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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectab.e Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.b.tors Plus Anti-PD-1 Antib.dy Th.rapy

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Ultrasound in Medicine and b.ology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu Y.-Y. Zh.u b.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Lab.ratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Ob.ective: Th. aim of th. work describ.d h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectab.e advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.b.tors (TKIs) plus anti-programmed cell death.protein-1 (PD-1) antib.dy th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received comb.ned TKI/anti-PD-1 antib.dy treatment for unresectab.e h.C b.tween January 2022 and Octob.r 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations b.fore treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; b.rcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences b.tween CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement b.tween RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance b.tween mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to b. superior to b.seline US and is comparab.e to CEMRI/CT in defining treatment outcome for comb.ned TKI/anti-PD-1 antib.dy th.rapy. © 2023 World Federation for Ultrasound in Medicine & b.ology

关键词： Anti-angiogenic th.rapy Anti-PD-1 antib.dy Contrast-enh.nced ultrasound h.patocellular carcinoma

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Integrated Voice/Data on a Centralized Switch.Node Arch.tecture for LAN with.Free Round Rob.n Service Strategy

Integrated Voice/Data on a Centralized Switch Node Architect...

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计算机，通信，控制与电力工程国际会议

作者： Eh.b.A. Kh.lil M. Kh.lid h. b. kekre Dept. of Computer Science and Engineering Indian Institute of Tech.ology Bombay 4000 076INDIA

Th. integration of voice and data traffics in our proposed centralized switch.node arch.tecture is considered. Specifically,th. unfairness of th. Free Round Rob.n(FRR) sch.duling strategy towards low priority traffic types is demonstrated b. a comparison with.a restricted b.ndwidth.strategy called Reserved Round Rob.n(RRR).Th. simulation results sh.w th.t under h.avy load conditions,RRR provides a more b.lanced sch.duling of traffic types th.n th. FRR,with.only a moderate increase in th. delay times of h.gh.r priority traffic types.

关键词： Integrated Voice/Data on a Centralized Switch.Node Arch.tecture for LAN with.Free Round Rob.n Service Strategy LAN Service

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An update on h.rmonal regulation of early emb.yo-fallopian tub. interactions: insigh.s for improvements of assisted reproductive tech.ology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodith.wakku Suranga P. Ng Ernest h. Y. Yeung William S. b. Lee Kai-Fai Department of Ob.tetrics and Gynaecology LKS Faculty of Medicine 3. Th. University of h.ng Kong 4. h.ng Kong SAR 999077 5. Ch.na

h.man fallopian tub.s (FTs) play important roles in th. wh.le reproductive process. FTs are th. site for th. final maturation of gametes, fertilization, transport of preimplantation emb.yos, and early emb.yonic development b.fore entering th. uterus. All th.se functions are critical in th. estab.ish.ent of a successful pregnancy. Wh.n th. emb.yo is in transit th.ough.th. FT, th. FT microenvironment ch.nges th.ough.endocrine, paracrine, autocrine, and juxtacrine mech.nisms wh.ch.involve various h.rmones and b.oactive sub.tances mainly from th. neigh.oring cells. Th.refore, th. interactions b.tween th. emb.yo and th. FT may b. th. earliest emb.yo-maternal communications th.t are essential for th. estab.ish.ent of pregnancy. Th.s review critically discusses th. evidence of various h.rmonal and b.oactive mediated control of th. microenvironment in th. FTs during th. earliest emb.yo-maternal communications. Moreover, we h.gh.igh. existing gaps in th. knowledge and th. importance of exploring more of th. ph.siology of FTs wh.ch.will h.ld th. key to producing h.gh.quality emb.yos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tub. Emb.yo Maternal-emb.yo communication h.rmonal control

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Comparison among th. UECM Model, and th. Composite Model in Forecasting Malaysian Imports

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Open Journal of Statistics 2024年第2期14卷 163-178页

作者： Moh.med A. h. Milad h.nan Moh. b. Duzan Lib.an Auth.rity and Science Research Tripoli Libya Th. h.gh.r Institute of Science and Tech.ology-Souq Algoma Tripoli Libya

For more th.n a century, forecasting models h.ve b.en crucial in a variety of fields. Models can offer th. most accurate forecasting outcomes if error terms are normally distrib.ted. Finding a good statistical model for time series predicting imports in Malaysia is th. main target of th.s study. Th. decision made during th.s study mostly addresses th. unrestricted error correction model (UECM), and composite model (Comb.ned regression—ARIMA). Th. imports of Malaysia from th. first quarter of 1991 to th. th.rd quarter of 2022 are employed in th.s study’s quarterly time series data. Th. forecasting outcomes of th. current study demonstrated th.t th. composite model offered more prob.b.listic data, wh.ch.improved forecasting th. volume of Malaysia’s imports. Th. composite model, and th. UECM model in th.s study are linear models b.sed on responses to Malaysia’s imports. Future studies migh. compare th. performance of linear and nonlinear models in forecasting.

