检索结果-南通市图书馆

Journal of Central South University 2011年第1期18卷 165-170页

作者： JANG Ki-Bong AN Ho-Jin kim gyu-tak School of Mechatronics Changwon National University

The use of design method considering a coil temperature to maximize the thrust density of a double side coreless permanent magnet linear synchronous motor(PMLSM) was *** optimal current density where the coil temperature reaches an allowable temperature with heat analysis was applied to a magnetic circuit *** optimal current density is verified whenever the design parameters of the motor are *** design parameters of the motor were applied to thrust *** this way,the optimal model,which is a reversal of the existing design method,is *** results were compared with the experimental data to verify their *** the convection heat transfer coefficient is applied to other models,the results of the analysis and test values show good *** method proposed has some limitations.

关键词： permanent magnet linear synchronous motor current density heat transfer temperature thickness of coil

Optimal design of auxiliary-teeth to solve circulation current reduction of permanent magnet linear synchronous motor

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第3期18卷 690-696页

作者： JANG Ki-bong kim Jee-hyun AN Ho-jin kim gyu-tak School of Mechatronics Changwon National University

A discontinuity of magnetic circuits according to the end effect is generated in the permanent magnet linear synchronous motor （PMLSM）. Due to the unbalanced back electro-motive force （EMF） and impedance produced, unbalanced current is generated. The cireulatin8 current, which is caused by a decrease in the thrust, is generated by the unbalanced current. The optimal design of auxiliary-teeth at the end of the mover was carried out to solve the unbalance of phase by using design of experiment （DOE）, and compared with the basic model through finite element analysis （FEA）. As a result, the auxiliary-teeth model compensates for the decrease of thrust caused by the unbalanced phase. Also, this model is proven to reduce the detent force by the vibration and noise of the PMLSM and copper loss caused by the circulating current.

关键词： permanent magnet linear synchronous motor auxiliary-teeth circulation current end effect thrust reduction

Optimal design of FRMSM to decrease detent force

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第2期18卷 458-464页

作者： JANG Ki-Bong PYO Se-Ho AN Ho-Jin kim gyu-tak School of Mechatronics Changwon National University

An optimal configuration of the flux-reversal linear synchronous motor (FRLSM) with the optimal number of attachment permanent magnets (PMs) was presented. The optimal model of 2 000 N was designed to reduce the detent force by redesigning the air-gap structure and skewing. The design parameters,mover PMs and stator core,were selected for optimal design by DOE. The thrust and the detent force of the designed optimal models were compared by finite element analysis (FEA). As a result,the thrust of the optimal model is slightly decreased by 1.97% compared with the basic model,and the detent force of the optimal model is greatly decreased by 88.47% compared with the basic model.

关键词： flux-reversal linear synchronous motor detent force thrust design of experiment skew and overhang

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2012年第2期19卷 357-364页

作者： CHO gyu-won WOO Seok-hyun JI Seung-hun PARK Kyoung-won JANG Ki-bong kim gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Mechanical properties of high-strength concrete subjected to high temperature by stressed test

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第B09期19卷 128-133页

作者： gyu-Yong kim Young-Sun kim Tae-gyu LEE Division of Architecture Engineering Chun gnam National University

Recently, the effects of high temperature on compressive strength and elastic modulus of high strength concrete were experimentally investigated. The present study is aimed to study the effect of elevated temperatures ranging from 20 ℃ to 700 ℃ on the material mechanical properties of high-strength concrete of 40, 60 and 80 MPa grade. During the strength test, the specimens are subjected to a 25% of ultimate compressive strength at room temperature and sustained during heating, and when the target temperature is reached, the specimens are loaded to failure. The tests were conducted at various temperatures (20-700 ℃) for concretes made with W/B ratios of 46%, 32% and 25%, respectively. The results show that the relative values of compressive strength and elastic modulus decrease with increasing compressive strength grade of specimen.

关键词：高强混凝土高温作用力学性能测试抗压强度温度升高弹性模量强度试验

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration