet seasons and from.five sites of th. river,nine environm.ntal factors(Turbidity,Total dissolved solids,ph.dissolved oxygen,Ch.oride,nitrate,ph.sph.te,sulfate,and Biological oxygen dem.nd)and th.ee PAEs(di-n-butyl ph.h.late(DBP),di-isononyl ph.h.late(DiNP),and di-2-eth.l h.xyl ph.h.late(DEh.))were *** revealed th.t th. river h.s h.gh.levels of turbidity and Total dissolved solids,sligh.ly alkaline,and well-aerated(dissolved oxygen>7 m./L).Ch.oride,nitrate,ph.sph.te,and sulfate values varied between seasons,as h.gh.values were recorded in th. wet *** oxygen dem.nd levels were h.gh.r during th. dry *** h.gh.st value of total PAEs(2.20μg/L)was observed during th. dry season,and th. lowest value was in th. wet season(1.16μg/L).Th. h. results revealed th.t th. river was ranked as a m.derate risk *** th. water quality index and environm.ntal risk index classified th. water quality as a poor category,with.a h.gh.risk score in th. study sites with.n Bagh.ad ***,despite th. acceptable lim.t of PAEs in th. river's water(m.to with.raw attention to its environm.ntal *** findings h.gh.igh. th. need for appropriate m.asures to control and rem.ve pollutants to ensure a safe and h.alth. water supply in th. Tigris River.

关键词： Ph.h.lic acid esters di-n-butyl ph.h.late(DBP) di-isononyl ph.h.late(DiNP) di-2-eth.l h.xyl ph.h.late(DEh.) Environm.ntal risk index Tigris River Water pollution

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Inclusion of CoTiO_(3) to am.liorate th. re/deh.drogenation properties of th. m.–Na–Al system

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Journal of m.gnesium.and Alloys 2024年第3期12卷 1215-1226页

作者： N.A.Ali N.Y.Yusnizam.N.A.Sazelee Sam.-ullah Rath.r h.izh.n Liu m.Ism.il Energy Storage Research.Group Faculty of Ocean Engineering TechnologyUniversiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia Departm.nt of Ch.m.cal and m.terials Engineering King Abdulaziz UniversityP.O.Box80204Jeddah 21589Saudi Arabia Guangxi Novel Battery m.terials Research.Center of Engineering Tech.ology School of Physical Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory of Featured m.tal m.terials and Life-Cycle Safety for Com.osite Structures Nanning 530004China

For th. first tim.,th. m.h.(2)–NaAlh.(4)(ratio 4:1)destabilized system.with.CoTiO_(3) addition h.s been *** CoTiO_(3)-doped m.h.(2)–NaAlh.(4) sam.le begins to deh.drogenate at 130℃,wh.ch.is declined by 40℃ com.ared to th. undoped m.h.(2)–NaAlh.(4).m.reover,th. de/reh.drogenation kinetics ch.racteristics of th. CoTiO_(3)-doped m.h.(2)–NaAlh.(4) were greatly *** th. inclusion of CoTiO_(3),th. m.h.(2)–NaAlh.(4) com.osite absorbed 5.2 wt.%h.(2),h.gh.r th.n undoped m.h.(2)–NaAlh.(4).In th. context of deh.drogenation,th. CoTiO_(3)-doped m.h.(2)–NaAlh.(4) sam.le desorbed 2.6 wt.%h.(2),alm.st doubled com.ared to th. am.unt of h.drogen desorbed from.th. undoped m.h.(2)–NaAlh.(4) *** activation energy obtained by th. Kissinger analysis for m.h.(2) decom.osition was significantly lower by 35.9 kJ/m.l th.n th. undoped m.h.(2)–NaAlh.(4) *** reaction m.ch.nism.dem.nstrated th.t new ph.ses of m.Co and AlTi_(3) were generated in situ during th. h.ating process and are likely to play a substantial catalytic function and be useful in am.liorating th. de/reh.drogenation properties of th. destabilized m.h.(2)–NaAlh.(4) system.with.th. inclusion of CoTiO_(3).

关键词： Destabilize system m.gnesium.h.dride Sodium.alanate h.drogen storage Additive.

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h.gh.y selective adsorption of rh.nium.by am.loid-like protein m.terial

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Science Ch.na(Tech.ological Sciences) 2024年第5期67卷 1417-1430页

作者： m.h.m.AD arif YANG Qingm.n KANWAL Aish. Zh.O Jian NAWAZ m.h.an REN h.o YANG Peng Key Laboratory of Applied Surface and Colloid Ch.m.stry Ministry of Education Xi’an Key Laboratory of Polym.ric Soft m.tter International Joint Research Center on Functional Fiber and Soft Smart TextileSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710119China Sch.ol of Ch.m.stry and Ch.m.cal Engineering Northwestern Polytechnical UniversityXi’an710072China

Rh.nium.separation from.m.lybdenum.in m.lybdenite m.nerals and waste leach.te h.s becom. an em.rging *** th.s ch.llenge,we prepared a set of protein-based alkylam.ne/alkylam.onium.salts com.lexes as extractants for selective uptake of rh.nium.from.m.lybdenum.wh.re th. protein com.onent turned into th. insoluble am.loid-like structure wh.n its internal disulfide bonds were reduced,nam.ly ph.se-transition *** th.m.th. ph.se-transited lysozym. and m.th.letrioctyleam.onium.ch.oride com.lex(PTL-N263)exh.bited th. m.st efficient adsorption at th. alkaline condition for th. electrostatic interaction between negatively ch.rged m.tal ions with.positively ch.rged center(R_(4)N^(+))in N263,wh.re negatively ch.rged protein residues h.ndered th. ion exch.nge of Cl^(-)in N263 for larger size m. species(m._(7)O_(24)^(6-))th.n sm.ller size Re species(ReO^(4-)).Th. adsorption follows th. Freundlich.m.del and pseudo-second-order kinetics,wh.ch.exh.bits toplevel adsorption perform.nce with.a m.xim.m.adsorption capacity of 124 m./g and a separation factor(β_(Re/m.))of 2.78×10^(3)for *** adsorption capacity per unit area(57.2 m./(g m.(2)))is 1.6–41 tim.s h.gh.r th.n previously reported adsorbents,and th. cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial *** adsorption strategy can be applied to separating Re from.m. in binary solutions and industrial wastewater with.oth.r com.eting ions.

关键词： am.loid ph.se-transited lysozym. selective adsorption rh.nium waste leach.te solution

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Free vibration and buckling analysis of polym.ric com.osite beam. reinforced by functionally graded bam.oo fbers

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Applied m.th.m.tics and m.ch.nics(English.Edition) 2024年第3期45卷 543-562页

作者： h.m.FEIZABAD m.h.YAS Departm.nt of m.ch.nical Engineering Razi UniversityKermanshah ***Iran

Natural fibers h.ve been extensively research.d as reinforcem.nt m.terials in polym.rs on account of th.ir environm.ntal and econom.c advantages in com.arison with.synth.tic fibers in th. recent *** fibers are renowned for th.ir good m.ch.nical properties,abundance,and sh.rt cycle *** beam. are one of th. fundam.ntal structural com.onents and are susceptible to m.ch.nical loads in engineering applications,th.s paper perform. a study on th. free vibration and buckling responses of bam.oo fiber reinforced com.osite(BFRC)beam. on th. elastic *** different functionally graded(FG)layouts and a uniform.one are th. considered distributions for unidirectional long bam.oo fibers across th. *** elastic properties of th. com.osite are determ.ned with.th. law of *** h.m.lton’s principle,th. governing equations of m.tion are *** generalized differential quadrature m.th.d(GDQm.is th.n applied to th. equations to obtain th. *** ach.eved outcom.s exh.bit th.t th. natural frequency and buckling load values vary as th. fiber volum. fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of th. beam.***,a com.arative study is conducted between th. derived analysis outcom.s for BFRC and h.m.genous polym.r beam. to exam.ne th. effectiveness of bam.oo fibers as reinforcem.nt m.terials,dem.nstrating th. significant enh.ncem.nts in both.vibration and buckling responses,with.th. exception of natural frequencies for cantilever beam. on th. Pasternak foundation with.th. FG-◇fiber ***,th. obtained analysis results of BFRC beam. are also com.ared with.th.se for carbon nanotube reinforced com.osite(CNTRC)beam. found in th. literature,indicating th.t th. buckling loads and natural frequencies of BFRC beam. are lower th.n th.se of CNTRC beam..

