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Mobilization of CD34^+CD38^- hematopoietic stem cells after priming in acute myeloid leukemia

World Journal of Stem Cells 2013年第4期5卷 196-204页

作者： Adriana Plesa Eve Mattei Charles Dumontet Youcef Chelghoum hélène labussière Giovanna Cannas Mauricette Michallet Xavier Thomas Mohamed Elhamri Stéphane Morisset Inès Tagoug laboratoire de Cytologie et d'Immunologie Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Department of hematology Centre Hospitalier Lyon-SudHospices Civils de Lyon Unité de recherche Clinique Service d'Hématologie Centre Hospitalier Lyon-SudHospices Civils de Lyon INSERM U590 Laboratoire de Cytologie Analy-tique Faculté de Médecine Rockefeller Université Lyon-I

AIM: To evaluate quantitatively and qualitatively the different CD34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid ***: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The CD34/CD38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(CD184), VlA-4(CD49d/CD29) and ***: Chemotherapy ± G-CSF mobilized immature cells(CD34+CD38 population), while the more mature cells(CD34+CD38lowand CD34+CD38+populations) decreased progressively after treatment. Circulating CD34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34+cell mobilization was correlated with a gradual increase in CXCR4 and CD47expression, suggesting a role in cell protection and the capacity of homing back to the ***: Chemotherapy ± G-CSF mobilizes into the circulation CD34+bone marrow cells, of which, the immature CD34+CD38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes.

关键词： Acute myeloid leukemia leukemia stem cell Immunophenotype Priming Timed sequential chemotherapy

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Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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neural regeneration research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

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Disaster Risk resilience:Conceptual Evolution,Key Issues,and Opportunities

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International Journal of Disaster Risk Science 2022年第3期13卷 330-341页

作者： Marie-hélène Graveline Daniel Germain Institut des Sciences de l’Environnement(ISE) Universitédu QuébecàMontréalMontréalH3C 3P8Canada Department of Geography Universitédu QuébecàMontréalMontréalH3C 3P8Canada

resilience has become a cornerstone for risk management and disaster ***,it has evolved extensively both etymologically and conceptually in time and across scientific *** concept has been(re)shaped by the evolution of research and practice *** the opposite of vulnerability for a long time,resilience was first defined as the ability to resist,bounce back,cope with,and recover quickly from the impacts of *** avoid the possible return to conditions of vulnerability and exposure to hazards,the notions of post-disaster development,transformation,and adaptation(build back better)and anticipation,innovation,and proactivity(bounce forward)were then ***,resilience is characterized by a multitude of components and several *** present a selection of 25 components used to define resilience,and an interesting linkage emerges between these components and the dimensions of risk management(prevention,preparedness,response,and recovery),offering a perspective to strengthen resilience through the development of *** its potential,resilience is subject to challenges regarding its operationalization,effectiveness,measurement,credibility,equity,and even its ***,it offers applicability and opportunities for local communities as well as an interdisciplinary look at global challenges.

关键词： Community Disaster risk resilience Sustainable development

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural regeneration research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Application of high silica zeolite ZSM-5 in a hybrid treatment process based on sequential adsorption and ozonation for VOCs elimination

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Journal of Environmental Sciences 2016年第3期28卷 59-68页

作者： hicham Zaitan Marie hélène Manero héctor Valdés laboratoire de Chirmie de la Matiere Condensee(lCMC) Faculte des Sciences et TechniquesUniversite Sidi Mohamed Ben AbdellahB.P.2202FesMaroc Universite de Toulouse INPTUPSLaboratoire de Genie Chimique4Allee Emile MonsoF-31030 ToulouseFrance CNRS Laboratoire de Genie ChimiqueF-31030 ToulouseFrance laboratorio de Tecnologias limpias(F.Ingenieria) Universidad Catolica de la Santisima ConcepcionAlonso de Ribera 2850ConcepcionChile

In this study,a hydrophobic synthetic zeolite,namely ZSM-5 is chosen as an adsorbent/catalyst for toluene *** results showed that toluene adsorption onto ZSM-5 was favourable,following a langmuir adsorption isotherm ***-5 zeolite was regenerated using gaseous ozone at low *** toluene was oxidised,releasing mainly CO_2 and h_*** of oxidation by-products such as acetic acid and acetaldehyde were formed and remained adsorbed after the oxidativate regeneration with *** four successive cycles of adsorption/ozonation,the adsorption efficiency was not affected（92%-99%）.These results showed that volatile organic compound（VOC）removal by adsorption onto ZSM-5 zeolite followed by ozone regeneration could be used as a promising hybrid process for the control of VOC emissions in terms of efficiency.

