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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun Shin Chul min Park Hong Gi Kim Dong-Eun Kim min Suk choi Jeong-ah Kim Byeong-Sun choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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State-of-the-art preoperative staging of gastric cancer by MDCT and magnetic resonance imaging

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World Journal of Gastroenterology 2014年第16期20卷 4546-4557页

作者： Joon-Il choi Ijin Joo Jeong min Lee Department of Radiology Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Radiology and Institute of Radiation Medicine Clinical Research InstituteSeoul National University HospitalSeoul National University College of MedicineSeoul 110-744South Korea

Gastric cancer is one of the most common and fatal cancers. The importance of accurate staging for gastric cancer has become more critical due to the recent introduction of less invasive treatment options, such as endoscopic mucosal resection or laparoscopic surgery. The tumor-node-metastasis staging system is the generally accepted staging system for predicting the prognosis of patients with gastric cancer. Multidetector row computed tomography (MDCT) is a widely accepted imaging modality for the preoperative staging of gastric cancer that can simultaneously assess locoregional staging, including the gastric mass, regional lymph nodes, and distant metastasis. The diagnostic performance of MDCT for T- and N-staging has been improved by the technical development of isotropic imaging and 3D reformation. Although magnetic resonance imaging (MRI) was not previously used to evaluate gastric cancer due to the modality’s limitations, the development of high-speed sequences has made MRI a feasible tool for the staging of gastric cancer.

关键词： Gastric cancer Multidetector row computed tomography Magnetic resonance imaging Preoperative staging The tumor-node-metastasis staging

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Case Report:Congenital atresia of the left main coronary artery in an infant

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 539-541页

作者： Su Ye SOHN Gi Young JANG Byung min choi Department of Pediatrics Korea University Hospital

Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularizationbypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A lO-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral atresia of the left main coronary artery with a severe papillary muscle and chordae. Coronary angiography showed hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully.

关键词： Conqenital heart disease Anomalous coronaries Infant

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Microstructure of fast tool servo machining on copper alloy

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中国有色金属学会会刊：英文版 2012年第S3期22卷 820-824页

作者： Hong LU Soo-chang choi Sang-min LEE Deug-woo LEE Department of Nano Fusion Technology Pusan National University Korea Institute of Machinery & Materials Department of Nano Mechatronics Engineering Pusan National University

The development of the fast tool servo (FTS) for precision machining was *** micron machining performance of a piezoelectric-assisted FTS on copper alloy was *** results indicate that the quality of the microstructure depends mainly on two important factors:the cutting speed (or spindle speed) and the driving frequency of the *** excessive driving frequency increases the formation of *** effect of the clearance angle of the diamond tool on the microstructure machining precision was also investigated.

关键词： fast tool servo microstructure piezoelectric diamond machining copper alloy

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Feedback Control of an Achiral Robotic Microswimmer

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Journal of Bionic Engineering 2017年第2期14卷 245-259页

作者： U Kei Cheang Hoyeon Kim Dejan Milutinovic Jongeun choi min Jun Kim Department of Mechanical Engineering and Mechanics Drexel University Philadelphia PA 19104 USA Department of Mechanical Engineering Southern Methodist University Dallas TX75275 USA Department of Computer Engineering University of California Santa Cruz Santa Cruz California 95064 USA School of Mechanical Engineering Yonsei University Seoul South Korea

Magnetic microswimmers are useful for navigating and performing tasks at small scales. To demonstrate effective control over such microswimmers, we implemented feedback control of the three-bead achiral microswimmers in both simulation and experiment. The achiral microswimmers with the ability to swim in bulk fluid are controlled wirelessly using magnetic fields generated from electromagnetic coils. The achirality of the microswimmers introduces unknown handedness resulting in uncertainty in swimming direction. We use a combination of rotating and static magnetic fields generated from an approximate Helmholtz coil system to overcome such uncertainty. There are also movement uncertainties due to environmental factors such as unsteady flow conditions. A kinematic model based feedback controller was created based on data fitting of experimental data. However, the controller was unable to yield satisfactory performance due to uncertainties from environmental factors; i.e., the time to reach target pose under adverse flow condition is too long. Following the implementation of an integral controller to control the microswimmers＇ swimming velocity, the mieroswimmers were able to reach the target in roughly half the time. Through simulation and experiments, we show that the feedback control law can move an achiral microswimmer from any initial conditions to a target pose.

关键词： microrobotics magnetic control low Reynold number chirality feedback control

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Wave-Tide-Surge Coupled Simulation for Typhoon Maemi

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China Ocean Engineering 2013年第2期27卷 141-158页

作者： Byung Ho choi Byung Il min Kyeong Ok Kim Jin Hee Yuk Department of Civil and Environmental Engineering Sungkyunkwan University Marine Environments & Conservation Research Division Korea Institute of Ocean Science & Technology Supercomputing Center Korea Institute of Science and Technology Information

The main task of this study focuses on studying the effect of wave-current interaction on currents, storm surge and wind wave as well as effects of current induced wave refraction and current on waves by using numerical models which consider the bottom boundary layer and sea surface roughness parameter for shallow and smooth bed area around Korean Peninsula. The coupled system （unstructured-mesh SWAN wave and ADCIRC） run on the same unstructured mesh. This identical and homogeneous mesh allows the physics of wave-circulation interactions to be correctly resolved in both models. The unstructured mesh can be applied to a large domain allowing all energy from deep to shallow waters to be seamlessly followed. There is no nesting or overlapping of structured wave meshes, and no interpolation is required. In response to typhoon Maemi （2003）, all model components were validated independently, and shown to provide a faithful representation of the system＇s response to this storm. The waves and storm surge were allowed to develop on the continental shelf and interact with the complex nearshore environment. The resulting modeling system can be used extensively for prediction of the typhoon surge. The result show that it is important to incorporate the wave-current interaction effect into coastal area in the wave-tide-surge coupled model. At the same time, it should consider effects of depth-induced wave breaking, wind field, currents and sea surface elevation in prediction of waves. Specially, we found that：（1） wave radiation stress enhanced the current and surge elevation otherwise wave enhanced nonlinear bottom boundary layer decreased that, （2） wind wave was significantly controlled by sea surface roughness thus we cautiously took the experimental expression. The resulting modeling system can be used for hindcasting （prediction） the wave-tide-surge coupled environments at complex coastline, shallow water and fine sediment area like areas around Korean Peninsula.

关键词： typhoon Maemi finite element model tide-surge-wave coupling

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Management of lymphedema is really a matter in patients with breast cancer

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World Journal of Clinical Cases 2024年第15期12卷 2482-2486页

作者： Jung Eun choi min Cheol Chang Department of Surgery College of MedicineYeungnam UniversityDaegu 705-717South Korea Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717South Korea

Lymphedema is a prevalent complication affecting patients with breast cancer,greatly impacting their quality of *** editorial describes diagnostic methods and therapeutic interventions for managing lymphedema in patients with breast *** relies on clinical evaluation and objective measures,including arm circumference and volumetric assessments,along with lymphoscintigraphy and ultrasonic *** primarily involves complex decongestive physical therapy,comprising manual lymphatic drainage,compression therapy,exercise,and meticulous skin *** interventions aim to reduce swelling,alleviate discomfort,and prevent further ***,lifestyle modifications such as avoiding extreme temperatures and maintaining proper hygiene are *** can be used for drug *** its prevalence,lymphedema often receives inadequate attention in clinical practice,emphasizing the importance of raising awareness and enhancing medical services for affected *** play a pivotal role in educating patients about preventive measures and ensuring timely ***,a comprehensive approach encompassing early diagnosis,multidisciplinary management,and patient education is essential to mitigate the burden of lymphedema in patients with breast cancer and improve their overall well-being.

关键词： Lymphedema Breast cancer Complex decongestive physical therapy Diagnosis Treatment

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Delayed inflammatory response evoked in nasal alloplastic implants after COVID-19 vaccination: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8298-8303页

作者： min-Gi Seo Eun Kyung choi Kyu Jin Chung Department of Plastic and Reconstructive Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Anesthesiology and Pain Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after *** exact causes and mechanisms are unclear,but several triggering factors,including infections,trauma,dental procedures,and vaccination,have been *** SUMMARY A 39-year-old male patient who had undergone augmentation rhinoplasty 8 years ago had DIRs after the administration of the first dose of the mRNA Pfizer coronavirus disease 2019(COVID-19)*** suddenly had tender,erythematous swelling on his face 6 d after *** there was no improvement in the patient’s condition after the conservative treatment,surgical removal of an alloplastic nasal implant was *** after the surgery,the DIRs and accompanying symptoms ameliorated rapidly.A histological study conducted during surgery was fibrosis and small fragments of the hyaline *** The correlation between DIRs and COVID-19 vaccination has not been reported yet and the exact mechanism is *** the uncontrolled inflammatory reactions on the nose leave serious sequelae,surgeons should be conscious of the correlation between COVID-19 vaccines and DIRs associated with nasal alloplastic *** further histological or microbiological studies should be performed to determine the cause of DIRs.

