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Celiac disease:Management of persistent symptoms in patients on a gluten-free diet

World Journal of Gastroenterology 2012年第12期18卷 1348-1356页

作者： David h Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson h julia ellis Paul J Ciclitira King's College London Division of Diabetes and Nutritional SciencesDepartment of GastroenterologyThe Rayne InstituteSt Thomas' HospitalLondon SE1 7EHUnited Kingdom

AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued ***:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo *** individuals were investigated to establish the eitiology of their continued *** patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody *** were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where ***,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms *** clinical progress was followed over a minimum of 2 ***:One hundred and twelve consecutive patients were referred with *** were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting *** colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal *** 2 years,78 patients remained well,eight had continuing symptoms,and four had ***:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading *** propose an algorithm for investigation.

关键词： Celiac disease Non-responsive celiac disea-se Refractory celiac disease Gluten Gluten-free diet

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An algorithm for family screening for coeliac disease

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World Journal of Gastroenterology 2006年第48期12卷 7805-7809页

作者： Jocelyn S Fraser Alistair L King h julia ellis Simon J Moodie Ingvar Bjarnason Jill Swift Paul J Ciclitira Division of Nutritional Sciences King's College London United Kingdom Division of Nutritional Sciences King’s College London United Kingdom

AIM: To assess the level of undiagnosed coeliac disease (CD) in relatives of patients affected by the condition. METhODS: We collected blood from 914 relatives of probands. We screened these individuals by ELISA for IgA and IgG tTG antibodies, confirming any positive IgA tTG results with an IgA EMA and looked for evidence of IgA deficiency in those who were IgG tTG positive alone, and performed IgG1 EMA in these individuals. We undertook hLA typing where positive screening was found, and this confirmed a strong prevalence of hLA- DQ2 in the coeliac population. Follow-up small intestinal biopsy was undertaken in cases with positive serological screening, wherever possible. RESULTS:Use of this serological screening algorithm revealed a prevalence of undiagnosed CD in 5%-6% of first degree relatives of probands. CONCLUSION:Our data suggests that first degree relatives of individuals with CD should be screened for this condition.

关键词： Coeliac disease Screening Endomysialantibody Familial study IgA deficiency Prevalence Tissue transglutaminase

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Approaches for handling high-dimensional cluster expansions of ionic systems

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npj Computational Materials 2022年第1期8卷 1254-1264页

作者： julia h.Yang Tina Chen Luis Barroso-Luque Zinab Jadidi Gerbrand Ceder Department of Materials Science and Engineering BerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Disordered multicomponent systems attract great interest due to their engineering design flexibility and subsequent rich space of ***,detailed characterization of the structure and atomic correlations remains challenging and hinders full navigation of these complex spaces.A lattice cluster expansion is one tool to obtain configurational and energetic *** in theory a cluster expansion can be applied to any system of any dimensionality,the method has primarily been used in binary systems or ternary *** we apply cluster expansions in high-component ionic systems,setting up the largest cluster expansion ever attempted to our *** doing so,we address and discuss challenges specific to high-component ionic systems,namely charge state assignments,structural relaxations,and rank-deficient *** introduce practical procedures to make the fitting and analysis of complex systems tractable,providing guidance for future computational studies of disordered ionic systems.

关键词： properties cluster ionic

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Environmental Impacts of the Yangtze Three Gorges Project: An Overview of the Chinese-German Research Cooperation

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Journal of Earth Science 2010年第6期21卷 817-823页

作者： Günter Subklew julia Ulrich Leander Fürst Agnes hltkemeier Forschungszentrum Jülich Gmbh

The construction of the Three Gorges Dam on the Yangtze River in China has a great influence on the ecosystems involved. In order to investigate these environmental effects in the Yangtze catchment area as well as downstream of the dam, Forschungszentrum Julich has organized a research network for the Chinese and Germaa partners. In the research fields of （1） interaction water/ sediment/contaminants, （2） vegetation/biodiversity, （3） changing land use/erosion/mass movements, and （4） atmosphere, the partners have accumulated a great deal of expertise in handling major issues and also in developing models and recommendations for action. The following provides an overview of the research network and the research tasks. On the German side, five projects in research field （3） have been in operation since 2008. The results are reported in contributions by Ehret et al., Jaehnig and Cai, Schonbrodt et al., and Seeber et al.. Another five projects in research field （1） have started by September 2010. The research tasks undertaken in these five projects are presented below.

关键词： Three Gorges Dam Yangtze River environmental research ecosystem.

