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Cardiovascular prevention in elderly patients

journal of geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio garcía-Blas jose Antonio Alarcon Pablo Díez-Villanueva Carmen Rus Mansilla héctor garcía-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de Pablo-Zarzoso Manuel Martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé Servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INCLIVA ValenciaSpain Servicio Cardiología hospital Universitario de jaén Spain Servicio Cardiología hospital de Donosti Spain Servicio de Cardiología Hospital Universitario La Princesa de MadridSpain Servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiología Hospital Rio Hortega de ValladolidSpain Servicio Cardiología hospital Clínico San Cecilio de granada Spain Servicio de Cardiología Hospital Universitario Central de AsturiasSpain Servicio de Cardiologia Hospital de LugoSpain Servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiología hospital Universitario de la Paz de Madrid Spain Servicio de Cardiología Hospital Ramón y Cajal de MadridSpain Department of Cardiology.hospital Universitario gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiología del hospital general de Alicante Spain Servicio de Cardiología hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing *** this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular ***,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation ***,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

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Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela hernández Bautista Elizabeth gil White joséAntonio gonzález Moreno Daniel Angel Torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez gómez Luis jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

hepatocellular carcinoma(hCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESh terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(hCC).however,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of hCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

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Recent advances and new insights in the management of early-stage epidermal growth factor receptor-mutated non-small-cell lung cancer

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World journal of Clinical Oncology 2021年第10期12卷 912-925页

作者： Miguel j Sotelo jose Luis garcía Cesar Torres-Mattos héctor Milián Carlos Carracedo María Angeles gonzález-Ruiz Xabier Mielgo-Rubio juan Carlos Trujillo-Reyes Felipe Couñago Department of Medical Oncology Hospital María AuxiliadoraDepartment of Medical OncologyCentro Oncológico AliadaOncological Research UnitClínica San GabrielLima 15801Peru Department of Thoracic Surgery Hospital Universitario La PrincesaDepartment of Thoracic SurgeryMD Anderson Cancer CenterDepartment of Thoracic SurgeryHospital HMMadrid 28006Spain Department of Medical Oncology Hospital Nacional Guillermo AlmenaraOncological Research UnitClínica San GabrielLima 15033Peru Department of Thoracic Surgery Hospital Universitario La PrincesaMadrid 28006Spain Department of Medical Oncology Centro Oncológico AliadaLima 15036Peru Department of Radiation Oncology Hospital Universitario Virgen MacarenaSevilla 41009Spain Department of Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08041Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

Patients with early-stage non-small-cell lung cancer(NSCLC)are candidates for curative surgery;however,despite multiple advances in lung cancer management,recurrence rates remain *** chemotherapy has been demonstrated to significantly prolong overall survival(OS),but this benefit is modest and there is an urgent need for effective new therapies to provide a cure for more *** high efficacy of tyrosine kinase inhibitors(TKIs)against epidermal growth factor receptor-mutated(EgFR)in patients with advanced EgFR-mutated NSCLC has led to the evaluation of these agents in early stages of the *** clinical trials have evaluated the safety and efficacy of EgFR TKIs as an adjuvant treatment,in patients with resected EgFR-mutated NSCLC,and shown that they significantly prolong disease-free survival(DFS),but this benefit does not translate to ***,an interim analysis of the ADAURA trial demonstrated that,surprisingly,osimertinib improved *** led to the study being stopped early,leaving many unanswered questions about its potential effect on OS and its incorporation as a standard adjuvant treatment in this patient *** targeted agents are also being evaluated in locally-advanced disease,with promising results,although prospective studies with larger sample sizes are needed to confirm these *** this article,we review the most relevant studies on the role of EgFR TKIs in the management of early-stage EgFR-mutated NSCLC.

关键词： Non-small-cell lung cancer Early stage Epidermal growth factor receptormutated Epidermal growth factor receptor-mutated-tyrosine kinase inhibitor Adjuvant Neoadjuvant

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Naringenin prevents experimental liver fibrosis by blocking TgFβ-Smad3 and jNK-Smad3 pathways

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World journal of gastroenterology 2017年第24期23卷 4354-4368页

作者： Erika hernández-Aquino Natanael Zarco Sael Casas-grajales Erika Ramos-Tovar Rosa E Flores-Beltrán jonathan Arauz Mineko Shibayama Liliana Favari Víctor Tsutsumi josé Segovia Pablo Muriel Laboratory of Experimental hepatology Department of PharmacologyCinvestav-IPNApartado Postal 14-740Mexico City Department of Physiology Biophysics and NeurosciencesCinvestav-IPNApartado Postal 14-740Mexico City Department of Pharmacology School of MedicineAutonomous University of Baja CaliforniaMexicaliApartado Postal 21100 Department of Infectomics and Molecular Pathogenesis Cinvestav-IPNApartado Postal 14-740Mexico City

To study the molecular mechanisms involved in the hepatoprotective effects of naringenin (NAR) on carbon tetrachloride (CCl4)-induced liver fibrosis. METhODSThirty-two male Wistar rats (120-150 g) were randomly divided into four groups: (1) a control group (n = 8) that received 0.7% carboxy methyl-cellulose (NAR vehicle) 1 mL/daily p.o.; (2) a CCl4 group (n = 8) that received 400 mg of CCl4/kg body weight i.p. 3 times a week for 8 wk; (3) a CCl4 + NAR (n = 8) group that received 400 mg of CCl4/kg body weight i.p. 3 times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.; and (4) an NAR group (n = 8) that received 100 mg of NAR/kg body weight daily for 8 wk p.o. After the experimental period, animals were sacrificed under ketamine and xylazine anesthesia. Liver damage markers such as alanine aminotransferase (ALT), alkaline phosphatase (AP), γ-glutamyl transpeptidase (γ-gTP), reduced glutathione (gSh), glycogen content, lipid peroxidation (LPO) and collagen content were measured. The enzymatic activity of glutathione peroxidase (gPx) was assessed. Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains. Zymography assays for MMP-9 and MMP-2 were carried out. hepatic TgF-β, α-SMA, CTgF, Col-I, MMP-13, NF-κB, IL-1, IL-10, Smad7, Smad3, pSmad3 and pjNK proteins were detected via western blot. RESULTSNAR administration prevented increases in ALT, AP, γ-gTP, and gPx enzymatic activity; depletion of gSh and glycogen; and increases in LPO and collagen produced by chronic CCl4 intoxication (P histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4. Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2 gelatinase activity; interestingly, NAR administration was associated with normal MMP-9 and MMP-2 activity (P he anti-inflammatory, antine

关键词： Fibrosis Transforming growth factor-β Naringenin pSmad3 Smad3 jNK Nuclear factor kappa Carbon tetrachloride

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Dietary carbohydrate-to-protein ratio influences growth performance,hepatic health and dynamic of gut microbiota in atlantic salmon(Salmo salar)

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Animal Nutrition 2022年第3期10卷 261-279页

作者： Alejandro Villasante Carolina Ramírez hector Rodríguez Patricio Dantagnan Adrian hernandez Elías Figueroa jaime Romero Facultad de Medicina Veterinaria y Agronomía Universidad de Las AmericasSantiagoChile Laboratorio de Biotecnología de Alimentos Unidad de AlimentosInstituto de Nutricion y Tecnología de Los Alimentos(INTA)Universidad de ChileSantiagoChile Programa de Anatomía y Biología Del Desarrollo Facultad de MedicinaUniversidad de ChileSantiagoChile Núcleo de Investigacion en Produccion Alimentaria Facultad de Recursos NaturalesUniversidad Catolica de TemucoTemucoChile

Atlantic salmon(Salmo salar)fed a carbohydrate-rich diet exhibit suboptimal growth performance,along with other metabolic *** is well known that gut microbes play a pivotal role in influencing metabolism of the host,and these microbes can be modified by the *** main goal of the present study was to determine the effect of feeding graded levels of digestible carbohydrates to Atlantic salmon on the distal intestine digesta microbiota at 3 sampling times(i.e.,weeks 4,8 and 12),during a 12-week trial.A low carbohydrate-to-high protein diet(LC/hP,0%wheat starch),a medium carbohydrate-tomedium protein diet(MC/MP,15%wheat starch)or a high carbohydrate-to-low protein diet(hC/LP,30%wheat starch)was fed to triplicate fish tanks(27 to 28 fish per tank).We performed an in-depth characterization of the distal intestine digesta ***,growth parameters,liver histology and the expression of genes involved in hepatic neolipogenesis in fish were *** fed a hC/LP diet showed greater hepatosomatic and viscerosomatic indexes(P=0.026 and P=0.018,respectively),lower final weight(P=0.005),weight gain(P=0.003),feed efficiency(P=0.033)and growth rate(P=0.003)compared with fish fed the LC/hP ***,feeding salmon a high digestible carbohydrate diet caused greater lipid vacuolization,steatosis index(P=0.007)and expression of fatty acid synthase(fas)and delta-6 fatty acyl desaturase(d6fad)(P=0.001 and P=0.001,respectively)in the liver compared with fish fed the LC/hP ***,the major impact of feeding a carbohydrate-rich diet to Atlantic salmon in beta diversity of distal intestine digesta microbiota was observed at week 4(hC/LP vs MC/MP and hC/LP vs LC/hP;P=0.007 and P=0.008,respectively)and week 8(hC/LP vs MC/MP;P=0.04),no differences between experimental groups were detected after 12 weeks of ***,at the end of the trial,there was a negative correlation between lactic acid bacteria(LAB)members,including Leuconostoc and Lactobacil

关键词： Microbiota Microbiome Atlantic salmon Steatosis Lactic acid bacteria Probiotics

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Room temperature synthesis of two-dimensional multi layer magnets based on α-Co^(Ⅱ) layered hydroxides

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Nano Materials Science 2022年第1期4卷 36-43页

作者： Victor Oestreicher Christian Dolle Diego hunt Michael Fickert gonzalo Abellan Instituto de Ciencia Molecular(ICMol).Universidad de Valencia Catedritico Jose Beltran 2PaternaValencia46980Spain Departamento de Física de la Materia Condensada GIy A.Instituto de Nanociencia y NanotecnologíaCNEA-CAC-CONICET.Av.Gral.PazSan MartinBuenas Aires1650Argentina Chair of Organic ChemistryⅡand joint Institute of Advanced Materials and Processes(ZMP).Friedrich-Alexander-Universitát Erlangen-Nürnberg(FAU) Nikolaus-Fiebiger Strasse 1091058 Erlangen and Dr.-Mack Strasse 81Furth 90762Germany

Research on two-dimensional(2D) materials is one of the most active fields in materials science and nanotechnology. Among the members of the 2D family, layered hydroxides(Lhs) represent an exceptional case of study due to their unparalleled chemical versatility which allows the modulation of their physicochemical properties at will. Nowadays, Lhs based on earth-abundant metals are key materials in the areas of energy storage and conversion, hybrid materials or magnetism. α-Co hydroxides(Simonkolleite-like structures) are promising phases with tuneable electronic and magnetic properties by ligand modification. however, even in the simple case of α-Co^(Ⅱ) hydroxychlorides, the preparation of well-defined large 2D crystals is not straightforward, hindering the development of fundamental studies. herein, we present the synthesis of 2D hexagonal crystals with outstanding sizethickness relationship(diameter > 5 μm and thickness of 20 ± 7 nm) by a simple homogeneous synthesis taking place at room temperature. In structural terms, no differences are observed between our layered materials and those obtained hydrothermally. however, dynamic susceptibility measurements alert about different arrangements of the magnetic sublattices, which have been rationalized with structural DFT calculations. This work provides an extremely easy bottom-up method to obtain high-quality 2D crystals based on α-CoIIhydroxides,paving the way for the development of fundamental studies and applications.

