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Decomposition behavior of yttria-stabilized zirconia and its effect on directed energy deposited Ti-based composite material

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Journal of Materials Science & Technology 2022年第17期112卷 138-150页

作者： gwanghyo choi Won Seok choi Yoon Sun Lee Dahye Kim Ji Hyun Sung Seungjun An Chang-Seok Oh Amine Hattal Madjid Djemai Brigitte Bacroix Guy Dirras Pyuck-Pa choi Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea 3D Additive Manufacturing Application Tech.Center Korea Institute of Industrial TechnologyDaegu 42994Republic of Korea InssTek Co. Daejeon 04763Republic of Korea Korea Institute of Materials Science 797 ChangwondaeroChangwon 51508Republic of Korea UniversitéSorbonne Paris Nord Laboratoire des Sciences des Procédés et des MatériauxLSPMCNRSUPR 3407F-93430VilletaneuseFrance Z3Dlab Parc Technologique26 Rue des SablonsMontmagny 95360France CNRS UPR3407Laboratoire des Sciences des Procédés et des MatériauxLSPMUniversitéSorbonne Paris NordF-93430VilletaneuseFrance

We report on the microstructure and the strengthening mechanisms of additively manufactured parts fabricated by directed energy deposition of Ti-6Al-4V(Ti64)powders blended with yttria-stabilized zirconia(YSZ)*** specimens showed refined microstructures as compared to bare as-deposited Ti64,where theαand columnar priorβgrain sizes decreased with increasing YSZ *** YSZ nanoparticles decomposed during the deposition process and led to the formation of yttrium oxide and some excess oxygen in the Ti64 *** decrease in the sizes of the priorβgrains could be attributed to the increasing amount of dissolved oxygen and yttrium,which promoted constitutional ***,the reduction in the size of theαgrains could be ascribed to a shift of the onset of theβ→α+βtransformation to a higher temperature and shorter time with increasing concentration of dissolved ***,the contributions of the underlying strengthening mechanisms for the as-deposited specimens were quantitatively determined.

关键词： Additive manufacturing Directed energy deposition Metal matrix composites Titanium alloys Yttrium-stabilized zirconia

Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

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Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Examples and effects of avalanches on the surface of mountain lakes:Morskie Oko,a case study from Poland(Tatra Mountains)

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Journal of Mountain Science 2025年第2期22卷 375-390页

作者： Adam choiŃSKI Wojciech DENEGA Andrzej MACIAS Witold PINIARSKI Department of Hydrology and Water Management Faculty of Geographical and Geological SciencesAdam Mickiewicz UniversityPoznań61680Poland Independent Researcher Poland Landscape Ecology Research Unit Faculty of Geographical and Geological SciencesAdam Mickiewicz UniversityPoznań61680Poland

This study represents a pioneering effort to analyze the impact of avalanches descending into Morskie Oko from Marchwiczny Gully,the most active avalanche path around the *** focuses on catastrophic avalanches that descended from the analyzed gully,as reported in the literature from the 1900s until ***,only the data collected in recent years,our field studies,combined with modern LIDAR data and GIS-based modeling,allowed us to perform a detailed *** GIS-based approach effectively uses spatial data to address snow avalanche modeling *** the study area lies within Tatra National Park,no official services carry out systematic avalanche monitoring or *** impact of hazardous events,such as snow avalanches,on the most famous Polish mountain lake,Morskie Oko,has been poorly described in the literature and has yet to be ***,to analyze the selected avalanche parameters,we mainly used our ground and additional aerial photographs taken by local mountain services and related field *** analysis resulted in figurative estimates of the extent and volume of avalanche snow and its weight,both on the surface of the ice sheet and the part of the avalanche that did not reach the lake's shore and remained on the slope of Marchwiczny *** example,the values for the mighty avalanche on February 3,2023,are 23,500 m~3 and 4,700 tons on the ice surface and 20,000 m~3 and 4,000 tons on the *** was determined that avalanches that descend onto the studied lake's surface result in its *** process occurs because of sedimentation of slope material carried by avalanches,especially during the final phase of ice cover *** openings appear in the solid ice cover in spring,floating ice can migrate,driven by wind pressure,and deposit avalanche material in various parts of the lake ***,avalanches contributed to the gradual disappearance of the lake.

关键词： Snow avalanches Mountain lakes Sedimentation Morskie Oko Tatra Mountains Avalanche modeling

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji Hyun Song Su-Yeon choi Young Sun Kim Sun Young Yang Kyung-Do Han Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using ***,even in participants without diabetes,a higher CV risk was associated with an increased CRC *** Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

Enhanced methanol production from photothermal CO2 reduction via multilevel interface design

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Nano Research 2025年第2期18卷 235-241页

作者： Hongmin Wang Bo Shang Chungseok choi Sungho Jeon Yuanzuo Gao Tyler Wang Nia J.Harmon Mengxia Liu Eric A.Stach Hailiang Wang Department of Chemistry Yale UniversityNew HavenCT 06520USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA School of Materials Science and Engineering Southeast UniversityNanjing 211189China Current address:SKKU Advanced Institute of Nanotechnology and Department of Nanoengineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Physics Yale UniversityNew HavenCT 06511USA Department of Electrical Engineering Yale UniversityNew HavenCT 06511USA

Photothermal CO_(2) hydrogenation is a promising route to produce methanol as a sustainable liquid solar ***,most existing catalysts require a combination of solar irradiation and additional heat input to achieve a satisfactory reaction *** the few that can be driven solely by light,their reaction rates are one order of magnitude *** develop a photothermal catalyst with multilevel interfaces that achieves improvedmethanol production from photothermal CO_(2) hydrogenation without external *** catalyst features a layered structure comprising Cu/ZnO/Al_(2)O_(3)(CZA)covered by oxidized carbon black(oCB),where the oCB/CZA interface promotes efficient heat generation and transfer,and the Cu/oxide interface contributes to high catalytic *** a mild pressure of 8 bar,our oCB/CZA catalyst shows a methanol selectivity of 64.7%with a superior production rate of 4.91 mmol-geza-1-h-1,at least one order of magnitude higher than other photothermal catalysts solely driven by *** work demonstrates a photothermal catalyst design strategy for liquid solar fuel production.

关键词： photothermal catalysis CO_(2)hydrogenation methanol production solar fuel multilevel interface Cu/ZnO/Al_(2)O_(3)(CZA)catalyst