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Emerging role of liquid.biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel Gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista id.lia Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepid.rmal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid.biopsy may provid. an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid.biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epid.rmal growth factor receptor therapy Case report

ADVANCED SYNTHESIS OF LIGHT METALS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 531-536页

作者： F.H. Froes(IMAP, University of id.ho, Moscow, id.838443026, USA ) Univ of id.ho Moscow United States

The synthesis, processing and mechanical properties of the light metals, aluminum,magnesium and titanium Produced by advanced techniques are reviewed. Synthesis techniques to be addressed will include rapid.solid.fica... 详细信息

关键词： synthesis/processing powder metallurgy lightweight metals,aluminum magnesium,titanium rapid.solid.fication spray depositin mechanical alloying Plasma processing,vapor deposition

Impact of China’s Outward Foreign Direct Investment on Enterprise Performance

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Journal of Donghua University(English Edition) 2019年第5期36卷 513-520页

作者： XU Qiqi WANG Lei id.Bouichou Said Glorious Sun School of Business and Management Donghua University

The present study seeks to address two fundamental questions.(1)Does outward foreign direct investment(OFDI)enhance enterprise performance ultimately?(2)How does this effect come about?A new dataset from the years 2011 to 2016 based on the micro-data of 88 Chinese multinational-listed enterprises was used to test research hypotheses with the mediating effect modeling *** study results reveal that:(1)the investment intensity has a positive influence,while investment span has a negative influence on enterprise performance;(2)the enhanced innovation capability can consid.rably increase the enterprise performance,while investment intensity and span both hinder the upgrading of innovation capability;and(3)the innovation capability of an enterprise plays a partial intermediary role among investment span and enterprise ***,there is no mediating effect between investment intensity,innovation ability,and enterprise performance.

关键词： outward foreign direct investment(OFDI) enterprise performance innovation capability mediating effect

Depth to the bottom of magnetic layer in South America and its relationship to Curie isotherm,Moho depth and seismicity behavior

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Geodesy and Geodynamics 2018年第1期9卷 93-107页

作者： Javier id.rraga-García Carlos A.Vargas Research Group on Geophysics Universidad Nacional de ColombiaBogotáColombia Deportment of Geosciences.Universid.d Nacional de Colombia.Bogota.Colombia

We have estimated the DBML（depth to the bottom of the magnetic layer） in South America from the inversion of magnetic anomaly data extracted from the EMAG2 grid. The results show that the DBML values, interpreted as the Curie isotherm, vary between -10 and -60 km. The deepest values（〉-45） are mainly observed forming two anomalous zones in the central part of the Andes Cordillera. To the east of the Andes, in most of the stable cratonic area of South America, intermediate values（between -25 and-45 km） are predominant. The shallowest values（〈-25 km） are present in northwestern corner of South America, southern Patagonia, and in a few sectors to the east of the Andes Cordillera. Based on these results, we estimated the heat flow variations along the study area and found a very good correlation with the DBML. Also striking is the observation that the thermal anomalies of low heat flow are closely related to segments of flat subduction, where the presence of a cold and thick subducting oceanic slab beneath the continent, with a virtual absence of hot mantle wedge, leads to a decrease in the heat transfer from the deeper parts of the *** comparing our results with the Moho depths reported by other authors, we have found that the Curie isotherm is deeper than Moho in most of the South American Platform（northward to -20°S）, which is located in the stable cratonic area at the east of the Andes. This is evid.nce that the lithospheric mantle here is magnetic and contributes to the long wavelength magnetic signal. Also, our results support the hypothesis that the Curie isotherm may be acting as a boundary above which most of the crustal seismicity is concentrated. Below this boundary the occurrence of seismic events decreases dramatically.

关键词： Magnetic layer depth Curie isotherm Heat flow Crustal seismicity Flat subduction South America

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作者： id.Book工作室

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Influence of Process Variables on the Structure of Mechanically Alloyed Ti_3Al-base Intermetallics

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Rare Metals 1993年第4期12卷 241-249页

作者： Chen Guohao Suryanarayana C.and Froes F.H.(Sam)Institute for Materials and Advanced Processes,University of id.ho,Moscow,id.83843-4195,U.S.A. University of id.ho 美国

During mechanical alloying variables such as the type of mill,milling intensity,milling time,milling at- mosphere and ball-to-powder weight ratio(BPR)affect the morphology and constitution of the product. The effect of milling time,milling atmosphere and BPR on the nature of the product formed in mechanical- ly alloyed pure Ti and blended elemental binary Ti-Al,and ternary Ti-AI-Nb alloy powders was described. Mechanical alloying of pure titanium results,after long milling times,in the formation of an fcc *** the binary alloy,a solid.solution of aluminum in titanium,an amorphous phase,and a fcc phase form with increasing milling *** fcc phase,which is probably a result of TiN formation,occurs more rapid.y in air or nitrogen than in an inert *** of the B2 phase in the ternary alloys depends both on alloy composition and the milling atmosphere,with 100％ formation in all atmospheres in Ti-25Al-25Nb but not in Ti-24Al-11Nb,and an inert atmosphere favoring *** times required for the formation of the different phases decrease as the BPR increases;but their sequence is *** on this infor- mation,“milling maps”which describe phase formation as a function of the BPR and milling time are con- *** from the milling balls increased as the BPR was increased.

关键词： Mechanical alloying Titanium alloys Structure evolution Process variables Milling maps