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Correlation between Thermal Expansion and Magnetic Characteristics of Fe-Ni Alloys in Fe_(1-x)Ni_x/Cu Superlattices

International Journal of Minerals,Metallurgy and Materials 1998年第3期12卷 169-174页

作者： Weizhong Tang h zabel(Matrial Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Institute of Experimental Physics/Solid State Physics, Ruhr University Bochum, 44780 Bochum, Germany) Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Institute of Experimental Physics/Solid State Physics Ruhr University Bochum 44780 Bochum Germany

Thermal expansion behaviors of FeNi alloys were investigated by means of X-ray diffraction technique within a Fe1 -xNix/Cu superiattice structure. It was found that with a Ni concentration of x = 0.35, FeNi alloy layers showed the well-known Invar behavior, but for alloy layers with either lower or higher Ni concentrations, thermal expansion coefficients were larger. Based on results of magnetic measurements it is concluded that FeNi alloy layers with Ni concentrations lower than the Invar composition are in a superparamagnetic state which leads not only to low spontaneous magnetizations but also to large thermal expansions of the alloy layers.

关键词： thermal expansion Invar behavior FeNi alloys superlattice magnetism

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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon ho Bae Ji hyeon Kang Mingyu Lee Brian A.zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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胃内折叠缝合术的预后预测指标

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 59-60页

作者： Schiefke I. Soeder h. zabel-Langhennig A. 王志宇 Dept. of Internal Medicine II University of Leipzig Leipzig Germany

Background: Endoluminal gastroplication (EndoCinch) has emerged as an endoscopic anti-reflux therapy, but predictive factors for symptom relief have not been established. The aim of this study was to evaluate the major determinants to predict outcome in patients treated with EndoCinch. Methods: A total of 53 consecutive patients, treated with EndoCinch at a single center were included in this prospective study. Inclusion criteria were symptoms of chronic heartburn, dependency on proton-pump inhibitors, documented pathological esophageal acid exposure, and a hiatal hernia smaller than 3 cm in length. All patients underwent endoscopy, 24-h ph monitoring, esophageal manometry, barium esophagram, and a detailed questionnaire regarding their symptoms before treatment. Patients were stratified into a responder and a non-responder group using a questionnaire at 3-month follow-up. A multivariate analysis was performed. Results: The success rate was 64%(34/53 patients). Three variables were significantly predictive for successful endoscopic anti-reflux treatment at the multivariate level: presence of typical symptoms (P = 0.01), complete symptom relief with acid suppressive therapy (P = 0.01), and normal lower esophageal sphincter pressure (P = 0.04). Not predictive of outcome were age, body mass index, esophagitis, other manometric findings, hiatal hernia size, or pathological level of ph h. Barium esophagram did not add any additional predictive information. Conclusions: Since no single factor can predict outcome after EndoCinch, a careful patient selection is mandatory to maximize the success rate. The ideal candidate for EndoCinch is a gastroesophageal (GERD) patient with a normal lower esophageal sphincter pressure, whose typical symptoms completely resolved with acid suppressive therapy.

关键词：缝合术预后预测食管钡餐造影抑酸治疗食管测压食管下括约肌裂孔疝胃食管反流预测意义食管炎

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内镜缝合装置在胃食管反流病中的使用:继EndoCinch腔内胃折叠术后又一个失败

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 23-23页

作者： Schiefke I. Neumann S. zabel-Langhennig A. K. Caca 尹勇 Department of Medicine II University of Leipzig Philipp-Rosenthal Str. 27 04103 Leipzig Germany Dr.

Background: Endoluminal gastroplication, using the Endo- Cinch procedure, has emerged as a potential endoscopic antireflux therapy. Although initial results have been promising, the long-term durability of the treatment is uncertain due to suture loss. A new endoscopic suturing device, the “ ESD," has been developed that promises excellent visibility and endoscopic control. at The aim of this study was to evaluate prospectively the feasibility and efficacy of the ESD method after EndoCinch failure. Methods: The study involved 20 patients with gastroesophageal reflux disease (GERD), who had been initially treated with an EndoCinch procedure, but had relapsed after a median of 7.5 months, with lost or dysfunctional sutures and with reflux symptoms that required proton pump inhibitor (PPI) treatment. Using the ESD, at least three plications were created at the gastroesophageal junction. Patients underwent endoscopy, 24-hour ph monitoring and esophageal manometry before treatment and 6 months afterwards. In addition, reflux symptoms as well as quality-of-life scores were assessed (using the SF-6 and GERD-hRQL scales). Results: The ESD procedure (median procedure time 45 min) was performed successfully in all patients without major complications. After 6 months only one patient (5% ) still had all sutures in situ, while no remaining sutures could be detected in 3/20 (15% ). No significant changes in reflux esophagitis; 24-hour ph monitoring results (median phh 9.9% vs. 12.3% ; P = 0.60);manometry findings (median lower esophageal sphincter pressure 7.2 mm hg vs. 9.9 mm hg; P = 0.22); PPI use; or reflux esophagitis could be detected after 6 months. While reflux symptoms improved (heartbu-rn severity score 30 vs. 48, P hanges in quality-of-life scores were detected. Conclusions: Endoluminal gastroplication using the ESD is an easy and safe, but unfortunately ineffective procedure for endoscopic GERD treatment. Endoluminal gastroplication techniques clea

关键词：胃折叠术 EndoCinch 胃食管反流食管测压反流症状食管下括约肌反流性食管炎胃灼热严重度功能不良

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