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Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications

Nano-Micro Letters 2025年第5期17卷 145-192页

作者： Wei Yue Yunjian Guo Jong‐Chul Lee Enkhzaya Ganbold Jia-Kang Wu Yang Li Cong Wang Hyun Soo kim Young-Kee Shin Jun-Ge Liang Eun-Seong kim Nam-Young kim RFIC Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Jiangnan UniversityWuxi 214122People’s Republic of China School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China Department of Electronics Engineering Kwangwoon UniversitySeoul 01897South Korea Laboratory of Molecular Pathology and Cancer Genomics Department of Molecular Medicine and Biopharmaceutical SciencesGraduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826South Korea

Recent advancements in passive wireless sensor technology have significantly extended the application scope of sensing,particularly in challenging environments for monitoring industry and healthcare *** systems are equipped with battery-free operation,wireless connectivity,and are designed to be both miniaturized and *** features enable the safe,real-time monitoring of industrial environments and support high-precision physiological measurements in confined internal body spaces and on wearable epidermal *** the exploration into diverse application environments,the development of a systematic and comprehensive research framework for system architecture remains elusive,which hampers further optimization of these *** review,therefore,begins with an examination of application scenarios,progresses to evaluate current system architectures,and discusses the function of each component—specifically,the passive sensor module,the wireless communication model,and the readout module—within the context of key implementations in target sensing ***,we present case studies that demonstrate the feasibility of proposed classified components for sensing scenarios,derived from this systematic *** outlining a research trajectory for the application of passive wireless systems in sensing technologies,this paper aims to establish a foundation for more advanced,user-friendly applications.

关键词： Wireless sensing Passive detection Harsh environment Biomedical monitoring Flexible sensors

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL kim JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE kim Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Mechanical properties of high-strength concrete subjected to high temperature by stressed test

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中国有色金属学会会刊：英文版 2009年第B09期19卷 128-133页

作者： gyu-Yong kim Young-Sun kim Tae-gyu LEE Division of Architecture Engineering Chun gnam National University

Recently, the effects of high temperature on compressive strength and elastic modulus of high strength concrete were experimentally investigated. The present study is aimed to study the effect of elevated temperatures ranging from 20 ℃ to 700 ℃ on the material mechanical properties of high-strength concrete of 40, 60 and 80 MPa grade. During the strength test, the specimens are subjected to a 25% of ultimate compressive strength at room temperature and sustained during heating, and when the target temperature is reached, the specimens are loaded to failure. The tests were conducted at various temperatures (20-700 ℃) for concretes made with W/B ratios of 46%, 32% and 25%, respectively. The results show that the relative values of compressive strength and elastic modulus decrease with increasing compressive strength grade of specimen.

关键词：高强混凝土高温作用力学性能测试抗压强度温度升高弹性模量强度试验

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Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

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World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee Young-Ju Lim Hee-Yeon kim Wansoo kim Wook-Tae Park Min-Jung Ma Junho Lee Min-Soo Seo Young In kim Sangbum Park Seong-Kyoon Choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life Science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung kim Gye Ryeol Park Jae Eun Ryu Ji Eun kim In Young Kang Hye Young kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2) Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2) Production

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Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon kim Jaebeom Park Sunmi Im Michael R.Hoffmann Kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2) production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2) overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2) marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

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Tuning surface-active sites of Ru catalysts for the selective deoxygenation of lignin monomers to fuels and chemicals

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Science China Chemistry 2025年

作者： Rizky Gilang Kurniawan Jongho Choi Neha Karanwal Seung Min kim Seok Ki kim Deepak Verma Jaehoon kim School of Chemical Engineering Sungkyunkwan University School of Mechanical Engineering Sungkyunkwan University SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Institute of Advanced Composite Materials Korea Institute of Science and Technology Department of Chemical Engineering Ajou University

Cycloalkanes and cyclohexanols find diverse applications, including sustainable aviation fuel, fuel additives, and value-added chemicals. These compounds can be produced via complete or selective hydrodeoxygenation（HDO） of lignin-derived phenolic monomers. In this study, a urea-assisted method was employed to control the size of Ru nanoparticles（NPs） and tune the surfaceactive sites on Ru metal supported on CNx. By adjusting the Ru-to-urea molar ratio, both the size of Ru NPs and the metallic-tooxide ratio of Ru were controlled, along with the incorporation of N atoms into the RuO2surface coordination. In the absence of urea, the Ru/CNx（1:0） catalyst, containing 4.8 nm Ru NPs, achieved complete HDO of 4-propyl guaiacol to n-propyl cyclohexane through ring saturation, followed by hydro-demethoxylation of the C–OCH3group, and hydrogenolysis of the –OH group, with a 97.0% yield at an initial H2pressure of 1.5 MPa, 200 °C, and 20 h in water. The final hydrogenolysis step was inhibited over the urea-assisted catalysts. The Ru/CNx（1:8） catalyst, containing 3.1 nm Ru NPs, achieved a maximum selectivity of 67.6% for n-propyl cyclohexanol, along with complete conversion of 4-propyl guaiacol. Similar trends were observed in the product distribution when upgrading reductive catalytic fractionation bio-oil over Ru/CNx（1:0） and Ru/CNx（1:8）.

