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Marinoan glaciation in the Indian subcontinent——Anatomy and global implications

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Journal of Palaeogeography 2024年第2期13卷 293-308页

作者： h.N.Bhattacharya Department of Earth Sciences Techno India UniversityWest BengalSector VSalt LakeKolkata700091India

Detailed sedimentological analysis of the Pokaran Boulder Bed,representing the most basal unit of the Neoproterozoic-Lower Cambrian Marwar Supergroup,clearly indicates its glacial *** glacial sediments are interpreted as an ice-contact submarine fan *** on the detrital and inherited zircon population of the Marwar Supergroup sediments and interlayered pyroclastic deposits,a Marinoan cryochron of the Cryogenian Period is envisaged for the Pokaran Boulder *** well-preserved Ediacaran elements in the post-glacial sedimentary succession also support a Cryogenian to Early Cambrian age of the Marwar *** glacial deposition at the base of the Marwar Supergroup strengthens the regional correlation between the studied sediments with the Lesser himalayan Blaini-Krol-Tal sediments and the haqf Supergroup of *** available zircon ages and paleomagnetic data of the Malani Igneous suite,along with the Marinoan glacial deposits,detrital zircon ages,and Ediacaran fossil elements of the Marwar Supergroup add significant information to the Neoproterozoic Earth history.

关键词： Neoproterozoic Marinoan glaciation Diamictites Pokaran Boulder Bed Marwar Supergroup

Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： Peter h.King Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

中国特色反腐败之路的生成逻辑、鲜明特征与发展趋向

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马克思主义研究 2024年第7期 128-138页

作者：阀道远复旦大学纪检监察研究院上海200433 复旦大学马克思主义学院上海200433 上海市习近平新时代中国特色社会主义思想研究中心上海200433

中国特色反腐败之路是党推进反腐败斗争和自我革命的规律性总结和战略性成果。其鲜明特征体现在:党中央对反腐败工作的集中统一领导,牢牢掌握正风肃纪反腐的领导权、主动权;始终为了人民、依靠人民,让人民群众在反腐败斗争中增强满意度... 详细信息

中国特色反腐败之路是党推进反腐败斗争和自我革命的规律性总结和战略性成果。其鲜明特征体现在:党中央对反腐败工作的集中统一领导,牢牢掌握正风肃纪反腐的领导权、主动权;始终为了人民、依靠人民,让人民群众在反腐败斗争中增强满意度和获得感;依靠制度优势、法治优势惩治腐败,党和国家监督制度、反腐败体制机制更加成熟定型;坚持不敢腐、不能腐、不想腐一体推进,同时发力、同向发力、综合发力;深化反腐败国际合作,推动构建国际反腐败治理新秩序。展望未来,要进一步深化对反腐败斗争的规律性认识,在铲除腐败问题产生的土壤和条件上持续发力,将反腐败制度性成果更好转化为反腐败治理效能,以反腐败斗争成效有力支撑实现中国式现代化,不断拓展反腐败斗争的深度广度,持续推动中国特色反腐败之路越走越宽广。

关键词：中国特色反腐败之路反腐败斗争全面从严治党党的自我革命

区域党建一体化驱动跨域协同治理:作用机制与实践框架——基于长三角一体化实践的研究

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治理研究 2024年第3期40卷 127-141,160页

作者：阚道远杨宁复旦大学纪检监察研究院复旦大学马克思主义学院

作为区域一体化的推动者和领导者,中国共产党在跨域治理中居于中轴地位,为破除地区及组织之间的壁垒、实现区域合作及资源优化配置提供了坚强政治保障。近年来,长三角地区以跨域党建共同体推动跨域治理共同体,探索出“区域党建一体化”... 详细信息