关键词： bam.oo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature m.th.d(GDQm.

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Exogenous application of bio-stim.lants and growth.retardants im.rove nutrient absorption and fiber quality in upland cotton

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Journal of Cotton Research 2024年第2期7卷 137-147页

作者： Al-Kh.yri Jam.el m. arif m.h.m.ad Kareem.Sh.dia h.m. Salih.Anwar Adeel Deh.h.nisanij h.ssein Em.m. Som.yeh.Yasm.en Azra Aftab Kom.l Negm.m.h.m.d Departm.nt of Agricultural Biotech.ology College of Agriculture and Food SciencesKing Faisal University31982 Al‑AhsaSaudi Arabia Water Resources Zone Irrigation Department PunjabD.G.KhanPakistan Departm.nt of Biotech.ology and Crop Science College of Agricultural Engineering SciencesUniversity of SulaimaniSulaimaniIraq Departm.nt of Agronom. PMAS-Arid Agriculture UniversityRawalpindiPakistan Agricultural Research Education and Extension OrganizationAgricultural Engineering Research InstituteKarajAlborzIran Departm.nt of Water Engineering University of TabrizTabrizIran Departm.nt of Agronom. Bahauddin Zakariya UniversityMultanPakistan Departm.nt of Plant Breeding and Genetics Bahauddin Zakariya UniversityMultanPakistan Agricultural Research.Center Cotton Research InstituteGiza 12619Egypt

Background Natural and synth.tic plant growth.regulators are essential for plant h.alth.likewise th.se regulators also play a role in increasing organic production productivity and im.roving quality and yield *** th. present study,we h.ve evaluated th. effects of foliar applied plant growth.regulators,i.e.,m.ringa leaf extract(m.E)and m.piquat ch.oride(m.)alone and in com.ination m. and m.E on th. conventional cotton cultivar(CIm.573)and transgenic one(CIm.598).Th. growth.regulators were applied at th. start of bloom.45 and 90 days after *** Th. application of m. and m.E at 90 days after bloom.ng significantly im.roved th. relative growth.rate,net assim.lation rate,th. num.er of bolls per plant,and seed cotton ***,th. com.ined application of m.E and m. at 90 days after bloom.ng significantly boosted th. nitrogen uptake in locules,as well as th. ph.sph.rus and potassium.uptake in th. leaves of both.cotton *** application of m.E alone h.s considerably im.roved th. nitrogen uptake in leaves,and ph.sph.rus and potassium.contents in locules of Bt and conventional cotton ***,Bt cotton treated with.m.E at 90 days after bloom.ng produced significantly h.gh.r ginning out turn and oil *** in com.ination(m.E+m.)at 90 days after bloom.ng produced considerably h.gh.r m.cronaire value,fiber strength.and staple length.in conventional *** Th. natural growth.enh.ncer,m.E is a rich.source of m.nerals and zeatin,im.roving th. nutrient absorption and quality of cotton fiber in both.conventional and Bt cotton cultivars.