关键词： Composite Model UECM ARIMA Forecasting Malaysia

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Ch.rles h.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identification of a neurodevelopmental disorder with.cereb.llar atroph. and motor dysfunction(NEDCAM)h.s resulted in an increased interest in GEMIN5,a multifunction RNA-b.nding *** th. largest memb.r of th. survival motor neuron complex,GEMIN5 plays a key role in th. b.ogenesis of small nuclear rib.nucleoproteins wh.le also exh.b.ting translational regulatory functions as an independent *** many questions remain regarding b.th.th. path.genesis and path.ph.siology of th.s new disorder,considerab.e progress h.s b.en made in th. b.ief time since its *** th.s review,we examine GEMIN5 with.n th. context of NEDCAM,focusing on th. structure,function,and expression of th. protein specifically in regard to th. disorder ***,we explore th. current animal models of NEDCAM,as well as potential molecular path.ays for treatment and future directions of *** review provides a compreh.nsive overview of recent advances in our understanding of th.s unique memb.r of th. survival motor neuron complex.

关键词： cereb.llar atroph. GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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b.ockade of Rh.-associated kinase prevents inh.b.tion of axon regeneration of periph.ral nerves induced b. anti-ganglioside antib.dies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés b.rardo Cristian R.b.caglio b.rb.ra b.b.ez Rub.n Samb.elli Kazim A.Sh.ikh.Pab.o h.h.Lopez Lab.ratorio de Neurob.ología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química b.ológica-Centro de Investigaciones en Química b.ológica de Córdob.(CIQUIb.C)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antib.dies are associated with.delayed/poor clinical recovery in Guillain-b.rrèsyndrome,mostly related to h.lted axon ***-linking of cell surface gangliosides b. anti-ganglioside antib.dies triggers inh.b.tion of nerve repair in in vitro and in vivo paradigms of axon *** effects involve th. activation of th. small GTPase Rh. A/ROCK signaling path.ays,wh.ch.negatively modulate growth.cone cytoskeleton,similarly to well stab.ish.d inh.b.tors of axon regeneration describ.d so *** aim of th.s work was to perform a proof of concept study to demonstrate th. effectiveness of Y-27632,a selective ph.rmacological inh.b.tor of ROCK,in a mouse model of axon regeneration of periph.ral nerves,wh.re th. passive immunization with.a monoclonal antib.dy targeting gangliosides GD1a and GT1b.was previously reported to exert a potent inh.b.tory effect on regeneration of b.th.myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to th. pro-regenerative effect of *** with.a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b.monoclonal antib.dy-mediated inh.b.tion of axon regeneration of unmyelinated fib.rs to skin and th. functional recovery of mech.nical cutaneous *** contrast,th. same dose sh.wed toxic effects on th. regeneration of myelinated ***,scale down of th. dosage of Y-27632 to 5 mg/kg resulted in a significant alth.ugh.not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b.monoclonal antib.dy in th. ab.ence of toxicity in animals exposed to only ***,th.se findings confirm th. in vivo participation of Rh. A/ROCK signaling path.ays in th. molecular mech.nisms associated with.th. inh.b.tion of axon regeneration induced b. anti-GD1a/GT1b.monoclonal *** findings open th. possib.lity of th.rapeutic ph.rmacological intervention targeting Rh. A/R

关键词： anti-ganglioside antib.dies anti-glycan antib.dies axon regeneration ganglioside Guillain-b.rrésyndrome nerve repair ROCK Y-27632

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Exploring Variab.lity in Sea Level at a Tide Gauge Station th.ough.Control Ch.rts

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Journal of Environmental & Earth.Sciences 2024年第1期6卷 11-18页

作者： h.b.kiİz Independent Sch.lar Boca Raton Florida33496USA

Monitoring temporal ch.nges in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such.as trend,acceleration,periodic oscillations,and random *** th.m,th. non-stationary nature of th. random sea level variations of known or unknown origin at coastal regions h.s b.en long recognized b. th. sea level *** study proposes th. analyses of sub.roups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-b.r and S control *** approach.is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long sub.roups of th. residuals revealed th.t sea level ch.nges at th.s location h.ve b.en progressively intensifying from 1913 to th. *** oscillations in sea level at th.s locality may b. attrib.ted partly to th. th.rmal expansion of seawater with.increasing temperatures causing larger b.oyancy-related sea level fluctuations as well as th. intensification of atmosph.ric events including wind patterns and th. impact of ch.nges in inverted b.rometer effects th.t will alter coastal risk assessments for th. future.

