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Prediction of overall survival following colorectal cancer surgery in elderly patients

World Journal of Gastrointestinal Surgery 2019年第5期11卷 247-260页

作者： Isaac Seow-En Winson Jianhong Tan Sreemanee Raaj Dorajoo Sharon Hui Ling Soh Yi Chye Law Soo Yeun Park gyu-seok choi Wah Siew Tan Choong Leong Tang Min Hoe Chew Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Department of General Surgery Sengkang General HospitalSingapore 544886Singapore Department of Pharmacy National University of SingaporeSingapore 117559Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Colorectal Cancer Center Kyungpook National University Chilgok HospitalKyungpook National University School of MedicineDaegu 702-210South Korea

BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid *** major surgery for these elderly patients can be *** accurate tool demonstrating post-operative survival probability would be useful for surgeons and their *** To integrate clinically significant prognostic factors relevant to elective colorectal surgery in the elderly into a validated pre-operative scoring *** In this retrospective cohort study,patients aged 70 and above who underwent surgery for CRC at Singapore General Hospital between 1 January 2005 and 31 December 2012 were identified from a prospectively maintained *** with evidence of metastatic disease,and those who underwent emergency surgery or had surgery for benign colorectal conditions were excluded from the *** primary outcome was overall 3-year overall survival(OS)following surgery.A multivariate model predicting survival was derived and validated against an equivalent external surgical cohort from Kyungpook National University Chilgok Hospital,South *** analyses were performed using Stata/MP Version *** A total of 1267 patients were identified for *** median post-operative length of stay was 8[interquartile range(IQR)6-12]d and median follow-up duration was 47(IQR 19-75)*** OS was 78(IQR 65-85)*** multivariate analysis,the factors significant for predicting overall mortality were serum albumin<35 g/dL,serum carcinoembryonic antigen≥20μg/L,T stage 3 or 4,moderate tumor cell differentiation or worse,mucinous histology,rectal tumors,and pre-existing chronic obstructive lung *** age alone was not found to be *** Korean cohort consisted of 910 *** Singapore cohort exhibited a poorer OS,likely due to a higher proportion of advanced *** the clinicopathologic di

关键词： Colorectal cancer surgery Elderly Overall survival Pre-operative prognostic score

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Steady-state probability density function in wave turbulence under large volume limit

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Chinese Physics B 2011年第5期20卷 139-145页

作者： Yeontaek choi Sang gyu Jo Division of Fusion and Convergence of Mathematical Sciences National Institute for Mathematical SciencesDaejeon 305-340Republic of Korea Department of Physics Kyungpook National UniversityDaegu 702-701Republic of Korea

We investigate the possibility for two-mode probability density function （PDF） to have a non-zero flux steady state solution. We take the large volume limit so that the space of modes becomes continuous. It is shown that in this limit all the steady-state twoor higher-mode PDFs are the product of one-mode PDFs. The flux of this steady-state solution turns out to be zero for any finite mode PDF.

关键词： wave turbulence probability flux multi-mode probability density function Larguerreequation

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Simultaneous laparoscopic multi-organ resection combined with colorectal cancer:Comparison with non-combined surgery

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World Journal of Gastroenterology 2012年第8期18卷 806-813页

作者： Hye Jin Kim gyu-Seog choi Jun seok Park Soo Yeun Park Soo Han Jun Department of Surgery Kyungpook National University Hospital School of Medicine Kyungpook National University Department of Surgery Daegu Catholic Medical Center Catholic University of Daegu

AIM: To access the short-term outcomes of simultaneous laparoscopic surgery combined with resection for synchronous lesions in patients with colorectal cancer. METHODS: Between March 1996 and April 2010 prospectively collected data were reviewed from 93 consecutive patients who had colorectal cancer and underwent simultaneous multiple organ resection (combined group) and 1090 patients who underwent conventional laparoscopic right hemicolectomy or laparoscopic low/ anterior resection for colorectal cancer (non-combined group). In the combined group, there were nine gastric resections, three nephrectomies, nine adrenalectomies, 56 cholecystectomies, and 21 gynecologic resections. In addition, f ive patients underwent simultaneous laparoscopic resection for three organs. The patient demographics, intra-operative outcomes, surgical morbidity, and short-term outcomes were compared between thetwo groups (the combined and non-combined groups). RESULTS: There were no signifi cant differences in the clinicopathological variables between the two groups. The operating time was signifi cantly longer in the combined group than in the non-combined group, regardless of tumor location (laparoscopic right hemicolectomy and laparoscopic low/anterior resection groups; P = 0.048 and P < 0.001, respectively). The other intraoperative outcomes, such as the complications and open conversion rate, were similar in both groups. The rate of post-operative morbidity in the combined group was similar to the non-combined group (combined vs non-combined, 15.1% vs 13.5%, P = 0.667). Oncological safety for the colon and synchronous lesions were obtained in the combined group. CONCLUSION: Simultaneous laparoscopic multiple organ resection combined with colorectal cancer is a safe and feasible option in selected patients.

