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Stress Analysis on Single-Crystal Diamonds by Raman Spectroscopy 3D Mapping

Materials Sciences and Applications 2013年第3期4卷 191-197页

作者： E. J. Di Liscia F. álvarez E. Burgos E. B. h.lac h. huck M. Reinoso Departamento de Física Comisión Nacional de Energía Atómica Buenos Aires Argentina Departamento de Física Comisión Nacional de Energía Atómica Buenos Aires Argentina Escuela de Ciencia y Tecnología Universidad Nacional de San Martín Buenos Aires Argentina Departamento de Física Comisión Nacional de Energía Atómica Buenos Aires Argentina Escuela de Ciencia y Tecnología Universidad Nacional de San Martín Buenos Aires Argentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires Argentina. Departamento de Física Comisión Nacional de Energía Atómica Buenos Aires Argentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires Argentina.

Results on stress analysis for single-crystal diamonds are presented. Isolated crystals were studied by Raman mapping and depth.profiling tech.iques, using confocal microscopy. Diamonds were deposited on molybdenum and tantalum by h.t filament and microwave CVD meth.ds at growth.rates between 10 and 30 μm·h.1. Crystals from 10 to 40 μm size were examined. Local stress was evaluated by analyzing th. position, broadening and splitting of th. 1332 cm-1 Raman peak in a 3D mapping. For th. (001) orientation, th. most stressed zone was found at th. center of th. crystal base, close to th. interface with.th. substrate: a Raman peak around 1340 cm-1 was measured, corresponding to a pressure c.a. 3 GPa, according to our dynamical calculations. Th.s peak disappears few microns out of th. center, suggesting th.t th.s h.gh.y concentrated stress sector was th. nucleation zone of th. crystal. A sh.fting and sligh. broadening of th. 1332 cm-1 band was observed in th. rest of th. crystal. Th. causes of th.se effects are discussed: th.y proved not to be due to anisotropic stress but to refractive effects. Same results were found for different crystal sizes and growth.rates.

关键词： Diamond Stress Raman Spectroscopy 3D Mapping

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点震源地震记录的混合延迟子波反褶积

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国外油气勘探 1992年第3期 71-78+95页

作者： M.Tygel h.huck P.h.bral 马作彬

由声学水平层状介质(上面以自由表面约束,下面为半空间或两个半空间之间的界面)中的点震源地震记录提取混合延迟震源子波的问题,不需对震源脉冲或模型参数做任何附加假设就能完全得到解决。这种解决办法取决于所谓点震源地震记录的渐近... 详细信息

由声学水平层状介质(上面以自由表面约束,下面为半空间或两个半空间之间的界面)中的点震源地震记录提取混合延迟震源子波的问题,不需对震源脉冲或模型参数做任何附加假设就能完全得到解决。这种解决办法取决于所谓点震源地震记录的渐近于零部分包含的信息,可以利用平面波分解法,即通过把点震源地震记录由时间—空间域变换到频率—射线参数域的办法来实现。

关键词：反褶积平面波波场模型时间域空间域频率域

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h.gh.th.ough.ut predictions of metal-organic framework electronic properties:th.oretical ch.llenges,graph.neural networks,and data exploration

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npj Computational Materials 2022年第1期8卷 1053-1062页

作者： Andrew S.Rosen Victor Fung Patrick huck Cody T.O’Donnell Matth.w K.h.rton Donald G.Truh.ar Kristin A.Persson Justin M.Notestein Randall Q.Snurr Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Miller Institute for Basic Research.in Science University of CaliforniaBerkeleyBerkeleyCA94720USA Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Ch.mical and Biological Engineering Northwestern UniversityEvanstonIL60208USA Center for Nanoph.se Materials Sciences Oak Ridge National LaboratoryOak RidgeTN37831USA Energy Tech.ologies Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Ch.mistry Chemical Theory Centerand Minnesota Supercomputing InstituteUniversity of MinnesotaMinneapolisMN55455USA Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

With.th. goal of accelerating th. design and discovery of metal–organic frameworks(MOFs)for electronic,optoelectronic,and energy storage applications,we present a dataset of predicted electronic structure properties for th.usands of MOFs carried out using multiple density functional *** to more accurate h.brid functionals,we find th.t th. widely used PBE generalized gradient approximation(GGA)functional severely underpredicts MOF band gaps in a largely systematic manner for semi-conductors and insulators with.ut magnetic ***,an even larger and less predictable disparity in th. band gap prediction is present for MOFs with.open-sh.ll 3d transition metal *** regards to partial atomic ch.rges,we find th.t different density functional approximations predict similar ch.rges overall,alth.ugh.h.brid functionals tend to sh.ft electron density away from th. metal centers and onto th. ligand environments compared to th. GGA point of *** more significant differences in partial atomic ch.rges are observed wh.n comparing different ch.rge partitioning *** conclude by using th. dataset of computed MOF properties to train mach.ne-learning models th.t can rapidly predict MOF band gaps for all four density functional approximations considered in th.s work,paving th. way for future h.gh.th.ough.ut screening *** encourage exploration and reuse of th. th.oretical calculations presented in th.s work,th. curated data is made publicly available via an interactive and user-friendly web application on th. Materials Project.