作为区域一体化的推动者和领导者,中国共产党在跨域治理中居于中轴地位,为破除地区及组织之间的壁垒、实现区域合作及资源优化配置提供了坚强政治保障。近年来,长三角地区以跨域党建共同体推动跨域治理共同体,探索出“区域党建一体化”这一涵盖诸多实践样态的新型党建模式。为了回应既有研究理论分析视角和“政党”主体关注的不足,在“区域党建一体化”概念理论化阐释基础上,构建出“政党驱动跨域协同治理”分析模型,为深刻揭示其驱动跨域协同治理的作用机制和实践框架提供了理论分析工具。在这一分析模型中,区域党建一体化以整合多元主体的公共权威体系、组织网络体系和资源共享体系,成为驱动跨域协同治理、进而实现区域一体化发展的“动力引擎”。区域党建一体化的作用机制既提供了目标赋予、关系网络、规则制度等结构支持,也提供了政治领导、思想引领、信息沟通、资源供给等行动支持。然而,区域党建一体化的实际意义,不只是为跨域协同治理提供了一种实践框架,也是为实现以区域现代化推动中国式现代化进程提供了一种制度安排。

关键词：区域党建一体化党建引领区域一体化跨域治理协同治理

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我国近海阵风预报研究

气象 2024年第6期50卷 711-722页

作者：胡海川代刊国家气象中心北京100081

利用2021年1—12月实况观测数据及ECMWF确定性模式24 h预报数据中的中低层风速与温度产品,采用支持向量机回归方法构建我国近海阵风预报模型,以提升海上阵风预报服务能力。利用2022年1—9月数据进行独立样本检验,通过与阵风系数法的对... 详细信息

利用2021年1—12月实况观测数据及ECMWF确定性模式24 h预报数据中的中低层风速与温度产品,采用支持向量机回归方法构建我国近海阵风预报模型,以提升海上阵风预报服务能力。利用2022年1—9月数据进行独立样本检验,通过与阵风系数法的对比检验得出以下结论:不同高度层的风速及温度或垂直风速及温度的变化均会对阵风预报产生影响,因而造成仅考虑模式10 m风速预报的阵风系数法在某些情况下对于阵风的高估或低估。在阵风系数法的基础上加入高空气象要素信息所构建的预报模型,能够取得更好的预报效果。对于9级阵风,该模型的预报准确率为50%,明显高于阵风系数法的30%,对不同海域的大量级阵风同样具有较好的预报效果。在ECMWF确定性模式的10 m风速预报与实况存在一定偏差时,考虑了高空要素信息的支持向量机回归预报模型的阵风预报结果较阵风系数法更接近实况。

关键词：支持向量机回归阵风系数阵风预报近海地区

Experimental and numerical investigation on alternatives to sandy gravel

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Defence Technology（防务技术） 2024年第1期31卷 130-141页

作者： V.Denefeld h.Aurich Fraunhofer Institute for high-Speed Dynamics Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunhofer Institute for high-Speed Dynamics Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

The NATO agreement STANAG 4569 defines the protection levels for the occupants of logistic and light armored *** Allied Engineering Publication,AEP-55,Volume 2 document outlines the test conditions for underbelly improvised explosive device(IEDs),which must be buried in water-saturated sandy *** use of sandy gravel has some drawbacks,for instance reproducibility,time consumption,and *** paper focuses on the investigation of four alternatives to sandy gravel,which could produce similar specific and cumulative impulses:a concrete pot filled with water,a concrete pot filled with quartz sand,a steel pot without filling and a concrete pot filled with glass spheres(diameter 200μm—300μm)and different water *** impulses are measured with a ring technology developed at the Fraunhofer EMI.A numerical soil model based on the work of Marrs,2014 and Fi serov a,2006 and considering the soil moisture was used to simulate the experiments with glass spheres at different water contents,showing much better agreement with the experiments than the classical Laine&Sandvik model,even for high saturation *** results can be used to create new test conditions at original scale that are more cost-effective,more reproducible and simpler to manage in comparison to the current tests carried out with STANAG sandy gravel.