关键词： Two-dimensional(2D)materials Layered hydroxides hexagonal morphology Bottom-up synthesis Magnetism

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Presence of <i>Actinobacillus pleuropneumoniae, Streptococcus suis, Pasteurella multocida, Bordetella bronchiseptica, haemophilus parasuis and Mycoplasma hyopneumoniae</i>in upper respiratory tract of swine in farms from Aguascalientes, Mexico

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Open journal of Animal Sciences 2013年第2期3卷 132-137页

作者： Abraham Loera-Muro Francisco j. Avelar-gonzález Víctor M. Loera-Muro Mario jacques Alma L. guerrero-Barrera Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes Aguascalientes México groupe de recherche sur les maladies infectieuses du porc Faculté de Médecine Vétérinaire Université de Montréal St-Hyacinthe Canada Laboratorio de Biología Celular y Tisular Departamento de Morfología Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes Aguascalientes México

Respiratory diseases are one of the most important health problems in pig herds. The porcine respiratory disease complex (PRDC) is the term used to describe pneumonic diseases caused by multiple infectious agents that provoke weight loss in animals or death. In the PRDC multiple pathogens (bacteria and/or viruses) work in combination to induce this respiratory disease. Within this complex, Actinobacillus pleuropneumoniae, Streptococcus suis, Pasteurella multocida, Bordetella bronchiseptica, haemophilus parasuis and Mycoplasma hyopneumoniae are the main bacterial pathogens involved in great economic losses to the swine industry. The aim of this work was to estimate the presence of A. pleuropneumoniae, S. suis, P. multocida, B. bronchiseptica, h. parasuis and M. hyopneumoniae in the upper respiratory tract of pigs in representative swine farms inAguascalientes,Mexico, using PCR technique. The study was performed in 14 swine farms. We obtained a total of 212 nasal swabs. Near 20% of samples were positive for A. pleuropneumoniae (located in the 79% of farms);17% were positive for S. suis (in 86% of farms), of these, 3% were S. suis serovar 2;30% were positive for h. parasuis (93% of farms);23% of the samples to P. multocida (in 79% of farms);and 19% to M. hyopneumoniae (in 64% of farms). B. bronchiseptica was not detected in this study. The results obtained show that bacterial pathogens of PRDC were present in the upper respiratory tract of pigs in all farms studied;therefore, these pathogens are widely disseminated in pig farms of Aguascalientes, Mexico.

关键词： Porcine Respiratory Disease Complex Actinobacillus pleuropneumoniae Streptococcus suis Pasteurella multocida Bordetella bronchiseptica haemophilus parasuis Mycoplasma hyopneumoniae

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LAND-USE INTENSIFICATION TRENDS IN ThE RIO DE LA PLATA REgION OF SOUTh AMERICA:TOWARD SPECIALIZATION OR RECOUPLINg CROP AND LIVESTOCK PRODUCTION

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Frontiers of Agricultural Science and Engineering 2021年第1期8卷 97-110页

作者： Paulo César DE FACCIO CARVALhO jean Víctor SAVIAN Tomas DELLA ChIESA William DE SOUZA FILhO joséAlfredo TERRA Priscila PINTO Amanda POSSELT MARTINS Sebastian VILLARINO júlio Kuhn DA TRINDADE Pedro Arthur DE ALBUQUERQUE NUNES gervasio PIÑEIRO Integrated Crop-Livestock Systems Research group Federal University of Rio Grande do Sul7712 Bento Gonçalves AvenuePorto Alegre RS 91540-000Brazil Instituto Nacional de Investigación Agropecuaria(INIA) Estación Experimental INIA Treinta y TresRuta 8 km 281Treinta y TresUruguay Facultad de Agronomía Universidad de Buenos AiresIFEVA/CONICETArgentina Unidad Integrada Balcarce Facultad de Ciencias AgrariasUniversidad Nacional de Mar del Plata(UNMdP)Estación Experimental Agropecuaria Balcarce(INTA)Argentina Department of Agricultural Research and Diagnosis Secretariat of AgricultureLivestock and Rural Development of Rio Grande do Sul Facultad de Agronomía Universidad de la RepúblicaUruguay