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Effects of experimental season of prescribed fire and nutrient addition on structure and function of previously grazed grassland

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Journal of Plant Ecology 2018年第4期11卷 576-584页

作者： Elizabeth h.Boughton Patrick J.Bohlen julia h.Maki MacArthur Agro-ecology Research Center 300 Buck Island Ranch RoadLake PlacidFL 33852USA University of Central Florida Biology 4110 Libra DriveOrlandoFL 32816USA School of Natural Resources and Environment University of Florida103 Black HallPO Box 116455GainesvilleFL 32611USA

Aims Understanding the drivers of grassland structure and function fol-lowing livestock removal will inform grassland restoration and ***,we investigated the effects of fire and nutri-ent addition on structure and function in a subtropical semi-native grassland recently released from grazing in south-central *** examined responses of soil nutrients,plant tissue nutrients,bio-mass of live,standing dead and litter,and plant species composi-tion to experimental annual prescribed fire applied during different seasons(wet season *** season),and nutrient additions(N,P and N+P)over 9 *** Experimental plots were set up in a randomized block split-plot design,with season of prescribed fire as the main treatment and nutrient addition as the subplot *** cover data were collected annually from 2002 to 2011 and plant tissue and plant biomass data were collected in 2002-2006 and *** nutrients were analyzed in 2004,2006 and *** Findings Soil total phosphorus(P)levels increased substantially with P addition but were not influenced by prescribed *** of P and N led to increased P and N concentrations in live plant tissues,but prescribed fire reduced N in live *** of tissue N were higher in all plots at the beginning of the exper-iment,an effect that was likely due to grazing activity prior to removal of *** tissue N steadily declined over time in all plots,with annually burned plots declining faster than unburned *** fire was an important driver of standing dead and litter biomass and was important for main-taining grass biomass and percent *** addition was also important:the addition of both N and P was associated with greater live biomass and woody *** of grazing,lack of prescribed fire,and addition of N+P led to a reduction of grass biomass and a large increase in biomass of a woody *** prescribed fire promoted N loss from the system by reducing

关键词： grassland nutrient enrichment nutrient limitation prescribed fire productivity

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What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis

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World Journal of Gastroenterology 2017年第13期23卷 2435-2442页

作者： Mohammad Yaghoobi julia McNabb-Baltar Raheleh Bijarchi Richard h hunt Division of Gastroenterology McMaster Universit Division of Gastroenterology Hepatology and EndoscopyBrigham and Women's HospitalHarvard Medical School Division of Respirology Department of MedicineSt.Michael's HospitalUniversity of Toronto Division of Gastroenterology Farncombe Family Digestive Disease Research Institute

AIMTo quantify the risk of gastric cancer in first-degree relatives of patients with the *** comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5.0.25. We performed subgroup analysis on Asian studies and a sensitivity analysis based on the quality of the studies, type of the outcome, sample size, and whether studies considered only first-degree ***-two relevant studies out of 612 potential abstracts (n = 80690 individuals) were included. 19.0% of the patients and 10.9% of the controls had at least one relative with gastric cancer (P he pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35 (95%CI: 1.96-2.81). The Cochran Q test for heterogeneity was positive (P he three outlier studies with the highest relative risks, heterogeneity remained significant (P he result was not different among Asian studies as compared to others and remained robust in several sensitivity analyses. In the 26 studies which exclusively analysed the history of gastric cancer in first-degree relatives, the relative risk was 2.71 (95%CI: 2.08-3.53; P h a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this high-risk population.

关键词： Gastric cancer Risk Relatives Family history Meta-analysis

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Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma

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Gastroenterology Report 2017年第1期5卷 67-71,I0003页

作者： Amir Kashani Jonathan C.ellis Melissa Kahn Laith h.Jamil Division of Gastroenterology Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology and Laboratory Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Alpha-fetoprotein(AFP)-producing adenocarcinoma,histologically mimicking hepatocellular carcinoma(hCC),is a distinct entity known as hepatoid adenocarcinoma(hAC).Reported cases of hAC arising from the esophagus are extremely *** to common liver metastasis and elevated AFP levels in patients with esophageal hAC,differentiation of hAC with liver metastasis from hCC could be *** describe a case of esophageal hAC that presented with a liver mass showing hepatoid features and elevated serum AFP *** presentation was suspicious for *** further diagnostic work-up,the patient was diagnosed with esophageal hAC with liver *** distinction between these two entities is particularly important because hAC is more aggressive,and its therapeutic options are very limited.

关键词： hepatoid adenocarcinoma alpha-fetoproteins hepatocellular carcinoma

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Weak correlation of flower color and nectar-tube depth in temperate grasslands

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Journal of Plant Ecology 2017年第2期10卷 397-405页

作者： julia Binkenstein Martina Stang Julien P.Renoult h.Martin Schaefer Chair of Nature Conservation and Landscape Ecology Faculty of Environment and Natural ResourcesUniversity of FreiburgTennenbacher Straße 479106 FreiburgGermany Section Plant Ecology and Phytochemistry Institute of Biology LeidenLeiden UniversitySylviusweg 722300 RA LeidenThe Netherlands Institute of Arts Creation Theory and Aesthetics UMR 8218-CNRS47 r.des bergers75015 ParisFrance Fundacion Jocotoco Lizardo GarcíaE9-104 y Andrés XauraP.O.Box 17-16-337QuitoEcuador

Aims Nectar is one of the most common floral rewards offered to pol-linators by *** on the plant species,nectar is offered openly or in tubes of various lengths restricting accessibility of this resource for flower visitors with short *** attract-ing pollinators that match floral morphology increases pollination efficiency,flowers could profit from signaling nectar-tube depth to *** flower colors are important signals in plant-pol-linator communication,we investigated whether and which differ-ent chromatic or achromatic aspects of flower color might indicate nectar-tube depth or whether flower colors facilitate the differen-tiation between flowers with long nectar tubes by means of high chromatic *** To this end,we collected flower reflectance spectra of 135 grassland plant *** analyzed flower colors as raw reflectance spectra in principal component analysis(PCA)and in the color space of *** Findings The correlation between flower colors and tube depths was *** the bee’s point of view,blue flowers had on average deeper tubes than green,blue-green and UV-green flowers potentially allow-ing insects to predict tube depths based on blue *** purity did not correlate with nectar-tube depth,nor did the chromatic uniqueness of flower colors in the honeybee color *** wavelength showed a significant but very weak correlation with tube *** achromatic green contrast decreased with increasing tube depth as did brightness;thus deep tubes were less conspicuous than shallow *** components resulting from PCA did not or only slightly correlate with tube *** results illustrate that flower colors may have a certain potential to indicate tube depth,*** accessibility,from a bee’s perspective.

关键词： vision pollination efficiency plant-animal interaction nectar tube depth

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From Tpex to Tex: a journey through CD8^(+) T cell responses in cancer immunotherapy

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4419-4420页

作者： julia M.Messmer Maike Effern Michael holzel Institute of Experimental Oncology University Hospital BonnUniversity of Bonn53127BonnGermany

In a recent study published in Cell,Rahim et *** that a subset of progenitor exhausted CD8+T cells(Tpex)in uninvolved,regional lymph nodes(uiLNs)are clonally related to exhausted CD8^(+)T cells(Tex)in tumors of patients with head and neck squamous cell carcinoma(hNSCC)and following adjuvant immune checkpoint blockade(ICB)these clones expanded in the tumor suggestive of migration from the uiLNs and differentiation into an exhaustion state.1 The work by Rahim et *** the great value of neoadjuvant ICB clinical trials to better understand the dynamics of T cell responses in patients.

关键词： al. Tpe patients

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Soil respiration in paludified forests of European Russia

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Journal of Forestry Research 2020年第5期31卷 1939-1948页

作者： Dmitry Ivanov Fedor Tatarinov julia Kurbatova A.N.Severtsov Institute of Ecology and Evolution RAS Leninsky Prospekt 33MoscowRussia 119071 Weizmann Institute of Science Herzl St 23476100 RehovotIsrael

Soil respiration studies in paludified forests of the European part of Russia are quite rare in comparison with those of open peat bogs,which make long-term observations in this region highly *** this study,soil CO2 emissions were measured by the close chamber method in different microlandscapes of paludified *** four summer seasons with different environments,soil respiration ranged from 1078 to 248 mg CO2 m^-2 h^-1 in a paludified spruce forest site with coarse woody debris to 659–820 mg CO2 m^-2 h^-1 in a paludified boggy pine *** most intensive soil respiration was observed during the hot summer of 2013 and the lowest in the hot and humid summer of *** total soil CO2 emissions in paludified forests in 2015–2016 were approximately 2000–3000 g CO2 *** the year,the lowest CO2 emission values were observed from November to April(14–84 mg CO2 m^-2 h^-1)and the maximum were in July and August(522–1205 mg CO2 m^-2 h^-1).The contributions of CO2 emissions in the cold November–April period were 6–8.5%.The impacts of temperature on soil respiration were higher(r2=0.45–0.57)than those of groundwater levels(r^2=0.17–0.49).Soil respiration in the paludified spruce forest and in the pine bog generally were higher than emissions from ecosystems with similar hydrothermal conditions in the boreal zone.

关键词： Carbon flux Chamber measurements CO2 emission Peatlands Southern taiga

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