关键词： Improvised explosive device(IED) Specific impulse Momentum transfer Sandy gravel Glass spheres Numerical model Soil moisture

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man hon hUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-herb formula(4hF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4hF(low dose 4hF),hD 4hF(high dose 4hF),LD 4hF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and hD groups received daily oral gavage of 658 and 2,630 mg/kg 4hF,*** LD 4hF+D group received daily oral gavage of 658 mg/kg 4hF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4hF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Phe hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(PhF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

Side-chain symmetry-breaking strategy on porphyrin donors enables high-efficiency binary all-small-molecule organic solar cells

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SusMat 2024年第3期4卷 204-213页

作者： Wentao Zou Xu Zhang haojiang Shen Wenqing Zhang Xinyue Jiang Liaohui Ni Can Shen Longlong Geng Xiaotao hao Yingguo Yang Xunchang Wang Renqiang Yang Yanna Sun Yuanyuan kan Ke Gao Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionInstitute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdaoChina School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinanChina Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhouChina School of Microelectronics Fudan UniversityShanghaiChina Key Laboratory of Optoelectronic Chemical Materials and Devices(Ministry of Education) School of Optoelectronic Materials&TechnologyJianghan UniversityWuhanChina

Side-chain symmetry-breaking strategy plays an important role in developing photovoltaic materials for high-efficiency all-small-molecule organic solar cells(ASM OSCs).however,the power conversion efficiencies(PCEs)of ASM OSCs still lag behind their polymer-based counterparts,which can be attributed to the difficulties in achieving favorable ***,two asymmetric porphyrin-based donors named DAPor-DPP and DDPor-DPP were synthesized,presenting stronger intermolecular interaction and closer molecular stacking compared to the symmetric *** DAPor-DPP:6TIC blend afforded a favorablemorphologywith nanoscale phase separation and more ordered molecular packing,thus achievingmore efficient charge transportation and suppressed charge ***,the DAPor-DPP:6TIC-based device exhibited superior photovoltaic parameters,yielding a champion PCE of 16.62%higher than that of the DDPor-DPP-based device(14.96%).To our knowledge,16.62%can be ranked as one of the highest PCE values among the binary ASM OSC *** provides a prospective approach to address the challenge ofASM OSCs in improving film morphology and further achieving high efficiency via side-chain symmetry-breaking strategy,exhibiting great potential in constructing efficient ASM OSCs.

关键词： all-small-molecule organic solar cells asymmetric side-chain engineering power conversion efficiency small molecule donors

Orbital angular momentum conversion of acoustic vortex beams via planar lattice coupling

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Chinese Physics B 2024年第9期33卷 413-420页

作者： Qingbang han Zhipeng Liu Cheng Yin Simeng Wu Yinlong Luo Zixin Yang Xiuyang Pang Yiqiu Wang Xuefen kan Yuqiu Zhang Qiang Yu Jian Wu College of Information Science and Engineering Hohai UniversityChangzhou 213200China College of Advanced Interdisciplinary Studies Nanhu Laser LaboratoryNational University ofDefense TechnologyChangsha 410073China School of Transportation Engineering Jiangsu Shipping CollegeNantong 226010China i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China

Orbital angular momentum(OAM)conversion is critical in understanding interactions between a structural sound field and a planar ***,we explore the evolution of a monochromatic acoustic vortex beam(AVB)that is scattered by a phononic crystal(PnC)or a correlated random *** phenomenon is ascribed to the enhanced orbit–orbit angular momentum coupling induced by the band *** modifying the coupling condition,accurate and continuous micromanipulation of AVBs can be achieved,including the transverse/lateral gravity shift,the dynamics of the phase singularities,and the spatial distribution of acoustic pressure,*** research provides insight to the inhomogeneous coupling of AVBs with both propagating Bloch waves and localized Anderson modes,and may facilitate development of novel OAM-based acoustic devices for active sound field manipulation.

关键词： acoustic vortex beam phononic crystal Anderson localization Imbert–Fedorov effect