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Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution

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Zoological Research 2025年第01期 165-176页

作者： Eun Jung Kwon Hyeon Mi Sung Hansong Lee Soyul Ahn Yejin kim Chae Rin Lee Kihun kim Kyungjae Myung Won Kyu kim Dokyoung kim Sanghwa Jeong Chang-Kyu Oh Yun Hak kim Medical Research Institute Pusan National University Institute for Future Earth Pusan National University Department of Convergence Medical Sciences School of Medicine Pusan National University Department of Biomedical Informatics School of Medicine Pusan National University Department of Anatomy School of Medicine Pusan National University Center for Genomic Integrity Institute for Basic Science Department of Biomedical Engineering College of Information-Bio Convergence Engineering Ulsan National Institute of Science and Technology Natural Product Research Center Korea Institute of Science and Technology (KIST) Department of Convergence Medicine Yonsei University Wonju College of Medicine Natural Product Applied Science KIST School University of Science and Technology (UST) Department of Biomedical Science Graduate School Kyung Hee University Department of Anatomy and Neurobiology College of Medicine Kyung Hee University Department of Precision Medicine Graduate School Kyung Hee University Center for Converging Humanities Kyung Hee University KHU-KIST Department of Converging Science and Technology Kyung Hee University UC San Diego Materials Research Science and Engineering Center Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Core Research Institute (CRI)Kyung Hee University Center for Brain Technology Brain Science Institute Korea Institute of Science and Technology (KIST) School of Biomedical Convergence Engineering Pusan National University Department of Biochemistry School of Medicine Pusan National University

Polystyrene nanoparticles pose significant toxicological risks to aquatic ecosystems, yet their impact on zebrafish(Danio rerio) embryonic development, particularly erythropoiesis, remains underexplored. This study used single-cell RNA sequencing to comprehensively evaluate the effects of polystyrene nanoparticle exposure on erythropoiesis in zebrafish embryos. In vivo validation experiments corroborated the transcriptomic findings,revealing that polystyrene nanoparticle exposure disrupted erythrocyte differentiation, as evidenced by the decrease in mature erythrocytes and concomitant increase in immature erythrocytes. Additionally, impaired heme synthesis further contributed to the diminished erythrocyte *** findings underscore the toxic effects of polystyrene nanoparticles on hematopoietic processes, highlighting their potential to compromise organismal health in aquatic environments.

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Identification of patients with advanced pancreatic cancer who might benefit from third-line chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 74-83页

作者： Bomi kim Jaihwan kim Soomin Yang Jinwoo Ahn Kwangrok Jung Jong-Chan Lee Jin-Hyeok Hwang Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Survival rates of patients with advanced pancreatic cancer(APC)have been improved with palliative chemotherapy *** current preferred first-line regimen consists of combination therapy of 5-fluorouracil(5-FU)/leucovorin(LV),irinotecan,and oxaliplatin(FOLFIRINOX)or gemcitabine plus albumin-bound paclitaxel(GNP).After failure of first-line chemotherapy,there are a few options for subsequent therapy including switch to the unused first-line regimen or nanoliposomal irinotecan and 5-FU/***,there are limited studies on the efficacy of third-line chemotherapy after failure of second-line *** To identify patients with APC who might benefit from third-line *** Medical records from a single tertiary hospital were retrospectively reviewed between 2012 and *** study included patients with histologically or cytologically confirmed metastatic or locally APC who underwent first-line FOLFIRINOX or GNP and subsequently received third-line *** survival(OS)after diagnosis and OS after third-line chemotherapy(OS3)were defined as the interval from the diagnosis to all-cause death and the time between the initiation of the third-line chemotherapy to all-cause death,*** A total of 141 patients were *** median patient age at diagnosis was 61.8 years(36.0-86.0),and 54.9%were *** first-line regimen was FOLFIRINOX(67.4%)or GNP(32.6%).The second-line regimen was FOLFIRINOX(27.0%),GNP(52.5%),or other(20.6%).The median OS was 19.0 months,and the median OS3 and progression-free survival after third-line treatment were 15.3 and 7.3 weeks,*** regard to the best tumor response during third-line chemotherapy,1.4%had partial response,24.8%had stable disease,and 59.6%had progressive *** following clinical factors before third-line chemotherapy affected OS3:Good performance status(PS),serum carbohydrate antigen 19-9(CA19-9)level<1000 U/mL,duration of second-line chemotherapy≥

关键词： Pancreatic cancer Chemotherapy Survival Performance status Carbohydrate antigen 19-9

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemical Engineering(Integrated process) Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Republic of Korea Department of Chemical Engineering and Materials Science Ewha Womans University52 Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical Engineering Pukyong National University45 Yongso-roNam-guBusan 48513Republic of Korea Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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