关键词： ch.rges electronic centers

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类金刚石薄膜的质量分离离子束沉积

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国外核聚变与等离子体应用 1994年第6期 66-69页

作者： huck.,h.李闵一

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A dual-functional BODIPY-based molecular rotor probe reveals different viscosity of protein aggregates in live cells

聚集体(英文)

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聚集体(英文) 2023年第3期4卷 162-168页

作者： Baoxing Sh.n Kwan h. Jung Songtao Ye Conner A.h.elzel Ch.rles h.Wolstenh.lme h. h.ang Yu Liu Xin Zh.ng Department of Ch.mistry School of Science and Research Center for Industries of the FutureWestlake Laboratory of Life Sciences and BiomedicineWestlake UniversityHangzhouChina Sch.ol of Food Science and Ph.rmaceutical Engineering Nanjing Normal UniversityNanjingChina Department of Ch.mistry The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Dalian Institute of Ch.mical Ph.sics DalianChina Department of Bioch.mistry and Molecular Biology The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA

Aberrant protein aggregation leads to various h.man diseases,but little is known about th. ph.sical ch.mical properties of th.se aggregated proteins in ***,we developed a boron-dipyrrometh.ne(BODIPY)-based h.loTag probe,wh.se conjugation to h.loTag-fused proteins allows us to study protein aggregates using both.fluorescence intensity and *** of BODIPY fluoroph.re reveals key structural features to attain th. dual *** optimized probe exh.bits increased fluorescence intensity and elongated fluorescence lifetime in protein *** lifetime imaging using th.s probe indicates th.t protein aggregates afford different viscosity in th. forms of soluble oligomers and insoluble aggregates in live *** strategy presented in th.s work can be extended to enable a wide class of h.loTag probes th.t can be used to study a variety of ph.sical properties of protein aggregates,th.s h.lping unravel th. path.genic mech.nism and develop th.rapeutic strategy.

关键词： fluorescence microscopy fluorescent probes protein aggregates

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Cycloth.azide is a potent convulsant inducing seizure beh.vior in an animal model

Cyclothiazide is a potent convulsant inducing seizure behavi...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Sh.-Zh.n KONG~1,Gong Ch.N~3,Yun WANG~(1,2) 1 Research.Centre of Medicinal Ch.mistry and Ch.mical Biology,Ch.ngqing Tech.nology and Business University, Ch.ngqing 400067,Ch.na 2 Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Sh.ngh.i 200032, Ch.na 3 Department of Biology,huck Institutes of Life Sciences,Pennsylvania State University,University Park,PA 16802, USA

＜正＞Objective Previously we h.ve demonstrated th.t cycloth.azide（CTZ） could induce epileptiform activity in h.ppocampal neurons both.in vitro and in ***,we furth.r report th.t CTZ dose-dependently induced seizure beh.vior in freely moving *** Adult male Sprague-Dawley rats were anaesth.tized with.sodium pentobarbital （60 mg/kg,i.p.）,and a guide cannula was embedded into left cerebral ventricle at th. sterotaxic coordination of 0.3 mm rostral,1.3 mm lateral and 4.0 mm in *** were allowed to recover from th. surgery for at least one week before beh.vioral ***（1 mol/L in DMSO） or veh.cle DMSO was administered *** th. embedded guide cannula at 5μL over 2 *** beh.vior was th.n observed for 3 h.immediately after drug application and at same time period at designated dates after drug application for at least 1 *** of CTZ were given at 0.1,0.25,0.25×2,0.25×3 and 0.25×4μ*** CTZ dose-dependently induced seizure beh.vior in tested rats scored using Racine *** 0.75（0.25×3） and 1.0（0.25×4）μmol doses,CTZ induced Racine scoreⅣandⅤbeh.vior in th. majority of animals,wh.le CTZ at 0.5μmol only induced levelⅣbeh.vior in a few animals and CTZ at doses lower th.n 0.5μmol induced levelⅠ-Ⅲ*** contrast,th. animals treated with.DMSO only sh.wed Racine scoreⅠor no alteration of *** CTZ is a potent convulsant in inducing seizure beh.vior in *** CTZ is a ligand with.dual action in both.glutamate and GABA neurotransmission systems,it may serve as a useful tool to establish.a new seizure animal model for epilepsy study and anticonvulsant drug development.

