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Prevalence of coronavirus from diarrheic calves in the Republic of Korea

Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 1-6页

作者： Jinho park Du-gyeong Han Su Hee Kim Jeong-Byoung Chae Joon-Seok Chae Do-Hyeon Yu Kyoung-Seong Choi College of Veterinary Medicine Chonbuk National University Department of Animal Science and Biotechnology College of Ecology and Environmental Science Kyungpook National University Animal Disease & Biosecurity Team National Institute of Animal Science Rural Development Administration Laboratory of Veterinary Internal Medicine BK21 PLUS Program for Creative Veterinary Science Research Research Institute for Veterinary Science and College of Veterinary Medicine Seoul National University College of Veterinary Medicine Gyeongsang National University

Objective: To investigate the prevalence of bovine coronavirus(BCo V), bovine rotavirus, and bovine viral diarrhea virus in the feces of normal and diarrheic Korean native calves aged 1-81 days between April and October of 2016 in the Republic of Korea. Methods: Samples were obtained from 50 normal and 93 diarrheic(56 semi-formed, 28 loose, and 9 watery feces) calves in six different regions of northern and southern Korea. These fecal samples were tested for BCo V, bovine rotavirus, and bovine viral diarrhea virus by RT-PCR. Results: Among the three pathogens examined, infection with BCo V was especially prominent in relation to diarrhea among calves aged 1-21 days [odds ratio(OR)=9.3, 95% confidence interval(CI): 1.1-78.9; P=0.02). Infection with BCo V alone(OR=2.9; 95% CI: 1.1-7.6; P=0.03) or coinfection of BCo V with bovine viral diarrhea virus(OR=3.6; 95% CI: 1.0-12.4; P=0.04) was significantly associated with the development of loose feces. Grazing and colostrum intake strongly reduced the occurrence of diarrhea as compared to housed calves(OR=0.2; 95% CI: 0.1-0.4; P=0.00) and calves that had not been fed colostrum(OR=0.2; 95% CI: 0.1-0.7; P=0.02), respectively. Conclusions: The present study suggests that BCo V is involved in calf diarrhea in the Republic of Korea. Therefore, grazing and colostrum intake is recommended for preventing and controlling calf diarrhea caused by BCoV.

关键词： Calf diarrhea Bovine coronavirus Bovine viral diarrhea virus Loose feces Grazing

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Cycloaddition of CO_2 with epoxides by using an amino-acid-based Cu(Ⅱ)–tryptophan MOF catalyst

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Chinese Journal of Catalysis 2018年第1期39卷 63-70页

作者： gyeong Seon Jeong Amal Cherian Kathalikkattil Robin Babu Yongchul Greg Chung Dae Won park Division of Chemical and Biomolecular Engineering Pusan National University Busan 609‐735 Korea School of Chemistry University of Dublin Trinity College Dublin 2 Ireland

Metal organic frameworks(MOFs)constructed from natural/biological units(amino acids)are prospective candidates as catalysts in CO2chemistry owing to their natural origin and high abundance of Lewis acid/base sites and functional ***,we report the catalytic efficiency of an amino‐acid‐based Cu‐containing MOF,denoted as CuTrp(Trp=L‐tryptophan).The CuTrp catalyst was synthesized by direct mixing at room temperature using methanol as a solvent-a synthetic route with notable energy *** catalyst was characterized using various physicochemical techniques,including XRD,FT‐IR,TGA,XPS,ICP‐OES,FE‐SEM,and BET *** catalytic activity of CuTrp was assessed in the synthesis of cyclic carbonates from epoxides and *** CuTrp operated in synergy with the co‐catalyst tetrabutylammonium bromide under solvent‐free *** reaction parameters were studied to identify the optimal reaction conditions and a reaction mechanism was proposed based on experimental evidence and previous density functional theory *** CuTrp also exhibited satisfactory stability in water and could be reused more than three times without any significant loss of activity.?2018,Dalian Institute of Chemical Physics,Chinese Academy of *** by Elsevier *** rights reserved.

关键词： Metal organic frameworks Amino acid Copper tryptophan complex Direct mixing Carbon dioxide Cyclic carbonate

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Fluoropolymer-based organic memristor with multifunctionality for flexible neural network system

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npj Flexible Electronics 2021年第1期5卷 296-303页

作者： Min-Hwi Kim Hea-Lim park Min-Hoi Kim Jaewon Jang Jin-Hyuk Bae In Man Kang sin-Hyung Lee School of Electrical and Computer Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Creative Convergence Engineering Hanbat National UniversityYuseong-guDaejeon 305-719Republic of Korea School of Electronics Engineering and School of Electronic and Electrical EngineeringKyungpook National University80 Daehak-roBuk-guDaegu 702-701Republic of Korea

In this study,we propose an effective strategy for achieving the flexible one organic transistor–one organic memristor(1T–1R)synapse using the multifunctional organic *** dynamics of the conductive nanofilament(CF)in a hydrophobic fluoropolymer medium is explored and a hydrophobic fluoropolymer-based organic memristor is *** flexible 1T–1R synapse can be fabricated using the solution process because the hydrophobic fluorinated polymer layer is produced on the organic transistor without degradation of the underlying *** developed flexible synapse exhibits multilevel conductance with high reliability and stability because of the fluoropolymer film,which acts as a medium for CF growth and an encapsulating layer for the organic ***,the synapse cell shows potential for high-density memory systems and practical neural *** effective concept for developing practical flexible neural networks would be a basic platform to realize the smart wearable electronics.

关键词： transistor network neural

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Nanotechnology and vaccine development

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Asian Journal of Pharmaceutical Sciences 2014年第5期9卷 227-235页

作者： Mi-gyeong Kim Joo Yeon park Yuna Shon Gunwoo Kim Gayong Shim Yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 151-742Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence ScienceSeoul National UniversityDaehak-dongGwanank-guSeoulRepublic of Korea

Despite the progress of conventional vaccines,improvements are clearly required due to concerns about the weak immunogenicity of these vaccines,intrinsic instability in vivo,toxicity,and the need for multiple *** overcome such problems,nanotechnology platforms have recently been incorporated into vaccine ***-based delivery systems offer an opportunity to enhance the humoral and cellular immune *** advantage is attributable to the nanoscale particle size,which facilitates uptake by phagocytic cells,the gut-associated lymphoid tissue,and the mucosa-associated lymphoid tissue,leading to efficient antigen recognition and *** the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors,thereby stimulating specific and selective immune *** this review,we introduce recent advances in nanocarrierbased vaccine delivery systems,with a focus on the types of carriers,including liposomes,emulsions,polymer-based particles,and carbon-based *** describe the remaining challenges and possible breakthroughs,including the development of needlefree nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems.

关键词： Nanotechnology Vaccine delivery Liposomes Emulsions Polymeric nanocarriers Carbon nanomaterials

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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6200-6205页

作者： Sungwoo park Eun Jeong Jeong Jung Hun Kang gyeong-Won Lee Se-Il Go Dong-Hyun Lee Eun-Ha Koh Division of Hematology and Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52727South Korea Department of Internal Medicine Institute of Health SciencesGyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwon 52828South Korea Department of Laboratory Medicine Gyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52828South Korea

BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid ***,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its *** SUMMARY A 55-year-old male was diagnosed with T/myeloid ***,prednisolone,daunorubicin,and L-asparaginase were administered as induction *** shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory *** and decitabine were administered as chemotherapy-free induction therapy to reduce the infection *** were no serious infections,including febrile neutropenia,at the end of the *** receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to *** CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.

关键词： Mixed-phenotype acute leukemia Venetoclax Decitabine Case report

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A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair

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Bioactive Materials 2024年第1期31卷 395-407页

作者： Mingyu Lee Yong Sook Kim Junggeon park Goeun Choe Sanghun Lee Bo gyeong Kang Ju Hee Jun Yoonmin Shin Minchul Kim Youngkeun Ahn Jae Young Lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Cell Regeneration Research Center Chonnam National UniversityGwangjuRepublic of Korea Biomedical Research Institute Chonnam National University HospitalGwangjuRepublic of Korea Department of Cardiology Chonnam National University HospitalGwangjuRepublic of Korea Chonnam National University Medical School GwangjuRepublic of Korea

The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart,frequently leading to fatal functional *** attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug *** this study,we developed a paintable and adhesive hydrogel patch using dextran-aldehyde(dex-ald)and gelatin,incorporating the anti-inflammatory protein,ANGPTL4,into the hydrogel for sustained release directly to the infarcted heart to alleviate *** optimized the material composition,including polymer concentration and molecular weight,to achieve a paintable,adhesive hydrogel using 10%gelatin and 5%dex-ald,which displayed in-situ gel formation within 135 s,cardiac tissue-like modulus(40.5 kPa),suitable tissue adhesiveness(4.3 kPa),and excellent mechanical ***4 was continuously released from the gelatin/dex-ald hydrogel without substantial burst *** gelatin/dex-ald hydrogel could be conveniently painted onto the beating heart and degraded in ***,in vivo studies using animal models of acute myocardial infarction revealed that our hydrogel cardiac patch containing ANGPTL4 significantly improved heart tissue repair,evaluated by echocardiography and histological *** heart tissues treated with ANGPTL4-loaded hydrogel patches exhibited increased vascularization,reduced inflammatory macrophages,and structural maturation of cardiac *** novel hydrogel system,which allows for facile paintability,appropriate tissue adhesiveness,and sustained release of anti-inflammatory drugs,will serve as an effective platform for the repair of various tissues,including heart,muscle,and cartilage.

关键词： Cardiac patch Hydrogel Angiopoietin-like 4 Myocardial infarction

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim gyeong Min park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

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IEEE/CAA Journal of Automatica sinica 2025年第1期 270-272页

作者： Geun Il Song Hae Yeon park Jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

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Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang park Pyo-Jin sin Dong Hyeon Lee Seung-Kuy Cha Min-Jeong Kim Na-Hyun Kim Soon-Koo Baik Seong-Woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant Communications 2023年第4期4卷 225-239页

作者： gyeongik Ahn Hee Jin park Song Yi Jeong gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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