The Rio de la Plata region comprises central Argentina,Uruguay,and southern *** agriculture developed around 1900 with recent decades being characterized by the advance of cropping areas over native *** specialized agriculture has decoupled crop and livestock production but has succeeded in intensifying ***,significant losses of ecosystem services have been ***,questions have been raised on the sustainability of this pathway.A glance at world regions that have experienced similar trends suggests that an urgent course correction is needed.A major concern has been the lack of diversity in regions with highly specialized agriculture,promoting renewed interest in integrated crop-livestock systems(ICLS),not only because ICLS are more diverse than specialized systems,but also because they are rare examples of reconciliation between agroecosystem intensification and environmental ***,this paper discusses alternatives to redesign multifunctional landscapes based on *** data provide evidence that recoupling crop and animal production increases the resilience of nutrient cycling functions and economic indicators to external stressors,enabling these systems to face climate-market uncertainty and reconcile food production with the provision of diverse ecosystem ***,these concepts are exemplified in case studies where this perspective has been successfully applied.

关键词： grazing integrated crop-livestock systems mixed crops-livestock Pampa

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基础结构系统的地震危害分析

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工程抗震与加固改造 1982年第S1期 40-48页

作者： hctor Monzn-Despang haresh C.Shah 钮泽蓁美国斯坦福大学美国斯坦福大学博士研究生 john A.Blume地震工程中心研究助理教授 johm A.Blume地震工程中心主任

本文讨论生命线及其他基础结构系统(Infrastructural!system)地震风险(Seismic hazard)和危害(risk)的定量估计。中心目的是确定基础结构系统由于地震而引起的不同程度损坏的可能性以及如何使用这些资料。地震风险通过系统对破坏性地震... 详细信息

本文讨论生命线及其他基础结构系统(Infrastructural!system)地震风险(Seismic hazard)和危害(risk)的定量估计。中心目的是确定基础结构系统由于地震而引起的不同程度损坏的可能性以及如何使用这些资料。地震风险通过系统对破坏性地震的总反应来度量。文章提及了描述总体反应的可能参数,但未作详细讨论,参考文献则已列出。重点是放在用这种参数作为风险量度的哲理。文中论述了算法的一般结构,所要做的假定,以及进行分析的模拟技术,介绍了地震危害分析,可靠性概念的应用及预期的性能。可以肯定,所需的分析方法都是以大量不确定的和(或)主观的资料为基础的。但是,这些方法却可以对基础结构系统的抗震性能提供一种非常有价值的见解。

关键词：结构系统强烈程度概率地震期望损失随机过程概率论地面运动地壳运动反应抗震性能危害分析

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西班牙中学校园欺负监测研究报告

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中国青年研究 2009年第8期 20-24页

作者： Cristna del Barrio Elena Mart N Ignacio Montero Isabel Fern.Nelez h.ctor gutirrEz 周华珍李家灿西班牙马德里自治大学法学院

校园欺负行为是中学校园中常见的现象,它严重地影响了中学生的身心健康。本报告采用问卷调查的方式对西班牙全国300多所中学中3000名学生和300名老师进行调查。从受害者、欺负者、观察者三个视角对西班牙中学校园欺负行为进行研究,报告... 详细信息

校园欺负行为是中学校园中常见的现象,它严重地影响了中学生的身心健康。本报告采用问卷调查的方式对西班牙全国300多所中学中3000名学生和300名老师进行调查。从受害者、欺负者、观察者三个视角对西班牙中学校园欺负行为进行研究,报告认真地分析了年级、性别、数量、地点等变量与欺负的相关度。

关键词：欺负受害者欺负者观察者关系

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