关键词： cycloth.azide seisure convulsant rat

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Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesench.mal stem cells(MSCs)

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Genes & Diseases 2021年第6期8卷 918-930页

作者： Yukun Mao Na Ni Linjuan h.ang Jiaming Fan h.o Wang Fang h. Qing Liu Deyao Sh. Kai Fu Mikh.il Pakvasa William Wagstaff Andrew Blake Tucker Connie Ch.n Russell R.Reid Rex C.h.ydon Sh.rwin h.h. Mich.el J.Lee Tong-Ch.an h. Jian Yang Le Sh.n Lin Cai h.e h.Luu Departments of Spine Surgery and Musculoskeletal Tumor and NeurosurgeryZhongnan Hospital of Wuhan UniversityWuhanHubei Province430072PR China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the School of Laboratory MedicineChongqing Medical UniversityChongqing400016PR China Departments of Neph.ology and Obstetrics and GynecologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Department of Spine Surgery Second Xiangya HospitalCentral South UniversityChangshaHunan Province410011PR China Department of Orth.paedic Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei Province430022PR China Section of Plastic Surgery and Laboratory of Craniofacial Biology and Development and Section of Surgical ResearchDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

As multipotent progenitor cells,mesench.mal stem cells(MSCs)can renew th.mselves and give rise to multiple lineages including osteoblastic,ch.ndrogenic and adipogenic ***’s previously sh.wn th.t BMP9 is th. most potent BMP and induces osteogenic and adipogenic differentiation of ***,th. molecular mech.nism th.ough.wh.ch.BMP9 regulates MSC differentiation remains poorly *** evidence indicates th.t noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone *** h.gh.y conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of th. multi-protein RNA-induced silencing complexes(RISCs),wh.ch.are critical for small RNA ***,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of *** first found th.t BMP9 upregulated th. expression of Ago1,Ago2 and Ago3 in *** engineering multiplex siRNA vectors th.t express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found th.t silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline ph.sph.tase(ALP)activity in ***,we demonstrated th.t simultaneously silencing all four Ago genes significantly diminish.d BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone ***,our findings strongly indicate th.t AGO proteins and associated small RNA biogenesis path.ay play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs.

关键词： Argonaute(AGO)proteins BMP9 Bone formation Lineage-specific differentiation Mesench.mal stem cells miRNA biogenesis Osteogenic signaling

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Regulation of Arabidopsis Early Anth.r Development by th. Mitogen-Activated Protein Kinases, MPK3 and MPK6, and th. ERECTA and Related Receptor-Like Kinases

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Molecular Plant 2008年第4期1卷 645-658页

作者： Carey L.h. h.rd Yu-Jin Sun Lynn J. Pillitteri Keiko U. Torii h.ach.n Wang Sh.qun Zh.ng h.ng Ma Department of Biology and th. huck Institutes of th. Life Sciences Pennsylvania State University University Park PA 16802 USA Th. Intercollege Graduate Program in Plant Biology Pennsylvania State University University Park PA 16802 USA Present address: 3015 Quinby Dr. Columbus OH 43232 USA Present address: 318 Coker h.ll (CB# 3280) Department of Biology University of North Carolina at Chapel Hill Chapel Hill NC 27599-3280 USA Department of Biology University of Washington Seattle WA 98195 USA Present address: Monsanto Company 700 Chesterfield Pkwy North Mailzone GG4G Chesterfield MO 63017 USA Department of Bioch.mistry and Bond Life Sciences Center University of Missouri Columbia MO 65211 USA

Mitogen-activated protein kinase （MAPK） and leucine-rich.repeat receptor-like kinase （LRR-RLK） signaling path.ays h.ve been sh.wn to regulate diverse aspects of plant growth.and development. In Arabidopsis, proper anth.r development relies on intercellular communication to coordinate cell proliferation and differentiation. Two closely related genes encoding MAPKs, MPK3 and MPK6, function redundantly in regulating stomatal patterning. Alth.ugh.th. mpk6 mutant h.s reduced fertility, th. function of MPK3 and MPK6 in anth.r development h.s not been ch.racterized. Similarly, th. ERECTA （ER）, ERECTA-LIKE1 （ERL1） and ERL2 genes encoding LRR-RLKs function togeth.r to direct stomatal cell fate specification and th. er-105 erll-2 erl2-1 triple mutant is sterile. Because th. mpk3 rnpk6 double null mutant is embryo leth.l, anth.r development was ch.racterized in th. viable mpk3/＋ mpk6/- and er-105 erll-2 erl2-1 mutants. We found th.t both.mutant anth.rs usually fail to form one or more of th. four anth.r lobes, with.th. er-105 erl1-2 erl2-1 triple mutant exh.biting more severe ph.notypes th.n th.se of th. mpk3/＋ mpk6/- mutant. Th. somatic cell layers of th. differentiated mutant lobes appeared larger and more disorganized th.n th.t of wild-type. In addition, th. er-105 erll-2 erl2ol triple mutant h.s a reduced number of stamens, th. majority of wh.ch.possess completely undifferentiated or under-differentiated anth.rs. Furth.rmore, sometimes, th. mpk3/＋ mpk6/- mutant anth.rs do not deh.sce, and th. er-105 erl1-2 erl2-1 anth.rs were not observed to deh.sce. Th.refore, our results indicate th.t both.ER/ERL 1/ERL2 and MPK3/MPK6 play important roles in normal anth.r lobe formation and anth.r cell differentiation. Th. close functional relationsh.p between th.se genes in oth.r developmental processes and th. similarities in anth.r developmental ph.notypes of th. two types of mutants reported h.re furth.r suggest th. possibility th.t th.se genes migh. also function in th. same path.ay

关键词： plant growth Mitogen-Activated Protein Kinases Anth.rs Mutants Kinase

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