关键词： Bio-stim.lant Cotton Fiber quality m.piquat ch.oride m.ringa leaf extract Potassium.accum.lation Oil contents

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Effects of arbuscular m.corrh.zal fungi on carbon assim.lation and ecological stoich.om.try of m.ize under com.ined abiotic stresses

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Journal of Plant Ecology 2024年第2期17卷 74-88页

作者： Qiong Ran Songlin Zh.ng m.h.m.ad arif Xueting Yin Sh.nsh.n Ch.n Guangqian Ren Sch.ol of m.nagem.nt Chongqing University of TechnologyChongqing 400054China Key Laboratory of Reservoir Aquatic Environm.nt Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Key Laboratory of Eco-environm.nts in Th.ee Gorges Reservoir Region(m.nistry of Education) State Cultivation Base of Eco-agriculture for Southwest Mountainous LandSchool of Life SciencesSouthwest UniversityChongqing 400715China Institute of Environm.nt and Ecology Academy of Environmental Health and Ecological SecuritySchool of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China

Arbuscular m.corrh.zal fungi(Am.)enh.nce plant tolerance to abiotic stresses like salinity and im.rove crop ***,th.ir effects are variable,and th. underlying cause of such.variation rem.ins largely *** study aim.d to assess h.w drough. m.difed th. effect of Am. on plant resistance to h.gh.calcium.saline stress.A pot experim.nt was perform.d to exam.ne h.w Am. inoculation affects th. growth.ph.tosynth.tic activity,nutrient uptake and carbon(C),nitrogen(N)and ph.sph.rus(P)stoich.om.tric ratio(C:N:P)of m.ize under h.gh.calcium.stress and contrasting water *** results sh.wed th.t h.gh.calcium.stress signifcantly reduced m.corrh.zal colonization,biom.ss accum.lation,C assim.lation rate and C:N stoich.om.tric ratio in plant ***,th. adverse effects of calcium.stress on ph.tosynth.sis were exacerbated under *** inoculation profoundly alleviated such.reductions under drough. and saline ***,it barely affected m.ize perform.nce wh.n subjected to calcium.stress under well-watered ***,watering ch.nged Am. im.act on nutrient allocation in plant *** well-watered conditions,Am. stim.lated P accum.lation in roots and plant growth.but did not induce leaf P accum.lation proportional to C and N,resulting in increased leaf C:P and N:P ratios under h.gh.calcium.*** contrast,Am. decreased N content and th. N:P ratio in leaves under ***,Am. inoculation im.roved m.ize resistance to calcium.salt stress th.ough.enh.nced ph.tosynth.sis and m.dulation of nutrient stoich.om.try,particularly under water defcit *** results h.gh.igh.ed th. regulatory role of Am. in carbon assim.lation and nutrient h.m.ostasis under com.ound stresses,and provide signifcant guidance on th. im.rovem.nt of crop yield in saline and arid regions.

关键词： arbuscular m.corrh.zal fungi com.ound abiotic stresses C:N:P stoich.om.try induced system.c resistance calcium.salt stress

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Ironing out biofortification in m.ize: NAC78 regulates iron concentrations in kernels

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m.lecular Plant 2024年第2期17卷 223-223页

作者： m.arif Ash.af Ah.et Bakirbas Departm.nt of Biology Howard UniversityWashingtonDC 20059USA Departm.nt of Biology University of Massachusetts AmherstAmherstMA 01003USA

Biofortification of staple crops th.ough.genetic m.dification is a sustainable way to overcom. nutrient deficiencies worldwide,especially in low-incom. developing *** is one of th. m.st im.ortant m.nerals required for th. h.m.n body and participates in crucial ph.siological processes including oxygen transport,electron transport for energy production,and so *** th.re are som. reports of genetically engineered crops with.increased iron content,such.as rice,wh.at,and cassava,iron biofortification of m.ize h.s been ch.llenging due to th. trade-off between kernel iron concentration and m.ize yield(Long et al.,2004).In a recent article publish.d in Science,research.rs used m.lecular-m.rker-assisted selection to elim.nate th.s trade-off and developed m.ize varieties with.increased iron concentration in kernels with.ut com.rom.sing yield(Yan et al.,2023).

关键词： crops kernels m.ize

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