检索结果-南通市图书馆

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

引用

Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang guyan wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Shizhang Bei (Sitsan Pai) and his theory of cell reformation

引用

Protein & Cell 2010年第4期1卷 315-318页

作者： guyan wang Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

THE DISCOVERY OF THE PHENOMENON OF CELL REFORMATION For a long period of time,people always studied the cell reproduction and proliferation from the traditional viewpoints and in particular focused on cell division and *** division was thought to be the only way of cell reproduction and proliferation,little attention was drawn to other *** the spring of 1932,Professor Shizhang Bei(Sitsan Pai)found an intersex strain of Chirocephalus nankinensis,which belongs to Phyllopod of Crustacea,among the specimens collected in a paddy field of Songmuchang on the outskirts of *** of intersex has characteristics of both sexes at the same time during a certain period of development stage,and intersex in Chirocephalus has not been recorded before.

关键词： paddy ang FORMAT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protection of Ndrg2 deficiency on renal ischemia-reperfusion injury via activating PINK1/Parkin-mediated mitophagy

引用

中华医学杂志(英文版) 2024年第21期137卷 2603页

作者： Liu Min Chen Jianwen Sun Miao Zhang Lixia Yu Yao Mi Weidong Ma Yulong wang guyan Department of Anesthesiology Beijing Tongren Hospital Capital Medical University Beijing China Department of Nephrology The First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People’s Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China Department of Anesthesiology The First Affiliated Hospital Jinzhou Medical University Jinzhou Liaoning China Department of Burn and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China Department of Anesthesiology Peking University Third Hospital Beijing China Department of Anesthesiology Chinese PLA General Hospital Beijing China Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital Beijing China

Background: Renal ischemia-reperfusion (R-I/R) injury is the most prevalent cause of acute kidney injury, with high mortality and poor prognosis. However, the underlying pathological mechanisms are not yet fully understood. Therefore, this study aimed to investigate the role of N-myc downstream-regulated gene 2 (Ndrg2) in R-I/R ***: We examined the expression of Ndrg2 in the kidney under normal physiological conditions and after R-I/R injury by immunofluorescence staining, real-time polymerase chain reaction, and western blotting. We then detected R-I/R injury in Ndrg2-deficient (Ndrg2-/-) mice and wild type (Ndrg2+/+) littermatesin vivo, and detected oxygen and glucose deprivation and reperfusion (OGD-R) injury in HK-2 cells. We further conducted transcriptomic sequencing to investigate the role ofNdrg2 in R-I/R injury and detected levels of oxidative stress and mitochondrial damage by dihydroethidium staining, biochemical assays, and western blot. Finally, we measured the levels of mitophagy inNdrg2+/+ andNdrg2-/- mice after R-I/R injury or HK-2 cells in OGD-R ***: Ndrg2 was primarily expressed in renal proximal tubules and its expression was significantly decreased 24 h after R-I/R ***2-/- mice exhibited significantly attenuated R-I/R injury compared toNdrg2+/+ mice. Transcriptomics profiling showed thatNdrg2 deficiency induced perturbations of multiple signaling pathways, downregulated inflammatory responses and oxidative stress, and increased autophagy following R-I/R injury. Further studies revealed thatNdrg2 deficiency reduced oxidative stress and mitochondrial damage. Notably,Ndrg2 deficiency significantly activated phosphatase and tensin homologue on chromosome ten-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy. The downregulation of NDRG2 expression significantly increased cell viability after OGD-R injury, increased the expression of heme oxygenase-1, decreased the expression of nicotinamide adenine dinucleotide

关键词： Ischemia-reperfusion injury N-myc downstream-regulated gene 2 Mitophagy Oxidative stress Renoprotection Oxygen and glucose deprivation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

引用

Chinese Medical Journal 2023年第24期136卷 2983-2992页

作者： Yingjie Du Yunfeng Li Xiangting Zhao Yishan Yao Bin wang Liming Zhang guyan wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijing 100850China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases Basic Medical College of Jiamusi University JiamusiHeilongjiang 154000China