关键词： Laparoscopic combined resection Colorectal cancer Laparoscopic surgery

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Intelligent Service Search Model Using Emerging Technologies

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Computers, Materials & Continua 2023年第10期77卷 1165-1181页

作者： Farhan Amin gyu Sang choi Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

In recent years,the Internet of Things(IoT)has played a vital role in providing various services to users in a smart ***,searching for services,objects,data,and frameworks remains a *** technological advancements in Cyber-Physical Systems(CPSs)and the Social Internet of Things(SIoT)open a new era of ***,we propose a Cyber-Physical-Social Systems(CPSs)for service ***,service search and object discovery operation carries with the suitable selection of friends in the *** proposed model constructs a graph and performs social network analysis(SNA).We suggest degree centrality,clustering,and scalefree emergence and show that a rational selection of friends per service exploration increases the overall network *** efficiency of our proposed system is verified using real-world datasets based on service processing time,path length,giant component,and network *** simulation results proved that our proposed system is efficient,robust,and scalable.

关键词： Internet of Things Social Internet of Things Cyber-Physical Social systems smart cities service search smart cities

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Model for Generating Scale-Free Artificial Social Networks Using Small-World Networks

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Computers, Materials & Continua 2022年第12期73卷 6367-6391页

作者： Farhan Amin gyu Sang choi Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

The Internet of Things(IoT)has the potential to be applied to social networks due to innovative characteristics and sophisticated solutions that challenge traditional *** network analysis(SNA)is a good example that has recently gained a lot of scientific *** has its roots in social and economic research,as well as the evaluation of network science,such as graph *** in this area have subverted predefined theories,offering revolutionary ones regarding interconnected networks,and they have highlighted the mystery of six degrees of separation with confirmation of the small-world *** motivation of this study is to understand and capture the clustering properties of large networks and social *** present a network growth model in this paper and build a scale-free artificial social network with controllable clustering *** random walk technique is paired with a triangle generating scheme in our proposed *** a result,the clustering controlmechanism and preferential attachment(PA)have been *** research builds on the present random walk *** took numerous measurements for validation,including degree behavior and the measure of clustering decay in terms of node degree,among other ***,we conclude that our suggested random walk model is more efficient and accurate than previous state-of-the-art methods,and hence it could be a viable alternative for societal evolution.

关键词： Social networks small-world networks network generation models graph theory random walk network design social network analysis

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Analysis and Modeling of Mobile Phone Activity Data Using Interactive Cyber-Physical Social System

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Computers, Materials & Continua 2024年第9期80卷 3507-3521页

作者： Farhan Amin gyu Sang choi School of Computer Science and Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Mobile networks possess significant information and thus are considered a gold mine for the researcher’s *** call detail records(CDR)of a mobile network are used to identify the network’s efficacy and the mobile user’s *** is evident from the recent literature that cyber-physical systems(CPS)were used in the analytics and modeling of telecom *** addition,CPS is used to provide valuable services in smart *** general,a typical telecom company hasmillions of subscribers and thus generatesmassive amounts of *** this aspect,data storage,analysis,and processing are the key *** solve these issues,herein we propose a multilevel cyber-physical social system(CPSS)for the analysis and modeling of large internet *** proposed multilevel system has three levels and each level has a specific ***,raw Call Detail Data(CDR)was collected at the first ***,the data preprocessing,cleaning,and error removal operations were *** the second level,data processing,cleaning,reduction,integration,processing,and storage were ***,suggested internet activity record measures were *** proposed system initially constructs a graph and then performs network *** proposed CPSS system accurately identifies different areas of internet peak usage in a city(Milan city).Our research is helpful for the network operators to plan effective network configuration,management,and optimization of resources.

关键词： Cyber-physical social systems big data cyber-physical systems pervasive computing smart city big data management techniques

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Advanced Community Identification Model for Social Networks

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Computers, Materials & Continua 2021年第11期69卷 1687-1707页

作者： Farhan Amin Jin-Ghoo choi gyu Sang choi Department of Computer Engineering Gachon UniversityGyeonggi-do13120Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

Community detection in social networks is a hard problem because of the size,and the need of a deep understanding of network structure and *** several methods with significant effort in this direction have been devised,an outstanding open problem is the unknown number of communities,it is generally believed that the role of influential nodes that are surrounded by neighbors is very *** addition,the similarity among nodes inside the same cluster is greater than among nodes from other ***,the global and local methods of community detection have been getting more ***,in this study,we propose an advanced communitydetection model for social networks in order to identify network communities based on global and local *** proposed model initially detects the most influential nodes by using an Eigen score then performs local expansion powered by label *** process is conducted with the same color till nodes reach maximum ***,the communities are formed,and a clear community graph is displayed to the *** proposed model is completely parameter-free,and therefore,no prior information is required,such as the number of communities,*** perform simulations and experiments using well-known synthetic and real network benchmarks,and compare them with well-known state-of-the-art *** results prove that our model is efficient in all aspects,because it quickly identifies communities in the ***,it can easily be used for friendship recommendations or in business recommendation systems.

关键词： Community detection social network analysis complex networks

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