关键词： Adsorption Ozone Toluene VOCs Zeolite

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h2O2-Activated Up-regulation of Glutathione in Arabidopsis Involves Induction of Genes Encoding Enzymes Involved in Cysteine Synthesis in the Chloroplast

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Molecular Plant 2009年第2期2卷 344-356页

作者： Guillaume Queval Dorothée Thominet hélène Vanacker Myroslawa Miginiac-Maslow Bertrand Gakière Graham Noctor Institut de Biotechnologie des Plantes UMR CNRS 8618 Universite de Paris Sud 91405 Orsay cedex France

Glutathione is a key player in cellular redox homeostasis and, therefore, in the response to h2O2, but the factors regulating oxidation-activated glutathione synthesis are still unclear. We investigated h2O2-induced glutathione synthesis in a conditional Arabidopsis catalase-deficient mutant （cat2）. Plants were grown from seed at elevated CO2 for 5 weeks, then transferred to air in either short-day or long-day conditions. Compared to cat2 at elevated CO2 or wild-type plants in any condition, transfer of cat2 to air in both photoperiods caused measurable oxidation of the leaf glutathione pool within hours. Oxidation continued on subsequent days and was accompanied by accumulation of glutathione. This effect was stronger in cat2 transferred to air in short days, and was not linked to appreciable increases in the extractable activities of or transcripts encoding enzymes involved in the committed pathway of glutathione synthesis. In contrast, it was accompanied by increases in serine, O-acetylserine, and cysteine. These changes in metabolites were accompanied by induction of genes encoding adenosine phosphosulfate reductase （APR）, particularly APR3, as well as a specific serine acetyltransferase gene （SAT2.1） encoding a chloroplastic SAT. Marked induction of these genes was only observed in cat2 transferred to air in short-day conditions, where cysteine and glutathione accumulation was most dramatic. Unlike other SAT genes, which showed negligible induction in cat2, the relative abundance of APR and SAT2.1 transcripts was closely correlated with marker transcripts for h2O2 signaling. Together, the data underline the importance of cysteine synthesis in oxidant-induced up-regulation of glutathione synthesis and suggest that the chloroplast makes an important contribution to cysteine production under these circumstances.

关键词： Oxidative stress catalase photoperiod 3,-glutamylcysteine synthetases (γ-ECS) adenosine phosphosulfate reductase (APR) serine acetyltransferase (SAT).

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reliability and validity of the French version of the Global Physical Activity Questionnaire

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Journal of Sport and health Science 2018年第3期7卷 339-345页

作者： Fabien Rivière Fatima Zahra Widad Elodie Speyer Marie-line Erpelding hélène Escalon Anne Vuillemin ea 4360 apemac university of lorraineparis descartes universityNancy 54505France inserm cic-1433 clinical epidemiologyNancy F-5400France university hospital center of nancy pole s2repidemiology and clinical evaluationNancy F-54000France the french public health agency Saint-Maurice 94410France

Background:The Global Physical Activity Questionnaire(GPAQ)has been used to measure physical activity(PA)and sedentary time in France,but no study has assessed its psychometric *** study aimed to compare the reliability as well as criterion and concurrent validity of the French version of the GPAQ with the French International Physical Activity Questionnaire long form(IPAQ-lF)and use of an accelerometer in a general adult ***:We included 92 participants(students or staff)from the Medicine Campus at the University of lorraine,Nancy(north-eastern France).The French GPAQ was completed twice,7 days apart,to study test-retest *** IPAQ-lF was used to assess concurrent validity of the GPAQ,and participants wore an accelerometer(ActiGraph GT3X+)for 7 days to study criterion *** as well as concurrent and criterion validity of the GPAQ were tested by the intraclass correlation coefficient(ICC),Spearman correlation coefficient for quantitative variables,and Kappa and Phi coefficients for qualitative *** concurrent and criterion validity of GPAQ were assessed by Bland-Altman ***:The GPAQ showed poor to good reliability(ICC=0.37-0.94;Kappa=0.50-0.62)and concurrent validity(Spearman r=0.41-0.86),but only poor criterion validity(Spearman r=-0.22-0.42).limits of agreement for the GPAQ and accelerometer were wide,with differences between 286.5 min/week and 601.3 min/***:The French version of the GPAQ provides limited but acceptable reliability and validity for the measurement of PA and sedentary *** may be used for assessing PA and sedentary time in a French adult population.

关键词： Measurement Physical activity Psychometric analysis Questionnaire reliability Self-report Sitting time Validity

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neuroinflammation as a therapeutic target in huntington's disease

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neural regeneration research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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neural regeneration research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Effect of Soluble Components From Plant Aggregates on the Setting of the lime-Based Binder

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Journal of renewable Materials 2019年第9期7卷 903-913页

作者： lepeng Wang hélène lenormand hafida Zmamou Nathalie leblanc UnilaSalle Transformations&Agro-Resources Research UnitVAM²IN(EA 7519 UniLaSalle-Universitéd’Artois)3 rue du Tronquet76130 Mont-Saint-AignanFrance

Plant aggregate-based building materials are a viable solution for reducing greenhouse gas emissions and providing good thermal and acoustic *** this study,the investigated lightweight mortars require a hydraulic *** and on-site empirical observations about plant aggregate-based materials indicate a delay in setting time and a decrease in the mechanical performances of concretes based on plant *** natural origin of plant-aggregates causes a lot of variability in their *** studies have shown that the incompatibility between plant aggregates and cement is mainly caused by the dissolved and decomposed components of plant aggregates in alkaline ***,no research on the specific impact of each component on the setting time of lime-based binder *** this work,the impact of some soluble compounds(e.g.,sucrose,glucose,fructose,pectin)on the setting reaction of the lime matrix was studied using Vicat test,thermogravimetric analysis(TGA)and FT-IR *** results showed that carbohydrates such as glucose and sucrose not only affect the setting time but also have a long-term impact on the carbonation of *** measure of the setting time by Vicat test appears as a possible indicator to predict the compatibility between the matrix and plant aggregates.

关键词： Plant aggregates setting time lime-based binder carbohydrates hydration

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