关键词： Delayed inflammatory reactions Alloplast rhinoplasty Silicone COVID-19 Vaccination Case report

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Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

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World Journal of Gastroenterology 2018年第16期24卷 1708-1724页

作者： Yu-min choi So-Young Lee Bum-Joon Kim Department of Microbiology and Immunology Biomedical Sciences Liver Research Institute and Cancer Research Institute Seoul National University College of Medicine

The annual number of deaths caused by hepatitis B virus(HBV)-related disease, including cirrhosis and hepatocellular carcinoma(HCC), is estimated as 887000. The reported prevalence of HBV reverse transcriptase(RT) mutation prior to treatment is varied and the impact of preexisting mutations on the treatment of na?ve patients remains controversial, and primarily depends on geographic factors, HBV genotypes, HBe Ag serostatus, HBV viral loads, disease progression, intergenotypic recombination and co-infection with HIV. Different sensitivity of detection methodology used could also affect their prevalence results. Several genotype-dependent HBV RT positions that can affect the emergence of drug resistance have also been reported. Eight mutations in RT(rtL80I, rtD134N, rtN139K/T/H, rtY141F, rtM204I/V, rtF221Y, rtI224V, and rtM309K) are significantly associated with HCC progression. HBe Ag-negative status, low viral load, and genotype C infection are significantly related to a higher frequency and prevalence of preexisting RT mutations. Preexisting mutations are most frequently found in the A-B interdomain of RT which overlaps with the HBs Ag "a" determinant region, mutations of which can lead to simultaneous viral immune escape. In conclusion, the presence of baseline RT mutations can affect drug treatment outcomes and disease progression in HBVinfected populations via modulation of viral fitness and host-immune responses.

关键词： polymerase hepatocellular carcinoma reverse transcriptase preexisting mutations hepatitis B virus

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Stabilizing lithium deposition within bimodal porous SiO_(2)-TiO_(2) microspheres as 3D host structure

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Nano Research 2024年第11期17卷 10179-10188页

作者： Noeul Kim Jae Hun choi min Kim Dae Soo Jung Yun Chan Kang Department of Materials Science and Engineering Korea University Anam-Dong Seongbuk-Gu Seoul 136-713 Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering and Technology Soho-ro Jinju-si Gyeongnam-do 52851 Republic of Korea

Three-dimensional (3D) host materials for lithium metal anodes (LMAs) have gained attention because they can mitigate volume expansion and local current density through their large surface area and suppress the dendritic growth of lithium. Recent research on 3D host materials has focused on conductive materials;however, the benefits of 3D host materials cannot be fully utilized because lithium deposition begins at the top of the structure. Herein, we fabricate SiO_(2)-TiO_(2) composite microspheres with bimodal pore structures (bi-SiTiO) by simple spray pyrolysis. These microspheres effectively store lithium within the structure from the bottom of the electrode while preventing lithium dendrite formation. Focused ion beam-scanning transmission electron microscopy (FIB-STEM) analysis reveals that the lithiophilic properties of composite microspheres enhanced their effectiveness in storing lithium, with small pores acting as “lithium-ion sieves” for a uniform lithium-ion flux and large pores that provide sufficient volume for lithium deposition. The bi-SiTiO composite microspheres exhibit a high Coulombic efficiency of 98.5% over 200 cycles at 2.0 mA·cm^(−2) when operated in a lithium half-cell. With a high lithium loading of 5.0 mAh·cm^(−2), the symmetrical cell of the bi-SiTiO electrode sustains more than 900 h. A full cell coupled with an LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) (NCM811) cathode also exhibits enhanced electrochemical properties in terms of cycling stability and rate capability.

关键词： lithium metal battery spray pyrolysis three-dimensional(3D)host materials bimodal pore structure lithiophilic materials

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