Background:Posttraumatic stress disorder(PTSD)and depression are highly *** exerts substantial therapeutic effects on depression by promoting *** extinction is a key process in the mechanism of first-line exposure-based therapies for *** hypothesized that psilocybin would facilitate fear extinction by promoting hippocampal ***:First,we assessed the effects of psilocybin on percentage of freezing time in an auditory cued fear conditioning(FC)and fear extinction paradigm in *** was administered 30 min before extinction *** extinction testing was performed on the first day;fear extinction retrieval and fear renewal were tested on the sixth and seventh days,***,we verified the effect of psilocybin on hippocampal neuroplasticity using Golgi staining for the dendritic complexity and spine density,Western blotting for the protein levels of brain derived neurotrophic factor(BDNF)and mechanistic target of rapamycin(mTOR),and immunofluorescence staining for the numbers of doublecortin(DCX)-and bromodeoxyuridine(BrdU)-positive ***:A single dose of psilocybin(2.5 mg/kg,i.p.)reduced the increase in the percentage of freezing time induced by FC at 24 h,6th day and 7th day after *** terms of structural neuroplasticity,psilocybin rescued the decrease in hippocampal dendritic complexity and spine density induced by FC;in terms of neuroplasticity related proteins,psilocybin rescued the decrease in the protein levels of hippocampal BDNF and mTOR induced by FC;in terms of neurogenesis,psilocybin rescued the decrease in the numbers of DCX-and BrdU-positive cells in the hippocampal dentate gyrus induced by ***:A single dose of psilocybin facilitated rapid and sustained fear extinction;this effect might be partially mediated by the promotion of hippocampal *** study indicates that psilocybin may be a useful adjunct to exposure-based therap

关键词： Brain-derived neurotrophic factor Bromodeoxyuridine Depression Doublecortin domain proteins Extinction,psychological Freezing Hippocampus Neuronal plasticity Psilocybin Stress disorders,post-traumatic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heparin-free veno-venous extracorporeal membrane oxygenation in non-trauma patients with difficult airways for surgery

引用

Chinese Medical Journal 2023年第10期136卷 1251-1252页

作者： Hongya Chen Jinsheng Liu Lili Wu Cunliang Ji Tong Li guyan wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Intensive Care Unit Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

To the Editor:For patients with critical tracheal stenosis in surgery,extracorporeal membrane oxygenation(ECMO)is probably the last,yet safest,choice to ensure definitive airway *** anticoagulation in the form of heparin is a typical ***,heparin is fraught with its own complications that include both bleeding in the patient and clotting within the circuitry.

关键词： airway surgery patients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6

引用

Chinese Medical Journal 2022年第20期135卷 2467-2477页

作者： Yimeng Chen Congya Zhang Yingjie Du Xiying Yang Min Liu Wenjing Yang Guiyu Lei guyan wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Weifang Medical University School of AnesthesiologyShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaWeifangShandong 261053China

Background:Acute kidney injury(AKI)is a common complication in patients,especially elderly patients,who undergo cardiac surgery with cardiopulmonary *** have indicated a protective role of autophagy in ***,the mechanisms underlying the regulatory effect of autophagy in AKI among patients undergoing cardiac surgeries are poorly *** this study,we aimed to test the hypothesis that exosomal microRNAs(miRNAs)regulate autophagy in tubular epithelial cells after ***:Plasma exosomal RNA was extracted from young and elderly AKI patients undergoing cardiac surgery,and the miRNAs expression during the perioperative period were analyzed using next-generation *** screened miRNAs and their target genes were subjected to gene oncology function and Kyoto Encyclopedia of Genes and Genome enrichment *** tubular epithelial cell line(HK-2 cells)was cultured and hypoxia/reoxygenation(H/R)model was established,which is an in vitro renal ischemia/reperfusion(I/R)*** used Western blot analysis,cell viability assay,transfection,luciferase assay to investigate the mechanisms underlying the observed increases in the levels of renal I/R injury-mediated exosomal miRNAs and their roles in regulating HK-2 cells ***:miR-590-3p was highly enriched in the plasma exosomes of young AKI patients after cardiac *** levels of miR-590-3p led to the increases in the expression of autophagy marker proteins,including Beclin-1 and microtubule associated protein 1 light chain 3 beta(LC3II),and prolonged the autophagic response in HK-2 cells after H/R *** effects were achieved mainly via increases in the exosomal miR-590-3p levels,and the tumor necrosis factor receptor-associated factor 6 protein was shown to play a key role in I/R injury-mediated autophagy ***:Exosomes released from HK-2 cells after renal I/R injury regulate autophagy by transferring miR-590-3p in a paracrine manner,which sug

关键词： Acute kidney injury Autophagy Exosome Hypoxia Ischemia miR-590-3p Reperfusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

做好眼科麻醉的几点思考

引用

中华医学杂志 2022年第21期102卷 1564-1567页

作者：甘小亮王古岩中山大学中山眼科中心麻醉科中山大学眼科学国家重点实验室广州510060 首都医科大学附属北京同仁医院麻醉科北京100730

由于大部分眼科手术在局部麻醉(球后阻滞或者表面麻醉)下完成,麻醉操作由手术医师兼顾,从而导致眼科麻醉经验不够,影响了眼科麻醉的质量与效率。笔者认为,做好眼科麻醉需要帮助患者做好术前准备,充分利用声门上通气技术和清醒镇静技术,... 详细信息

由于大部分眼科手术在局部麻醉(球后阻滞或者表面麻醉)下完成,麻醉操作由手术医师兼顾,从而导致眼科麻醉经验不够,影响了眼科麻醉的质量与效率。笔者认为,做好眼科麻醉需要帮助患者做好术前准备,充分利用声门上通气技术和清醒镇静技术,完善B超引导的眼部区域阻滞技术,加强与眼科手术医师的合作交流,从而满足眼科手术患者对舒适化的麻醉要求及适应日间手术的发展趋势。

关键词：麻醉眼科学清醒镇静球后阻滞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抗击新型冠状病毒肺炎疫情:麻醉相关感染控制的改良

引用

中华麻醉学杂志 2020年第3期40卷 257-261页

作者：王古岩郭向阳首都医科大学附属北京同仁医院麻醉科 100730 北京大学第三医院麻醉科 100191

新型冠状病毒肺炎(新冠肺炎)疫情引起包括中国在内的全世界各国人民密切关注。面对疫情,麻醉医师对于标准预防、消毒隔离、手卫生、环境物表卫生、无菌操作、职业防护等感染控制方面的专业知识和实践操作有待提高和规范。本文结合新冠... 详细信息

新型冠状病毒肺炎(新冠肺炎)疫情引起包括中国在内的全世界各国人民密切关注。面对疫情,麻醉医师对于标准预防、消毒隔离、手卫生、环境物表卫生、无菌操作、职业防护等感染控制方面的专业知识和实践操作有待提高和规范。本文结合新冠肺炎疫情,针对中国麻醉感染控制存在的主要问题,梳理了相关的法律、法规、规范要求,提出如下建议。(1)在标准预防方面,在诊治疑似或确诊患者时,麻醉科医护人员应按照三级防护措施进行穿戴防护用具,包括戴N95医用防护口罩,护目镜或面屏,穿防护服等。(2)在手卫生方面,对新冠肺炎确诊或疑似病例进行麻醉时,应严格按照手卫生的规范要求进行洗手或卫生手消毒。在实施各类操作时,麻醉医师应戴双层手套;接触患者后,如需要碰触麻醉机等或其他区域,应脱掉并丢弃外层手套。(3)在环境物表卫生方面,对新冠肺炎疑似或确诊病例手术时,麻醉医师要对发生小面积的患者血液等污染及时清洁和消毒。手术后,严格执行《医疗机构消毒技术规范》,做好手术室(空气、物体表面、地面等)、医疗器械、患者用物等的清洁消毒,严格终末消毒,尤其不能忽略手频繁接触的物表。(4)在麻醉机消毒方面,面对新冠肺炎疫情,建议联合使用麻醉内回路消毒机与在呼气端及吸气端同时使用呼吸通路过滤器。首选高效低容量的疏水性过滤器,以使细菌和病毒清除率>99.999%,每3~4 h更换1次。(5)在隔离方面,新冠肺炎确诊或疑似病例应当在负压手术室进行手术。应有医务人员通知层流工程技术人员及时检查,必要时更换负压手术间高效过滤器。(6)其他方面,对新冠肺炎患者进行麻醉时,应谨慎处理麻醉操作中的锐器,防止刺伤,一旦发生应立即启动医源性职业暴露处理流程。

关键词：新型冠状病毒肺炎麻醉感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

五官科手术麻醉气道与循环管理的核心技术

引用

中华医学杂志 2022年第21期102卷 1559-1563页

作者：杨文婧王古岩首都医科大学附属北京同仁医院麻醉科北京100730

随着麻醉技术、设备以及研究领域的不断更新,五官科手术麻醉的技术与理念也在不断地优化发展。五官科手术麻醉有其独特的技术特点及难题,本文结合国内外相关文献及自身经验,对五官科手术麻醉中的常见问题如困难气道的处理、共用气道的... 详细信息

随着麻醉技术、设备以及研究领域的不断更新,五官科手术麻醉的技术与理念也在不断地优化发展。五官科手术麻醉有其独特的技术特点及难题,本文结合国内外相关文献及自身经验,对五官科手术麻醉中的常见问题如困难气道的处理、共用气道的通气维持、气道高反应的预防及处理、控制性降压的进展等进行分析和探讨,对各类技术的优缺点进行总结和评价。

关键词：麻醉困难气道控制性降压气道高反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

复方甘菊利多卡因凝胶对喉罩正压通气患者术后口咽部并发症的影响

引用

中华医学杂志 2023年第31期103卷 2420-2426页

作者：王惠军王珊珊王古岩首都医科大学附属北京同仁医院麻醉科北京100730

目的评估复方甘菊利多卡因凝胶对喉罩正压通气患者术后口咽部并发症的影响。方法前瞻性选取首都医科大学附属北京同仁医院2023年1至3月在全身麻醉喉罩正压通气下行择期手术的患者64例,采用随机数字表法分为2组:生理盐水组(n=32),男18例,... 详细信息

目的评估复方甘菊利多卡因凝胶对喉罩正压通气患者术后口咽部并发症的影响。方法前瞻性选取首都医科大学附属北京同仁医院2023年1至3月在全身麻醉喉罩正压通气下行择期手术的患者64例,采用随机数字表法分为2组:生理盐水组(n=32),男18例,女14例,年龄28~64(48.4±10.6)岁;复方甘菊利多卡因凝胶组(简称甘菊凝胶组,n=32),男18例,女14例,年龄24~64(46.3±10.8)岁。两组患者都采用全凭静脉麻醉,生理盐水组喉罩置入前,对喉罩的前、肩、背部进行生理盐水润滑处理,甘菊凝胶组使用复方甘菊利多卡因凝胶润滑处理。主要观察指标为喉罩拔除后0.5、3.0、6.0、24.0 h不同时间点的术后口咽黏膜炎发生率;次要观察指标包括喉罩拔除后不同时间点的口咽黏膜炎评分、咽喉痛评分、声音嘶哑评分、咳嗽评分和咽干评分,喉罩置入次数、成功置入用时和漏气压,拔除喉罩前后的呛咳、躁动等应激反应和苏醒期舌麻、保护性咽反射受限等不良反应发生率。结果甘菊凝胶组患者的口咽黏膜炎发生率在喉罩拔除后0.5、3.0、6.0、24.0 h分别为25.0%(8/32)、31.3%(10/32)、28.1%(9/32)和3.1%(1/32),均低于生理盐水组的53.1%(17/32)、59.4%(19/32)、59.4%(19/32)和21.9%(7/32)(均P0.05);两组患者均未见拔除喉罩前后的呛咳、躁动等应激反应和苏醒期舌麻、保护性咽反射受限等不良反应。结论复方甘菊利多卡因凝胶用于全身麻醉喉罩正压通气手术患者,可降低术后口咽黏膜炎的发生率,减轻术后口咽黏膜炎、咽干和咳嗽的症状,提高患者术后的舒适度。

关键词：间歇正压通气复方甘菊利多卡因凝胶生理盐水喉罩黏膜炎

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：