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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

World Journal of pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon péter Hauser györgy péter Csongor Kiss Miklós Garami István peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of pharmacology and pharmacotherapy Semmelweis UniversityBudapestHungary Department of pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support pediatric tumors precision oncology Tumor board

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Almost Everywhere Convergence of Fejér Means of L^1 Functions on Rarely Unbounded Vilenkin Groups

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2269-2294页

作者： gyrgy GT College of Nyíregyháza Institute of Mathematics and Computer Science

A highly celebrated problem in dyadic harmonic analysis is the pointwise convergence of the Fejér （or （C, 1）） means of functions on unbounded Vilenkin groups. There are several papers of the author of this paper concerning this. That is, we know the a.e. convergence σnf → f （n → ∞） for functions f ∈ L^p, where p 〉 1 （Journal of Approximation Theory, 101（1）, 1-36, （1999）） and also the a.e. convergence σMnf → f （n → ∞） for functions f ∈ L^1 （Journal of Approximation Theory, 124（1）, 25-43, （2003））. The aim of this paper is to prove the a.e. relation limn→∞ σnf = f for each integrable function f on any rarely unbounded Vilenkin group. The concept of the rarely unbounded Vilenkin group is discussed in the paper. Basically, it means that the generating sequence m may be an unbounded one, but its ＂big elements＂ are not ＂too dense＂.

关键词： rarely unbounded Vilenkin groups Vilenkin series Fejér means a.e. convergence

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Almost Everywhere Convergence of Sequences of Cesàro and Riesz Means of Integrable Functions with Respect to the Multidimensional Walsh System

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Acta Mathematica Sinica,English Series 2014年第2期30卷 311-322页

作者： gyrgy GT Institute of Mathematics and Computer Science College of Nyíregyhza

The aim of this paper is to prove the *** of sequences of the Cesaro and Riesz means of the Walsh–Fourier series of d variable integrable *** is,let a=（a1,...,ad）：N→Nd（d∈p）such that aj（n＋1）≥δsupk≤n aj（k）（j=1,...,d,n∈N）for someδ〉0 and a1（＋∞）=···=ad（＋∞）=＋∞.Then,for each integrable function f∈L1（Id）,we have the *** for the Cesaro means limn→∞σαa（n）f=f and for the Riesz means limn→∞σα,γa（n）f=f for any 0〈αj≤1≤γj（j=1,...,d）.A straightforward consequence of our result is the so-called cone restricted *** of the multidimensional Cesaro and Riesz means of integrable functions,which was proved earlier by Weisz.

关键词： Walsh system d-dimensional Fejer and Riesz means subsequence almost everywhereconvergence

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On the Divergence of N(?)rlund Logarithmic Means of Walsh-Fourier Series

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Acta Mathematica Sinica,English Series 2009年第6期25卷 903-916页

作者： gyrgy GAT Ushangi GOGINAVA Institute of Mathematics and Computer Science College of Nyíregyháza Department of Mechanics and Mathematics Tbilisi State University

It is well known in the literature that the logarithmic means 1/logn ^n-1∑k=1 Sk（f）/k of Walsh or trigonometric Fourier series converge a.e. to the function for each integrable function on the unit interval. This is not the case if we take the partial sums. In this paper we prove that the behavior of the so-called NSrlund logarithmic means 1/logn ^n-1∑k=1 Sk（f）/n-k is closer to the properties of partial sums in this point of view.

关键词： Walsh function Norlund logarithmic means a.e. divergence.

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Convergence in L^p-norm of Fourier Series on the Complete product of Quaternion Groups with Bounded Orders

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1566-1578页

作者： gyrgy GAT Rodolfo TOLEDO College of Nyiregyhza Inst.of Math.and Comp.Sci.Nyiregyhza

A well-known result for Vilenkin systems is the fact that for all 1 〈 p 〈 oc the n-th partial sums of Fourier series of all functions in the space Lp converge to the function in Lp-norm. This statement can not be generalized to any representative product system on the complete product of finite non-abelian groups, but even then it is true for the complete product of quaternion groups with bounded orders and monomial representative product system ordered in a specific way.

关键词： Fourier analysis Walsh-paley system representative product systems complete product of quaternion groups convergence in norm

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Role of Orvosi Hetilap in the development of Hungarian gastroenterology

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World Journal of Gastroenterology 2010年第18期16卷 2317-2320页

作者： gyrgy Miklós Buzás Department of Gastroenterology Ferencváros Health Service Non-profit Ltd.

AIM:To analyze the contribution of Orvosi Hetilap(Hungarian Medical Journal) to the field of ***:All issues of the journal between 1857 and 2008 and identified original articles and reviews dealing with gastroenterology were *** rate of publications,the thematic distribution and foreign sources of knowledge were *** dates that major achievements in gastroenterology were introduced in Hungary were compared to those dates in Western ***:A total of 4799 original/research articles on gastroenterology were published,which represents 11.1% of the total *** rankings showed that liver and biliary diseases represented 20.36% of the total,followed by gastric diseases(9.35%) and surgery(8.77%).A total of 268 foreign journals were reviewed:50.9% were German,30.4% English,12.1% French and only 6.6% were in other *** major achievements of gastroenterology were introduced with varying delays compared to Western ***:Orvosi Hetilap has made a large contribution to the development of Hungarian *** high proportion of gastroenterology studies underlines the importance of digestive diseases in public health.

关键词： Content analysis Gastroenterology Hepatology Orvosi Hetilap Scientometrics

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pointwise Convergence of Cone-like Restricted Two-dimensional Fejér Means of Walsh-Fourier Series

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Acta Mathematica Sinica,English Series 2010年第12期26卷 2295-2304页

作者： gyrgy GT Kroly NAgy Institute of Mathematics and Computer Sciences College of Nyíregyhza

For the two-dimensional Walsh system, Gat and Weisz proved the a.e. convergence of Fejer means σnf of integrable functions, where the set of indices is inside a positive cone around the identical function, that is, β^-1≤n1/n2 ≤β is provided with some fixed parameter ~ 〉 1. In this paper we generalize the result of Gat and Weisz. We not only generalize this theorem, but give a necessary and sufficient condition for cone-like sets in order to preserve this convergence property.

关键词： Walsh group Walsh system pointwise convergence Fejer means

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Factors Influencing Cities’ publishing Efficiency

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Journal of Data and Information Science 2018年第3期3卷 43-80页

作者： Csomós györgy Department of Civil Engineering University of Debrecen

purpose:Recently,a vast number of scientific publications have been produced in cities in emerging *** has long been observed that the publication output of Beijing has exceeded that of any other city in the world,including such leading centres of science as Boston,New York,London,paris,and *** have suggested that,instead of focusing on cities'total publication output,the quality of the output in terms of the number of highly cited papers should be ***,in the period from 2014 to 2016,Beijing produced as many highly cited papers as Boston,London,or New *** this paper,another method is proposed to measure cities'publishing performance by focusing on cities'publishing efficiency(i.e.,the ratio of highly cited articles to all articles produced in that city).Design/methodology/approach:First,554 cities are ranked based on their publishing efficiency,then some general factors influencing cities'publishing efficiency are *** general factors examined in this paper are as follows:the linguistic environment of cities,cities'economic development level,the location of excellent organisations,cities'international collaboration patterns,and their scientific field ***,the paper examines the fundamental differences between the general factors influencing the publishing efficiency of the top 100 most efficient cities and the bottom 100 least efficient ***:Based on the research results,the conclusion can be drawn that a city's publishing efficiency will be high if meets the following general conditions:it is in a country in the Anglosphere-Core;it is in a high-income country;it is home to top-ranked universities and/or world-renowned research institutions;researchers affiliated with that city most intensely collaborate with researchers affiliated with cities in the United States,Germany,England,France,Canada,Australia,and Italy;and the most productive scientific disciplines of highly cited articles are publi

关键词： Cities publishing efficiency Spatial scientometrics Highly cited articles Web of Science

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First-line eradication of Helicobacter pylori:Are the standard triple therapies obsolete? A different perspective

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World Journal of Gastroenterology 2010年第31期16卷 3865-3870页

作者： gyrgy Miklós Buzás Department of Gastroenterology Fe-rencváros Health Service Non-Profit Ltd.

Studies concerning the eradication of Helicobacter pylori have resulted in a proliferation of meta-analyses. To date, there are 303 meta-analyses cited in pubMed, 113 dealing with the therapy of the infection. A chronological analysis of the results of meta-analyses performed between 1998 and 2010 shows that first-line standard triple therapies achieved eradication rates on an intention-to-treat basis of around 80%; prolonging treatment to 14, but not 10 d should improve the results. The proton pump inhibitors have a similar efficiency, and giving a double dose is more efficient than the standard doses of these drugs. Triple and quadruple therapies proved to be equivalent. Based on meta-analytical data, the decrease in efficiency over time cannot be substantiated: eradication rates ple therapies. As alternatives, ranitidine bismuth citrate-, levofloxacinor furazolidone-based therapies were shown to obtain the same eradication rates as standard triple regimens. Sequential therapies and quadruple non-bismuth-based therapies were superior to standard triple therapies but their use is limited to certain countries. In the author's opinion, and from a meta-analytical viewpoint, standard triple therapies cannot yet be considered obsolete. Furthermore, noninferiority trials are proposed for the future, including assessment of local contemporary antimicrobial resistance profi les and the CagA and CYp2C19 status of the enrolled patients.

关键词： Antibiotics Eradication Helicobacter pylori Meta-analysis

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Metabolic consequences of Helicobacter pylori infection and eradication

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World Journal of Gastroenterology 2014年第18期20卷 5226-5234页

作者： gy?rgy Miklós Buzás Department of Gastroenterology Ferencváros Health Centre1095 BudapestHungary

Helicobacter pylori(***)is still the most prevalent infection of the *** of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications(peptic ulcer,gastric cancer,lymphoma)and remote *** *** does not enter circulation,these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed *** epidemiologic link between the *** infection and metabolic changes is inconstant and *** delay was described mainly in low-income regions with high prevalence of the infection,where probably other nutritional and social factors contribute to *** timely eradication of the infection will lead to a more healthy development of the young population,along with preventing peptic ulcers and gastric cancer An increase of total,low density lipoprotein and high density liporotein cholesterol levels in some infected people creates an atherogenic lipid profile which could promote atherosclerosis with its complications,myocardial infarction,stroke and peripheral vascular *** designed and adequately powered long-term studies are required to see whether eradication of the infection will prevent these *** case of glucose metabolism,the most consistent association was found between *** and insulin resistance:again,proof that eradication prevents this common metabolic disturbance is *** results of eradication with standard regimens in diabetics are significantly worse than in non-diabetic patients,thus,more active regimens must be found to obtain better *** eradication itself led to an increase of body mass index and cholesterol levels in some populations,while in others no such changes were *** of the metabolic consequences of *** infection must be clarified in the future.

关键词： Diabetes mellitus Cytokines Glucose homeostasis Growth Helicobacter pylori Interleukins Lipid metabolism Metabolic syndrome

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