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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psych.atric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with.a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apathy,and cognitive symptoms,such.as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.aL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the h.avy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting h.avy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with.a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with.a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Boosting efficiency in state estimation of power systems by leveraging attention mechanism

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Energy and AI 2024年第2期16卷 438-449页

作者： elson Cibaku Fernando Gama SangWoo Park Industrial Engineering New Jersey Institute of TechnologyNewarkNJUnited States Pendulum Systems DenverCOUnited States

Ensuring stability and reliability in power systems requires accurate state estimation, which is challenging due to the growing network size, noisy measurements, and nonlinear power-flow equations. In this paper, we introduce the Graph.attention Estimation Network (GAEN) model to tackle power system state estimation (PSSE) by capitalizing on the inherent graph structure of power grids. This approach facilitates efficient information exchange among interconnected buses, yielding a distributed, computationally efficient architecture that is also resilient to cyber-attacks. We develop a thorough.approach by utilizing Graph Convolutional Neural Networks (GCNNs) and attention mechanism in PSSE based on Supervisory Control and Data Acquisition (SCADA) and Phasor Measurement Unit (PMU) measurements, addressing the limitations of previous learning architectures. In accordance with the empirical results obtained from the experiments, the proposed method demonstrates superior performance and scalability compared to existing techniques. Furthermore, the amalgamation of local topological configurations with nodal-level data yields a heightened efficacy in the domain of state estimation. This work marks a significant achievement in the design of advanced learning architectures in PSSE, contributing and fostering the development of more reliable and secure power system operations.

关键词： Power grids State estimation Attention mechanism Graph neural networks Distributed computation Grid cyber-security

Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies

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Journal of Genetics and Genomics 2015年第4期42卷 169-172页

作者： Antonio Salas Joanna L.elson Unidade de Xenética Instituto de Medicina Legaland Departamento de Anatomía Patolóxica e Ciencias ForensesFacultad de MedicinaUniversidad de Santiago de CompostelaGalicia 15782Spain Mitochondrial Research Group Institute of Genetic MedicineCentre for LifeNewcastle University Centre for human Metabolomics North-West University

During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA （mtDNA） variants and/or haplogroups （clades） and particular diseases （generally com- mon/complex diseases）（Fig. 1）. however, several authors have gathered evidence indicating a high incidence of false positive findings in mtDNA case-control association studies. Raule et al. （2007） and herrnstadt and howell （2004） showed various problems affecting mtDNA case-control association studies. Salas et al.

关键词： DNA Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies

Characterization of partial melting events in garnet-cordierite gneiss from the Kerala Khondalite Belt,India

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Geoscience Frontiers 2020年第2期11卷 597-611页

作者： Nilanjana Sorcar Kumar Batuk Joshi elson POliveira JKTomson VNandakumar ESSO–National Centre For Earth Science Studies ThiruvananthapuramKeralaIndia Department of Geology Institute of GeosciencesUniversity of CampinasBrazil

Phase equilibria modelling coupled with U–Pb zircon and monazite ages of garnet–cordierite gneiss from Vallikodu Kottayam in the Kerala Khondalite Belt,southern India are presented *** results suggest that the area attained peak P–T conditions of^900C at 7.5–8 kbar,followed by decompression to 3.5–5 kbar and cooling to 450–480C,preserving signatures of the partial melting event in the field of high to ultra-high temperature *** reintegration models suggest that up to 35%granitic melt could have been produced during metamorphism at^950*** U–Pb age data from zircons(~1.0–~0.7 Ga)and chemical ages from monazites(~540 Ma and^941 Ma)reflect a complex tectonometamorphic evolution of the ***^941 Ma age reported from these monazites indicate a Tonian ultra-high temperature event,linked to juvenile magmatism/deformation episodes reported from the Southern Granulite Terrane and associated fragments in Rodinia,which were subsequently overprinted by the Cambrian(~540 Ma)tectonothermal episode.

关键词： Kerala khondalite belt(KKB) Garnet-cordierite gneiss Partial melting Pseudosection Monazite-zircon geochronology

Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira elson Paiva Oliveira Daniel Francisco Martins de Sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Arch.an Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South.america’s primitive ***,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-hf isotope data for the recently identified Eoarch.an to Neoarch.an gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarch.an(ca.3.65–3.60 Ga),early Paleoarch.an(ca.3.55–3.52 Ga),middle-late Paleoarch.an(ca.3.49–3.33 Ga)and Neoarch.an(ca.2.74–2.58 Ga),with no records of Mesoarch.an ***-hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarch.an,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarch.an,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarch.an.A different stage of crustal growth.and recycling dominated the Neoarch.an,probably owing to the thickening of the continental crust by collision,continental arc growth.and mantle differentiation.

关键词： São Francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-hf isotope geochemistry