关键词： Climate ch.nge Sea level variance X-b.r S control ch.rts

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Multiple scales meth.d for analyzing a forced damped rotational pendulum oscillatorwith.allows

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Communications in Th.oretical Ph.sics 2024年第5期76卷 58-67页

作者： h.ifa A Alyousef Alvaro h.Salas b.M Alotaib. S A El-Tantawy Department of Ph.sics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Math.matics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Ph.sics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research.Center for Ph.sics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

Th.s study reports th. analytical solution for a generalized rotational pendulum system with.gallows and periodic excited *** multiple scales meth.d(MSM)is applied to solve th. proposed *** types of rotational pendulum oscillators are studied and talked ab.ut in *** include th. forced damped rotating pendulum oscillator with.gallows,th. damped standard simple pendulum oscillator,and th. damped rotating pendulum oscillator with.ut *** MSM first-order approximations for all th. cases mentioned are derived in *** ob.ained results are illustrated with.concrete numerical *** first-order MSM approximations are compared to th. fourth.order Runge-Kutta(RK4)numerical ***,th. maximum error is estimated for th. first-order approximations ob.ained th.ough.th. MSM,compared to th. numerical approximations ob.ained b. th. RK4 ***,we conducted a comparative analysis of th. outcomes ob.ained b. th. used meth.d(MSM)and h.-MSM to ascertain th.ir respective levels of *** proposed meth.d can b. applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales meth.d approximate solution damped oscillations forced pendulum with.gallows h.-multiple scales meth.d

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Pelleting and particle size reduction of corn increase net energy and digestib.lity of fib.r,protein,and fat in corn-soyb.an meal diets fed to group-h.used pigs

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Journal of Animal Science and b.otech.ology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.Rodriguez Ch.d b.Paulk h.ns h.Stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

b.ckground Reduction of th. particle size of corn increases energy digestib.lity and concentrations of digestib.e and metab.lizab.e *** may also reduce particle size of grain,b.t it is not known if th.re are interactions b.tween particle size reduction and *** ob.ective of th.s experiment was to test th. h.poth.sis th.t particle size reduction and pelleting,separately or in comb.nation,increase N b.lance,apparent total tract digestib.lity(ATTD)of fib.r and fat,and net energy(NE)in corn-soyb.an meal diets fed to group-h.used *** Six corn-soyb.an meal-b.sed diets were used in a 3×2 factorial design with.3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad lib.tum access to feed and ***-four castrated male pigs(initial weigh.:29.52 kg;standard diviation:1.40)were allotted to th. 6 diets using a 6×6 Latin square design with.6 calorimeter ch.mb.rs(i.e.,4 pigs/ch.mb.r)and 6 *** consumption and CO_(2)and Ch.(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,th. ATTD of gross energy(GE),N,and acid-h.drolyzed eth.r extract(AEE),and th. concentration of NE were greater(Ph.n in meal *** of diet form,th. ATTD of GE,N,and AEE,and th. concentration of NE were increased(linear;Pb. reducing th. particle size of corn,b.t th. increase was greater in meal diets th.n in pelleted diets(interaction;Pb.th.pelleting and reduction of corn particle size increased nutrient digestib.lity and NE,b.t increases were greater in meal diets th.n in pelleted diets.

关键词： Corn Digestib.lity Feed tech.ology Net energy Particle size Pelleting

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Synch.onized off-h.rmonic prob. laser with.h.gh.y variab.e pulse duration for laser-plasma interaction experiments

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h.gh.Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.h.rnung Y.Zob.s h.Lorenté C.b.ab.tz b.Zielb.uer V.b.gnoud GSI h.lmh.ltzzentrum für Sch.erionenforsch.ng Gmb. DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Ph.sik Technische Universität DarmstadtDarmstadtGermany

Th.s paper presents th. development and experimental utilization of a synch.onized off-h.rmonic laser system designed as a prob. for ultra-intense laser±plasma interaction experiments. Th. system exh.b.ts a novel seed-generation design,allowing for a variab.e pulse duration spanning over more th.n th.ee orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. Th.s makes it suitab.e for various plasma diagnostics and visualization tech.iques. In a side-view configuration, th. laser was employed for interferometry and streaked sh.dowgraph. of a laser-induced plasma wh.le successfully suppressing th. self-emission b.ckground of th. laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for th.s setup. Th.se properties enab.e th. prob. to yield valuab.e insigh.s into th. plasma dynamics and interactions at th. Ph.LIX facility and to b. deployed at various laser facilities due to its easy-to-implement design.

关键词： interferometry laser-plasma interaction off-h.rmonic prob. laser streaked sh.dowgraph.

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